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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM354663'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM354663
PNG
(US9809582, Example 5)
Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNCC(C(=O)OC2CCN(C)CC2)c2ccccc2)s1 |r|
Show InChI InChI=1S/C36H39Cl2N3O7S/c1-40-15-13-25(14-16-40)47-35(42)28(23-7-5-4-6-8-23)20-39-19-26-10-12-34(49-26)36(43)48-32(18-27-29(37)21-41(44)22-30(27)38)24-9-11-31(45-2)33(17-24)46-3/h4-12,17,21-22,25,28,32,39H,13-16,18-20H2,1-3H3/t28?,32-/m0/s1
PDB

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US Patent
n/an/a<1n/an/an/an/an/an/a



CHIESI FARMACEUTICI S.p.A.

US Patent


Assay Description
PDE4B2 activity is detected using the LANCE Ultra cAMP homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay from Perkin E...

US Patent US9809582 (2017)


BindingDB Entry DOI: 10.7270/Q2H1345N
More data for this
Ligand-Target Pair