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Found 1 hit Enz. Inhib. hit(s) with Target = 'tRNA (guanine-N(1)-)-methyltransferase' and Ligand = 'BDBM50519367'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
tRNA (guanine-N(1)-)-methyltransferase


(Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22...)		BDBM50519367
PNG
(CHEMBL4437560)
Show SMILES Cl.NCCCCCCCNCc1ccc(CNC(=O)c2csc3nc[nH]c(=O)c23)cc1
Show InChI InChI=1S/C22H29N5O2S/c23-10-4-2-1-3-5-11-24-12-16-6-8-17(9-7-16)13-25-20(28)18-14-30-22-19(18)21(29)26-15-27-22/h6-9,14-15,24H,1-5,10-13,23H2,(H,25,28)(H,26,27,29)
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n/an/a 140n/an/an/an/an/an/a



Singapore-MIT Alliance for Research and Technology

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas aeruginosa tRNA (guanine(37)-N1)-methyltransferase (Leu5 to Asp25 residues) expressed in Escherichia coli BL21 (DE3) Rosett...

J Med Chem 62: 7788-7805 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00582
BindingDB Entry DOI: 10.7270/Q2C250TC
More data for this
Ligand-Target Pair