Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D' and Ligand = 'BDBM50134434'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50134434 (CHEMBL3746046) Show SMILES Cc1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c3C(=O)NCCc3nc12)S(C)(=O)=O Show InChI InChI=1S/C17H15Cl2N5O3S/c1-8-14-22-12-3-4-20-16(25)13(12)15(24(14)23-17(8)28(2,26)27)21-11-6-9(18)5-10(19)7-11/h5-7,21H,3-4H2,1-2H3,(H,20,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Research Center Curated by ChEMBL					Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP				Bioorg Med Chem Lett 26: 454-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M
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