Found 478 hits of ec50 for UniProtKB: P54619 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563544
(US11407768, Compound 1)Show SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC(=O)c1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563546
(US11407768, Compound 3)Show SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563547
(US11407768, Compound 4)Show SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNCc1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565695
(US11407768, Compound 74)Show SMILES OCCOCCNCc1ccc(c(O)c1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565454
(US11407768, Compound 53)Show SMILES OCC(CO)(CO)NCc1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565696
(US11407768, Compound 75)Show SMILES OCCOCCNC(=O)c1ccc(c(O)c1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563553
(US11407768, Compound 10)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCCNc1cccc2c(cccc12)S(O)(=O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563498
((2S)-2-amino-3-(4-(2- amino-6-((R)-1-(4- chloro-2-...)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCCc1ccc(cc1)S(O)(=O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563556
(US11407768, Compound 14)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCCCP(O)(O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237992
(US9394285, 75)Show SMILES OCC1(CC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C19H16ClNO3/c20-16-8-17-14(15(9-21-17)18(23)24)7-13(16)11-1-3-12(4-2-11)19(10-22)5-6-19/h1-4,7-9,21-22H,5-6,10H2,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563558
(US11407768, Compound 29)Show SMILES C[N+](C)(C)CCNC(=O)c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565456
(US11407768, Compound 54)Show SMILES OCC1(CO)CCN(Cc2ccc(cc2)-c2ccc(cc2)-c2nc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)CC1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.570 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563549
(US11407768, Compound 6)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCCCS(O)(=O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563501
((2S)-2-amino-3-(4-(2- amino-6-((R)-2,2,2- trifluor...)Show SMILES OC(CNCc1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl)C(O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.630 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565561
(US11407768, Compound 71)Show SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.630 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563503
((2S)-2-amino-3-(4-(2- amino-6-((R)-1-(4- chloro-2-...)Show SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC(=O)c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565449
(US11407768, Compound 51)Show SMILES OCCN1CCN(Cc2ccc(cc2)-c2ccc(cc2)-c2nc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)CC1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.720 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563505
((S)-2-amino-3-(4-(4- ((R)-1-(4-chloro-2- (5,6-dihy...)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCC[N+]12CCN(CC1)CC2 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565498
(US11407768, Compound 65)Show SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNCc1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.770 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565503
(US11407768, Compound 66)Show SMILES OCC1(CO)CN(Cc2ccc(cc2)-c2ccc(cc2)-c2cc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)C1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565452
(US11407768, Compound 52)Show SMILES OCC1(CO)CN(Cc2ccc(cc2)-c2ccc(cc2)-c2nc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)C1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.810 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563563
(US11407768, Compound 36)Show SMILES OCC(CO)(CO)NCc1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.840 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565483
(US11407768, Compound 60)Show SMILES OCC1(CO)CCN(Cc2ccc(cc2)-c2ccc(cc2)-c2cc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)CC1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563560
(US11407768, Compound 31)Show SMILES OCCOCCNC(=O)c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565483
(US11407768, Compound 60)Show SMILES OCC1(CO)CCN(Cc2ccc(cc2)-c2ccc(cc2)-c2cc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)CC1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563548
(US11407768, Compound 5)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCCS(O)(=O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.860 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565476
(US11407768, Compound 57)Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(cc2)-c2cc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)CC1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.890 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565506
(US11407768, Compound 67)Show SMILES NCC1CN(Cc2ccc(cc2)-c2ccc(cc2)-c2cc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)C1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.930 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565474
(US11407768, Compound 56)Show SMILES OCCN1CCN(Cc2ccc(cc2)-c2ccc(cc2)-c2cc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)CC1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.930 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565478
(US11407768, Compound 58)Show SMILES OCCOCCNCc1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.930 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563562
(US11407768, Compound 33)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCCC[N+]12CCN(CC1)CC2 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.960 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM213202
(US9290517, 133)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CNCCO1 |r| | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... |
US Patent US9290517 (2016)
BindingDB Entry DOI: 10.7270/Q2C24V7Q |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM213209
(US9290517, 150)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1ccc(=O)[nH]1 |r| | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... |
US Patent US9290517 (2016)
BindingDB Entry DOI: 10.7270/Q2C24V7Q |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM213199
(US9290517, 129)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1cnc(=O)[nH]1 |r| | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | 7.3 | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat... |
US Patent US9290517 (2016)
BindingDB Entry DOI: 10.7270/Q2C24V7Q |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM50195478
(CHEMBL3959081)Show SMILES Cc1ccc(Oc2nc3nc(c(Cl)cc3[nH]2)-c2ccc(cc2)N2CCCC2)cc1C(O)=O Show InChI InChI=1S/C24H21ClN4O3/c1-14-4-9-17(12-18(14)23(30)31)32-24-26-20-13-19(25)21(27-22(20)28-24)15-5-7-16(8-6-15)29-10-2-3-11-29/h4-9,12-13H,2-3,10-11H2,1H3,(H,30,31)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using 5'-FAM-SAMS peptide substrate... |
Bioorg Med Chem Lett 26: 5139-5148 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.065 BindingDB Entry DOI: 10.7270/Q25M67PH |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565481
(US11407768, Compound 59)Show SMILES O[C@@H]1CCN(Cc2ccc(cc2)-c2ccc(cc2)-c2cc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)C1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.04 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563566
(US11407768, Compound 40)Show SMILES OCC(CO)NCc1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.08 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565494
(US11407768, Compound 63)Show SMILES OCC1CN(Cc2ccc(cc2)-c2ccc(cc2)-c2cc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)C1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.09 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563568
(US11407768, Compound 48)Show SMILES CN(CCOCCO)C(=O)c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.16 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM50195538
(CHEMBL3898977)Show SMILES Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)N2CCOCC2)cc1P(O)(O)=O Show InChI InChI=1S/C24H23ClN3O5P/c1-15-2-7-18(12-23(15)34(29,30)31)33-24-26-21-13-19(20(25)14-22(21)27-24)16-3-5-17(6-4-16)28-8-10-32-11-9-28/h2-7,12-14H,8-11H2,1H3,(H,26,27)(H2,29,30,31) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using SAMS peptide substrate after ... |
Bioorg Med Chem Lett 26: 5139-5148 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.065 BindingDB Entry DOI: 10.7270/Q25M67PH |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563550
(US11407768, Compound 7)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCC(CS(O)(=O)=O)c1ccc(Cl)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.22 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237984
(US9394285, 67)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)-c1ccccc1O Show InChI InChI=1S/C21H14ClNO3/c22-18-10-19-16(17(11-23-19)21(25)26)9-15(18)13-7-5-12(6-8-13)14-3-1-2-4-20(14)24/h1-11,23-24H,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl... |
J Med Chem 59: 8068-81 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00866 BindingDB Entry DOI: 10.7270/Q2PZ5BRC |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565492
(US11407768, Compound 62)Show SMILES CN(CCOCCO)Cc1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565694
(US11407768, Compound 73)Show SMILES CC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.33 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565486
(US11407768, Compound 61)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(CN2C[C@H](O)[C@H](O)C2)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.36 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565693
(US11407768, Compound 72)Show SMILES CN(CCOCCO)S(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.38 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565496
(US11407768, Compound 64)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(CN2C[C@H](O)[C@@H](O)C2)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM563545
(US11407768, Compound 2)Show SMILES O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)P(O)(O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565446
(US11407768, Compound 50)Show SMILES OCCOCC1CN(Cc2ccc(cc2)-c2ccc(cc2)-c2cc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)C1 |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.46 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM565530
(US11407768, Compound 70)Show SMILES OCCOCCNS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl |r| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.51 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2KD223Z |
More data for this Ligand-Target Pair | |