Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 1 (RAT) | BDBM50258185 (CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258224 (CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258223 (CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258186 (4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258226 (CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258141 (CHEMBL492570 | rac-2-fluoro-N-(4-(trifluoromethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258184 (CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50127985 (CHEMBL3628113) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 41 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay | J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50127985 (CHEMBL3628113) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 41 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay | J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258142 (2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 44 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258227 (4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258139 (CHEMBL492378 | N-(5-methyl-1,2,4-oxadiazol-3-yl)-9...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 52 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 56 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258224 (CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 67 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258142 (2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 90 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258185 (CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 102 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50127993 (CHEMBL3628115) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 112 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay | J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50127965 (CHEMBL3628112) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 112 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay | J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50127965 (CHEMBL3628112) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 113 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay | J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50127993 (CHEMBL3628115) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 113 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay | J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258225 (2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 124 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258223 (CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 131 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258225 (2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258227 (4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 161 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258186 (4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 162 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM17660 ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
CNS Research Curated by ChEMBL | Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat | J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 202 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258139 (CHEMBL492378 | N-(5-methyl-1,2,4-oxadiazol-3-yl)-9...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258184 (CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 260 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 275 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 277 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50128021 (CHEMBL3628116) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 356 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay | J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50258226 (CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 394 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology | Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM17660 ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 750 | n/a | n/a | n/a | n/a |
CNS Research Curated by ChEMBL | Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1c in rat | J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM55081 (ML182 | VU0400195-3 | cid_46869947) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a |
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay | Assay Description Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2HH6HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay | J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay | J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50500949 (CHEMBL3797793) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50500949 (CHEMBL3797793) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.86E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50293721 (CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 2.34E+3 | n/a | n/a | n/a | n/a |
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay | Assay Description Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2HH6HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50500951 (CHEMBL3799685) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50500951 (CHEMBL3799685) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM17660 ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a |
CNS Research Curated by ChEMBL | Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1b in rat | J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
Universit£ Ren£ Descartes Curated by ChEMBL | Assay Description Agonist activity in rat at Metabotropic glutamate receptor 1 expressed in HEK293 cells | Bioorg Med Chem Lett 11: 1569-72 (2001) BindingDB Entry DOI: 10.7270/Q2M61KRJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50500948 (CHEMBL3800589) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50500948 (CHEMBL3800589) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.72E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization | Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM50034501 ((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a |
CNS Research Curated by ChEMBL | Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat | J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a |
Universit£ di Perugia Curated by ChEMBL | Assay Description Activity at rat recombinant mGluR1 expressed in CHO cells assessed as intracellular calcium concentration | Bioorg Med Chem 15: 3161-70 (2007) Article DOI: 10.1016/j.bmc.2007.02.040 BindingDB Entry DOI: 10.7270/Q2CN74RR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a |
Universit£ di Perugia Curated by ChEMBL | Assay Description Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cells | Bioorg Med Chem Lett 16: 196-9 (2005) Article DOI: 10.1016/j.bmcl.2005.09.014 BindingDB Entry DOI: 10.7270/Q2DZ0932 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (RAT) | BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
CNS Research Curated by ChEMBL | Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat | J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R | |||||||||||
More data for this Ligand-Target Pair |
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