Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G protein-activated inward rectifier potassium channel 1 (Rattus norvegicus) | BDBM34572 (BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | n/a | 0.0372 | n/a | n/a | n/a | n/a |
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay | Assay Description Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q21G0JR7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM34572 (BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB | n/a | n/a | n/a | n/a | 0.617 | n/a | n/a | n/a | n/a |
TBA | Assay Description Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphate | Citation and Details BindingDB Entry DOI: 10.7270/Q2DV1N3J | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM34572 (BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a |
Allergan Pharmaceuticals Curated by ChEMBL | Assay Description Effective concentration at Alpha-2C adrenergic receptor from CHO-C4 cells | J Med Chem 40: 18-23 (1997) Article DOI: 10.1021/jm9605142 BindingDB Entry DOI: 10.7270/Q2RV0MST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM34572 (BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a |
Allergan Pharmaceuticals Curated by ChEMBL | Assay Description Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cells | J Med Chem 40: 18-23 (1997) Article DOI: 10.1021/jm9605142 BindingDB Entry DOI: 10.7270/Q2RV0MST | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM34572 (BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | |
TBA | Assay Description Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis | Citation and Details BindingDB Entry DOI: 10.7270/Q2DV1N3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2B adrenergic receptor (NEONATAL RAT) | BDBM34572 (BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
Allergan Pharmaceuticals Curated by ChEMBL | Assay Description Effective Concentration at Alpha-2B adrenergic receptor from CHO-RNG cells | J Med Chem 40: 18-23 (1997) Article DOI: 10.1021/jm9605142 BindingDB Entry DOI: 10.7270/Q2RV0MST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM34572 (BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a |
University of Dublin Curated by ChEMBL | Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay | J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM34572 (BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a |
University of Dublin Curated by ChEMBL | Assay Description Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assay | J Med Chem 52: 601-9 (2009) Article DOI: 10.1021/jm800838r BindingDB Entry DOI: 10.7270/Q26M39MM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |