Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM442787'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442787 (US10647727, Example 44 | [7-({(1R)-1-[3-Fluoro-4-(...) Show SMILES Cc1cc(N[C@@H](c2ccc(c(F)c2)C(F)(F)F)C(C)(C)C)n2nc(CO)cc2n1 |r| Show InChI InChI=1S/C20H22F4N4O/c1-11-7-16(28-17(25-11)9-13(10-29)27-28)26-18(19(2,3)4)12-5-6-14(15(21)8-12)20(22,23)24/h5-9,18,26,29H,10H2,1-4H3/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	259	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
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