BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D' and Ligand = 'BDBM50064858'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50064858 ((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Displacement of [3H]rolipram binding to guinea pig brain membrane				Bioorg Med Chem Lett 8: 175-8 (1998) BindingDB Entry DOI: 10.7270/Q26T0PTS
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50064858 ((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Inhibition of guinea pig macrophage Phosphodiesterase 4				Bioorg Med Chem Lett 8: 175-8 (1998) BindingDB Entry DOI: 10.7270/Q26T0PTS
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50064858 ((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 4 carried out in the cytosol of human neutrophils				J Med Chem 45: 2526-33 (2002) Article DOI: 10.1021/jm0110338 BindingDB Entry DOI: 10.7270/Q24F1TFG
Vrije Universiteit Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50064858 ((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Inhibitory concentration against phosphodiesterase 4 (PDE4) in cytosol of human neutrophils				J Med Chem 45: 2520-5 (2002) Article DOI: 10.1021/jm0110340 BindingDB Entry DOI: 10.7270/Q2862K56
Vrije Universiteit Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50064858 ((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibitory activity on human eosinophil phosphodiesterase 4.				J Med Chem 41: 2268-77 (1998) Article DOI: 10.1021/jm9800090 BindingDB Entry DOI: 10.7270/Q27S7RH6
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair