Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Integrase (Human immunodeficiency virus 1) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of HIV integrase strand transfer activity | Bioorg Med Chem 27: 3836-3845 (2019) Article DOI: 10.1016/j.bmc.2019.07.011 BindingDB Entry DOI: 10.7270/Q2ZW1QBT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank PDB | n/a | n/a | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research & Development Curated by ChEMBL | Assay Description Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured afte... | J Med Chem 56: 5901-16 (2013) Article DOI: 10.1021/jm400645w BindingDB Entry DOI: 10.7270/Q21G0Q64 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of HIV1 recombinant integrase expressed in Escherichia coli using [32P]-labeled oligonucleotide as substrate after 60 mins by strand trans... | J Med Chem 59: 6136-48 (2016) Article DOI: 10.1021/acs.jmedchem.6b00040 BindingDB Entry DOI: 10.7270/Q24T6NVG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase strand transfer activity using 5'-biotinylated oligonucleotide as substrate preincubated for 10 mins followed by substra... | Eur J Med Chem 166: 390-399 (2019) Article DOI: 10.1016/j.ejmech.2019.01.081 BindingDB Entry DOI: 10.7270/Q2FJ2M7H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of HIV integrase strand transfer activity using 5'-biotin/3'-Cy5-labeled DNA substrate preincubated for 5 mins followed by substrate addit... | Eur J Med Chem 156: 652-665 (2018) Article DOI: 10.1016/j.ejmech.2018.07.039 BindingDB Entry DOI: 10.7270/Q20C4ZFB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Solute carrier family 22 member 2 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human OCT2 expressed in MDCK2 cells using [14C]metformin as substrate by liquid scintillation counting analysis | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of RNase H activity of full length HIV1 reverse transcriptase using RNA-DNA duplex HTS-1 substrate | J Med Chem 59: 6136-48 (2016) Article DOI: 10.1021/acs.jmedchem.6b00040 BindingDB Entry DOI: 10.7270/Q24T6NVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of HIV1 reverse transcriptase RNase H expressed in Escherichia coli JM109 using RNA/DNA duplex substrate HTS-1 | Eur J Med Chem 166: 390-399 (2019) Article DOI: 10.1016/j.ejmech.2019.01.081 BindingDB Entry DOI: 10.7270/Q2FJ2M7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of HIV1 reverse transcriptase RNaseH activity using 3'-fluorescein/5'-Dabcyl labeled HTS-1 substrate | Eur J Med Chem 156: 652-665 (2018) Article DOI: 10.1016/j.ejmech.2018.07.039 BindingDB Entry DOI: 10.7270/Q20C4ZFB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Broad substrate specificity ATP-binding cassette transporter ABCG2 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of BCRP (unknown origin) expressed in MDCK2 cells assessed as basolateral to apical transport of [14C]cimetidine after 90 mins by liquid s... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank Article PubMed | n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Metabolism-dependent inhibition of CYP3A4 in human liver microsomes using atorvastatin as substrate preincubated for 20 mins with NADPH prior to init... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank Article PubMed | n/a | n/a | 5.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of CYP3A4 in human liver microsomes using atorvastatin as substrate preincubated for 20 mins with substrate prior to initiation of reactio... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank Article PubMed | n/a | n/a | 6.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Metabolism-dependent inhibition of CYP3A4 in human liver microsomes using nifedipine as substrate preincubated for 20 mins with NADPH prior to initia... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Broad substrate specificity ATP-binding cassette transporter ABCG2 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human BCRP | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human MDR1 | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-binding cassette sub-family C member 2 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human MRP2 | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 20 mins with substrate prior to initiation of reaction ... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C19 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 20 mins with substrate prior to initiation of react... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2B6 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 20 mins with substrate prior to initiation of reaction w... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2A6 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate preincubated for 20 mins with substrate prior to initiation of reaction wi... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 1A2 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 20 mins with substrate prior to initiation of reaction ... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK2 cells assessed as basolateral to apical transport of [3H]digoxin after 90 mins by liquid scint... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 20 mins with substrate prior to initiation of reaction w... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-binding cassette sub-family C member 2 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human MRP2 expressed in baculovirus-infected Sf9 cell membrane vesicle using [3H]estradiol 17beta-D-glucuronide as substrate preincubat... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier organic anion transporter family member 1B1 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human OATP1B1 expressed in CHO cells using [3H]estradiol 17beta-D-glucuronide as substrate by liquid scintillation counting analysis | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier organic anion transporter family member 1B3 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human OATP1B3 expressed in BacMam baculovirus virus infected HEK MSR2 cells using [3H]estradiol 17beta-D-glucuronide as substrate by li... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of CYP3A4 in human liver microsomes using nifedipine as substrate preincubated for 20 mins with substrate prior to initiation of reaction ... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 1A2 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Metabolism-dependent inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 20 mins with NADPH prior to initia... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2A6 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Metabolism-dependent inhibition of CYP2A6 in human liver microsomes using coumarin as substrate preincubated for 20 mins with NADPH prior to initiati... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2B6 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Metabolism-dependent inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 20 mins with NADPH prior to initiat... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C8 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Metabolism-dependent inhibition of CYP2C8 in human liver microsomes using rosiglitazone as substrate preincubated for 20 mins with NADPH prior to ini... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Metabolism-dependent inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 20 mins with NADPH prior to initia... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C19 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Metabolism-dependent inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 20 mins with NADPH prior to in... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Metabolism-dependent inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 20 mins with NADPH prior to initiat... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
UDP-glucuronosyltransferase 1A1 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant UGT1A1 expressed in supersomes assessed as scopoletin glucuronidation by fluorescence analysis | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C8 (Homo sapiens (Human)) | BDBM50062551 (CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of CYP2C8 in human liver microsomes using rosiglitazone as substrate preincubated for 20 mins with substrate prior to initiation of reacti... | Drug Metab Dispos 41: 353-61 (2013) Article DOI: 10.1124/dmd.112.048918 BindingDB Entry DOI: 10.7270/Q20003TM | |||||||||||
More data for this Ligand-Target Pair |