Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]3-beta-(4-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to dopamine transporter of cynomolgus monkey striatum | J Med Chem 36: 855-62 (1993) BindingDB Entry DOI: 10.7270/Q2NC61V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.26 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Inhibition of [3H]WIN-35428 binding to Dopamine transporter | J Med Chem 39: 4139-41 (1996) Article DOI: 10.1021/jm960515u BindingDB Entry DOI: 10.7270/Q2JD4XGP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 binding | J Med Chem 38: 379-88 (1995) BindingDB Entry DOI: 10.7270/Q2D50NM0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Inhibition of [3H]WIN-35428 binding to Dopamine transporter | J Med Chem 39: 4139-41 (1996) Article DOI: 10.1021/jm960515u BindingDB Entry DOI: 10.7270/Q2JD4XGP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description inhibition of [3H]WIN-35428 binding to the dopamine transporter (DAT) in monkey caudate-putamen. | J Med Chem 40: 2661-73 (1997) Article DOI: 10.1021/jm9703045 BindingDB Entry DOI: 10.7270/Q23T9HXJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Ability to inhibit [3H]citalopram binding to serotonin transporter in cynomolgus monkey striatum | J Med Chem 36: 855-62 (1993) BindingDB Entry DOI: 10.7270/Q2NC61V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description inhibition of [3H]WIN-35428 binding to the dopamine transporter (DAT) in monkey caudate-putamen. | J Med Chem 40: 2661-73 (1997) Article DOI: 10.1021/jm9703045 BindingDB Entry DOI: 10.7270/Q23T9HXJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]citalopram binding to the serotonin transporter (5-HT) in monkey caudate-putamen. | J Med Chem 40: 2661-73 (1997) Article DOI: 10.1021/jm9703045 BindingDB Entry DOI: 10.7270/Q23T9HXJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Binding potency for Serotonin transporter using [3H]- paroxetine | J Med Chem 39: 4139-41 (1996) Article DOI: 10.1021/jm960515u BindingDB Entry DOI: 10.7270/Q2JD4XGP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Binding affinity at the Serotonin transporter in rat midbrain by inhibition of 0.5 nM [3H]-paroxetine binding | J Med Chem 38: 379-88 (1995) BindingDB Entry DOI: 10.7270/Q2D50NM0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.21 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Binding potency for Serotonin transporter using [3H]- paroxetine | J Med Chem 39: 4139-41 (1996) Article DOI: 10.1021/jm960515u BindingDB Entry DOI: 10.7270/Q2JD4XGP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transporter (Rattus norvegicus) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Binding affinity at the Norepinephrine transporter in rat frontal cortex by inhibition of 0.5 nM [3H]nisoxetine binding | J Med Chem 38: 379-88 (1995) BindingDB Entry DOI: 10.7270/Q2D50NM0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transporter (Rattus norvegicus) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Binding potency for Norepinephrine transporter using [3H]NE | J Med Chem 39: 4139-41 (1996) Article DOI: 10.1021/jm960515u BindingDB Entry DOI: 10.7270/Q2JD4XGP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transporter (Rattus norvegicus) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Binding potency for Norepinephrine transporter using [3H]NE | J Med Chem 39: 4139-41 (1996) Article DOI: 10.1021/jm960515u BindingDB Entry DOI: 10.7270/Q2JD4XGP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]citalopram binding to the serotonin transporter (5-HT) in monkey caudate-putamen. | J Med Chem 40: 2661-73 (1997) Article DOI: 10.1021/jm9703045 BindingDB Entry DOI: 10.7270/Q23T9HXJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals Inc. Curated by ChEMBL | Assay Description Compound was tested for binding affinity to dopamine reuptake sites in the tissue homogenates prepared from primate rat striatum using [3H]CFT as rad... | J Med Chem 34: 3144-6 (1991) BindingDB Entry DOI: 10.7270/Q23R0TGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50010195 ((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals Inc. Curated by ChEMBL | Assay Description Compound was tested for binding affinity to Serotonin transporter sites in homogenates prepared from rat cortical membranes using [3H]paroxetine as r... | J Med Chem 34: 3144-6 (1991) BindingDB Entry DOI: 10.7270/Q23R0TGB | |||||||||||
More data for this Ligand-Target Pair |