Compile Data Set for Download or QSAR

Found 16 hits Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM284781'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26H4NHR
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...				US Patent US10023575 (2018) BindingDB Entry DOI: 10.7270/Q2KH0QCP
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10875867 (2020) BindingDB Entry DOI: 10.7270/Q2WQ06W2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10479794 (2019) BindingDB Entry DOI: 10.7270/Q27083TT
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10875867 (2020) BindingDB Entry DOI: 10.7270/Q2WQ06W2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26H4NHR
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10479794 (2019) BindingDB Entry DOI: 10.7270/Q27083TT
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...				US Patent US10023575 (2018) BindingDB Entry DOI: 10.7270/Q2KH0QCP
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10875867 (2020) BindingDB Entry DOI: 10.7270/Q2WQ06W2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10479794 (2019) BindingDB Entry DOI: 10.7270/Q27083TT
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...				US Patent US10023575 (2018) BindingDB Entry DOI: 10.7270/Q2KH0QCP
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26H4NHR
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description All reactions were performed in 384 well plates, Perkin Elmer black optiplates and IMAP reaction buffer with 0.1% Tween20 (kit component)Compounds we...				US Patent US10023575 (2018) BindingDB Entry DOI: 10.7270/Q2KH0QCP
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q26H4NHR
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10479794 (2019) BindingDB Entry DOI: 10.7270/Q27083TT
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM284781 (US10023575, Example 72 | US10023575, Example 73 | ...) Show SMILES Cc1cnc2c(cnn2c1)C(=O)NC1(COCC1O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O3/c1-10-5-24-16-12(6-25-27(16)7-10)17(29)26-18(9-30-8-15(18)28)13-3-2-11(4-14(13)20)19(21,22)23/h2-7,15,28H,8-9H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US10875867 (2020) BindingDB Entry DOI: 10.7270/Q2WQ06W2
					More data for this Ligand-Target Pair