Compile Data Set for Download or QSAR

Found 73 hits of ic50 for UniProtKB: P00533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555115 (3-[(3,5-difluorophenyl)amino]-2-[3-(2-methoxyethox...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cc(F)cc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.0720	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555116 (3-[(3,5-difluorophenyl)amino]-2-[3-(2-methoxy-2-me...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cc(F)cc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.0720	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555112 (3-[(3-fluorophenyl)amino]-2-[3-(2-methoxy-2-methyl...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.0720	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555110 (3-[(3-fluorophenyl)amino]-2-[3-(2-hydroxy-2-methyl...) Show SMILES CC(C)(O)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.0720	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555118 (3-[(2-bromo-3-fluorophenyl)amino]-2-[3-(2-methoxye...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0860	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555136 (3-[(3,5-difluoro-2-methoxyphenyl)amino]-2-[3-(2-me...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cc(F)cc(F)c1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555137 (3-[(3,5-difluoro-2-methoxyphenyl)amino]-2-[3-(2-me...) Show SMILES COc1c(F)cc(F)cc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCC(C)(C)OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0990	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555123 (3-[(3-fluoro-2-methoxyphenyl)amino]-2-[3-(2-methox...) Show SMILES COc1c(F)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCC(C)(C)OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.113	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555124 (3-{[2-(difluoromethoxy)-3-fluorophenyl]amino}-2-[3...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1OC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555110 (3-[(3-fluorophenyl)amino]-2-[3-(2-hydroxy-2-methyl...) Show SMILES CC(C)(O)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.131	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555127 (3-[(3-fluoro-2-methylphenyl)amino]-2-[3-(2-methoxy...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.138	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555122 (3-[(3-fluoro-2-methoxyphenyl)amino]-2-[3-(2-methox...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.138	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555126 (3-[(3-fluoro-2-methylphenyl)amino]-2-[3-(2-methoxy...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.149	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555125 (3-{[2-(difluoromethoxy)-3-fluorophenyl]amino}-2-[3...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1OC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.155	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552588 (N-[2-({4-[3-(3-chloro-2-methoxyanilino)-4-oxo-4,5,...) Show SMILES COc1c(Cl)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCCNC(=O)C=C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555137 (3-[(3,5-difluoro-2-methoxyphenyl)amino]-2-[3-(2-me...) Show SMILES COc1c(F)cc(F)cc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCC(C)(C)OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.161	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552593 (N-[2-({4-[3-(3-fluoro-2-methoxyanilino)-4-oxo-4,5,...) Show SMILES COc1c(F)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCCN(C)C(=O)C=C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555128 (3-{[2-(2,2-difluoroethyl)-3-fluorophenyl]amino}-2-...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1CC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.176	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555123 (3-[(3-fluoro-2-methoxyphenyl)amino]-2-[3-(2-methox...) Show SMILES COc1c(F)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCC(C)(C)OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.177	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555136 (3-[(3,5-difluoro-2-methoxyphenyl)amino]-2-[3-(2-me...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cc(F)cc(F)c1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.209	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552600 (3-(3-chloro-2-methoxyanilino)-2-(3-{[(2S)-1-(prop-...) Show SMILES COc1c(Cl)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OC[C@@H]1CCCN1C(=O)C=C |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555122 (3-[(3-fluoro-2-methoxyphenyl)amino]-2-[3-(2-methox...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.212	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555112 (3-[(3-fluorophenyl)amino]-2-[3-(2-methoxy-2-methyl...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.212	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555127 (3-[(3-fluoro-2-methylphenyl)amino]-2-[3-(2-methoxy...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.213	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555118 (3-[(2-bromo-3-fluorophenyl)amino]-2-[3-(2-methoxye...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.218	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555117 (3-{[2-(difluoromethoxy)phenyl]amino}-2-[3-(2-metho...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1ccccc1OC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552592 (N-[2-({4-[3-(3-chloro-2-methoxyanilino)-4-oxo-4,5,...) Show SMILES COc1c(Cl)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCCN(C)C(=O)C=C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.230	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555125 (3-{[2-(difluoromethoxy)-3-fluorophenyl]amino}-2-[3...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1OC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.239	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555135 (3-[(3,4-difluoro-2-methoxyphenyl)amino]-2-[3-(2-me...) Show SMILES COc1c(F)c(F)ccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCC(C)(C)OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.246	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555129 (3-{[2-(2,2-difluoroethyl)-3-fluorophenyl]amino}-2-...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1CC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.259	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555132 (3-[(2-ethoxy-3-fluorophenyl)amino]-2-[3-(2-methoxy...) Show SMILES CCOc1c(F)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCC(C)(C)OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.268	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552590 (N-[2-({4-[3-(3-chloro-2-methylanilino)-4-oxo-4,5,6...) Show SMILES Cc1c(Cl)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCCNC(=O)C=C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555103 (2-[3-(benzyloxy)pyridin-4-yl]-3-[(3-fluorophenyl)a...) Show SMILES Fc1cccc(Nc2c([nH]c3CCNC(=O)c23)-c2ccncc2OCc2ccccc2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555124 (3-{[2-(difluoromethoxy)-3-fluorophenyl]amino}-2-[3...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1OC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555128 (3-{[2-(2,2-difluoroethyl)-3-fluorophenyl]amino}-2-...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1CC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.309	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552591 (N-[3-({4-[3-(3-chloro-2-methoxyanilino)-4-oxo-4,5,...) Show SMILES COc1c(Cl)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCCCNC(=O)C=C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555114 (3-[(3-fluorophenyl)amino]-2-(3-{[(2S)-1-methylpyrr...) Show SMILES CN1CCC[C@H]1COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555126 (3-[(3-fluoro-2-methylphenyl)amino]-2-[3-(2-methoxy...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.322	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555129 (3-{[2-(2,2-difluoroethyl)-3-fluorophenyl]amino}-2-...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1CC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.342	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552589 (N-[2-({4-[3-(3-fluoro-2-methylanilino)-4-oxo-4,5,6...) Show SMILES Cc1c(F)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCCNC(=O)C=C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552598 (N-[2-({4-[3'-(3-chloro-2-methoxyanilino)-4'-oxo-1'...) Show SMILES COc1c(Cl)cccc1Nc1c([nH]c2CC3(CCC3)NC(=O)c12)-c1ccncc1OCCN(C)C(=O)C=C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555121 (3-{[2-(2,2-difluoroethyl)phenyl]amino}-2-[3-(2-met...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1ccccc1CC(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.489	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555130 (3-[(3-fluoro-2-hydroxyphenyl)amino]-2-[3-(2-methox...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.541	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552595 ((2E)-4-(dimethylamino)-N-[2-({4-[3-(3-fluoro-2-met...) Show SMILES COc1c(F)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCCN(C)C(=O)\C=C\CN(C)C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552601 (N-(2-{[4-(3-{[2-(difluoromethoxy)phenyl]amino}-4-o...) Show SMILES CN(CCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1ccccc1OC(F)F)C(=O)C=C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM552599 (N-[2-({4-[3-(3-chloro-2-methoxyanilino)-6,6-dimeth...) Show SMILES COc1c(Cl)cccc1Nc1c([nH]c2CC(C)(C)NC(=O)c12)-c1ccncc1OCCN(C)C(=O)C=C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022101184	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...				Citation and Details BindingDB Entry DOI: 10.7270/Q2542RSQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555130 (3-[(3-fluoro-2-hydroxyphenyl)amino]-2-[3-(2-methox...) Show SMILES COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.634	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555113 (3-[(3-fluorophenyl)amino]-2-{3-[2-methyl-2-(morpho...) Show SMILES CC(C)(COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1)N1CCOCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.718	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555134 (US11339157, Example 28) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1ccc(F)c(F)c1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.738	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [669-770,'SVD',771-1210] (Homo sapiens (Human))	BDBM555101 (2-[3-(2-methoxyethoxy)pyridin-4-yl]-3-(phenylamino...) Show SMILES COCCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.779	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2H70K0Q
					More data for this Ligand-Target Pair

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