Found 4 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D' and Ligand = 'BDBM50219405' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219405
(CHEMBL81020)Show SMILES CNC(=O)N1Cc2cc(OC)ccc2C(Cc2c(Cl)cncc2Cl)=N1 |c:25| Show InChI InChI=1S/C17H16Cl2N4O2/c1-20-17(24)23-9-10-5-11(25-2)3-4-12(10)16(22-23)6-13-14(18)7-21-8-15(13)19/h3-5,7-8H,6,9H2,1-2H3,(H,20,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 235 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zambon Group
Curated by ChEMBL
| Assay Description Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4) |
Bioorg Med Chem Lett 12: 5-8 (2002)
BindingDB Entry DOI: 10.7270/Q2SB47Z5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219405
(CHEMBL81020)Show SMILES CNC(=O)N1Cc2cc(OC)ccc2C(Cc2c(Cl)cncc2Cl)=N1 |c:25| Show InChI InChI=1S/C17H16Cl2N4O2/c1-20-17(24)23-9-10-5-11(25-2)3-4-12(10)16(22-23)6-13-14(18)7-21-8-15(13)19/h3-5,7-8H,6,9H2,1-2H3,(H,20,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
Zambon Group
Curated by ChEMBL
| Assay Description Inhibition of human neutrophil phosphodiesterase type IV (PDE4) |
Bioorg Med Chem Lett 12: 5-8 (2002)
BindingDB Entry DOI: 10.7270/Q2SB47Z5 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219405
(CHEMBL81020)Show SMILES CNC(=O)N1Cc2cc(OC)ccc2C(Cc2c(Cl)cncc2Cl)=N1 |c:25| Show InChI InChI=1S/C17H16Cl2N4O2/c1-20-17(24)23-9-10-5-11(25-2)3-4-12(10)16(22-23)6-13-14(18)7-21-8-15(13)19/h3-5,7-8H,6,9H2,1-2H3,(H,20,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against phosphodiesterase 4. |
Bioorg Med Chem Lett 13: 2473-9 (2003)
BindingDB Entry DOI: 10.7270/Q24F1SXB |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219405
(CHEMBL81020)Show SMILES CNC(=O)N1Cc2cc(OC)ccc2C(Cc2c(Cl)cncc2Cl)=N1 |c:25| Show InChI InChI=1S/C17H16Cl2N4O2/c1-20-17(24)23-9-10-5-11(25-2)3-4-12(10)16(22-23)6-13-14(18)7-21-8-15(13)19/h3-5,7-8H,6,9H2,1-2H3,(H,20,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against phosphodiesterase 4. |
Bioorg Med Chem Lett 13: 2473-9 (2003)
BindingDB Entry DOI: 10.7270/Q24F1SXB |
More data for this Ligand-Target Pair | |