Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM284710'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284710 (US10023575, Example 1 | US10479794, Example 1 | US...) Show SMILES Fc1cc(ccc1C1(CCOCC1)NC(=O)c1cnn2cc(cnc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C22H20F4N4O2/c23-18-9-15(22(24,25)26)3-4-17(18)21(5-7-32-8-6-21)29-20(31)16-11-28-30-12-14(13-1-2-13)10-27-19(16)30/h3-4,9-13H,1-2,5-8H2,(H,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26H4NHR
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284710 (US10023575, Example 1 | US10479794, Example 1 | US...) Show SMILES Fc1cc(ccc1C1(CCOCC1)NC(=O)c1cnn2cc(cnc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C22H20F4N4O2/c23-18-9-15(22(24,25)26)3-4-17(18)21(5-7-32-8-6-21)29-20(31)16-11-28-30-12-14(13-1-2-13)10-27-19(16)30/h3-4,9-13H,1-2,5-8H2,(H,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10875867 (2020) BindingDB Entry DOI: 10.7270/Q2WQ06W2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284710 (US10023575, Example 1 | US10479794, Example 1 | US...) Show SMILES Fc1cc(ccc1C1(CCOCC1)NC(=O)c1cnn2cc(cnc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C22H20F4N4O2/c23-18-9-15(22(24,25)26)3-4-17(18)21(5-7-32-8-6-21)29-20(31)16-11-28-30-12-14(13-1-2-13)10-27-19(16)30/h3-4,9-13H,1-2,5-8H2,(H,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10479794 (2019) BindingDB Entry DOI: 10.7270/Q27083TT
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284710 (US10023575, Example 1 | US10479794, Example 1 | US...) Show SMILES Fc1cc(ccc1C1(CCOCC1)NC(=O)c1cnn2cc(cnc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C22H20F4N4O2/c23-18-9-15(22(24,25)26)3-4-17(18)21(5-7-32-8-6-21)29-20(31)16-11-28-30-12-14(13-1-2-13)10-27-19(16)30/h3-4,9-13H,1-2,5-8H2,(H,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...				US Patent US10023575 (2018) BindingDB Entry DOI: 10.7270/Q2KH0QCP
					More data for this Ligand-Target Pair