| Reaction Details |
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 | Report a problem with these data |
| Target | Replication protein A 70 kDa DNA-binding subunit |
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| Ligand | BDBM50080674 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1475234 (CHEMBL3425032) |
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| Kd | 83±n/a nM |
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| Citation |  Waterson, AG; Kennedy, JP; Patrone, JD; Pelz, NF; Feldkamp, MD; Frank, AO; Vangamudi, B; Souza-Fagundes, EM; Rossanese, OW; Chazin, WJ; Fesik, SW Diphenylpyrazoles as replication protein a inhibitors. ACS Med Chem Lett6:140-5 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Replication protein A 70 kDa DNA-binding subunit |
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| Name: | Replication protein A 70 kDa DNA-binding subunit |
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| Synonyms: | REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 68139.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27694 |
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| Residue: | 616 |
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| Sequence: | MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLAT
QLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNE
GLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGT
QSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNE
QVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQF
DFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATL
WGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQ
ALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQA
CPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAIL
GQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYR
EYGRRLVMSIRRSALM
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| BDBM50080674 |
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| n/a |
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| Name | BDBM50080674 |
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| Synonyms: | CHEMBL3422455 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H17Cl2N3O3 |
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| Mol. Mass. | 466.316 |
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| SMILES | OC(=O)c1cc(-c2ccc(cc2)C(=O)NCc2ccccc2)n(n1)-c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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