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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A' and Ligand = 'BDBM50125073'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))		BDBM50125073
PNG
(CHEMBL164199 | {5-[1-(3,4-Bis-difluoromethoxy-phen...)
Show SMILES Cc1ccc(CCNc2ccc(cn2)C(Cc2cc[n+]([O-])cc2)c2ccc(OC(F)F)c(OC(F)F)c2)cc1
Show InChI InChI=1S/C29H27F4N3O3/c1-19-2-4-20(5-3-19)10-13-34-27-9-7-23(18-35-27)24(16-21-11-14-36(37)15-12-21)22-6-8-25(38-28(30)31)26(17-22)39-29(32)33/h2-9,11-12,14-15,17-18,24,28-29H,10,13,16H2,1H3,(H,34,35)
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PC cid
PC sid
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Similars
PubMed
n/an/a 2.30n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against human PDE4A expressed isoform using construct representing the common region of spliced variants as GST-fusion protein in...

Bioorg Med Chem Lett 13: 741-4 (2003)


BindingDB Entry DOI: 10.7270/Q2PG1R3G
More data for this
Ligand-Target Pair