Compile Data Set for Download or QSAR

Found 1656 hits of ic50 for UniProtKB: P35498   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM190233 (US9174999, Table 1, Compound 1) Show SMILES NC(=O)OC[C@@H]1NC(=N)N2CCC(O)(O)[C@@]22NC(=N)N[C@@H]12 |r| Show InChI InChI=1S/C10H17N7O4/c11-6-15-5-4(3-21-8(13)18)14-7(12)17-2-1-9(19,20)10(5,17)16-6/h4-5,19-20H,1-3H2,(H2,12,14)(H2,13,18)(H3,11,15,16)/t4-,5-,10-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
SiteOne Therapeutics Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay				J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50344821 (10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...) Show SMILES NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO |r,t:1,TLB:13:12:16:6.7.5,18:11:16:6.7.5,18:6:16:11.10.12,19:18:7:16.14.5,20:18:7:16.14.5,THB:12:11:7:16.14.5,3:5:16:11.10.12| Show InChI InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
SiteOne Therapeutics Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay				J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM145591 (US8952169, 389) Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC2(CC2)CC1 Show InChI InChI=1S/C23H30FNO4S/c1-22(6-8-23(9-7-22)10-11-23)14-29-20-13-19(24)18(12-17(20)15-2-3-15)21(26)25-30(27,28)16-4-5-16/h12-13,15-16H,2-11,14H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM145591 (US8952169, 389) Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC2(CC2)CC1 Show InChI InChI=1S/C23H30FNO4S/c1-22(6-8-23(9-7-22)10-11-23)14-29-20-13-19(24)18(12-17(20)15-2-3-15)21(26)25-30(27,28)16-4-5-16/h12-13,15-16H,2-11,14H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
SiteOne Therapeutics Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay				J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM145285 (US8952169, 64 | US9771376, Example 64) Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:9:13.12.11,15:6:13:9.10.11,THB:15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7| Show InChI InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full length human Nav1.1 expressed in HEK cells by whole cell voltage clamp analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00049 BindingDB Entry DOI: 10.7270/Q2WW7NKS
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM145285 (US8952169, 64 | US9771376, Example 64) Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:9:13.12.11,15:6:13:9.10.11,THB:15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7| Show InChI InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
SiteOne Therapeutics Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay				J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50051073 (CHEMBL3318132) Show SMILES [H][C@]12CSSC[C@]3([H])NC(=O)[C@@]([H])(NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSSC[C@]([H])(NC(=O)[C@]([H])(CSSC[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC3=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N2)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
SiteOne Therapeutics Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay				J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50118516 (CHEMBL3617053) Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C23H19N3O3S2/c27-22(21(17-7-3-1-4-8-17)18-9-5-2-6-10-18)25-19-11-13-20(14-12-19)31(28,29)26-23-24-15-16-30-23/h1-16,21H,(H,24,26)(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	<20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human NaV1.1 channel by patch clamp electrophysiology assay				J Med Chem 58: 7093-118 (2015) Article DOI: 10.1021/jm501981g BindingDB Entry DOI: 10.7270/Q2XS5X6P
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50344821 (10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...) Show SMILES NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO |r,t:1,TLB:13:12:16:6.7.5,18:11:16:6.7.5,18:6:16:11.10.12,19:18:7:16.14.5,20:18:7:16.14.5,THB:12:11:7:16.14.5,3:5:16:11.10.12| Show InChI InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of voltage-gated Na channel 1.1 (unknown origin)				J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525934 (5-chloro-2-fluoro-N-(thiazol-2-yl)-4-((3,3,3-trifl...) Show SMILES Fc1cc(NC(CC(F)(F)F)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50505258 (CHEMBL4588728) Show SMILES CSCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC3=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N2)NC(=O)[C@@H](N)CC(O)=O |r| Show InChI InChI=1S/C183H265N49O54S8/c1-93(2)69-120-151(255)198-85-139(238)203-132-86-289-292-89-135-178(282)212-116(54-56-140(239)240)160(264)205-112(42-22-27-63-187)158(262)222-129(79-144(247)248)169(273)211-117(55-57-141(241)242)161(265)223-131(81-146(251)252)171(275)229-137(179(283)230-136(177(281)209-113(43-23-28-64-188)157(261)221-127(167(271)216-120)76-103-83-194-92-200-103)90-293-291-88-134(226-150(254)107(189)77-142(243)244)176(280)210-115(45-30-66-196-183(192)193)159(263)218-122(73-100-46-50-104(235)51-47-100)164(268)214-119(59-68-288-7)163(267)217-121(70-97-31-11-8-12-32-97)152(256)199-84-138(237)202-128(78-143(245)246)168(272)228-135)91-294-290-87-133(227-165(269)123(74-101-48-52-105(236)53-49-101)219-156(260)111(41-21-26-62-186)206-162(266)118(58-67-287-6)213-154(258)109(39-19-24-60-184)204-155(259)114(44-29-65-195-182(190)191)207-153(257)110(208-175(132)279)40-20-25-61-185)174(278)201-94(3)149(253)215-126(75-102-82-197-108-38-18-17-37-106(102)108)166(270)224-130(80-145(249)250)170(274)220-124(71-98-33-13-9-14-34-98)172(276)231-147(95(4)233)180(284)225-125(72-99-35-15-10-16-36-99)173(277)232-148(96(5)234)181(285)286/h8-18,31-38,46-53,82-83,92-96,107,109-137,147-148,197,233-236H,19-30,39-45,54-81,84-91,184-189H2,1-7H3,(H,194,200)(H,198,255)(H,199,256)(H,201,278)(H,202,237)(H,203,238)(H,204,259)(H,205,264)(H,206,266)(H,207,257)(H,208,279)(H,209,281)(H,210,280)(H,211,273)(H,212,282)(H,213,258)(H,214,268)(H,215,253)(H,216,271)(H,217,267)(H,218,263)(H,219,260)(H,220,274)(H,221,261)(H,222,262)(H,223,265)(H,224,270)(H,225,284)(H,226,254)(H,227,269)(H,228,272)(H,229,275)(H,230,283)(H,231,276)(H,232,277)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,285,286)(H4,190,191,195)(H4,192,193,196)/t94-,95+,96+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
SiteOne Therapeutics Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay				J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM268418 (N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...) Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1 |TLB:21:12:19:15.17.16,11:12:19:15.17.16,THB:17:18:13:15.16.21,17:16:13:19.18.20,21:16:19:12.13.20| Show InChI InChI=1S/C23H30N4O3S/c28-31(29,18-3-4-18)26-22-25-24-21-8-20(19(12-27(21)22)17-1-2-17)30-13-23-9-14-5-15(10-23)7-16(6-14)11-23/h8,12,14-18H,1-7,9-11,13H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of inactivated state of recombinant human NaV1.1 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...				J Med Chem 61: 4810-4831 (2018) Article DOI: 10.1021/acs.jmedchem.7b01826 BindingDB Entry DOI: 10.7270/Q2BV7K92
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM145466 (US8952169, 245) Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC(F)(F)CC1 Show InChI InChI=1S/C21H26F3NO4S/c1-20(6-8-21(23,24)9-7-20)12-29-18-11-17(22)16(10-15(18)13-2-3-13)19(26)25-30(27,28)14-4-5-14/h10-11,13-14H,2-9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM526158 ((S)-5-chloro-2-fluoro-N-(5-fluorothiazol-2-yl)-4-(...) Show SMILES CC[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)s1)c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM268423 (N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...) Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1 |TLB:22:13:20:16.18.17,16:17:21:15.20.14,THB:22:17:20:21.13.14,16:15:21:22.18.17,12:13:20:16.18.17| Show InChI InChI=1S/C21H28N4O3S/c1-29(26,27)24-20-23-22-19-7-18(17(11-25(19)20)16-2-3-16)28-12-21-8-13-4-14(9-21)6-15(5-13)10-21/h7,11,13-16H,2-6,8-10,12H2,1H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of inactivated state of recombinant human NaV1.1 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...				J Med Chem 61: 4810-4831 (2018) Article DOI: 10.1021/acs.jmedchem.7b01826 BindingDB Entry DOI: 10.7270/Q2BV7K92
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50568138 (CHEMBL4854735) Show SMILES Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Nav1.1 by V1/2 protocol based analysis				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128133 BindingDB Entry DOI: 10.7270/Q2CJ8J7B
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50505257 (CHEMBL4471012) Show SMILES C[C@@H](N1CC[C@H](C1)n1nc(C)c2cc(C(=O)NS(=O)(=O)C3CC3)c(F)cc12)c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C24H25Cl2FN4O3S/c1-13-20-10-21(24(32)29-35(33,34)19-3-4-19)22(27)11-23(20)31(28-13)18-5-6-30(12-18)14(2)15-7-16(25)9-17(26)8-15/h7-11,14,18-19H,3-6,12H2,1-2H3,(H,29,32)/t14-,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin				Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525920 ((S)-2,6-difluoro-4-((1-(2-fluorophenyl)ethyl)amino...) Show SMILES C[C@H](Nc1cc(F)c(c(F)c1)S(=O)(=O)Nc1nccs1)c1ccccc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM268527 (N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...) Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(cn12)C1CC1 Show InChI InChI=1S/C17H16Cl2N4O3S/c1-27(24,25)22-17-21-20-16-4-11(15(8-23(16)17)10-2-3-10)9-26-14-6-12(18)5-13(19)7-14/h4-8,10H,2-3,9H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of inactivated state of recombinant human NaV1.1 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...				J Med Chem 61: 4810-4831 (2018) Article DOI: 10.1021/acs.jmedchem.7b01826 BindingDB Entry DOI: 10.7270/Q2BV7K92
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525940 ((S)-5-chloro-2-fluoro-4-((1-(2-fluorophenyl)propyl...) Show SMILES CC[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM526159 ((S)-5-chloro-2-fluoro-4-((1-(2-fluorophenyl)ethyl)...) Show SMILES C[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ncc(F)s1)c1ccccc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	133	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525987 (5-chloro-2-fluoro-4-((5,6,7,8-tetrahydroisoquinoli...) Show SMILES Fc1cc(NC2CCCc3cnccc23)c(Cl)cc1S(=O)(=O)Nc1nccs1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM526019 ((S)-2-fluoro-5-methyl-4-((1-phenylpropyl)thio)-N-(...) Show SMILES CC[C@H](Sc1cc(F)c(cc1C)S(=O)(=O)Nc1nccs1)c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM526036 (5-chloro-2-fluoro-4-(3-methyl-1-phenylbutylamino)-...) Show SMILES CCC(C)CC(Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525933 ((S)-5-chloro-2-fluoro-4-((1-phenylpropyl)amino)-N-...) Show SMILES CC[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM76858 (US9546164, 580 | US9694002, 580) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3cc(ccc3Cl)C(F)(F)F)CC2)cc1F Show InChI InChI=1S/C25H27ClF4N2O4S/c1-37(34,35)31-24(33)20-11-19(16-2-3-16)23(12-22(20)27)36-14-15-6-8-32(9-7-15)13-17-10-18(25(28,29)30)4-5-21(17)26/h4-5,10-12,15-16H,2-3,6-9,13-14H2,1H3,(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		n/a	n/a	192	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin				Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM70937 (US9546164, 100 | US9694002, 100) Show SMILES C[C@H](N1CCC(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CC1)c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C25H29Cl2FN2O4S/c1-15(18-9-19(26)11-20(27)10-18)30-7-5-16(6-8-30)14-34-24-13-23(28)22(12-21(24)17-3-4-17)25(31)29-35(2,32)33/h9-13,15-17H,3-8,14H2,1-2H3,(H,29,31)/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	202	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full length human Nav1.1 expressed in HEK cells by whole cell voltage clamp analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00049 BindingDB Entry DOI: 10.7270/Q2WW7NKS
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50257215 (CHEMBL2324411) Show SMILES Cn1nccc1-c1cc(Cl)ccc1Oc1ccc(cc1F)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C18H13ClFN5O3S2/c1-25-15(6-7-22-25)13-8-11(19)2-4-16(13)28-17-5-3-12(9-14(17)20)30(26,27)24-18-21-10-23-29-18/h2-10H,1H3,(H,21,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States. Curated by ChEMBL					Assay Description Inhibition of human NaV1.1 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...				J Med Chem 60: 7029-7042 (2017) Article DOI: 10.1021/acs.jmedchem.7b00598 BindingDB Entry DOI: 10.7270/Q21G0PQF
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM492965 (5-((2-bromo-3,6-difluorobenzyl)amino)-3-fluoro-6-m...) Show SMILES Cc1nc(c(F)cc1NCc1c(F)ccc(F)c1Br)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C16H12BrF3N4O2S2/c1-8-13(21-5-9-10(18)2-3-11(19)15(9)17)4-12(20)16(23-8)28(25,26)24-14-6-27-7-22-14/h2-4,6-7,21,24H,5H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q25B06DG
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM492965 (5-((2-bromo-3,6-difluorobenzyl)amino)-3-fluoro-6-m...) Show SMILES Cc1nc(c(F)cc1NCc1c(F)ccc(F)c1Br)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C16H12BrF3N4O2S2/c1-8-13(21-5-9-10(18)2-3-11(19)15(9)17)4-12(20)16(23-8)28(25,26)24-14-6-27-7-22-14/h2-4,6-7,21,24H,5H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				US Patent US10981905 (2021) BindingDB Entry DOI: 10.7270/Q2N019N4
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525942 ((S)-5-chloro-2-fluoro-4-((1-(3-fluorophenyl)ethyl)...) Show SMILES C[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cccc(F)c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM526034 (5-chloro-2-fluoro-4-(1-phenylpropylamino)-N-(thiaz...) Show SMILES CCCC(Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	277	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525954 (5-chloro-2-fluoro-4-((isoquinolin-8-ylmethyl)amino...) Show SMILES Fc1cc(NCc2cccc3ccncc23)c(Cl)cc1S(=O)(=O)Nc1nccs1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	283	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525928 ((R)-3-chloro-4-((2,3-dihydro-1H-inden-1-yl)amino)-...) Show SMILES Clc1cc(ccc1N[C@@H]1CCc2ccccc12)S(=O)(=O)Nc1ncns1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	301	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525991 (5-chloro-2-fluoro-4-((5,6,7,8-tetrahydroquinolin-5...) Show SMILES Fc1cc(NC2CCCc3ncccc23)c(Cl)cc1S(=O)(=O)Nc1nccs1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	303	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50451447 (CHEMBL4217988) Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ncns2)c(c1)-c1ccnc(CNCCC2CCNCC2)c1 Show InChI InChI=1S/C35H32F3N7O3S2/c36-35(37,38)28-3-1-2-24(16-28)25-4-6-33(48-32-7-5-30(18-27(32)20-39)50(46,47)45-34-43-22-44-49-34)31(19-25)26-11-15-42-29(17-26)21-41-14-10-23-8-12-40-13-9-23/h1-7,11,15-19,22-23,40-41H,8-10,12-14,21H2,(H,43,44,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	309	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 expressed in HEK cells by patch clamp electrophysiology method				Bioorg Med Chem Lett 27: 4805-4811 (2017) Article DOI: 10.1016/j.bmcl.2017.09.056 BindingDB Entry DOI: 10.7270/Q25Q4ZN1
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50451447 (CHEMBL4217988) Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ncns2)c(c1)-c1ccnc(CNCCC2CCNCC2)c1 Show InChI InChI=1S/C35H32F3N7O3S2/c36-35(37,38)28-3-1-2-24(16-28)25-4-6-33(48-32-7-5-30(18-27(32)20-39)50(46,47)45-34-43-22-44-49-34)31(19-25)26-11-15-42-29(17-26)21-41-14-10-23-8-12-40-13-9-23/h1-7,11,15-19,22-23,40-41H,8-10,12-14,21H2,(H,43,44,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
SiteOne Therapeutics Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay				J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525986 (5-chloro-2-fluoro-4-((5,6,7,8-tetrahydroisoquinoli...) Show SMILES Fc1cc(NC2CCCc3ccncc23)c(Cl)cc1S(=O)(=O)Nc1nccs1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	314	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM526161 ((S)-5-chloro-4-((1-(2,5-difluorophenyl)ethyl)amino...) Show SMILES C[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cc(F)ccc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	332	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525934 (5-chloro-2-fluoro-N-(thiazol-2-yl)-4-((3,3,3-trifl...) Show SMILES Fc1cc(NC(CC(F)(F)F)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	364	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM526161 ((S)-5-chloro-4-((1-(2,5-difluorophenyl)ethyl)amino...) Show SMILES C[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cc(F)ccc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	388	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50173134 (CHEMBL3809595) Show SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc2nnc(n2c1)C(F)(F)F Show InChI InChI=1S/C14H7F6N3O/c15-13(16,17)12-22-21-11-6-3-9(7-23(11)12)8-1-4-10(5-2-8)24-14(18,19)20/h1-7H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc. Curated by ChEMBL					Assay Description Inhibition of 10 Hz stimulated Nav1.1 (unknown origin) by manual patch clamp method				Bioorg Med Chem Lett 26: 3207-11 (2016) Article DOI: 10.1016/j.bmcl.2016.03.096 BindingDB Entry DOI: 10.7270/Q2PG1TNG
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525901 ((S)-5-chloro-4-((1-(5-chloro-2-fluorophenyl)ethyl)...) Show SMILES C[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cc(Cl)ccc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525920 ((S)-2,6-difluoro-4-((1-(2-fluorophenyl)ethyl)amino...) Show SMILES C[C@H](Nc1cc(F)c(c(F)c1)S(=O)(=O)Nc1nccs1)c1ccccc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	476	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525910 (5-chloro-4-((2-cyanobenzyl)amino)-2-fluoro-N-(thia...) Show SMILES Fc1cc(NCc2ccccc2C#N)c(Cl)cc1S(=O)(=O)Nc1nccs1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	494	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525978 (2,5-difluoro-4-((1-phenylpropyl)amino)-N-(1,2,4-th...) Show SMILES CCC(Nc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	516	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM525938 ((S)-5-chloro-2-fluoro-4-((1-(2-fluorophenyl)ethyl)...) Show SMILES C[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	539	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM50568138 (CHEMBL4854735) Show SMILES Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by sodium influx assay				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128133 BindingDB Entry DOI: 10.7270/Q2CJ8J7B
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Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM373868 ((S)-2-fluoro-5-methyl-4-(methyl(1-((2-phenylthiazo...) Show SMILES CN([C@H]1CCN(Cc2csc(n2)-c2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C25H26FN5O2S3/c1-17-10-23(36(32,33)29-24-15-34-16-27-24)21(26)11-22(17)30(2)20-8-9-31(13-20)12-19-14-35-25(28-19)18-6-4-3-5-7-18/h3-7,10-11,14-16,20,29H,8-9,12-13H2,1-2H3/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	564	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM373868 ((S)-2-fluoro-5-methyl-4-(methyl(1-((2-phenylthiazo...) Show SMILES CN([C@H]1CCN(Cc2csc(n2)-c2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C25H26FN5O2S3/c1-17-10-23(36(32,33)29-24-15-34-16-27-24)21(26)11-22(17)30(2)20-8-9-31(13-20)12-19-14-35-25(28-19)18-6-4-3-5-7-18/h3-7,10-11,14-16,20,29H,8-9,12-13H2,1-2H3/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	564	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...				US Patent US10815229 (2020) BindingDB Entry DOI: 10.7270/Q2MS3WTS
					More data for this Ligand-Target Pair

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