Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
tRNA (guanine-N(1)-)-methyltransferase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...) | BDBM50009672 (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a |
Singapore-MIT Alliance for Research and Technology Curated by ChEMBL | Assay Description Binding affinity to full length Mycobacterium tuberculosis tRNA (guanine(37)-N1)-methyltransferase expressed in Escherichia coli BL21 (DE3) by surfac... | J Med Chem 62: 7788-7805 (2019) Article DOI: 10.1021/acs.jmedchem.9b00582 BindingDB Entry DOI: 10.7270/Q2C250TC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
tRNA (guanine-N(1)-)-methyltransferase (Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22...) | BDBM50009672 (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a |
Singapore-MIT Alliance for Research and Technology Curated by ChEMBL | Assay Description Binding affinity to Pseudomonas aeruginosa tRNA (guanine(37)-N1)-methyltransferase (Leu5 to Asp25 residues) expressed in Escherichia coli BL21 (DE3) ... | J Med Chem 62: 7788-7805 (2019) Article DOI: 10.1021/acs.jmedchem.9b00582 BindingDB Entry DOI: 10.7270/Q2C250TC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
tRNA (guanine-N(1)-)-methyltransferase (Staphylococcus aureus (strain NCTC 8325 / PS 47)) | BDBM50009672 (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a |
Singapore-MIT Alliance for Research and Technology Curated by ChEMBL | Assay Description Binding affinity to full length Staphylococcus aureus tRNA (guanine(37)-N1)-methyltransferase expressed in Escherichia coli BL21 (DE3) by surface pla... | J Med Chem 62: 7788-7805 (2019) Article DOI: 10.1021/acs.jmedchem.9b00582 BindingDB Entry DOI: 10.7270/Q2C250TC | |||||||||||
More data for this Ligand-Target Pair |