BindingDB PrimarySearch

Found 20 hits of kd for UniProtKB: P35354
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50366159 (CHEMBL1957450) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to COX2 by surface plasmon resonance spectroscopy				Bioorg Med Chem 20: 2221-6 (2012) Article DOI: 10.1016/j.bmc.2012.02.021 BindingDB Entry DOI: 10.7270/Q2RV0P5K
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM222296 (4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(4-fluorophen...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM222295 (4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(4-phenylpiperaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50514417 (CHEMBL4540374) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a
Univ. Lille Curated by ChEMBL					Assay Description Binding affinity to human COX2				J Med Chem 63: 3817-3833 (2020) Article DOI: 10.1021/acs.jmedchem.9b01183 BindingDB Entry DOI: 10.7270/Q2NZ8C0R
Univ. Lille Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM222293 (4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(3,4-dimethoxyph...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	14.0	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM222292 (4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(3-methylpiperid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	40.8	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50486822 (CHEBI:76249 \| Miroprofen) Show SMILES CC(C(O)=O)c1ccc(cc1)-c1cn2ccccc2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to COX2 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9870-3 BindingDB Entry DOI: 10.7270/Q2GM8B61
TBA					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50486825 (CHEMBL2235865) Show SMILES OC(=O)c1nc2ccccn2c1[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to COX2 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9870-3 BindingDB Entry DOI: 10.7270/Q2GM8B61
TBA					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM222291 (4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-piperidin-1-yl-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	51.1	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM222289 (4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-pyrrolidin-1-yl-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	51.3	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM222294 (4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-(4-methylpiperaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	56.4	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article	n/a	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to COX2 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9870-3 BindingDB Entry DOI: 10.7270/Q2GM8B61
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM222290 (4-(Benzo[d][1,3]dioxol-5-yl)-2-(2-morpholin-4-yl-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	203	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50486824 (CHEMBL2235864) Show SMILES CCOC(=O)c1nc2ccccn2c1[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article	n/a	n/a	n/a	227	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to COX2 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9870-3 BindingDB Entry DOI: 10.7270/Q2GM8B61
TBA					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM222288 (2-(Methoxycarbonylmethyl)-4-(benzo[d][1,3]dioxol-5...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50486823 (CHEMBL2235866) Show SMILES Nc1c(nc2ccccn12)C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article	n/a	n/a	n/a	448	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to COX2 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9870-3 BindingDB Entry DOI: 10.7270/Q2GM8B61
TBA					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50427217 (CHEMBL2324850) Show SMILES OC(=O)c1cn2ccccc2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article	n/a	n/a	n/a	652	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to COX2 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9870-3 BindingDB Entry DOI: 10.7270/Q2GM8B61
TBA					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	789	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM22319 ((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid \| ...) Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	8.07E+3	n/a	n/a	n/a	n/a	n/a
Panjab University					Assay Description Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...				Bioorg Chem 71: 201-210 (2017) Article DOI: 10.1016/j.bioorg.2017.02.006 BindingDB Entry DOI: 10.7270/Q25T3JBP
Panjab University					More data for this Ligand-Target Pair				3D Structure (crystal)