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Compile Data Set for Download or QSAR

Found 401 hits of ec50 for UniProtKB: P27958   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM245925
PNG
(US9433609, 18)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2cc(ccc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC |r|
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t24-,25+,34-,35-,36-,37-/m0/s1
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n/an/an/an/a 0.0180n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243437
PNG
(US9427428, 18)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC |r|
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34+,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243439
PNG
(US9427428, 9 | US9433609, 9)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33+,34+,35+,36+/m1/s1
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Janssen Sciences Ireland UC

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Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243439
PNG
(US9427428, 9 | US9433609, 9)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33+,34+,35+,36+/m1/s1
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Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM245918
PNG
(US9433609, 2 | US9433609, 4)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc(cc1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C38H46N8O7/c1-21(2)31(43-37(49)52-5)35(47)45-17-7-9-29(45)33-39-20-28(42-33)24-13-11-23(12-14-24)25-15-16-26-27(19-25)41-34(40-26)30-10-8-18-46(30)36(48)32(22(3)51-4)44-38(50)53-6/h11-16,19-22,29-32H,7-10,17-18H2,1-6H3,(H,43,49)(H,44,50)/b25-23-,28-24-/t22-,29+,30+,31+,32+/m1/s1
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n/an/an/an/a 0.0330n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243435
PNG
(US9427428, 4)
Show SMILES CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC |r|
Show InChI InChI=1S/C42H48N8O8/c1-23(55-3)35(47-41(53)57-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(2)56-4)48-42(54)58-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t23-,24-,33+,34+,35+,36+/m1/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243438
PNG
(US9427428, 11)
Show SMILES CO[C@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26-,32-29+/t24-,33-,34+,35-,36-/m1/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM245921
PNG
(US9433609, 11)
Show SMILES CO[C@@H](C)[C@@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O7/c1-23(2)35(47-41(53)56-5)39(51)50-18-8-10-34(50)38-44-30-16-15-28(21-31(30)45-38)26-11-12-27-20-29(14-13-25(27)19-26)32-22-43-37(46-32)33-9-7-17-49(33)40(52)36(24(3)55-4)48-42(54)57-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t24-,33-,34-,35-,36+/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM245924
PNG
(US9433609, 17)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC |r|
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t24-,25+,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243436
PNG
(US9427428, 17 | US9427428, 21)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC |r|
Show InChI InChI=1S/C43H50N8O7/c1-7-24(2)36(48-42(54)57-5)40(52)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)41(53)37(25(3)56-4)49-43(55)58-6/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t24-,25+,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243449
PNG
(US9427428, 13 | US9433609, 13)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1ccc2cc(ccc2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)51-19-9-11-35(51)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-50(34)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27-,33-30+/t25-,34-,35-,36-,37-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243443
PNG
(US9427428, 3 | US9433609, 3)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O6/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243443
PNG
(US9427428, 3 | US9433609, 3)
Show SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C42H48N8O6/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,53)(H,48,54)/b28-26+,32-29-/t33-,34-,35-,36-/m0/s1
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Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a 0.0980n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243452
PNG
(US9427428, 16 | US9433609, 16)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Show InChI InChI=1S/C43H50N8O6/c1-7-25(4)37(49-43(55)57-6)41(53)50-18-8-10-34(50)38-44-23-33(47-38)30-15-14-26-20-27(12-13-28(26)21-30)29-16-17-31-32(22-29)46-39(45-31)35-11-9-19-51(35)40(52)36(24(2)3)48-42(54)56-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,48,54)(H,49,55)/b29-27+,33-30-/t25-,34-,35-,36-,37-/m0/s1
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n/an/an/an/a 0.0980n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243440
PNG
(US9427428, 6 | US9433609, 6)
Show SMILES COC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)O |r|
Show InChI InChI=1S/C40H44N8O8/c1-21(49)33(45-39(53)55-3)37(51)47-15-5-7-31(47)35-41-20-30(44-35)27-12-11-23-17-24(9-10-25(23)18-27)26-13-14-28-29(19-26)43-36(42-28)32-8-6-16-48(32)38(52)34(22(2)50)46-40(54)56-4/h9-14,17-22,31-34,49-50H,5-8,15-16H2,1-4H3,(H,45,53)(H,46,54)/b26-24-,30-27+/t21-,22-,31+,32+,33+,34+/m1/s1
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n/an/an/an/a 0.181n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243440
PNG
(US9427428, 6 | US9433609, 6)
Show SMILES COC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)O |r|
Show InChI InChI=1S/C40H44N8O8/c1-21(49)33(45-39(53)55-3)37(51)47-15-5-7-31(47)35-41-20-30(44-35)27-12-11-23-17-24(9-10-25(23)18-27)26-13-14-28-29(19-26)43-36(42-28)32-8-6-16-48(32)38(52)34(22(2)50)46-40(54)56-4/h9-14,17-22,31-34,49-50H,5-8,15-16H2,1-4H3,(H,45,53)(H,46,54)/b26-24-,30-27+/t21-,22-,31+,32+,33+,34+/m1/s1
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n/an/an/an/a 0.181n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243446
PNG
(US9427428, 8 | US9433609, 8)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC |r|
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,34-31-/t25-,26-,35-,36-,37-,38-/m0/s1
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n/an/an/an/a 0.204n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243446
PNG
(US9427428, 8 | US9433609, 8)
Show SMILES CC[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC |r|
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,34-31-/t25-,26-,35-,36-,37-,38-/m0/s1
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n/an/an/an/a 0.204n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243448
PNG
(US9427428, 12 | US9433609, 12)
Show SMILES COC(=O)NC(C1CCOCC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)C(NC(=O)OC)C1CCOCC1 |r|
Show InChI InChI=1S/C46H52N8O8/c1-59-45(57)51-39(27-13-19-61-20-14-27)43(55)53-17-3-5-37(53)41-47-26-36(50-41)33-10-9-29-23-30(7-8-31(29)24-33)32-11-12-34-35(25-32)49-42(48-34)38-6-4-18-54(38)44(56)40(52-46(58)60-2)28-15-21-62-22-16-28/h7-12,23-28,37-40H,3-6,13-22H2,1-2H3,(H,51,57)(H,52,58)/b32-30+,36-33-/t37-,38-,39?,40?/m0/s1
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n/an/an/an/a 0.268n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243448
PNG
(US9427428, 12 | US9433609, 12)
Show SMILES COC(=O)NC(C1CCOCC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)C(NC(=O)OC)C1CCOCC1 |r|
Show InChI InChI=1S/C46H52N8O8/c1-59-45(57)51-39(27-13-19-61-20-14-27)43(55)53-17-3-5-37(53)41-47-26-36(50-41)33-10-9-29-23-30(7-8-31(29)24-33)32-11-12-34-35(25-32)49-42(48-34)38-6-4-18-54(38)44(56)40(52-46(58)60-2)28-15-21-62-22-16-28/h7-12,23-28,37-40H,3-6,13-22H2,1-2H3,(H,51,57)(H,52,58)/b32-30+,36-33-/t37-,38-,39?,40?/m0/s1
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n/an/an/an/a 0.268n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243451
PNG
(US9427428, 15 | US9433609, 15)
Show SMILES COC(=O)N[C@@H](C1CCCC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CCCC1 |r|
Show InChI InChI=1S/C46H52N8O6/c1-59-45(57)51-39(27-9-3-4-10-27)43(55)53-21-7-13-37(53)41-47-26-36(50-41)33-18-17-29-23-30(15-16-31(29)24-33)32-19-20-34-35(25-32)49-42(48-34)38-14-8-22-54(38)44(56)40(52-46(58)60-2)28-11-5-6-12-28/h15-20,23-28,37-40H,3-14,21-22H2,1-2H3,(H,51,57)(H,52,58)/b32-30+,36-33-/t37-,38-,39-,40-/m0/s1
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n/an/an/an/a 0.277n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243451
PNG
(US9427428, 15 | US9433609, 15)
Show SMILES COC(=O)N[C@@H](C1CCCC1)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C1CCCC1 |r|
Show InChI InChI=1S/C46H52N8O6/c1-59-45(57)51-39(27-9-3-4-10-27)43(55)53-21-7-13-37(53)41-47-26-36(50-41)33-18-17-29-23-30(15-16-31(29)24-33)32-19-20-34-35(25-32)49-42(48-34)38-14-8-22-54(38)44(56)40(52-46(58)60-2)28-11-5-6-12-28/h15-20,23-28,37-40H,3-14,21-22H2,1-2H3,(H,51,57)(H,52,58)/b32-30+,36-33-/t37-,38-,39-,40-/m0/s1
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n/an/an/an/a 0.277n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229576
PNG
(US9334279, 1052)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cscn1 |r,c:46|
Show InChI InChI=1S/C48H59F3N6O10S2/c1-28(2)65-33-13-11-31(12-14-33)36-20-34(21-37(53-36)38-25-68-27-52-38)66-35-22-39-41(58)55-47(43(60)56-69(62,63)45(5)16-17-45)23-32(47)10-7-6-9-29(3)19-30(4)40(42(59)57(39)24-35)54-44(61)67-46(48(49,50)51)15-8-18-64-26-46/h7,10-14,20-21,25,27-30,32,35,39-40H,6,8-9,15-19,22-24,26H2,1-5H3,(H,54,61)(H,55,58)(H,56,60)/b10-7-/t29-,30-,32?,35-,39+,40+,46?,47-/m1/s1
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n/an/an/an/a 0.300n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229547
PNG
(US9334279, 1023)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(nc(c1)-c1nccs1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:4|
Show InChI InChI=1S/C40H48F3N7O8S3/c1-22-8-6-7-9-24-20-39(24,35(53)49-61(55,56)38(5)10-11-38)48-31(51)29-19-26(57-25-17-27(32-44-12-14-59-32)46-28(18-25)33-45-13-15-60-33)21-50(29)34(52)30(23(2)16-22)47-36(54)58-37(3,4)40(41,42)43/h7,9,12-15,17-18,22-24,26,29-30H,6,8,10-11,16,19-21H2,1-5H3,(H,47,54)(H,48,51)(H,49,53)/b9-7-/t22-,23-,24?,26-,29+,30+,39-/m1/s1
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n/an/an/an/a 0.460n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM245926
PNG
(US9433609, 19)
Show SMILES CC[C@@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@H](C)CC |r|
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,34-31-/t25-,26-,35+,36+,37+,38+/m1/s1
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n/an/an/an/a 0.471n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243434
PNG
(US9427428, 19)
Show SMILES CC[C@@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC |r|
Show InChI InChI=1S/C44H52N8O6/c1-7-25(3)37(49-43(55)57-5)41(53)51-19-9-11-35(51)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-52(36)42(54)38(26(4)8-2)50-44(56)58-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28-,34-31+/t25-,26+,35+,36+,37+,38+/m1/s1
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n/an/an/an/a 0.471n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229565
PNG
(US9334279, 1041)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1nccs1 |r,c:46|
Show InChI InChI=1S/C48H59F3N6O10S2/c1-28(2)65-33-13-11-31(12-14-33)36-22-34(23-37(53-36)41-52-18-20-68-41)66-35-24-38-40(58)55-47(43(60)56-69(62,63)45(5)16-17-45)25-32(47)10-7-6-9-29(3)21-30(4)39(42(59)57(38)26-35)54-44(61)67-46(48(49,50)51)15-8-19-64-27-46/h7,10-14,18,20,22-23,28-30,32,35,38-39H,6,8-9,15-17,19,21,24-27H2,1-5H3,(H,54,61)(H,55,58)(H,56,60)/b10-7-/t29-,30-,32?,35-,38+,39+,46?,47-/m1/s1
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n/an/an/an/a 0.75n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229559
PNG
(US9334279, 1035)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:8|
Show InChI InChI=1S/C48H59F3N6O11S2/c1-6-38-39(54-44(61)68-46(48(49,50)51)16-9-20-64-27-46)42(59)57-26-34(67-33-22-35(53-36(23-33)41-52-19-21-69-41)30-12-14-32(15-13-30)65-28(2)3)24-37(57)40(58)55-47(25-31(47)11-8-7-10-29(4)66-38)43(60)56-70(62,63)45(5)17-18-45/h8,11-15,19,21-23,28-29,31,34,37-39H,6-7,9-10,16-18,20,24-27H2,1-5H3,(H,54,61)(H,55,58)(H,56,60)/b11-8-/t29-,31?,34-,37+,38+,39+,46?,47-/m1/s1
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n/an/an/an/a 0.75n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229560
PNG
(US9334279, 1036)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1cscn1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:8|
Show InChI InChI=1S/C48H59F3N6O11S2/c1-6-39-40(54-44(61)68-46(48(49,50)51)16-9-19-64-26-46)42(59)57-24-34(67-33-20-35(53-36(21-33)37-25-69-27-52-37)30-12-14-32(15-13-30)65-28(2)3)22-38(57)41(58)55-47(23-31(47)11-8-7-10-29(4)66-39)43(60)56-70(62,63)45(5)17-18-45/h8,11-15,20-21,25,27-29,31,34,38-40H,6-7,9-10,16-19,22-24,26H2,1-5H3,(H,54,61)(H,55,58)(H,56,60)/b11-8-/t29-,31?,34-,38+,39+,40+,46?,47-/m1/s1
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n/an/an/an/a 0.75n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229564
PNG
(US9334279, 1040)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(cc1)C(F)(F)F)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:8|
Show InChI InChI=1S/C46H52F6N6O10S2/c1-4-35-36(55-41(62)68-43(46(50,51)52)14-7-18-65-25-43)39(60)58-24-31(67-30-20-32(54-33(21-30)38-53-17-19-69-38)27-10-12-28(13-11-27)45(47,48)49)22-34(58)37(59)56-44(23-29(44)9-6-5-8-26(2)66-35)40(61)57-70(63,64)42(3)15-16-42/h6,9-13,17,19-21,26,29,31,34-36H,4-5,7-8,14-16,18,22-25H2,1-3H3,(H,55,62)(H,56,59)(H,57,61)/b9-6-/t26-,29?,31-,34+,35+,36+,43?,44-/m1/s1
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n/an/an/an/a 0.75n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229567
PNG
(US9334279, 1043)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1ccnc(c1)-c1ncc(C)s1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:4|
Show InChI InChI=1S/C38H49F3N6O8S2/c1-21-9-7-8-10-24-18-37(24,33(50)46-57(52,53)36(6)12-13-36)45-30(48)28-17-26(54-25-11-14-42-27(16-25)31-43-19-23(3)56-31)20-47(28)32(49)29(22(2)15-21)44-34(51)55-35(4,5)38(39,40)41/h8,10-11,14,16,19,21-22,24,26,28-29H,7,9,12-13,15,17-18,20H2,1-6H3,(H,44,51)(H,45,48)(H,46,50)/b10-8-/t21-,22-,24?,26-,28+,29+,37-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229584
PNG
(US9334279, 1060)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(nc(c1)-c1ccccc1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:4|
Show InChI InChI=1S/C43H51F3N6O8S2/c1-25-11-9-10-14-28-23-42(28,38(55)51-62(57,58)41(5)15-16-41)50-35(53)33-22-30(24-52(33)37(54)34(26(2)19-25)49-39(56)60-40(3,4)43(44,45)46)59-29-20-31(27-12-7-6-8-13-27)48-32(21-29)36-47-17-18-61-36/h6-8,10,12-14,17-18,20-21,25-26,28,30,33-34H,9,11,15-16,19,22-24H2,1-5H3,(H,49,56)(H,50,53)(H,51,55)/b14-10-/t25-,26-,28?,30-,33+,34+,42-/m1/s1
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n/an/an/an/a 0.75n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229583
PNG
(US9334279, 1059)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(nc(c1)-c1ccc(C)cc1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:4|
Show InChI InChI=1S/C44H53F3N6O8S2/c1-25-11-13-28(14-12-25)32-20-30(21-33(49-32)37-48-17-18-62-37)60-31-22-34-36(54)51-43(39(56)52-63(58,59)42(6)15-16-42)23-29(43)10-8-7-9-26(2)19-27(3)35(38(55)53(34)24-31)50-40(57)61-41(4,5)44(45,46)47/h8,10-14,17-18,20-21,26-27,29,31,34-35H,7,9,15-16,19,22-24H2,1-6H3,(H,50,57)(H,51,54)(H,52,56)/b10-8-/t26-,27-,29?,31-,34+,35+,43-/m1/s1
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n/an/an/an/a 0.75n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243450
PNG
(US9427428, 14 | US9433609, 14)
Show SMILES COC(=O)NC(C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)C(NC(=O)OC)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C48H44N8O6/c1-61-47(59)53-41(29-11-5-3-6-12-29)45(57)55-23-9-15-39(55)43-49-28-38(52-43)35-20-19-31-25-32(17-18-33(31)26-35)34-21-22-36-37(27-34)51-44(50-36)40-16-10-24-56(40)46(58)42(54-48(60)62-2)30-13-7-4-8-14-30/h3-8,11-14,17-22,25-28,39-42H,9-10,15-16,23-24H2,1-2H3,(H,53,59)(H,54,60)/b34-32+,38-35-/t39-,40-,41?,42?/m0/s1
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n/an/an/an/a 0.836n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243450
PNG
(US9427428, 14 | US9433609, 14)
Show SMILES COC(=O)NC(C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)C(NC(=O)OC)c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C48H44N8O6/c1-61-47(59)53-41(29-11-5-3-6-12-29)45(57)55-23-9-15-39(55)43-49-28-38(52-43)35-20-19-31-25-32(17-18-33(31)26-35)34-21-22-36-37(27-34)51-44(50-36)40-16-10-24-56(40)46(58)42(54-48(60)62-2)30-13-7-4-8-14-30/h3-8,11-14,17-22,25-28,39-42H,9-10,15-16,23-24H2,1-2H3,(H,53,59)(H,54,60)/b34-32+,38-35-/t39-,40-,41?,42?/m0/s1
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n/an/an/an/a 0.836n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229541
PNG
(US9334279, 1017)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cncs1 |r,c:46|
Show InChI InChI=1S/C48H59F3N6O10S2/c1-28(2)65-33-13-11-31(12-14-33)36-20-34(21-37(53-36)39-24-52-27-68-39)66-35-22-38-41(58)55-47(43(60)56-69(62,63)45(5)16-17-45)23-32(47)10-7-6-9-29(3)19-30(4)40(42(59)57(38)25-35)54-44(61)67-46(48(49,50)51)15-8-18-64-26-46/h7,10-14,20-21,24,27-30,32,35,38,40H,6,8-9,15-19,22-23,25-26H2,1-5H3,(H,54,61)(H,55,58)(H,56,60)/b10-7-/t29-,30-,32?,35-,38+,40+,46?,47-/m1/s1
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n/an/an/an/a 0.950n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-3011]


(Hepatitis C virus genotype 1a (isolate H) (HCV))		BDBM243445
PNG
(US9427428, 7 | US9433609, 7)
Show SMILES COC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)OC |r|
Show InChI InChI=1S/C44H52N8O6/c1-25(2)19-34(49-43(55)57-5)41(53)51-17-7-9-37(51)39-45-24-36(48-39)31-14-13-27-21-28(11-12-29(27)22-31)30-15-16-32-33(23-30)47-40(46-32)38-10-8-18-52(38)42(54)35(20-26(3)4)50-44(56)58-6/h11-16,21-26,34-35,37-38H,7-10,17-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,36-31-/t34-,35-,37-,38-/m0/s1
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n/an/an/an/a 0.989n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9427428 (2016)


BindingDB Entry DOI: 10.7270/Q2JD4VPJ
More data for this
Ligand-Target Pair
Genome polyprotein [1657-3011]


(Hepatitis C virus genotype 1a (isolate H77) (HCV))		BDBM243445
PNG
(US9427428, 7 | US9433609, 7)
Show SMILES COC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc2cc(ccc2c1)-c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)OC |r|
Show InChI InChI=1S/C44H52N8O6/c1-25(2)19-34(49-43(55)57-5)41(53)51-17-7-9-37(51)39-45-24-36(48-39)31-14-13-27-21-28(11-12-29(27)22-31)30-15-16-32-33(23-30)47-40(46-32)38-10-8-18-52(38)42(54)35(20-26(3)4)50-44(56)58-6/h11-16,21-26,34-35,37-38H,7-10,17-20H2,1-6H3,(H,49,55)(H,50,56)/b30-28+,36-31-/t34-,35-,37-,38-/m0/s1
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n/an/an/an/a 0.989n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...

US Patent US9433609 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60FD
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM65581
PNG
(US9693997, 1)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(cc1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F
Show InChI InChI=1S/C25H28ClF3N6O4S/c1-24(2,3)39-23(36)35-10-8-17(9-11-35)40(37,38)16-6-4-14(5-7-16)20-18(25(27,28)29)12-15(13-19(20)26)31-22-32-21(30)33-34-22/h4-7,12-13,17H,8-11H2,1-3H3,(H4,30,31,32,33,34)
PDB
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n/an/an/an/a 1n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...

US Patent US9693997 (2017)


BindingDB Entry DOI: 10.7270/Q2833Q56
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229529
PNG
(US9334279, 1005)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cccnc1 |r,c:42|
Show InChI InChI=1S/C48H59F3N6O9S/c1-28(2)64-34-16-14-31(15-17-34)37-22-35(23-38(53-37)32-12-10-20-52-26-32)65-36-24-39-41(58)55-47(43(60)56-67(62,63)46(7)18-19-46)25-33(47)13-9-8-11-29(3)21-30(4)40(42(59)57(39)27-36)54-44(61)66-45(5,6)48(49,50)51/h9-10,12-17,20,22-23,26,28-30,33,36,39-40H,8,11,18-19,21,24-25,27H2,1-7H3,(H,54,61)(H,55,58)(H,56,60)/b13-9-/t29-,30-,33?,36-,39+,40+,47-/m1/s1
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UniProtKB/SwissProt

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n/an/an/an/a 1.48n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM70703
PNG
(US9693997, 221)
Show SMILES COc1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)OC(C)(C)C)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F |$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;$|
Show InChI InChI=1S/C26H31ClF3N7O5S/c1-25(2,3)42-24(38)37-9-7-15(8-10-37)36-43(39,40)20-11-14(5-6-19(20)41-4)21-17(26(28,29)30)12-16(13-18(21)27)32-23-33-22(31)34-35-23/h5-6,11-13,15,36H,7-10H2,1-4H3,(H4,31,32,33,34,35)
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US Patent
n/an/an/an/a 3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...

US Patent US9693997 (2017)


BindingDB Entry DOI: 10.7270/Q2833Q56
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229588
PNG
(US9334279, 1064)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1ccc(cn1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:4|
Show InChI InChI=1S/C37H47F3N6O8S2/c1-21-8-6-7-9-24-18-36(24,32(49)45-56(51,52)35(5)12-13-35)44-29(47)26-17-25(53-27-11-10-23(19-42-27)30-41-14-15-55-30)20-46(26)31(48)28(22(2)16-21)43-33(50)54-34(3,4)37(38,39)40/h7,9-11,14-15,19,21-22,24-26,28H,6,8,12-13,16-18,20H2,1-5H3,(H,43,50)(H,44,47)(H,45,49)/b9-7-/t21-,22-,24?,25-,26+,28+,36-/m1/s1
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n/an/an/an/a 3n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229527
PNG
(US9334279, 1003)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cncs1 |r,c:42|
Show InChI InChI=1S/C46H57F3N6O9S2/c1-26(2)62-31-14-12-29(13-15-31)34-19-32(20-35(51-34)37-23-50-25-65-37)63-33-21-36-39(56)53-45(41(58)54-66(60,61)44(7)16-17-44)22-30(45)11-9-8-10-27(3)18-28(4)38(40(57)55(36)24-33)52-42(59)64-43(5,6)46(47,48)49/h9,11-15,19-20,23,25-28,30,33,36,38H,8,10,16-18,21-22,24H2,1-7H3,(H,52,59)(H,53,56)(H,54,58)/b11-9-/t27-,28-,30?,33-,36+,38+,45-/m1/s1
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n/an/an/an/a 3n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229531
PNG
(US9334279, 1007)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1nccs1 |r,c:42|
Show InChI InChI=1S/C46H57F3N6O9S2/c1-26(2)62-31-14-12-29(13-15-31)34-21-32(22-35(51-34)39-50-18-19-65-39)63-33-23-36-38(56)53-45(41(58)54-66(60,61)44(7)16-17-44)24-30(45)11-9-8-10-27(3)20-28(4)37(40(57)55(36)25-33)52-42(59)64-43(5,6)46(47,48)49/h9,11-15,18-19,21-22,26-28,30,33,36-37H,8,10,16-17,20,23-25H2,1-7H3,(H,52,59)(H,53,56)(H,54,58)/b11-9-/t27-,28-,30?,33-,36+,37+,45-/m1/s1
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n/an/an/an/a 3n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229533
PNG
(US9334279, 1009)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ccncc1 |r,c:42|
Show InChI InChI=1S/C48H59F3N6O9S/c1-28(2)64-34-14-12-31(13-15-34)37-23-35(24-38(53-37)32-16-20-52-21-17-32)65-36-25-39-41(58)55-47(43(60)56-67(62,63)46(7)18-19-46)26-33(47)11-9-8-10-29(3)22-30(4)40(42(59)57(39)27-36)54-44(61)66-45(5,6)48(49,50)51/h9,11-17,20-21,23-24,28-30,33,36,39-40H,8,10,18-19,22,25-27H2,1-7H3,(H,54,61)(H,55,58)(H,56,60)/b11-9-/t29-,30-,33?,36-,39+,40+,47-/m1/s1
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n/an/an/an/a 3n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229535
PNG
(US9334279, 1011)
Show SMILES COc1cccc(n1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ccc(OC(C)C)cc1 |r,c:40|
Show InChI InChI=1S/C49H61F3N6O10S/c1-28(2)66-33-18-16-31(17-19-33)37-23-34(24-38(53-37)36-14-11-15-40(54-36)65-8)67-35-25-39-42(59)56-48(44(61)57-69(63,64)47(7)20-21-47)26-32(48)13-10-9-12-29(3)22-30(4)41(43(60)58(39)27-35)55-45(62)68-46(5,6)49(50,51)52/h10-11,13-19,23-24,28-30,32,35,39,41H,9,12,20-22,25-27H2,1-8H3,(H,55,62)(H,56,59)(H,57,61)/b13-10-/t29-,30-,32?,35-,39+,41+,48-/m1/s1
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n/an/an/an/a 3n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229537
PNG
(US9334279, 1013)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-n1cccn1 |r,c:42|
Show InChI InChI=1S/C46H58F3N7O9S/c1-27(2)63-32-15-13-30(14-16-32)35-22-33(24-37(51-35)56-20-10-19-50-56)64-34-23-36-39(57)53-45(41(59)54-66(61,62)44(7)17-18-44)25-31(45)12-9-8-11-28(3)21-29(4)38(40(58)55(36)26-34)52-42(60)65-43(5,6)46(47,48)49/h9-10,12-16,19-20,22,24,27-29,31,34,36,38H,8,11,17-18,21,23,25-26H2,1-7H3,(H,52,60)(H,53,57)(H,54,59)/b12-9-/t28-,29-,31?,34-,36+,38+,45-/m1/s1
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n/an/an/an/a 3n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
Genome polyprotein [1027-1711]


(Hepatitis C virus genotype 1a (strain H77) (HCV))		BDBM229543
PNG
(US9334279, 1019)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ncccn1 |r,c:42|
Show InChI InChI=1S/C47H58F3N7O9S/c1-27(2)64-32-15-13-30(14-16-32)35-22-33(23-36(53-35)39-51-19-10-20-52-39)65-34-24-37-40(58)55-46(42(60)56-67(62,63)45(7)17-18-45)25-31(46)12-9-8-11-28(3)21-29(4)38(41(59)57(37)26-34)54-43(61)66-44(5,6)47(48,49)50/h9-10,12-16,19-20,22-23,27-29,31,34,37-38H,8,11,17-18,21,24-26H2,1-7H3,(H,54,61)(H,55,58)(H,56,60)/b12-9-/t28-,29-,31?,34-,37+,38+,46-/m1/s1
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n/an/an/an/a 3n/an/an/a37



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...

US Patent US9334279 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R1W
More data for this
Ligand-Target Pair
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