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Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM50258935'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50258935
PNG
(CHEMBL4072924)
Show SMILES CCC(NC(=O)N1CC(=O)Nc2cccnc12)c1ccc(OC)cc1
Show InChI InChI=1S/C18H20N4O3/c1-3-14(12-6-8-13(25-2)9-7-12)21-18(24)22-11-16(23)20-15-5-4-10-19-17(15)22/h4-10,14H,3,11H2,1-2H3,(H,20,23)(H,21,24)
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Article
PubMed
n/an/a 610n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay

J Med Chem 60: 7677-7702 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00807
BindingDB Entry DOI: 10.7270/Q2P271JR
More data for this
Ligand-Target Pair