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Compile Data Set for Download or QSAR

Found 72 hits of ki for UniProtKB: P14598   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
BDBP50000595


(Homo sapiens)		BDBM139370
PNG
(ACP-103 | Nuplazid | Pimavanserin | Pimavanserin h...)
Show SMILES CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1
Show InChI InChI=1S/C25H34FN3O2/c1-19(2)18-31-24-10-6-20(7-11-24)16-27-25(30)29(23-12-14-28(3)15-13-23)17-21-4-8-22(26)9-5-21/h4-11,19,23H,12-18H2,1-3H3,(H,27,30)
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WIPO WO2023288027
 2.75n/an/an/an/an/an/an/an/a


TBA

Assay Description
The affinity of ligands was determined via radioligand binding techniques using human recombinant receptors expressed in mammalian clonal cells. Deta...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5KWF
More data for this
Ligand-Target Pair
BDBP50000595


(Homo sapiens)		BDBM50001885
PNG
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
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WIPO WO2023288027
 19n/an/an/an/an/an/an/an/a


TBA

Assay Description
The affinity of ligands was determined via radioligand binding techniques using human recombinant receptors expressed in mammalian clonal cells. Deta...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5KWF
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM34233
PNG
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Show SMILES O=c1n([se]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
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 1.20E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520360
PNG
(CHEMBL4564915)
Show SMILES Nc1cc(OCCOCCOCCOCCOc2cc(N)nc3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H30N4O5/c27-25-17-23(19-5-1-3-7-21(19)29-25)34-15-13-32-11-9-31-10-12-33-14-16-35-24-18-26(28)30-22-8-4-2-6-20(22)24/h1-8,17-18H,9-16H2,(H2,27,29)(H2,28,30)
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 2.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520367
PNG
(CHEMBL4438544)
Show SMILES Nc1cc(N2CCN(CCOCCOCCOCCN3CCN(CC3)c3cc(N)nc4ccccc34)CC2)c2ccccc2n1
Show InChI InChI=1S/C34H46N8O3/c35-33-25-31(27-5-1-3-7-29(27)37-33)41-13-9-39(10-14-41)17-19-43-21-23-45-24-22-44-20-18-40-11-15-42(16-12-40)32-26-34(36)38-30-8-4-2-6-28(30)32/h1-8,25-26H,9-24H2,(H2,35,37)(H2,36,38)
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 3.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520361
PNG
(CHEMBL4554830)
Show SMILES Nc1ccc2cc(OCCOCCOCCOCCOc3ccc4nc(N)ccc4c3)ccc2n1
Show InChI InChI=1S/C26H30N4O5/c27-25-7-1-19-17-21(3-5-23(19)29-25)34-15-13-32-11-9-31-10-12-33-14-16-35-22-4-6-24-20(18-22)2-8-26(28)30-24/h1-8,17-18H,9-16H2,(H2,27,29)(H2,28,30)
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 3.27E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM34233
PNG
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Show SMILES O=c1n([se]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
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 6.30E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520358
PNG
(CHEMBL4460780)
Show SMILES Nc1cc(N2CCCCC2)c2ccccc2n1
Show InChI InChI=1S/C14H17N3/c15-14-10-13(17-8-4-1-5-9-17)11-6-2-3-7-12(11)16-14/h2-3,6-7,10H,1,4-5,8-9H2,(H2,15,16)
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 1.86E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520357
PNG
(CHEMBL4517396)
Show SMILES Nc1cc(N2CCNCC2)c2ccccc2n1
Show InChI InChI=1S/C13H16N4/c14-13-9-12(17-7-5-15-6-8-17)10-3-1-2-4-11(10)16-13/h1-4,9,15H,5-8H2,(H2,14,16)
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 1.96E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520347
PNG
(CHEMBL4590803)
Show SMILES Brc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C13H14BrN3/c14-10-1-2-12-11(9-10)13(3-4-16-12)17-7-5-15-6-8-17/h1-4,9,15H,5-8H2
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 2.31E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50154590
PNG
(6-Methoxy-quinolin-2-ylamine | CHEMBL188730)
Show SMILES COc1ccc2nc(N)ccc2c1
Show InChI InChI=1S/C10H10N2O/c1-13-8-3-4-9-7(6-8)2-5-10(11)12-9/h2-6H,1H3,(H2,11,12)
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 2.41E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520356
PNG
(CHEMBL4465101)
Show SMILES COc1ccc(CNc2cc(N)nc3ccccc23)cc1
Show InChI InChI=1S/C17H17N3O/c1-21-13-8-6-12(7-9-13)11-19-16-10-17(18)20-15-5-3-2-4-14(15)16/h2-10H,11H2,1H3,(H3,18,19,20)
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 2.43E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520353
PNG
(CHEMBL4586122)
Show SMILES CCOCCOc1ccc2ccc(N)nc2c1
Show InChI InChI=1S/C13H16N2O2/c1-2-16-7-8-17-11-5-3-10-4-6-13(14)15-12(10)9-11/h3-6,9H,2,7-8H2,1H3,(H2,14,15)
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 2.54E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520345
PNG
(CHEMBL4567046)
Show SMILES Cc1cc(N2CCCNCC2)c2ccccc2n1
Show InChI InChI=1S/C15H19N3/c1-12-11-15(18-9-4-7-16-8-10-18)13-5-2-3-6-14(13)17-12/h2-3,5-6,11,16H,4,7-10H2,1H3
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 2.71E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM34233
PNG
(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Show SMILES O=c1n([se]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
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>3.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50106393
PNG
(1-(pyridin-4-yl)piperazine | 1-Pyridin-4-yl-pipera...)
Show SMILES C1CN(CCN1)c1ccncc1
Show InChI InChI=1S/C9H13N3/c1-3-10-4-2-9(1)12-7-5-11-6-8-12/h1-4,11H,5-8H2
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 3.02E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520340
PNG
(CHEMBL4453672)
Show SMILES CCOCCOc1ccc2nc(N)ccc2c1
Show InChI InChI=1S/C13H16N2O2/c1-2-16-7-8-17-11-4-5-12-10(9-11)3-6-13(14)15-12/h3-6,9H,2,7-8H2,1H3,(H2,14,15)
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 3.73E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520374
PNG
(CHEMBL4532576)
Show SMILES Cc1cc(N2CCCCC2)c2ccccc2n1
Show InChI InChI=1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)13-7-3-4-8-14(13)16-12/h3-4,7-8,11H,2,5-6,9-10H2,1H3
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 4.03E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM14322
PNG
(2-Aminoquinoline 1 | 2-aminoquinoline | CHEMBL6123...)
Show SMILES Nc1ccc2ccccc2n1
Show InChI InChI=1S/C9H8N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H,(H2,10,11)
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 4.28E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520341
PNG
(CHEMBL4465199)
Show SMILES Nc1cc(N2CCOCC2)c2ccccc2n1
Show InChI InChI=1S/C13H15N3O/c14-13-9-12(16-5-7-17-8-6-16)10-3-1-2-4-11(10)15-13/h1-4,9H,5-8H2,(H2,14,15)
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 4.35E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520348
PNG
(CHEMBL4434889)
Show SMILES COc1ccc2nccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C14H17N3O/c1-18-11-2-3-13-12(10-11)14(4-5-16-13)17-8-6-15-7-9-17/h2-5,10,15H,6-9H2,1H3
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 4.66E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520366
PNG
(CHEMBL4566235)
Show SMILES CC(=O)N1CCN(CC1)c1cc(N)nc2ccccc12
Show InChI InChI=1S/C15H18N4O/c1-11(20)18-6-8-19(9-7-18)14-10-15(16)17-13-5-3-2-4-12(13)14/h2-5,10H,6-9H2,1H3,(H2,16,17)
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 4.75E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520355
PNG
(CHEMBL4567093)
Show SMILES CCOCCOc1cc(N)nc2ccccc12
Show InChI InChI=1S/C13H16N2O2/c1-2-16-7-8-17-12-9-13(14)15-11-6-4-3-5-10(11)12/h3-6,9H,2,7-8H2,1H3,(H2,14,15)
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 5.12E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM56192
PNG
(7-chloranyl-4-piperazin-1-yl-quinoline | 7-chloro-...)
Show SMILES Clc1ccc2c(ccnc2c1)N1CCNCC1
Show InChI InChI=1S/C13H14ClN3/c14-10-1-2-11-12(9-10)16-4-3-13(11)17-7-5-15-6-8-17/h1-4,9,15H,5-8H2
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 5.83E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520359
PNG
(CHEMBL4525491)
Show SMILES COCCNc1cc(N)nc2ccccc12
Show InChI InChI=1S/C12H15N3O/c1-16-7-6-14-11-8-12(13)15-10-5-3-2-4-9(10)11/h2-5,8H,6-7H2,1H3,(H3,13,14,15)
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 5.92E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM14320
PNG
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
Show SMILES Nc1nccc2ccccc12
Show InChI InChI=1S/C9H8N2/c10-9-8-4-2-1-3-7(8)5-6-11-9/h1-6H,(H2,10,11)
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 5.94E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520369
PNG
(CHEMBL4444863)
Show SMILES CN1CCN(CC1)c1cc(N)nc2ccccc12
Show InChI InChI=1S/C14H18N4/c1-17-6-8-18(9-7-17)13-10-14(15)16-12-5-3-2-4-11(12)13/h2-5,10H,6-9H2,1H3,(H2,15,16)
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 5.97E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520349
PNG
(CHEMBL4562924)
Show SMILES COc1cc2nccc(N3CCNCC3)c2cc1OC
Show InChI InChI=1S/C15H19N3O2/c1-19-14-9-11-12(10-15(14)20-2)17-4-3-13(11)18-7-5-16-6-8-18/h3-4,9-10,16H,5-8H2,1-2H3
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 5.98E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520362
PNG
(CHEMBL2335165)
Show SMILES Cc1cc(N2CCNCC2)c2ccccc2n1
Show InChI InChI=1S/C14H17N3/c1-11-10-14(17-8-6-15-7-9-17)12-4-2-3-5-13(12)16-11/h2-5,10,15H,6-9H2,1H3
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 6.06E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520337
PNG
(CHEMBL4462687)
Show SMILES CN(C)CCNc1cc(N)nc2ccccc12
Show InChI InChI=1S/C13H18N4/c1-17(2)8-7-15-12-9-13(14)16-11-6-4-3-5-10(11)12/h3-6,9H,7-8H2,1-2H3,(H3,14,15,16)
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 6.58E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520368
PNG
(CHEMBL2441621)
Show SMILES C1CN(CCN1)c1ccnc2ccccc12
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)13(5-6-15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
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 6.97E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520346
PNG
(CHEMBL4448693)
Show SMILES CN(C)CCNc1cc(C)nc2ccccc12
Show InChI InChI=1S/C14H19N3/c1-11-10-14(15-8-9-17(2)3)12-6-4-5-7-13(12)16-11/h4-7,10H,8-9H2,1-3H3,(H,15,16)
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 7.22E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520382
PNG
(CHEMBL4591176)
Show SMILES CC(=O)N1CCN(CC1)c1cc(C)nc2ccccc12
Show InChI InChI=1S/C16H19N3O/c1-12-11-16(14-5-3-4-6-15(14)17-12)19-9-7-18(8-10-19)13(2)20/h3-6,11H,7-10H2,1-2H3
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 8.15E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520376
PNG
(CHEMBL2441615)
Show SMILES FC(F)(F)c1ccc2c(ccnc2c1)N1CCNCC1
Show InChI InChI=1S/C14H14F3N3/c15-14(16,17)10-1-2-11-12(9-10)19-4-3-13(11)20-7-5-18-6-8-20/h1-4,9,18H,5-8H2
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 8.94E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520375
PNG
(CHEMBL4472230)
Show SMILES Cc1cc(N2CCN(Cc3ccccc3)CC2)c2ccccc2n1
Show InChI InChI=1S/C21H23N3/c1-17-15-21(19-9-5-6-10-20(19)22-17)24-13-11-23(12-14-24)16-18-7-3-2-4-8-18/h2-10,15H,11-14,16H2,1H3
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 1.00E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50431276
PNG
(CHEMBL1559535)
Show SMILES Cc1cc(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C14H17N3/c1-11-10-14(17-8-6-15-7-9-17)16-13-5-3-2-4-12(11)13/h2-5,10,15H,6-9H2,1H3
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 1.07E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM10443
PNG
(2-methylquinolin-4-amine | 4-Aminoquinaldine 4)
Show SMILES Cc1cc(N)c2ccccc2n1
Show InChI InChI=1S/C10H10N2/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3,(H2,11,12)
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 1.07E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520365
PNG
(CHEMBL1906835)
Show SMILES COCCNc1cc(C)nc2ccccc12
Show InChI InChI=1S/C13H16N2O/c1-10-9-13(14-7-8-16-2)11-5-3-4-6-12(11)15-10/h3-6,9H,7-8H2,1-2H3,(H,14,15)
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 1.12E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50152453
PNG
(8-(2-Ethoxy-ethoxy)-quinolin-2-ylamine | CHEMBL185...)
Show SMILES CCOCCOc1cccc2ccc(N)nc12
Show InChI InChI=1S/C13H16N2O2/c1-2-16-8-9-17-11-5-3-4-10-6-7-12(14)15-13(10)11/h3-7H,2,8-9H2,1H3,(H2,14,15)
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 1.25E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50084506
PNG
(CHEMBL319543 | Methyl-quinolin-2-yl-amine)
Show SMILES CNc1ccc2ccccc2n1
Show InChI InChI=1S/C10H10N2/c1-11-10-7-6-8-4-2-3-5-9(8)12-10/h2-7H,1H3,(H,11,12)
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 1.37E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50149208
PNG
(2-Amino-quinolin-8-ol | CHEMBL119647)
Show SMILES Nc1ccc2cccc(O)c2n1
Show InChI InChI=1S/C9H8N2O/c10-8-5-4-6-2-1-3-7(12)9(6)11-8/h1-5,12H,(H2,10,11)
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 1.38E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50014407
PNG
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
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PubMed
 1.41E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50007407
PNG
(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Show SMILES C1CN(CCN1)c1cccc2ccccc12
Show InChI InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
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 1.52E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM10450
PNG
(4-Aminoquinoline 7 | quinolin-4-amine)
Show SMILES Nc1ccnc2ccccc12
Show InChI InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)
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 1.52E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520370
PNG
(CHEMBL4471481)
Show SMILES FC(F)(F)c1cccc2c(ccnc12)N1CCNCC1
Show InChI InChI=1S/C14H14F3N3/c15-14(16,17)11-3-1-2-10-12(4-5-19-13(10)11)20-8-6-18-7-9-20/h1-5,18H,6-9H2
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 1.54E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520344
PNG
(CHEMBL4445044)
Show SMILES Cc1cc(N2CCOCC2)c2ccccc2n1
Show InChI InChI=1S/C14H16N2O/c1-11-10-14(16-6-8-17-9-7-16)12-4-2-3-5-13(12)15-11/h2-5,10H,6-9H2,1H3
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 1.60E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520350
PNG
(CHEMBL4563388)
Show SMILES CN(C)c1ccc2ccccc2n1
Show InChI InChI=1S/C11H12N2/c1-13(2)11-8-7-9-5-3-4-6-10(9)12-11/h3-8H,1-2H3
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 1.66E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520371
PNG
(CHEMBL4470702)
Show SMILES COCCNc1ccc2ccccc2n1
Show InChI InChI=1S/C12H14N2O/c1-15-9-8-13-12-7-6-10-4-2-3-5-11(10)14-12/h2-7H,8-9H2,1H3,(H,13,14)
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>2.00E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520372
PNG
(CHEMBL4461653)
Show SMILES Nc1cc(Cl)c2ccccc2n1
Show InChI InChI=1S/C9H7ClN2/c10-7-5-9(11)12-8-4-2-1-3-6(7)8/h1-5H,(H2,11,12)
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>2.00E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
Neutrophil cytosol factor 1


(Homo sapiens)		BDBM50520377
PNG
(CHEMBL4586378)
Show SMILES NCc1ccc2ccccc2n1
Show InChI InChI=1S/C10H10N2/c11-7-9-6-5-8-3-1-2-4-10(8)12-9/h1-6H,7,11H2
PDB
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>2.00E+6n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...

J Med Chem 63: 1156-1177 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01492
BindingDB Entry DOI: 10.7270/Q2TQ64XB
More data for this
Ligand-Target Pair
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