| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [669-770,'SVD',771-1210] |
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| Ligand | BDBM555127 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | 0.213±n/a nM |
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| Citation |  Siegel, S; Siegel, F; Schulze, V; Berger, M; Graham, K; Klar, U; Eis, K; Sülzle, D; Bömer, U; Korr, D; Petersen, K; Mönning, U; Eberspächer, U; Moosmayer, D; Meyerson, M; Greulich, H; Kaplan, B; Harb, HY; Dinh, PM 4H-pyrrolo[3,2-c]pyridin-4-one derivatives US Patent US11339157 Publication Date 5/24/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [669-770,'SVD',771-1210] |
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| Name: | Epidermal growth factor receptor [669-770,'SVD',771-1210] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor [669-769,''ASV'',770-1210] | Epidermal growth factor receptor [669-769,'ASV',770-1210] | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 61473.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[669-770,'SVD',771-1210] |
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| Residue: | 545 |
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| Sequence: | RRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYK
GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDSVDNPHVCRLLGICLTST
VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV
KTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVW
ELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELI
IEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFS
SPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDT
FLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPT
CVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSS
EFIGA
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| BDBM555127 |
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| n/a |
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| Name | BDBM555127 |
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| Synonyms: | 3-[(3-fluoro-2-methylphenyl)amino]-2-[3-(2-methoxy-2-methylpropoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one | US11339157, Example 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27FN4O3 |
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| Mol. Mass. | 438.4946 |
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| SMILES | COC(C)(C)COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1C |
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| Structure | 
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