Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D' and Ligand = 'BDBM50215957'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50215957 (CHEMBL55867) Show SMILES Cc1cn(C2CCCC2)c2cc(ccc12)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C20H19Cl2N3O/c1-12-11-25(14-4-2-3-5-14)18-8-13(6-7-15(12)18)20(26)24-19-16(21)9-23-10-17(19)22/h6-11,14H,2-5H2,1H3,(H,23,24,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	374	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assay				Bioorg Med Chem Lett 8: 1867-72 (1998) BindingDB Entry DOI: 10.7270/Q2CJ8GPB
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50215957 (CHEMBL55867) Show SMILES Cc1cn(C2CCCC2)c2cc(ccc12)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C20H19Cl2N3O/c1-12-11-25(14-4-2-3-5-14)18-8-13(6-7-15(12)18)20(26)24-19-16(21)9-23-10-17(19)22/h6-11,14H,2-5H2,1H3,(H,23,24,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase type IV (PDE4) obtained from guinea-pig macrophage was evaluated				Bioorg Med Chem Lett 8: 1867-72 (1998) BindingDB Entry DOI: 10.7270/Q2CJ8GPB
					More data for this Ligand-Target Pair