Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-specific 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM258395'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM258395 (US9505786, 33) Show SMILES CCOC(=O)C1(C)C(=O)Nc2nc(ncc12)-c1nn(Cc2ccccc2F)c2ncccc12 Show InChI InChI=1S/C23H19FN6O3/c1-3-33-22(32)23(2)15-11-26-19(27-18(15)28-21(23)31)17-14-8-6-10-25-20(14)30(29-17)12-13-7-4-5-9-16(13)24/h4-11H,3,12H2,1-2H3,(H,26,27,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	870	n/a	n/a	n/a	n/a	7.5	25
BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9505786 (2016) BindingDB Entry DOI: 10.7270/Q2WS8S6V
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