Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM50085599'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085599 (CHEMBL3427725 | US11419874, Example 29) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(COCC(F)(F)F)ccc1Cl Show InChI InChI=1S/C18H13ClF3N5O/c1-10-16-25-26-17(27(16)15-7-23-5-4-14(15)24-10)12-6-11(2-3-13(12)19)8-28-9-18(20,21)22/h2-7H,8-9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CR5XK9
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085599 (CHEMBL3427725 | US11419874, Example 29) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(COCC(F)(F)F)ccc1Cl Show InChI InChI=1S/C18H13ClF3N5O/c1-10-16-25-26-17(27(16)15-7-23-5-4-14(15)24-10)12-6-11(2-3-13(12)19)8-28-9-18(20,21)22/h2-7H,8-9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair