Compile Data Set for Download or QSAR

Found 138 hits of ic50 for UniProtKB: P34897   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285658 (US10077273, Compound 4 | US10584132, Compound 4 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(O)=O |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285658 (US10077273, Compound 4 | US10584132, Compound 4 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(O)=O |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285659 (US10077273, Compound 68 | US10584132, Compound 68 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285659 (US10077273, Compound 68 | US10584132, Compound 68 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285663 (US10077273, Compound 11 | US10584132, Compound 11 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(N)=O |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285660 (US10077273, Compound 1 | US10584132, Compound 1 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285660 (US10077273, Compound 1 | US10584132, Compound 1 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285660 (US10077273, Compound 1 | US10584132, Compound 1 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285660 (US10077273, Compound 1 | US10584132, Compound 1 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285661 (US10077273, Compound 69 | US10584132, Compound 69 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)N[C@@H](CCC(O)=O)C(O)=O |r,c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285661 (US10077273, Compound 69 | US10584132, Compound 69 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)N[C@@H](CCC(O)=O)C(O)=O |r,c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285662 (US10077273, Compound 70 | US10584132, Compound 70 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)N[C@H](CCC(O)=O)C(O)=O |r,c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285662 (US10077273, Compound 70 | US10584132, Compound 70 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)N[C@H](CCC(O)=O)C(O)=O |r,c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285663 (US10077273, Compound 11 | US10584132, Compound 11 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(N)=O |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285663 (US10077273, Compound 11 | US10584132, Compound 11 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(N)=O |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285664 (US10077273, Compound 71 | US10584132, Compound 71 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCCO)C#N |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285664 (US10077273, Compound 71 | US10584132, Compound 71 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCCO)C#N |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285659 (US10077273, Compound 68 | US10584132, Compound 68 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285666 (US10077273, Compound 2 | US10584132, Compound 2 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285665 (US10077273, Compound 72 | US10584132, Compound 72 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)NC(C)(C)C(O)=O |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285665 (US10077273, Compound 72 | US10584132, Compound 72 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)NC(C)(C)C(O)=O |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285664 (US10077273, Compound 71 | US10584132, Compound 71 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCCO)C#N |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285666 (US10077273, Compound 2 | US10584132, Compound 2 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285665 (US10077273, Compound 72 | US10584132, Compound 72 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(=O)NC(C)(C)C(O)=O |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285666 (US10077273, Compound 2 | US10584132, Compound 2 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM485192 (US10934305, Compound HK-16 (PK-2)) Show SMILES CC(C)[C@@]1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285688 (US10077273, Compound HK-X2 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1 |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285667 (US10077273, Compound 73 | US10584132, Compound 73 ...) Show SMILES COC(=O)CCC#Cc1cc(cc(c1)C1(C(C)C)c2c(C)n[nH]c2OC(N)=C1C#N)C(F)(F)F |c:28| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285667 (US10077273, Compound 73 | US10584132, Compound 73 ...) Show SMILES COC(=O)CCC#Cc1cc(cc(c1)C1(C(C)C)c2c(C)n[nH]c2OC(N)=C1C#N)C(F)(F)F |c:28| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285689 (US10077273, Compound HK-X3 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1cccc(CC(N)=O)c1 |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.80	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285668 (US10077273, Compound 8 | US10584132, Compound 8 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCN |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285688 (US10077273, Compound HK-X2 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1 |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285687 (US10077273, Compound HK-X1 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1 |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285686 (US10077273, Compound HK-16 | US10077273, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285686 (US10077273, Compound HK-16 | US10077273, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285689 (US10077273, Compound HK-X3 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1cccc(CC(N)=O)c1 |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.9	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285669 (US10077273, Compound 74 | US10584132, Compound 74 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)C#CCCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285669 (US10077273, Compound 74 | US10584132, Compound 74 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)C#CCCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285669 (US10077273, Compound 74 | US10584132, Compound 74 ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)C#CCCCO |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285685 (US10077273, Compound HK-15 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(c1)C(F)(F)F |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285686 (US10077273, Compound HK-16 | US10077273, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285686 (US10077273, Compound HK-16 | US10077273, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285685 (US10077273, Compound HK-15 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(c1)C(F)(F)F |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285690 (6-amino-4-(3-bromo-5-(trifluoromethyl)phenyl)-4-is...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Br)cc(c1)C(F)(F)F |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285668 (US10077273, Compound 8 | US10584132, Compound 8 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCN |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285668 (US10077273, Compound 8 | US10584132, Compound 8 | ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCCN |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285687 (US10077273, Compound HK-X1 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1 |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285684 (US10077273, Compound HK-14 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(Cl)c1 |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021) BindingDB Entry DOI: 10.7270/Q2KK9FXN
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285681 (US10077273, Compound HK-11) Show SMILES Cc1n[nH]c2OC(N)=C(C#N)C(C3CCC3)(c12)c1cc(Cl)cc(c1)C(F)(F)F |t:7| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285684 (US10077273, Compound HK-14 | US10934305, Compound ...) Show SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(Cl)c1 |c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	131	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
					More data for this Ligand-Target Pair

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