Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM50199693'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50199693 (CHEMBL3948448) Show SMILES CCOc1cc(cc(c1)-c1cccc(c1)-c1cc(NC(=O)Nc2c(Cl)cncc2Cl)c(=O)n(CC)n1)C(=O)NC1CC1 Show InChI InChI=1S/C30H28Cl2N6O4/c1-3-38-29(40)26(35-30(41)36-27-23(31)15-33-16-24(27)32)14-25(37-38)18-7-5-6-17(10-18)19-11-20(13-22(12-19)42-4-2)28(39)34-21-8-9-21/h5-7,10-16,21H,3-4,8-9H2,1-2H3,(H,34,39)(H2,33,35,36,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydrolysis to [3H]AMP incubated for 60 mins by PDE-SPA assay				J Med Chem 59: 10479-10497 (2016) Article DOI: 10.1021/acs.jmedchem.6b00829 BindingDB Entry DOI: 10.7270/Q21G0P75
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