Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50258896 (CHEMBL4060569 | US11419874, TAK-915) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CR5XK9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50258896 (CHEMBL4060569 | US11419874, TAK-915) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay | J Med Chem 60: 7677-7702 (2017) Article DOI: 10.1021/acs.jmedchem.7b00807 BindingDB Entry DOI: 10.7270/Q2P271JR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |