Compile Data Set for Download or QSAR

Found 166 hits of kd for UniProtKB: P27694   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080828 (CHEMBL3422471) Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=S)NCc2ccc(cc2Cl)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H18Cl3N3O5S/c30-20-8-7-19(12-22(20)32)35-24(13-23(34-35)28(36)37)15-1-3-16(4-2-15)27(41)33-14-18-6-5-17(11-21(18)31)25-9-10-26(40-25)29(38)39/h1-13H,14H2,(H,33,41)(H,36,37)(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080825 (CHEMBL3422472) Show SMILES OC(=O)c1cc(-c2ccc(CN3CCc4cc(ccc4C3=S)-c3ccc(o3)C(O)=O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C31H21Cl2N3O5S/c32-23-8-6-21(14-24(23)33)36-26(15-25(34-36)30(37)38)18-3-1-17(2-4-18)16-35-12-11-19-13-20(5-7-22(19)29(35)42)27-9-10-28(41-27)31(39)40/h1-10,13-15H,11-12,16H2,(H,37,38)(H,39,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair				3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080853 (CHEMBL3422469) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3)-c3ccc(o3)C(O)=O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H19Cl2N3O5S/c30-21-10-9-20(13-22(21)31)34-24(14-23(33-34)28(35)36)17-3-1-16(2-4-17)15-32-27(40)19-7-5-18(6-8-19)25-11-12-26(39-25)29(37)38/h1-14H,15H2,(H,32,40)(H,35,36)(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair				3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080855 (CHEMBL3422468) Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=S)NCc2ccc(cc2)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H19Cl2N3O5S/c30-21-10-9-20(13-22(21)31)34-24(14-23(33-34)28(35)36)17-5-7-19(8-6-17)27(40)32-15-16-1-3-18(4-2-16)25-11-12-26(39-25)29(37)38/h1-14H,15H2,(H,32,40)(H,35,36)(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair				3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080820 (CHEMBL3422476) Show SMILES OC(=O)c1ccc(o1)-c1ccc(C(=S)NCc2ccc(cc2)-c2ccnn2-c2ccc(Cl)c(Cl)c2)c(Cl)c1 Show InChI InChI=1S/C28H18Cl3N3O3S/c29-21-8-6-19(14-23(21)31)34-24(11-12-33-34)17-3-1-16(2-4-17)15-32-27(38)20-7-5-18(13-22(20)30)25-9-10-26(37-25)28(35)36/h1-14H,15H2,(H,32,38)(H,35,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair				3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080823 (CHEMBL3422474) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3)-c3nnn[nH]3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C25H17Cl2N7O2S/c26-19-10-9-18(11-20(19)27)34-22(12-21(31-34)25(35)36)15-3-1-14(2-4-15)13-28-24(37)17-7-5-16(6-8-17)23-29-32-33-30-23/h1-12H,13H2,(H,28,37)(H,35,36)(H,29,30,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080856 (CHEMBL3422467) Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=S)NCc2cccc(c2)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H19Cl2N3O5S/c30-21-9-8-20(13-22(21)31)34-24(14-23(33-34)28(35)36)17-4-6-18(7-5-17)27(40)32-15-16-2-1-3-19(12-16)25-10-11-26(39-25)29(37)38/h1-14H,15H2,(H,32,40)(H,35,36)(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080858 (CHEMBL3422465) Show SMILES CC(=O)N(Cc1ccc(cc1)-c1ccc(o1)C(O)=O)Cc1cccc(c1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O Show InChI InChI=1S/C31H23Cl2N3O6/c1-18(37)35(16-19-5-7-21(8-6-19)28-11-12-29(42-28)31(40)41)17-20-3-2-4-22(13-20)27-15-26(30(38)39)34-36(27)23-9-10-24(32)25(33)14-23/h2-15H,16-17H2,1H3,(H,38,39)(H,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080822 (CHEMBL3422475) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3)-c3nc(=O)o[nH]3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C26H17Cl2N5O4S/c27-19-10-9-18(11-20(19)28)33-22(12-21(31-33)25(34)35)15-3-1-14(2-4-15)13-29-24(38)17-7-5-16(6-8-17)23-30-26(36)37-32-23/h1-12H,13H2,(H,29,38)(H,34,35)(H,30,32,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080829 (CHEMBL3422470) Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=O)NCc2ccc(cc2Cl)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H18Cl3N3O6/c30-20-8-7-19(12-22(20)32)35-24(13-23(34-35)28(37)38)15-1-3-16(4-2-15)27(36)33-14-18-6-5-17(11-21(18)31)25-9-10-26(41-25)29(39)40/h1-13H,14H2,(H,33,36)(H,37,38)(H,39,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080862 (CHEMBL3422461) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(Br)cc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H16BrCl2N3O2S/c25-17-7-5-16(6-8-17)23(33)28-13-14-1-3-15(4-2-14)22-12-21(24(31)32)29-30(22)18-9-10-19(26)20(27)11-18/h1-12H,13H2,(H,28,33)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080864 (CHEMBL3422459) Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=S)NCc2ccccc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H17Cl2N3O2S/c25-19-11-10-18(12-20(19)26)29-22(13-21(28-29)24(30)31)16-6-8-17(9-7-16)23(32)27-14-15-4-2-1-3-5-15/h1-13H,14H2,(H,27,32)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50006680 (CHEMBL3236301) Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)[C@@H](C)O)C(N)=O |r,wU:74.77,87.90,13.13,136.145,102.106,40.43,58.61,4.3,wD:26.27,8.8,91.94,82.85,66.69,49.52,(61.33,-8.28,;61.33,-9.81,;62.67,-10.58,;60,-10.58,;60,-12.12,;58.67,-12.89,;57.33,-12.12,;57.33,-10.58,;55.99,-12.89,;55.99,-14.43,;54.66,-12.11,;53.33,-12.89,;53.33,-14.43,;51.99,-12.11,;51.99,-10.57,;53.33,-9.8,;54.67,-10.58,;56,-9.81,;56,-8.27,;57.34,-7.51,;54.67,-7.49,;54.68,-5.96,;53.33,-8.27,;50.66,-12.88,;49.33,-12.11,;49.33,-10.57,;48,-12.88,;48,-14.42,;49.33,-15.19,;50.73,-14.57,;51.76,-15.72,;50.99,-17.05,;51.46,-18.51,;50.43,-19.67,;48.92,-19.35,;48.44,-17.88,;49.49,-16.72,;46.66,-12.1,;45.32,-12.88,;45.32,-14.42,;43.99,-12.1,;43.99,-10.56,;45.32,-9.79,;45.32,-8.26,;43.99,-7.48,;46.66,-7.48,;42.66,-12.87,;41.32,-12.1,;41.32,-10.56,;39.98,-12.87,;39.98,-14.41,;41.32,-15.18,;41.32,-16.72,;39.98,-17.5,;42.65,-17.49,;38.65,-12.09,;37.32,-12.87,;37.32,-14.41,;35.98,-12.09,;35.98,-10.55,;37.32,-9.78,;37.32,-8.25,;38.66,-10.55,;34.64,-12.86,;33.31,-12.09,;33.31,-10.55,;31.98,-12.86,;31.98,-14.4,;33.31,-15.17,;34.64,-14.4,;33.31,-16.71,;30.64,-12.08,;29.31,-12.86,;29.31,-14.4,;27.98,-12.08,;27.98,-10.54,;29.31,-9.77,;30.65,-10.54,;29.31,-8.24,;26.63,-12.85,;25.29,-12.08,;25.29,-10.54,;23.96,-12.85,;23.96,-14.39,;22.63,-12.07,;21.3,-12.85,;21.3,-14.39,;19.96,-12.07,;18.63,-12.84,;17.3,-12.07,;17.3,-10.53,;15.96,-12.84,;15.96,-14.38,;17.3,-15.15,;18.62,-14.39,;19.94,-15.16,;19.93,-16.7,;18.6,-17.47,;17.29,-16.69,;14.64,-12.07,;13.3,-12.84,;13.3,-14.38,;11.96,-12.07,;11.96,-10.52,;13.3,-9.75,;14.63,-10.52,;13.3,-8.22,;10.62,-12.84,;9.31,-12.06,;9.33,-10.53,;7.97,-12.81,;6.66,-12.03,;5.33,-12.77,;4.01,-11.98,;4.03,-10.44,;5.37,-9.7,;6.69,-10.49,;5.78,-8.22,;7.26,-7.83,;4.7,-7.13,;2.7,-9.65,;1.37,-10.4,;1.35,-11.93,;0,-12.67,;-1.32,-11.89,;-2.67,-12.63,;-1.29,-10.35,;.06,-9.61,;.07,-8.07,;1.42,-7.34,;1.44,-5.8,;2.79,-5.05,;2.8,-3.5,;4.1,-5.84,;4.07,-7.37,;2.73,-8.12,;19.96,-10.53,;18.63,-9.77,;21.3,-9.76,;61.33,-12.9,;62.67,-12.12,;61.33,-14.44,)| Show InChI InChI=1S/C94H108Cl2N16O29S/c1-42(2)29-63(80(97)126)104-81(127)44(5)99-85(131)66(33-48-17-24-58(95)59(96)31-48)108-87(133)67(34-49-41-98-60-16-12-11-15-53(49)60)109-84(130)62(26-28-74(118)119)102-83(129)61(25-27-73(116)117)103-86(132)64(30-43(3)4)106-89(135)69(39-76(122)123)110-88(134)68(38-75(120)121)105-82(128)45(6)100-92(138)79(46(7)113)112-91(137)65(32-47-13-9-8-10-14-47)107-90(136)70(40-77(124)125)111-94(142)101-50-18-21-54(57(35-50)93(139)140)78-55-22-19-51(114)36-71(55)141-72-37-52(115)20-23-56(72)78/h8-24,31,35-37,41-46,61-70,79,98,113-114H,25-30,32-34,38-40H2,1-7H3,(H2,97,126)(H,99,131)(H,100,138)(H,102,129)(H,103,132)(H,104,127)(H,105,128)(H,106,135)(H,107,136)(H,108,133)(H,109,130)(H,110,134)(H,112,137)(H,116,117)(H,118,119)(H,120,121)(H,122,123)(H,124,125)(H,139,140)(H2,101,111,142)/t44-,45-,46+,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,79-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat...				J Med Chem 57: 2455-61 (2014) Article DOI: 10.1021/jm401730y BindingDB Entry DOI: 10.7270/Q29888H7
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080857 (CHEMBL3422466) Show SMILES OC(=O)c1cc(-c2cccc(c2)C(=O)NCc2ccc(cc2)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H19Cl2N3O6/c30-21-9-8-20(13-22(21)31)34-24(14-23(33-34)28(36)37)18-2-1-3-19(12-18)27(35)32-15-16-4-6-17(7-5-16)25-10-11-26(40-25)29(38)39/h1-14H,15H2,(H,32,35)(H,36,37)(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080863 (CHEMBL3422460) Show SMILES COc1ccc(CNC(=S)c2ccc(cc2)-c2cc(nn2-c2ccc(Cl)c(Cl)c2)C(O)=O)cc1 Show InChI InChI=1S/C25H19Cl2N3O3S/c1-33-19-9-2-15(3-10-19)14-28-24(34)17-6-4-16(5-7-17)23-13-22(25(31)32)29-30(23)18-8-11-20(26)21(27)12-18/h2-13H,14H2,1H3,(H,28,34)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080824 (CHEMBL3422473) Show SMILES NS(=O)(=O)c1ccc(cc1)C(=S)NCc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O Show InChI InChI=1S/C24H18Cl2N4O4S2/c25-19-10-7-17(11-20(19)26)30-22(12-21(29-30)24(31)32)15-3-1-14(2-4-15)13-28-23(35)16-5-8-18(9-6-16)36(27,33)34/h1-12H,13H2,(H,28,35)(H,31,32)(H2,27,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080865 (CHEMBL3422458) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=O)c3ccc(Br)cc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H16BrCl2N3O3/c25-17-7-5-16(6-8-17)23(31)28-13-14-1-3-15(4-2-14)22-12-21(24(32)33)29-30(22)18-9-10-19(26)20(27)11-18/h1-12H,13H2,(H,28,31)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50006726 (CHEMBL3236545) Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@]1(C)CCC\C=C/CCC[C@@](C)(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=S)Nc2ccc(c(c2)C(O)=O)-c2c3ccc(O)cc3oc3cc(=O)ccc23)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(O)=O |r,wU:123.131,109.118,60.63,4.3,75.79,13.13,50.53,40.43,wD:115.123,131.139,64.67,55.58,26.27,8.8,c:48,(68.86,-13.3,;68.86,-14.83,;70.19,-15.6,;67.52,-15.6,;67.52,-17.13,;66.19,-17.9,;64.87,-17.12,;64.87,-15.59,;63.54,-17.89,;63.54,-19.44,;62.2,-17.12,;60.88,-17.89,;60.88,-19.43,;59.54,-17.12,;59.54,-15.59,;60.88,-14.82,;62.21,-15.59,;63.54,-14.82,;63.54,-13.29,;64.88,-12.53,;62.21,-12.51,;62.22,-10.97,;60.88,-13.29,;58.21,-17.88,;56.87,-17.11,;56.87,-15.58,;55.54,-17.88,;55.54,-19.42,;56.87,-20.19,;58.28,-19.57,;59.31,-20.71,;58.53,-22.04,;59.02,-23.51,;57.98,-24.65,;56.47,-24.33,;56.01,-22.86,;57.03,-21.72,;54.22,-17.11,;52.89,-17.88,;52.89,-19.42,;51.55,-17.11,;52.64,-16,;50.78,-15.76,;51.54,-14.43,;50.78,-13.1,;51.54,-11.77,;50.78,-10.44,;37.84,-13.7,;37.45,-15.18,;35.97,-15.6,;35.58,-17.08,;34.8,-15.75,;34.26,-17.86,;32.92,-17.08,;32.92,-15.55,;31.59,-17.86,;31.59,-19.39,;30.25,-17.08,;28.93,-17.85,;28.93,-19.39,;27.59,-17.07,;26.26,-17.85,;24.94,-17.07,;24.94,-15.54,;23.61,-17.85,;23.61,-19.38,;24.94,-20.15,;26.26,-19.39,;27.59,-20.16,;27.59,-21.69,;26.26,-22.46,;24.93,-21.69,;22.28,-17.07,;20.94,-17.85,;20.94,-19.38,;19.6,-17.07,;19.6,-15.53,;20.94,-14.77,;22.28,-15.53,;20.94,-13.23,;18.27,-17.85,;16.89,-17.02,;16.91,-15.41,;15.48,-17.81,;14.09,-16.99,;12.7,-17.77,;11.31,-16.94,;11.32,-15.32,;12.74,-14.54,;14.13,-15.37,;13.17,-12.98,;14.73,-12.57,;12.03,-11.83,;9.93,-14.49,;8.53,-15.27,;8.51,-16.88,;7.08,-17.67,;5.7,-16.84,;4.27,-17.63,;5.73,-15.22,;7.14,-14.44,;7.15,-12.82,;8.58,-12.05,;8.6,-10.43,;10.02,-9.63,;10.03,-8,;11.4,-10.47,;11.37,-12.08,;9.96,-12.87,;27.59,-15.54,;26.26,-14.78,;28.93,-14.78,;36.91,-17.86,;36.91,-19.4,;38.24,-17.09,;39.58,-17.87,;39.58,-19.4,;40.9,-20.17,;42.23,-19.4,;40.9,-21.71,;40.9,-17.09,;40.9,-15.56,;42.24,-17.87,;43.57,-17.09,;43.57,-15.57,;44.9,-14.79,;44.9,-13.27,;46.23,-15.57,;44.9,-17.88,;44.9,-19.41,;46.23,-17.1,;47.56,-17.88,;47.56,-19.41,;48.89,-20.17,;48.89,-21.72,;47.56,-22.49,;50.22,-22.49,;48.89,-17.1,;48.89,-15.57,;50.23,-17.88,;68.86,-17.9,;70.18,-17.13,;68.86,-19.44,)| Show InChI InChI=1S/C99H119Cl2N17O24S/c1-49(2)37-69-86(129)108-68(33-34-80(124)125)91(134)118-99(9,96(141)113-72(42-56-48-104-67-24-18-17-23-60(56)67)87(130)111-71(41-55-25-32-65(100)66(101)39-55)85(128)105-51(5)83(126)112-75(94(138)139)38-50(3)4)36-20-13-11-10-12-19-35-98(8,95(140)114-73(46-78(102)122)88(131)109-69)117-84(127)52(6)106-92(135)82(53(7)119)116-90(133)70(40-54-21-15-14-16-22-54)110-89(132)74(47-79(103)123)115-97(143)107-57-26-29-61(64(43-57)93(136)137)81-62-30-27-58(120)44-76(62)142-77-45-59(121)28-31-63(77)81/h10-11,14-18,21-32,39,43-45,48-53,68-75,82,104,119-120H,12-13,19-20,33-38,40-42,46-47H2,1-9H3,(H2,102,122)(H2,103,123)(H,105,128)(H,106,135)(H,108,129)(H,109,131)(H,110,132)(H,111,130)(H,112,126)(H,113,141)(H,114,140)(H,116,133)(H,117,127)(H,118,134)(H,124,125)(H,136,137)(H,138,139)(H2,107,115,143)/b11-10-/t51-,52-,53+,68-,69-,70-,71-,72-,73-,74-,75-,82-,98+,99+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat...				J Med Chem 57: 2455-61 (2014) Article DOI: 10.1021/jm401730y BindingDB Entry DOI: 10.7270/Q29888H7
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080673 (CHEMBL3422456) Show SMILES COc1ccc(CNC(=O)c2ccc(cc2)-c2cc(nn2-c2ccc(Cl)c(Cl)c2)C(O)=O)cc1 Show InChI InChI=1S/C25H19Cl2N3O4/c1-34-19-9-2-15(3-10-19)14-28-24(31)17-6-4-16(5-7-17)23-13-22(25(32)33)29-30(23)18-8-11-20(26)21(27)12-18/h2-13H,14H2,1H3,(H,28,31)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50006725 (CHEMBL3236544) Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@]1(C)CCC\C=C/CCC[C@@](C)(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=S)Nc2ccc(c(c2)C(O)=O)-c2c3ccc(O)cc3oc3cc(=O)ccc23)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(O)=O |r,wU:50.53,40.43,109.118,123.131,60.63,75.79,13.13,4.3,wD:8.8,26.27,55.58,115.123,64.67,131.139,c:48,(73.25,-15.83,;71.91,-15.06,;71.91,-13.53,;70.58,-15.83,;70.58,-17.36,;69.25,-18.13,;67.93,-17.36,;67.93,-15.83,;66.6,-18.13,;66.6,-19.67,;65.26,-17.35,;63.94,-18.12,;63.94,-19.67,;62.6,-17.35,;62.6,-15.82,;63.94,-15.05,;65.27,-15.83,;66.6,-15.06,;66.6,-13.52,;67.94,-12.76,;65.27,-12.74,;65.27,-11.21,;63.94,-13.52,;61.26,-18.12,;59.93,-17.35,;59.93,-15.82,;58.6,-18.12,;58.6,-19.66,;59.93,-20.42,;61.34,-19.81,;62.36,-20.94,;61.59,-22.28,;62.08,-23.74,;61.04,-24.88,;59.53,-24.56,;59.07,-23.09,;60.09,-21.96,;57.28,-17.34,;55.95,-18.11,;55.95,-19.66,;54.61,-17.34,;55.7,-16.24,;53.84,-16,;54.6,-14.67,;53.84,-13.34,;54.6,-12.01,;53.83,-10.68,;40.9,-13.94,;40.51,-15.42,;39.03,-15.83,;38.64,-17.32,;37.86,-15.98,;37.32,-18.1,;35.98,-17.32,;35.98,-15.79,;34.65,-18.09,;34.65,-19.63,;33.32,-17.31,;31.99,-18.09,;31.99,-19.62,;30.65,-17.31,;29.33,-18.08,;28,-17.31,;28,-15.78,;26.67,-18.08,;26.67,-19.62,;28,-20.39,;28,-21.92,;29.32,-22.69,;30.65,-21.92,;30.65,-20.39,;29.32,-19.62,;25.34,-17.3,;24,-18.08,;24,-19.61,;22.67,-17.3,;22.67,-15.77,;24,-15.01,;25.34,-15.77,;24,-13.47,;21.34,-18.08,;19.95,-17.26,;19.97,-15.64,;18.54,-18.04,;17.16,-17.22,;15.76,-18,;14.37,-17.17,;14.39,-15.55,;15.8,-14.77,;17.19,-15.6,;16.23,-13.22,;17.8,-12.8,;15.1,-12.06,;12.99,-14.72,;11.59,-15.51,;11.57,-17.12,;10.15,-17.9,;8.77,-17.08,;7.33,-17.86,;8.79,-15.46,;10.2,-14.67,;10.22,-13.06,;11.65,-12.28,;11.66,-10.66,;13.08,-9.87,;13.1,-8.24,;14.47,-10.71,;14.43,-12.32,;13.02,-13.11,;30.65,-15.78,;29.33,-15.02,;31.99,-15.02,;39.97,-18.1,;39.97,-19.63,;41.3,-17.32,;42.64,-18.1,;42.64,-19.64,;43.96,-20.41,;45.29,-19.64,;43.96,-21.94,;43.96,-17.33,;43.96,-15.8,;45.3,-18.11,;46.63,-17.33,;46.63,-15.8,;47.96,-15.03,;47.96,-13.5,;49.29,-15.8,;47.96,-18.11,;47.96,-19.64,;49.29,-17.33,;50.62,-18.11,;50.62,-19.65,;51.95,-20.41,;51.95,-21.95,;50.62,-22.72,;53.28,-22.72,;51.95,-17.34,;51.95,-15.81,;53.29,-18.12,;71.91,-18.13,;73.24,-17.36,;71.91,-19.68,)| Show InChI InChI=1S/C99H118Cl2N16O25S/c1-49(2)37-69-86(129)107-68(33-34-79(122)123)91(134)117-99(9,96(141)112-72(42-56-48-103-67-24-18-17-23-60(56)67)87(130)110-71(41-55-25-32-65(100)66(101)39-55)85(128)104-51(5)83(126)111-75(94(138)139)38-50(3)4)36-20-13-11-10-12-19-35-98(8,95(140)113-74(47-80(124)125)89(132)108-69)116-84(127)52(6)105-92(135)82(53(7)118)115-90(133)70(40-54-21-15-14-16-22-54)109-88(131)73(46-78(102)121)114-97(143)106-57-26-29-61(64(43-57)93(136)137)81-62-30-27-58(119)44-76(62)142-77-45-59(120)28-31-63(77)81/h10-11,14-18,21-32,39,43-45,48-53,68-75,82,103,118-119H,12-13,19-20,33-38,40-42,46-47H2,1-9H3,(H2,102,121)(H,104,128)(H,105,135)(H,107,129)(H,108,132)(H,109,131)(H,110,130)(H,111,126)(H,112,141)(H,113,140)(H,115,133)(H,116,127)(H,117,134)(H,122,123)(H,124,125)(H,136,137)(H,138,139)(H2,106,114,143)/b11-10-/t51-,52-,53+,68-,69-,70-,71-,72-,73-,74-,75-,82-,98+,99+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat...				J Med Chem 57: 2455-61 (2014) Article DOI: 10.1021/jm401730y BindingDB Entry DOI: 10.7270/Q29888H7
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080785 (CHEMBL3422435) Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-8-14(16(22)23)20-21(15)11-5-6-12(18)13(19)7-11/h1-8H,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080860 (CHEMBL3422463) Show SMILES OC(=O)c1cc(-c2ccc(CNS(=O)(=O)c3ccc(OC(F)(F)F)cc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H16Cl2F3N3O5S/c25-19-10-5-16(11-20(19)26)32-22(12-21(31-32)23(33)34)15-3-1-14(2-4-15)13-30-38(35,36)18-8-6-17(7-9-18)37-24(27,28)29/h1-12,30H,13H2,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080859 (CHEMBL3422464) Show SMILES OC(=O)c1cc(-c2cccc(CNCc3ccc(cc3)-c3ccc(o3)C(O)=O)c2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H21Cl2N3O5/c30-22-9-8-21(13-23(22)31)34-25(14-24(33-34)28(35)36)20-3-1-2-18(12-20)16-32-15-17-4-6-19(7-5-17)26-10-11-27(39-26)29(37)38/h1-14,32H,15-16H2,(H,35,36)(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080772 (CHEMBL3422448) Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H10Cl2N2O4/c18-12-6-5-11(7-13(12)19)21-15(8-14(20-21)17(24)25)9-1-3-10(4-2-9)16(22)23/h1-8H,(H,22,23)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080785 (CHEMBL3422435) Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-8-14(16(22)23)20-21(15)11-5-6-12(18)13(19)7-11/h1-8H,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080861 (CHEMBL3422462) Show SMILES OC(=O)c1cc(-c2ccc(CNS(=O)(=O)c3ccccc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C23H17Cl2N3O4S/c24-19-11-10-17(12-20(19)25)28-22(13-21(27-28)23(29)30)16-8-6-15(7-9-16)14-26-33(31,32)18-4-2-1-3-5-18/h1-13,26H,14H2,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080774 (CHEMBL3422446) Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O Show InChI InChI=1S/C17H12Cl2N2O2/c1-10-2-4-11(5-3-10)16-9-15(17(22)23)20-21(16)12-6-7-13(18)14(19)8-12/h2-9H,1H3,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080866 (CHEMBL3422457) Show SMILES COc1ccc(cc1)C(=O)NCc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O Show InChI InChI=1S/C25H19Cl2N3O4/c1-34-19-9-6-17(7-10-19)24(31)28-14-15-2-4-16(5-3-15)23-13-22(25(32)33)29-30(23)18-8-11-20(26)21(27)12-18/h2-13H,14H2,1H3,(H,28,31)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080778 (CHEMBL3422442) Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O Show InChI InChI=1S/C17H12Cl2N2O3/c1-24-12-5-2-10(3-6-12)16-9-15(17(22)23)20-21(16)11-4-7-13(18)14(19)8-11/h2-9H,1H3,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080674 (CHEMBL3422455) Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=O)NCc2ccccc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H17Cl2N3O3/c25-19-11-10-18(12-20(19)26)29-22(13-21(28-29)24(31)32)16-6-8-17(9-7-16)23(30)27-14-15-4-2-1-3-5-15/h1-13H,14H2,(H,27,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080775 (CHEMBL3422445) Show SMILES Cc1cccc(c1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O Show InChI InChI=1S/C17H12Cl2N2O2/c1-10-3-2-4-11(7-10)16-9-15(17(22)23)20-21(16)12-5-6-13(18)14(19)8-12/h2-9H,1H3,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080584 (CHEMBL3421641) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=O)c3ccccc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H17Cl2N3O3/c25-19-11-10-18(12-20(19)26)29-22(13-21(28-29)24(31)32)16-8-6-15(7-9-16)14-27-23(30)17-4-2-1-3-5-17/h1-13H,14H2,(H,27,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080768 (CHEMBL3422452) Show SMILES OC(=O)c1cc(-c2ccc(O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H10Cl2N2O3/c17-12-6-3-10(7-13(12)18)20-15(8-14(19-20)16(22)23)9-1-4-11(21)5-2-9/h1-8,21H,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080776 (CHEMBL3422444) Show SMILES OC(=O)c1cc(-c2ccccc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H10Cl2N2O2/c17-12-7-6-11(8-13(12)18)20-15(9-14(19-20)16(21)22)10-4-2-1-3-5-10/h1-9H,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	123	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080773 (CHEMBL3422447) Show SMILES OC(=O)c1cc(-c2cccc(c2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H10Cl2N2O4/c18-12-5-4-11(7-13(12)19)21-15(8-14(20-21)17(24)25)9-2-1-3-10(6-9)16(22)23/h1-8H,(H,22,23)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080782 (CHEMBL3422438) Show SMILES COc1ccc(cc1)-c1cc(nn1-c1cccc(Br)c1)C(O)=O Show InChI InChI=1S/C17H13BrN2O3/c1-23-14-7-5-11(6-8-14)16-10-15(17(21)22)19-20(16)13-4-2-3-12(18)9-13/h2-10H,1H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50443300 (CHEMBL3088230) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3Cl)-c3ccc(o3)C(O)=O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H18Cl3N3O5S/c30-20-8-6-18(12-22(20)32)35-24(13-23(34-35)28(36)37)16-3-1-15(2-4-16)14-33-27(41)19-7-5-17(11-21(19)31)25-9-10-26(40-25)29(38)39/h1-13H,14H2,(H,33,41)(H,36,37)(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N (1 to 120) (unknown origin) expressed in Escherichia coli BL21-DE3 cells by FPA assay				J Med Chem 56: 9242-50 (2013) Article DOI: 10.1021/jm401333u BindingDB Entry DOI: 10.7270/Q2B56M5D
					More data for this Ligand-Target Pair				3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50443300 (CHEMBL3088230) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3Cl)-c3ccc(o3)C(O)=O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H18Cl3N3O5S/c30-20-8-6-18(12-22(20)32)35-24(13-23(34-35)28(36)37)16-3-1-15(2-4-16)14-33-27(41)19-7-5-17(11-21(19)31)25-9-10-26(40-25)29(38)39/h1-13H,14H2,(H,33,41)(H,36,37)(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Displacement of FITC-ATRIP2 from RPA70N (1 to 120) (unknown origin) by FPA assay				J Med Chem 56: 9242-50 (2013) Article DOI: 10.1021/jm401333u BindingDB Entry DOI: 10.7270/Q2B56M5D
					More data for this Ligand-Target Pair				3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080769 (CHEMBL3422451) Show SMILES Nc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O Show InChI InChI=1S/C16H11Cl2N3O2/c17-12-6-5-11(7-13(12)18)21-15(8-14(20-21)16(22)23)9-1-3-10(19)4-2-9/h1-8H,19H2,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	227	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080816 (CHEMBL1576514) Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C16H10Cl2N2O2/c17-11-3-1-10(2-4-11)15-9-14(16(21)22)19-20(15)13-7-5-12(18)6-8-13/h1-9H,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50443300 (CHEMBL3088230) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3Cl)-c3ccc(o3)C(O)=O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H18Cl3N3O5S/c30-20-8-6-18(12-22(20)32)35-24(13-23(34-35)28(36)37)16-3-1-15(2-4-16)14-33-27(41)19-7-5-17(11-21(19)31)25-9-10-26(40-25)29(38)39/h1-13H,14H2,(H,33,41)(H,36,37)(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70NAB (unknown origin) by FPA assay				J Med Chem 56: 9242-50 (2013) Article DOI: 10.1021/jm401333u BindingDB Entry DOI: 10.7270/Q2B56M5D
					More data for this Ligand-Target Pair				3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080771 (CHEMBL3422449) Show SMILES OC(=O)c1cc(-c2ccc(cc2)C#N)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H9Cl2N3O2/c18-13-6-5-12(7-14(13)19)22-16(8-15(21-22)17(23)24)11-3-1-10(9-20)2-4-11/h1-8H,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50443300 (CHEMBL3088230) Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3Cl)-c3ccc(o3)C(O)=O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H18Cl3N3O5S/c30-20-8-6-18(12-22(20)32)35-24(13-23(34-35)28(36)37)16-3-1-15(2-4-16)14-33-27(41)19-7-5-17(11-21(19)31)25-9-10-26(40-25)29(38)39/h1-13H,14H2,(H,33,41)(H,36,37)(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	323	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Displacement of FITC-ATRIP2 from RPA70NAB domain (unknown origin) by FPA assay				J Med Chem 56: 9242-50 (2013) Article DOI: 10.1021/jm401333u BindingDB Entry DOI: 10.7270/Q2B56M5D
					More data for this Ligand-Target Pair				3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50006678 (CHEMBL3236299) Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)[C@@H](C)O)C(N)=O |r,wU:38.41,100.104,13.13,56.59,85.88,4.3,72.75,134.143,wD:89.92,8.8,24.25,64.67,80.83,47.50,(70,-11.58,;70,-13.12,;71.33,-13.88,;68.66,-13.88,;68.66,-15.42,;67.34,-16.19,;66,-15.42,;66,-13.88,;64.67,-16.19,;64.67,-17.73,;63.34,-15.41,;62,-16.18,;62,-17.73,;60.67,-15.41,;60.67,-13.87,;62,-13.11,;62.01,-11.57,;63.35,-10.8,;64.68,-11.57,;64.68,-13.11,;63.35,-13.88,;59.34,-16.18,;58.01,-15.41,;58.01,-13.87,;56.67,-16.18,;56.67,-17.72,;58.01,-18.48,;59.41,-17.87,;60.45,-19.01,;59.67,-20.34,;60.15,-21.81,;59.11,-22.96,;57.6,-22.63,;57.14,-21.17,;58.16,-20.02,;55.34,-15.4,;54.02,-16.17,;54.02,-17.72,;52.68,-15.4,;52.68,-13.86,;54.02,-13.1,;54.02,-11.56,;52.69,-10.79,;55.35,-10.79,;51.35,-16.17,;50.01,-15.4,;50.01,-13.86,;48.68,-16.17,;48.68,-17.71,;50.01,-18.47,;50.01,-20.01,;48.68,-20.79,;51.34,-20.79,;47.35,-15.39,;46.02,-16.16,;46.02,-17.71,;44.69,-15.39,;44.69,-13.85,;46.02,-13.09,;47.36,-13.85,;46.02,-11.55,;43.36,-16.16,;42.02,-15.39,;42.02,-13.85,;40.69,-16.16,;40.69,-17.7,;42.02,-18.47,;43.35,-17.7,;42.02,-20,;39.36,-15.39,;38.03,-16.16,;38.03,-17.7,;36.69,-15.39,;36.69,-13.84,;38.03,-13.08,;39.36,-13.84,;38.03,-11.54,;35.37,-16.16,;34.03,-15.38,;34.03,-13.84,;32.7,-16.15,;32.7,-17.7,;31.36,-15.38,;30.03,-16.15,;30.03,-17.69,;28.7,-15.38,;27.37,-16.15,;26.04,-15.37,;26.04,-13.84,;24.71,-16.15,;24.71,-17.69,;26.04,-18.45,;27.37,-17.69,;28.7,-18.46,;28.7,-20,;27.36,-20.77,;26.03,-19.99,;23.38,-15.37,;22.04,-16.15,;22.04,-17.68,;20.7,-15.37,;20.7,-13.83,;22.04,-13.07,;23.38,-13.83,;22.04,-11.53,;19.38,-16.14,;18.06,-15.36,;18.08,-13.82,;16.72,-16.11,;15.4,-15.33,;14.07,-16.07,;12.74,-15.28,;12.76,-13.74,;14.1,-12.99,;15.43,-13.78,;14.51,-11.51,;16,-11.12,;13.43,-10.41,;11.43,-12.94,;10.09,-13.69,;10.07,-15.23,;8.71,-15.97,;7.4,-15.19,;6.03,-15.93,;7.42,-13.65,;8.77,-12.9,;8.78,-11.36,;10.14,-10.62,;10.16,-9.07,;11.51,-8.32,;11.52,-6.76,;12.83,-9.12,;12.8,-10.65,;11.46,-11.41,;28.7,-13.84,;27.37,-13.08,;30.03,-13.08,;70,-16.19,;71.33,-15.42,;70,-17.74,)| Show InChI InChI=1S/C94H110N16O29S/c1-44(2)32-63(80(95)124)102-81(125)46(5)97-85(129)65(34-49-16-10-8-11-17-49)105-87(131)67(36-51-43-96-60-21-15-14-20-55(51)60)107-84(128)62(29-31-74(116)117)100-83(127)61(28-30-73(114)115)101-86(130)64(33-45(3)4)104-89(133)69(41-76(120)121)108-88(132)68(40-75(118)119)103-82(126)47(6)98-92(136)79(48(7)111)110-91(135)66(35-50-18-12-9-13-19-50)106-90(134)70(42-77(122)123)109-94(140)99-52-22-25-56(59(37-52)93(137)138)78-57-26-23-53(112)38-71(57)139-72-39-54(113)24-27-58(72)78/h8-27,37-39,43-48,61-70,79,96,111-112H,28-36,40-42H2,1-7H3,(H2,95,124)(H,97,129)(H,98,136)(H,100,127)(H,101,130)(H,102,125)(H,103,126)(H,104,133)(H,105,131)(H,106,134)(H,107,128)(H,108,132)(H,110,135)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,122,123)(H,137,138)(H2,99,109,140)/t46-,47-,48+,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,79-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat...				J Med Chem 57: 2455-61 (2014) Article DOI: 10.1021/jm401730y BindingDB Entry DOI: 10.7270/Q29888H7
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080815 (CHEMBL3422434) Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-8-13(16(22)23)20-21(15)14-6-5-11(18)7-12(14)19/h1-8H,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50006665 (CHEMBL3236288) Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r,wU:100.104,85.88,72.75,56.59,134.143,4.3,38.41,13.13,145.153,wD:64.67,80.83,140.148,89.92,8.8,47.50,24.25,(64.07,-11.82,;62.73,-11.04,;62.73,-9.51,;61.4,-11.82,;61.4,-13.36,;60.06,-14.12,;58.73,-13.36,;58.73,-11.82,;57.39,-14.12,;57.39,-15.67,;56.06,-13.36,;54.72,-14.12,;54.72,-15.66,;53.39,-13.35,;53.39,-11.82,;54.72,-11.04,;54.73,-9.5,;56.06,-8.74,;57.4,-9.5,;57.4,-11.04,;56.06,-11.82,;52.05,-14.12,;50.71,-13.35,;50.71,-11.81,;49.38,-14.11,;49.38,-15.66,;50.71,-16.43,;52.12,-15.8,;53.13,-16.95,;52.36,-18.29,;52.85,-19.75,;51.81,-20.91,;50.3,-20.58,;49.84,-19.12,;50.87,-17.97,;48.05,-13.35,;46.71,-14.11,;46.71,-15.65,;45.38,-13.34,;45.38,-11.81,;46.71,-11.03,;46.71,-9.49,;45.38,-8.73,;48.05,-8.72,;44.04,-14.11,;42.71,-13.34,;42.71,-11.8,;41.37,-14.1,;41.37,-15.65,;42.71,-16.42,;42.71,-17.97,;41.37,-18.73,;44.04,-18.73,;40.03,-13.34,;38.7,-14.1,;38.7,-15.64,;37.37,-13.33,;37.37,-11.8,;38.7,-11.02,;40.03,-11.8,;38.7,-9.48,;36.03,-14.1,;34.69,-13.33,;34.69,-11.79,;33.37,-14.09,;33.37,-15.64,;34.69,-16.41,;36.03,-15.64,;34.69,-17.96,;32.03,-13.33,;30.7,-14.09,;30.7,-15.63,;29.35,-13.33,;29.35,-11.79,;30.7,-11.01,;32.03,-11.79,;30.7,-9.47,;28.03,-14.09,;26.69,-13.32,;26.69,-11.78,;25.36,-14.08,;25.36,-15.63,;24.01,-13.32,;22.69,-14.08,;22.69,-15.62,;21.35,-13.32,;20.02,-14.08,;18.68,-13.31,;18.68,-11.77,;17.35,-14.07,;17.35,-15.62,;18.68,-16.4,;18.67,-17.94,;19.99,-18.71,;21.33,-17.95,;21.33,-16.41,;20,-15.62,;16.01,-13.31,;14.67,-14.07,;14.67,-15.62,;13.34,-13.31,;13.34,-11.77,;14.68,-10.99,;16.01,-11.77,;14.68,-9.45,;12.01,-14.07,;10.69,-13.29,;10.71,-11.76,;9.36,-14.04,;8.04,-13.26,;6.72,-14,;5.39,-13.21,;5.41,-11.67,;6.75,-10.93,;8.07,-11.72,;7.16,-9.45,;8.65,-9.06,;6.08,-8.36,;4.08,-10.88,;2.75,-11.63,;2.73,-13.16,;1.38,-13.9,;.07,-13.12,;-1.29,-13.86,;.09,-11.58,;1.44,-10.84,;1.45,-9.3,;2.8,-8.57,;2.82,-7.03,;4.17,-6.27,;4.18,-4.72,;5.48,-7.07,;5.45,-8.6,;4.11,-9.35,;21.35,-11.78,;20.02,-11,;22.69,-11,;62.73,-14.13,;62.73,-15.67,;64.07,-13.37,;65.4,-14.13,;65.4,-15.68,;66.74,-13.37,;66.74,-11.83,;68.07,-14.13,;69.41,-13.37,;69.41,-11.83,;70.74,-11.05,;70.74,-14.14,;72.07,-13.38,;70.74,-15.68,)| Show InChI InChI=1S/C100H120N18O32S/c1-46(2)33-66(90(139)103-49(6)87(136)116-74(45-119)84(101)133)109-85(134)48(5)104-91(140)68(35-52-17-11-9-12-18-52)112-93(142)70(37-54-44-102-63-22-16-15-21-58(54)63)114-89(138)65(30-32-78(125)126)107-88(137)64(29-31-77(123)124)108-92(141)67(34-47(3)4)111-95(144)72(42-80(129)130)115-94(143)71(41-79(127)128)110-86(135)50(7)105-98(147)83(51(8)120)118-97(146)69(36-53-19-13-10-14-20-53)113-96(145)73(43-81(131)132)117-100(151)106-55-23-26-59(62(38-55)99(148)149)82-60-27-24-56(121)39-75(60)150-76-40-57(122)25-28-61(76)82/h9-28,38-40,44,46-51,64-74,83,102,119-121H,29-37,41-43,45H2,1-8H3,(H2,101,133)(H,103,139)(H,104,140)(H,105,147)(H,107,137)(H,108,141)(H,109,134)(H,110,135)(H,111,144)(H,112,142)(H,113,145)(H,114,138)(H,115,143)(H,116,136)(H,118,146)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,148,149)(H2,106,117,151)/t48-,49-,50-,51+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,83-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat...				J Med Chem 57: 2455-61 (2014) Article DOI: 10.1021/jm401730y BindingDB Entry DOI: 10.7270/Q29888H7
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080767 (CHEMBL3422453) Show SMILES OC(=O)c1cc(-c2ccco2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C14H8Cl2N2O3/c15-9-4-3-8(6-10(9)16)18-12(13-2-1-5-21-13)7-11(17-18)14(19)20/h1-7H,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080693 (CHEMBL3422454) Show SMILES OC(=O)c1cc(Cc2ccc(O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H12Cl2N2O3/c18-14-6-3-11(8-15(14)19)21-12(9-16(20-21)17(23)24)7-10-1-4-13(22)5-2-10/h1-6,8-9,22H,7H2,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50080815 (CHEMBL3422434) Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-8-13(16(22)23)20-21(15)14-6-5-11(18)7-12(14)19/h1-8H,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit (Homo sapiens (Human))	BDBM50443304 (CHEMBL3088227) Show SMILES Cc1cccc(c1)-n1nc(cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C17H14N2O2/c1-12-6-5-9-14(10-12)19-16(11-15(18-19)17(20)21)13-7-3-2-4-8-13/h2-11H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...				ACS Med Chem Lett 6: 140-5 (2015) Article DOI: 10.1021/ml5003629 BindingDB Entry DOI: 10.7270/Q2HM5B5R
					More data for this Ligand-Target Pair				3D Structure (crystal)

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