Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus) | BDBM50042058 ((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosol | J Med Chem 41: 821-35 (1998) Article DOI: 10.1021/jm970090r BindingDB Entry DOI: 10.7270/Q2WD439M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human)) | BDBM50042058 ((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE4C | J Med Chem 50: 344-9 (2007) Article DOI: 10.1021/jm060904g BindingDB Entry DOI: 10.7270/Q2K0753Z | |||||||||||
More data for this Ligand-Target Pair |