Found 57 hits of ic50 for UniProtKB: P50391 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532414
(CHEMBL4456859)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C180H278N52O53S/c1-19-89(10)140(170(279)222-121(81-133(185)242)159(268)217-117(75-87(6)7)162(271)226-141(95(16)233)171(280)213-112(32-23-66-198-180(193)194)173(282)230-69-26-35-127(230)165(274)210-107(31-22-65-197-179(191)192)150(259)214-114(143(186)252)76-97-38-46-101(235)47-39-97)225-163(272)119(78-99-42-50-103(237)51-43-99)219-151(260)106(30-21-64-196-178(189)190)206-149(258)105(29-20-63-195-177(187)188)207-157(266)115(73-85(2)3)216-161(270)123(83-138(250)251)215-146(255)92(13)200-144(253)91(12)202-155(264)118(77-98-40-48-102(236)49-41-98)218-154(263)108(54-58-130(182)239)205-145(254)93(14)201-148(257)111(62-72-286-18)209-152(261)109(55-59-131(183)240)208-153(262)110(56-60-135(244)245)211-166(275)128-36-28-71-232(128)176(285)142(96(17)234)227-147(256)94(15)203-156(265)120(80-132(184)241)220-160(269)122(82-137(248)249)204-134(243)84-199-164(273)125-33-24-68-229(125)175(284)124(79-100-44-52-104(238)53-45-100)223-169(278)139(88(8)9)224-168(277)129-37-27-70-231(129)174(283)113(57-61-136(246)247)212-158(267)116(74-86(4)5)221-167(276)126-34-25-67-228(126)172(281)90(11)181/h38-53,85-96,105-129,139-142,233-238H,19-37,54-84,181H2,1-18H3,(H2,182,239)(H2,183,240)(H2,184,241)(H2,185,242)(H2,186,252)(H,199,273)(H,200,253)(H,201,257)(H,202,264)(H,203,265)(H,204,243)(H,205,254)(H,206,258)(H,207,266)(H,208,262)(H,209,261)(H,210,274)(H,211,275)(H,212,267)(H,213,280)(H,214,259)(H,215,255)(H,216,270)(H,217,268)(H,218,263)(H,219,260)(H,220,269)(H,221,276)(H,222,279)(H,223,278)(H,224,277)(H,225,272)(H,226,271)(H,227,256)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,187,188,195)(H4,189,190,196)(H4,191,192,197)(H4,193,194,198)/t89-,90+,91-,92-,93-,94-,95-,96+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,139-,140-,141-,142-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532414
(CHEMBL4456859)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C180H278N52O53S/c1-19-89(10)140(170(279)222-121(81-133(185)242)159(268)217-117(75-87(6)7)162(271)226-141(95(16)233)171(280)213-112(32-23-66-198-180(193)194)173(282)230-69-26-35-127(230)165(274)210-107(31-22-65-197-179(191)192)150(259)214-114(143(186)252)76-97-38-46-101(235)47-39-97)225-163(272)119(78-99-42-50-103(237)51-43-99)219-151(260)106(30-21-64-196-178(189)190)206-149(258)105(29-20-63-195-177(187)188)207-157(266)115(73-85(2)3)216-161(270)123(83-138(250)251)215-146(255)92(13)200-144(253)91(12)202-155(264)118(77-98-40-48-102(236)49-41-98)218-154(263)108(54-58-130(182)239)205-145(254)93(14)201-148(257)111(62-72-286-18)209-152(261)109(55-59-131(183)240)208-153(262)110(56-60-135(244)245)211-166(275)128-36-28-71-232(128)176(285)142(96(17)234)227-147(256)94(15)203-156(265)120(80-132(184)241)220-160(269)122(82-137(248)249)204-134(243)84-199-164(273)125-33-24-68-229(125)175(284)124(79-100-44-52-104(238)53-45-100)223-169(278)139(88(8)9)224-168(277)129-37-27-70-231(129)174(283)113(57-61-136(246)247)212-158(267)116(74-86(4)5)221-167(276)126-34-25-67-228(126)172(281)90(11)181/h38-53,85-96,105-129,139-142,233-238H,19-37,54-84,181H2,1-18H3,(H2,182,239)(H2,183,240)(H2,184,241)(H2,185,242)(H2,186,252)(H,199,273)(H,200,253)(H,201,257)(H,202,264)(H,203,265)(H,204,243)(H,205,254)(H,206,258)(H,207,266)(H,208,262)(H,209,261)(H,210,274)(H,211,275)(H,212,267)(H,213,280)(H,214,259)(H,215,255)(H,216,270)(H,217,268)(H,218,263)(H,219,260)(H,220,269)(H,221,276)(H,222,279)(H,223,278)(H,224,277)(H,225,272)(H,226,271)(H,227,256)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,187,188,195)(H4,189,190,196)(H4,191,192,197)(H4,193,194,198)/t89-,90+,91-,92-,93-,94-,95-,96+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,139-,140-,141-,142-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532414
(CHEMBL4456859)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C180H278N52O53S/c1-19-89(10)140(170(279)222-121(81-133(185)242)159(268)217-117(75-87(6)7)162(271)226-141(95(16)233)171(280)213-112(32-23-66-198-180(193)194)173(282)230-69-26-35-127(230)165(274)210-107(31-22-65-197-179(191)192)150(259)214-114(143(186)252)76-97-38-46-101(235)47-39-97)225-163(272)119(78-99-42-50-103(237)51-43-99)219-151(260)106(30-21-64-196-178(189)190)206-149(258)105(29-20-63-195-177(187)188)207-157(266)115(73-85(2)3)216-161(270)123(83-138(250)251)215-146(255)92(13)200-144(253)91(12)202-155(264)118(77-98-40-48-102(236)49-41-98)218-154(263)108(54-58-130(182)239)205-145(254)93(14)201-148(257)111(62-72-286-18)209-152(261)109(55-59-131(183)240)208-153(262)110(56-60-135(244)245)211-166(275)128-36-28-71-232(128)176(285)142(96(17)234)227-147(256)94(15)203-156(265)120(80-132(184)241)220-160(269)122(82-137(248)249)204-134(243)84-199-164(273)125-33-24-68-229(125)175(284)124(79-100-44-52-104(238)53-45-100)223-169(278)139(88(8)9)224-168(277)129-37-27-70-231(129)174(283)113(57-61-136(246)247)212-158(267)116(74-86(4)5)221-167(276)126-34-25-67-228(126)172(281)90(11)181/h38-53,85-96,105-129,139-142,233-238H,19-37,54-84,181H2,1-18H3,(H2,182,239)(H2,183,240)(H2,184,241)(H2,185,242)(H2,186,252)(H,199,273)(H,200,253)(H,201,257)(H,202,264)(H,203,265)(H,204,243)(H,205,254)(H,206,258)(H,207,266)(H,208,262)(H,209,261)(H,210,274)(H,211,275)(H,212,267)(H,213,280)(H,214,259)(H,215,255)(H,216,270)(H,217,268)(H,218,263)(H,219,260)(H,220,269)(H,221,276)(H,222,279)(H,223,278)(H,224,277)(H,225,272)(H,226,271)(H,227,256)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,187,188,195)(H4,189,190,196)(H4,191,192,197)(H4,193,194,198)/t89-,90+,91-,92-,93-,94-,95-,96+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,139-,140-,141-,142-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of Mono-sCy5-(2R,7R)-Diaminooctanedioyl-bis(Tyr-Arg-Leu-ArgTyr-amide) from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expre... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532414
(CHEMBL4456859)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C180H278N52O53S/c1-19-89(10)140(170(279)222-121(81-133(185)242)159(268)217-117(75-87(6)7)162(271)226-141(95(16)233)171(280)213-112(32-23-66-198-180(193)194)173(282)230-69-26-35-127(230)165(274)210-107(31-22-65-197-179(191)192)150(259)214-114(143(186)252)76-97-38-46-101(235)47-39-97)225-163(272)119(78-99-42-50-103(237)51-43-99)219-151(260)106(30-21-64-196-178(189)190)206-149(258)105(29-20-63-195-177(187)188)207-157(266)115(73-85(2)3)216-161(270)123(83-138(250)251)215-146(255)92(13)200-144(253)91(12)202-155(264)118(77-98-40-48-102(236)49-41-98)218-154(263)108(54-58-130(182)239)205-145(254)93(14)201-148(257)111(62-72-286-18)209-152(261)109(55-59-131(183)240)208-153(262)110(56-60-135(244)245)211-166(275)128-36-28-71-232(128)176(285)142(96(17)234)227-147(256)94(15)203-156(265)120(80-132(184)241)220-160(269)122(82-137(248)249)204-134(243)84-199-164(273)125-33-24-68-229(125)175(284)124(79-100-44-52-104(238)53-45-100)223-169(278)139(88(8)9)224-168(277)129-37-27-70-231(129)174(283)113(57-61-136(246)247)212-158(267)116(74-86(4)5)221-167(276)126-34-25-67-228(126)172(281)90(11)181/h38-53,85-96,105-129,139-142,233-238H,19-37,54-84,181H2,1-18H3,(H2,182,239)(H2,183,240)(H2,184,241)(H2,185,242)(H2,186,252)(H,199,273)(H,200,253)(H,201,257)(H,202,264)(H,203,265)(H,204,243)(H,205,254)(H,206,258)(H,207,266)(H,208,262)(H,209,261)(H,210,274)(H,211,275)(H,212,267)(H,213,280)(H,214,259)(H,215,255)(H,216,270)(H,217,268)(H,218,263)(H,219,260)(H,220,269)(H,221,276)(H,222,279)(H,223,278)(H,224,277)(H,225,272)(H,226,271)(H,227,256)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,187,188,195)(H4,189,190,196)(H4,191,192,197)(H4,193,194,198)/t89-,90+,91-,92-,93-,94-,95-,96+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,139-,140-,141-,142-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of Mono-sCy5-(2R,7R)-Diaminooctanedioyl-bis(Tyr-Arg-Leu-ArgTyr-amide) from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expre... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532414
(CHEMBL4456859)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C180H278N52O53S/c1-19-89(10)140(170(279)222-121(81-133(185)242)159(268)217-117(75-87(6)7)162(271)226-141(95(16)233)171(280)213-112(32-23-66-198-180(193)194)173(282)230-69-26-35-127(230)165(274)210-107(31-22-65-197-179(191)192)150(259)214-114(143(186)252)76-97-38-46-101(235)47-39-97)225-163(272)119(78-99-42-50-103(237)51-43-99)219-151(260)106(30-21-64-196-178(189)190)206-149(258)105(29-20-63-195-177(187)188)207-157(266)115(73-85(2)3)216-161(270)123(83-138(250)251)215-146(255)92(13)200-144(253)91(12)202-155(264)118(77-98-40-48-102(236)49-41-98)218-154(263)108(54-58-130(182)239)205-145(254)93(14)201-148(257)111(62-72-286-18)209-152(261)109(55-59-131(183)240)208-153(262)110(56-60-135(244)245)211-166(275)128-36-28-71-232(128)176(285)142(96(17)234)227-147(256)94(15)203-156(265)120(80-132(184)241)220-160(269)122(82-137(248)249)204-134(243)84-199-164(273)125-33-24-68-229(125)175(284)124(79-100-44-52-104(238)53-45-100)223-169(278)139(88(8)9)224-168(277)129-37-27-70-231(129)174(283)113(57-61-136(246)247)212-158(267)116(74-86(4)5)221-167(276)126-34-25-67-228(126)172(281)90(11)181/h38-53,85-96,105-129,139-142,233-238H,19-37,54-84,181H2,1-18H3,(H2,182,239)(H2,183,240)(H2,184,241)(H2,185,242)(H2,186,252)(H,199,273)(H,200,253)(H,201,257)(H,202,264)(H,203,265)(H,204,243)(H,205,254)(H,206,258)(H,207,266)(H,208,262)(H,209,261)(H,210,274)(H,211,275)(H,212,267)(H,213,280)(H,214,259)(H,215,255)(H,216,270)(H,217,268)(H,218,263)(H,219,260)(H,220,269)(H,221,276)(H,222,279)(H,223,278)(H,224,277)(H,225,272)(H,226,271)(H,227,256)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,187,188,195)(H4,189,190,196)(H4,191,192,197)(H4,193,194,198)/t89-,90+,91-,92-,93-,94-,95-,96+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,139-,140-,141-,142-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of Mono-sCy5-(2R,7R)-Diaminooctanedioyl-bis(Tyr-Arg-Leu-ArgTyr-amide) from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expre... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532414
(CHEMBL4456859)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C180H278N52O53S/c1-19-89(10)140(170(279)222-121(81-133(185)242)159(268)217-117(75-87(6)7)162(271)226-141(95(16)233)171(280)213-112(32-23-66-198-180(193)194)173(282)230-69-26-35-127(230)165(274)210-107(31-22-65-197-179(191)192)150(259)214-114(143(186)252)76-97-38-46-101(235)47-39-97)225-163(272)119(78-99-42-50-103(237)51-43-99)219-151(260)106(30-21-64-196-178(189)190)206-149(258)105(29-20-63-195-177(187)188)207-157(266)115(73-85(2)3)216-161(270)123(83-138(250)251)215-146(255)92(13)200-144(253)91(12)202-155(264)118(77-98-40-48-102(236)49-41-98)218-154(263)108(54-58-130(182)239)205-145(254)93(14)201-148(257)111(62-72-286-18)209-152(261)109(55-59-131(183)240)208-153(262)110(56-60-135(244)245)211-166(275)128-36-28-71-232(128)176(285)142(96(17)234)227-147(256)94(15)203-156(265)120(80-132(184)241)220-160(269)122(82-137(248)249)204-134(243)84-199-164(273)125-33-24-68-229(125)175(284)124(79-100-44-52-104(238)53-45-100)223-169(278)139(88(8)9)224-168(277)129-37-27-70-231(129)174(283)113(57-61-136(246)247)212-158(267)116(74-86(4)5)221-167(276)126-34-25-67-228(126)172(281)90(11)181/h38-53,85-96,105-129,139-142,233-238H,19-37,54-84,181H2,1-18H3,(H2,182,239)(H2,183,240)(H2,184,241)(H2,185,242)(H2,186,252)(H,199,273)(H,200,253)(H,201,257)(H,202,264)(H,203,265)(H,204,243)(H,205,254)(H,206,258)(H,207,266)(H,208,262)(H,209,261)(H,210,274)(H,211,275)(H,212,267)(H,213,280)(H,214,259)(H,215,255)(H,216,270)(H,217,268)(H,218,263)(H,219,260)(H,220,269)(H,221,276)(H,222,279)(H,223,278)(H,224,277)(H,225,272)(H,226,271)(H,227,256)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,187,188,195)(H4,189,190,196)(H4,191,192,197)(H4,193,194,198)/t89-,90+,91-,92-,93-,94-,95-,96+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,139-,140-,141-,142-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of Mono-sCy5-(2R,7R)-Diaminooctanedioyl-bis(Tyr-Arg-Leu-ArgTyr-amide) from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expre... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532410
(CHEMBL4456247)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)CCCC[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H124N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h17-32,43-44,53-64,107-110H,5-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t53-,54-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532410
(CHEMBL4456247)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)CCCC[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H124N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h17-32,43-44,53-64,107-110H,5-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t53-,54-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532410
(CHEMBL4456247)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)CCCC[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H124N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h17-32,43-44,53-64,107-110H,5-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t53-,54-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532410
(CHEMBL4456247)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)CCCC[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H124N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h17-32,43-44,53-64,107-110H,5-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t53-,54-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532411
(CHEMBL4559081)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)C\C=C/C[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H122N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h5-6,17-32,43-44,53-64,107-110H,7-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/b6-5-/t53-,54-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532411
(CHEMBL4559081)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)C\C=C/C[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H122N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h5-6,17-32,43-44,53-64,107-110H,7-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/b6-5-/t53-,54-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532420
(CHEMBL4475071)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H124N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h17-32,43-44,53-64,107-110H,5-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532412
(CHEMBL4566802)Show SMILES [Cl-].CCN(CC)c1ccc2c(-c3ccccc3C(=O)N3CCN(CC3)C(=O)CCC(=O)N[C@@H](C\C=C/C[C@H](N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:42.43,65.67,84.86,99.102,122.126,141.145,37.37,wD:54.56,73.75,111.115,130.134,32.33,(52.05,-12.95,;46.38,-.37,;46.36,-1.9,;45.02,-2.65,;43.7,-1.87,;43.73,-.34,;45,-4.18,;43.65,-4.94,;43.63,-6.48,;44.95,-7.26,;44.94,-8.79,;43.61,-9.54,;42.29,-8.76,;40.95,-9.52,;40.95,-11.06,;42.27,-11.83,;43.59,-11.07,;44.91,-11.84,;45.57,-10.33,;44.91,-13.37,;46.23,-14.15,;46.22,-15.67,;44.89,-16.43,;43.56,-15.67,;43.57,-14.13,;44.89,-17.96,;43.56,-18.72,;46.21,-18.73,;46.21,-20.26,;47.53,-21.03,;48.86,-20.26,;47.53,-22.56,;48.87,-23.33,;48.87,-24.87,;47.53,-25.64,;47.53,-27.18,;48.87,-27.95,;48.87,-29.5,;47.53,-30.26,;50.2,-30.26,;50.2,-31.8,;51.53,-29.5,;52.9,-30.2,;54.19,-29.35,;55.57,-30.04,;55.65,-31.58,;57.03,-32.28,;58.32,-31.44,;59.7,-32.13,;58.24,-29.89,;56.86,-29.2,;52.99,-31.73,;51.7,-32.57,;54.37,-32.43,;54.46,-33.97,;53.17,-34.81,;53.25,-36.35,;51.96,-37.19,;52.05,-38.73,;53.41,-39.43,;53.5,-40.96,;54.7,-38.59,;55.83,-34.66,;57.12,-33.82,;55.92,-36.2,;57.29,-36.89,;58.58,-36.05,;59.96,-36.74,;61.25,-35.9,;60.04,-38.28,;57.38,-38.43,;56.09,-39.28,;58.75,-39.13,;58.84,-40.66,;57.55,-41.51,;57.63,-43.04,;56.35,-43.89,;56.43,-45.43,;55.14,-46.28,;53.77,-45.58,;55.23,-47.81,;60.21,-41.36,;61.5,-40.51,;60.3,-42.9,;61.68,-43.6,;62.97,-42.75,;64.34,-43.44,;64.43,-44.99,;65.8,-45.67,;67.09,-44.83,;68.47,-45.53,;67.01,-43.29,;65.63,-42.6,;61.76,-45.13,;63.14,-45.83,;60.48,-45.97,;50.2,-22.56,;50.2,-21.02,;51.54,-23.33,;52.22,-21.95,;51.35,-20.67,;52.02,-19.29,;53.57,-19.18,;54.24,-17.79,;53.38,-16.51,;54.05,-15.13,;51.84,-16.62,;51.16,-18.01,;53.75,-21.84,;54.61,-23.11,;54.43,-20.45,;55.96,-20.34,;56.83,-21.62,;58.36,-21.51,;59.22,-22.79,;60.77,-22.68,;61.63,-23.96,;60.95,-25.34,;63.16,-23.85,;56.64,-18.96,;55.78,-17.68,;58.18,-18.85,;58.85,-17.47,;57.99,-16.19,;58.66,-14.8,;57.8,-13.52,;60.2,-14.7,;60.39,-17.35,;61.25,-18.63,;61.06,-15.97,;62.6,-15.86,;63.46,-17.14,;65,-17.03,;65.86,-18.31,;67.4,-18.2,;68.26,-19.48,;67.58,-20.86,;69.8,-19.36,;63.27,-14.48,;62.41,-13.2,;64.81,-14.37,;65.49,-12.98,;64.63,-11.71,;65.3,-10.32,;66.84,-10.21,;67.51,-8.83,;66.65,-7.55,;67.32,-6.16,;65.11,-7.65,;64.43,-9.04,;67.02,-12.87,;67.7,-11.49,;67.88,-14.15,;46.26,-9.57,;46.24,-11.09,;47.55,-11.87,;48.88,-11.11,;48.89,-9.6,;47.59,-8.82,;47.61,-7.29,;46.3,-6.51,;46.32,-4.98,;50.2,-11.89,;50.18,-13.43,;48.85,-14.18,;51.53,-11.14,;51.55,-9.61,)| Show InChI InChI=1S/C116H162N30O20.ClH/c1-9-143(10-2)73-37-47-81-95(65-73)166-96-66-74(144(11-3)12-4)38-48-82(96)99(81)79-21-13-14-22-80(79)112(165)146-57-55-145(56-58-146)98(152)50-49-97(151)132-84(103(156)142-94(64-72-35-45-78(150)46-36-72)111(164)136-88(28-20-54-131-116(126)127)107(160)141-92(60-68(7)8)109(162)134-86(26-18-52-129-114(122)123)105(158)138-90(101(119)154)62-70-31-41-76(148)42-32-70)24-16-15-23-83(117)102(155)139-93(63-71-33-43-77(149)44-34-71)110(163)135-87(27-19-53-130-115(124)125)106(159)140-91(59-67(5)6)108(161)133-85(25-17-51-128-113(120)121)104(157)137-89(100(118)153)61-69-29-39-75(147)40-30-69;/h13-16,21-22,29-48,65-68,83-94H,9-12,17-20,23-28,49-64,117H2,1-8H3,(H34-,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,147,148,149,150,151,153,154,155,156,157,158,159,160,161,162,163,164);1H/b16-15-;/t83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-;/m0./s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532420
(CHEMBL4475071)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H124N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h17-32,43-44,53-64,107-110H,5-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532412
(CHEMBL4566802)Show SMILES [Cl-].CCN(CC)c1ccc2c(-c3ccccc3C(=O)N3CCN(CC3)C(=O)CCC(=O)N[C@@H](C\C=C/C[C@H](N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:42.43,65.67,84.86,99.102,122.126,141.145,37.37,wD:54.56,73.75,111.115,130.134,32.33,(52.05,-12.95,;46.38,-.37,;46.36,-1.9,;45.02,-2.65,;43.7,-1.87,;43.73,-.34,;45,-4.18,;43.65,-4.94,;43.63,-6.48,;44.95,-7.26,;44.94,-8.79,;43.61,-9.54,;42.29,-8.76,;40.95,-9.52,;40.95,-11.06,;42.27,-11.83,;43.59,-11.07,;44.91,-11.84,;45.57,-10.33,;44.91,-13.37,;46.23,-14.15,;46.22,-15.67,;44.89,-16.43,;43.56,-15.67,;43.57,-14.13,;44.89,-17.96,;43.56,-18.72,;46.21,-18.73,;46.21,-20.26,;47.53,-21.03,;48.86,-20.26,;47.53,-22.56,;48.87,-23.33,;48.87,-24.87,;47.53,-25.64,;47.53,-27.18,;48.87,-27.95,;48.87,-29.5,;47.53,-30.26,;50.2,-30.26,;50.2,-31.8,;51.53,-29.5,;52.9,-30.2,;54.19,-29.35,;55.57,-30.04,;55.65,-31.58,;57.03,-32.28,;58.32,-31.44,;59.7,-32.13,;58.24,-29.89,;56.86,-29.2,;52.99,-31.73,;51.7,-32.57,;54.37,-32.43,;54.46,-33.97,;53.17,-34.81,;53.25,-36.35,;51.96,-37.19,;52.05,-38.73,;53.41,-39.43,;53.5,-40.96,;54.7,-38.59,;55.83,-34.66,;57.12,-33.82,;55.92,-36.2,;57.29,-36.89,;58.58,-36.05,;59.96,-36.74,;61.25,-35.9,;60.04,-38.28,;57.38,-38.43,;56.09,-39.28,;58.75,-39.13,;58.84,-40.66,;57.55,-41.51,;57.63,-43.04,;56.35,-43.89,;56.43,-45.43,;55.14,-46.28,;53.77,-45.58,;55.23,-47.81,;60.21,-41.36,;61.5,-40.51,;60.3,-42.9,;61.68,-43.6,;62.97,-42.75,;64.34,-43.44,;64.43,-44.99,;65.8,-45.67,;67.09,-44.83,;68.47,-45.53,;67.01,-43.29,;65.63,-42.6,;61.76,-45.13,;63.14,-45.83,;60.48,-45.97,;50.2,-22.56,;50.2,-21.02,;51.54,-23.33,;52.22,-21.95,;51.35,-20.67,;52.02,-19.29,;53.57,-19.18,;54.24,-17.79,;53.38,-16.51,;54.05,-15.13,;51.84,-16.62,;51.16,-18.01,;53.75,-21.84,;54.61,-23.11,;54.43,-20.45,;55.96,-20.34,;56.83,-21.62,;58.36,-21.51,;59.22,-22.79,;60.77,-22.68,;61.63,-23.96,;60.95,-25.34,;63.16,-23.85,;56.64,-18.96,;55.78,-17.68,;58.18,-18.85,;58.85,-17.47,;57.99,-16.19,;58.66,-14.8,;57.8,-13.52,;60.2,-14.7,;60.39,-17.35,;61.25,-18.63,;61.06,-15.97,;62.6,-15.86,;63.46,-17.14,;65,-17.03,;65.86,-18.31,;67.4,-18.2,;68.26,-19.48,;67.58,-20.86,;69.8,-19.36,;63.27,-14.48,;62.41,-13.2,;64.81,-14.37,;65.49,-12.98,;64.63,-11.71,;65.3,-10.32,;66.84,-10.21,;67.51,-8.83,;66.65,-7.55,;67.32,-6.16,;65.11,-7.65,;64.43,-9.04,;67.02,-12.87,;67.7,-11.49,;67.88,-14.15,;46.26,-9.57,;46.24,-11.09,;47.55,-11.87,;48.88,-11.11,;48.89,-9.6,;47.59,-8.82,;47.61,-7.29,;46.3,-6.51,;46.32,-4.98,;50.2,-11.89,;50.18,-13.43,;48.85,-14.18,;51.53,-11.14,;51.55,-9.61,)| Show InChI InChI=1S/C116H162N30O20.ClH/c1-9-143(10-2)73-37-47-81-95(65-73)166-96-66-74(144(11-3)12-4)38-48-82(96)99(81)79-21-13-14-22-80(79)112(165)146-57-55-145(56-58-146)98(152)50-49-97(151)132-84(103(156)142-94(64-72-35-45-78(150)46-36-72)111(164)136-88(28-20-54-131-116(126)127)107(160)141-92(60-68(7)8)109(162)134-86(26-18-52-129-114(122)123)105(158)138-90(101(119)154)62-70-31-41-76(148)42-32-70)24-16-15-23-83(117)102(155)139-93(63-71-33-43-77(149)44-34-71)110(163)135-87(27-19-53-130-115(124)125)106(159)140-91(59-67(5)6)108(161)133-85(25-17-51-128-113(120)121)104(157)137-89(100(118)153)61-69-29-39-75(147)40-30-69;/h13-16,21-22,29-48,65-68,83-94H,9-12,17-20,23-28,49-64,117H2,1-8H3,(H34-,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,147,148,149,150,151,153,154,155,156,157,158,159,160,161,162,163,164);1H/b16-15-;/t83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-;/m0./s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532413
(CHEMBL4546224)Show SMILES [Cl-].CCN(CC)c1ccc2c(-c3ccccc3C(=O)N3CCN(CC3)C(=O)CCC(=O)N[C@H](C\C=C/C[C@@H](N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:42.43,65.67,84.86,99.102,122.126,141.145,32.33,wD:54.56,73.75,111.115,130.134,37.37,(18.79,-12.44,;12.91,-.41,;12.89,-1.94,;11.55,-2.69,;10.23,-1.91,;10.25,-.37,;11.53,-4.22,;10.18,-4.98,;10.16,-6.52,;11.48,-7.3,;11.47,-8.83,;10.14,-9.58,;8.81,-8.8,;7.48,-9.56,;7.48,-11.1,;8.8,-11.87,;10.12,-11.1,;11.44,-11.88,;12.1,-10.37,;11.43,-13.41,;12.76,-14.19,;12.75,-15.71,;11.42,-16.46,;10.09,-15.71,;10.1,-14.17,;11.41,-18,;10.08,-18.76,;12.74,-18.77,;12.74,-20.3,;14.06,-21.07,;15.39,-20.3,;14.06,-22.6,;15.39,-23.37,;15.39,-24.91,;14.06,-25.68,;14.06,-27.22,;15.39,-27.99,;15.39,-29.53,;14.06,-30.3,;16.73,-30.3,;16.73,-31.84,;18.06,-29.53,;19.43,-30.23,;20.72,-29.39,;22.1,-30.08,;22.18,-31.62,;23.56,-32.32,;24.85,-31.47,;26.23,-32.16,;24.76,-29.93,;23.38,-29.24,;19.52,-31.77,;18.23,-32.61,;20.89,-32.47,;20.98,-34.01,;19.7,-34.85,;19.78,-36.39,;18.49,-37.23,;18.57,-38.77,;19.94,-39.46,;20.03,-40.99,;21.22,-38.63,;22.35,-34.7,;23.64,-33.86,;22.45,-36.24,;23.81,-36.93,;25.1,-36.09,;26.48,-36.78,;27.77,-35.94,;26.57,-38.32,;23.91,-38.47,;22.62,-39.31,;25.28,-39.16,;25.37,-40.7,;24.08,-41.55,;24.16,-43.08,;22.87,-43.93,;22.96,-45.47,;21.67,-46.31,;20.29,-45.61,;21.76,-47.85,;26.74,-41.4,;28.03,-40.55,;26.83,-42.94,;28.2,-43.64,;29.49,-42.79,;30.87,-43.48,;30.95,-45.02,;32.33,-45.71,;33.62,-44.87,;35,-45.57,;33.54,-43.33,;32.16,-42.64,;28.29,-45.17,;29.67,-45.87,;27,-46.01,;16.73,-22.6,;16.73,-21.06,;18.06,-23.37,;18.74,-21.99,;17.88,-20.71,;18.55,-19.32,;20.09,-19.22,;20.77,-17.83,;19.91,-16.55,;20.57,-15.16,;18.36,-16.66,;17.69,-18.05,;20.27,-21.88,;21.14,-23.15,;20.95,-20.49,;22.49,-20.38,;23.35,-21.66,;24.89,-21.55,;25.75,-22.83,;27.29,-22.72,;28.16,-24,;27.48,-25.38,;29.69,-23.89,;23.16,-19,;22.3,-17.72,;24.7,-18.89,;25.38,-17.51,;24.51,-16.23,;25.19,-14.84,;24.33,-13.56,;26.73,-14.74,;26.91,-17.39,;27.78,-18.67,;27.59,-16.01,;29.13,-15.9,;29.99,-17.18,;31.52,-17.07,;32.38,-18.35,;33.93,-18.24,;34.79,-19.52,;34.11,-20.9,;36.33,-19.4,;29.8,-14.52,;28.94,-13.24,;31.34,-14.41,;32.02,-13.02,;31.15,-11.75,;31.82,-10.36,;33.37,-10.25,;34.03,-8.87,;33.17,-7.59,;33.85,-6.2,;31.64,-7.69,;30.96,-9.08,;33.55,-12.91,;34.23,-11.53,;34.41,-14.19,;12.79,-9.6,;12.76,-11.12,;14.07,-11.9,;15.41,-11.15,;15.42,-9.64,;14.12,-8.86,;14.14,-7.33,;12.82,-6.55,;12.85,-5.01,;16.72,-11.93,;16.71,-13.47,;15.38,-14.22,;18.06,-11.18,;18.07,-9.65,)| Show InChI InChI=1S/C116H162N30O20.ClH/c1-9-143(10-2)73-37-47-81-95(65-73)166-96-66-74(144(11-3)12-4)38-48-82(96)99(81)79-21-13-14-22-80(79)112(165)146-57-55-145(56-58-146)98(152)50-49-97(151)132-84(103(156)142-94(64-72-35-45-78(150)46-36-72)111(164)136-88(28-20-54-131-116(126)127)107(160)141-92(60-68(7)8)109(162)134-86(26-18-52-129-114(122)123)105(158)138-90(101(119)154)62-70-31-41-76(148)42-32-70)24-16-15-23-83(117)102(155)139-93(63-71-33-43-77(149)44-34-71)110(163)135-87(27-19-53-130-115(124)125)106(159)140-91(59-67(5)6)108(161)133-85(25-17-51-128-113(120)121)104(157)137-89(100(118)153)61-69-29-39-75(147)40-30-69;/h13-16,21-22,29-48,65-68,83-94H,9-12,17-20,23-28,49-64,117H2,1-8H3,(H34-,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,147,148,149,150,151,153,154,155,156,157,158,159,160,161,162,163,164);1H/b16-15-;/t83-,84-,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+;/m1./s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532419
(CHEMBL4558218)Show SMILES [Cl-].CCN(CC)c1ccc2c(-c3ccccc3C(=O)N3CCN(CC3)C(=O)CCC(=O)N[C@@H](CCCC[C@H](N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:42.43,65.67,84.86,99.102,122.126,141.145,37.37,wD:54.56,73.75,111.115,130.134,32.33,(14.92,-9.28,;8.53,2.83,;8.51,1.3,;7.17,.56,;5.86,1.34,;5.88,2.87,;7.15,-.98,;5.8,-1.74,;5.79,-3.27,;7.1,-4.06,;7.09,-5.59,;5.76,-6.33,;4.44,-5.56,;3.11,-6.32,;3.11,-7.86,;4.43,-8.63,;5.75,-7.86,;7.07,-8.64,;7.73,-7.13,;7.06,-10.17,;8.38,-10.94,;8.38,-12.47,;7.04,-13.22,;5.72,-12.47,;5.73,-10.93,;7.04,-14.75,;5.71,-15.52,;8.37,-15.52,;8.36,-17.06,;9.69,-17.82,;11.02,-17.06,;9.69,-19.36,;11.02,-20.13,;11.02,-21.67,;9.69,-22.44,;9.69,-23.98,;11.02,-24.75,;11.02,-26.29,;9.69,-27.06,;12.36,-27.06,;12.36,-28.6,;13.68,-26.29,;15.06,-26.99,;16.35,-26.15,;17.72,-26.84,;17.81,-28.38,;19.19,-29.08,;20.48,-28.23,;21.85,-28.92,;20.39,-26.69,;19.01,-25.99,;15.15,-28.52,;13.86,-29.37,;16.52,-29.22,;16.61,-30.76,;15.32,-31.61,;15.4,-33.14,;14.11,-33.99,;14.2,-35.53,;15.57,-36.22,;15.65,-37.75,;16.85,-35.38,;17.98,-31.46,;19.27,-30.61,;18.07,-33,;19.44,-33.69,;20.73,-32.84,;22.11,-33.54,;23.4,-32.7,;22.19,-35.08,;19.53,-35.23,;18.25,-36.07,;20.9,-35.92,;21,-37.46,;19.71,-38.3,;19.79,-39.84,;18.5,-40.68,;18.58,-42.23,;17.3,-43.07,;15.92,-42.37,;17.39,-44.61,;22.37,-38.15,;23.65,-37.31,;22.46,-39.69,;23.83,-40.39,;25.12,-39.55,;26.5,-40.24,;26.58,-41.78,;27.96,-42.47,;29.25,-41.63,;30.63,-42.32,;29.16,-40.09,;27.78,-39.39,;23.92,-41.93,;25.29,-42.63,;22.63,-42.77,;12.36,-19.36,;12.36,-17.82,;13.69,-20.13,;14.37,-18.74,;13.51,-17.47,;14.18,-16.08,;15.72,-15.97,;16.39,-14.58,;15.53,-13.31,;16.2,-11.92,;13.99,-13.42,;13.32,-14.81,;15.9,-18.63,;16.76,-19.91,;16.58,-17.25,;18.12,-17.14,;18.98,-18.41,;20.52,-18.31,;21.38,-19.59,;22.92,-19.48,;23.78,-20.75,;23.1,-22.14,;25.31,-20.64,;18.79,-15.76,;17.93,-14.48,;20.33,-15.64,;21,-14.26,;20.14,-12.99,;20.82,-11.6,;19.96,-10.32,;22.35,-11.49,;22.54,-14.15,;23.4,-15.43,;23.21,-12.77,;24.75,-12.66,;25.61,-13.93,;27.15,-13.83,;28.01,-15.11,;29.55,-15,;30.42,-16.27,;29.74,-17.66,;31.95,-16.16,;25.43,-11.28,;24.56,-10,;26.96,-11.16,;27.64,-9.78,;26.78,-8.5,;27.45,-7.12,;28.99,-7.01,;29.66,-5.62,;28.8,-4.35,;29.48,-2.96,;27.26,-4.45,;26.59,-5.84,;29.17,-9.67,;29.85,-8.29,;30.04,-10.95,;8.41,-6.36,;8.39,-7.88,;9.7,-8.66,;11.03,-7.91,;11.05,-6.39,;9.74,-5.62,;9.77,-4.09,;8.45,-3.31,;8.48,-1.77,;12.35,-8.69,;12.34,-10.22,;11,-10.98,;13.69,-7.94,;13.7,-6.4,)| Show InChI InChI=1S/C116H164N30O20.ClH/c1-9-143(10-2)73-37-47-81-95(65-73)166-96-66-74(144(11-3)12-4)38-48-82(96)99(81)79-21-13-14-22-80(79)112(165)146-57-55-145(56-58-146)98(152)50-49-97(151)132-84(103(156)142-94(64-72-35-45-78(150)46-36-72)111(164)136-88(28-20-54-131-116(126)127)107(160)141-92(60-68(7)8)109(162)134-86(26-18-52-129-114(122)123)105(158)138-90(101(119)154)62-70-31-41-76(148)42-32-70)24-16-15-23-83(117)102(155)139-93(63-71-33-43-77(149)44-34-71)110(163)135-87(27-19-53-130-115(124)125)106(159)140-91(59-67(5)6)108(161)133-85(25-17-51-128-113(120)121)104(157)137-89(100(118)153)61-69-29-39-75(147)40-30-69;/h13-14,21-22,29-48,65-68,83-94H,9-12,15-20,23-28,49-64,117H2,1-8H3,(H34-,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,147,148,149,150,151,153,154,155,156,157,158,159,160,161,162,163,164);1H/t83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-;/m0./s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532419
(CHEMBL4558218)Show SMILES [Cl-].CCN(CC)c1ccc2c(-c3ccccc3C(=O)N3CCN(CC3)C(=O)CCC(=O)N[C@@H](CCCC[C@H](N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:42.43,65.67,84.86,99.102,122.126,141.145,37.37,wD:54.56,73.75,111.115,130.134,32.33,(14.92,-9.28,;8.53,2.83,;8.51,1.3,;7.17,.56,;5.86,1.34,;5.88,2.87,;7.15,-.98,;5.8,-1.74,;5.79,-3.27,;7.1,-4.06,;7.09,-5.59,;5.76,-6.33,;4.44,-5.56,;3.11,-6.32,;3.11,-7.86,;4.43,-8.63,;5.75,-7.86,;7.07,-8.64,;7.73,-7.13,;7.06,-10.17,;8.38,-10.94,;8.38,-12.47,;7.04,-13.22,;5.72,-12.47,;5.73,-10.93,;7.04,-14.75,;5.71,-15.52,;8.37,-15.52,;8.36,-17.06,;9.69,-17.82,;11.02,-17.06,;9.69,-19.36,;11.02,-20.13,;11.02,-21.67,;9.69,-22.44,;9.69,-23.98,;11.02,-24.75,;11.02,-26.29,;9.69,-27.06,;12.36,-27.06,;12.36,-28.6,;13.68,-26.29,;15.06,-26.99,;16.35,-26.15,;17.72,-26.84,;17.81,-28.38,;19.19,-29.08,;20.48,-28.23,;21.85,-28.92,;20.39,-26.69,;19.01,-25.99,;15.15,-28.52,;13.86,-29.37,;16.52,-29.22,;16.61,-30.76,;15.32,-31.61,;15.4,-33.14,;14.11,-33.99,;14.2,-35.53,;15.57,-36.22,;15.65,-37.75,;16.85,-35.38,;17.98,-31.46,;19.27,-30.61,;18.07,-33,;19.44,-33.69,;20.73,-32.84,;22.11,-33.54,;23.4,-32.7,;22.19,-35.08,;19.53,-35.23,;18.25,-36.07,;20.9,-35.92,;21,-37.46,;19.71,-38.3,;19.79,-39.84,;18.5,-40.68,;18.58,-42.23,;17.3,-43.07,;15.92,-42.37,;17.39,-44.61,;22.37,-38.15,;23.65,-37.31,;22.46,-39.69,;23.83,-40.39,;25.12,-39.55,;26.5,-40.24,;26.58,-41.78,;27.96,-42.47,;29.25,-41.63,;30.63,-42.32,;29.16,-40.09,;27.78,-39.39,;23.92,-41.93,;25.29,-42.63,;22.63,-42.77,;12.36,-19.36,;12.36,-17.82,;13.69,-20.13,;14.37,-18.74,;13.51,-17.47,;14.18,-16.08,;15.72,-15.97,;16.39,-14.58,;15.53,-13.31,;16.2,-11.92,;13.99,-13.42,;13.32,-14.81,;15.9,-18.63,;16.76,-19.91,;16.58,-17.25,;18.12,-17.14,;18.98,-18.41,;20.52,-18.31,;21.38,-19.59,;22.92,-19.48,;23.78,-20.75,;23.1,-22.14,;25.31,-20.64,;18.79,-15.76,;17.93,-14.48,;20.33,-15.64,;21,-14.26,;20.14,-12.99,;20.82,-11.6,;19.96,-10.32,;22.35,-11.49,;22.54,-14.15,;23.4,-15.43,;23.21,-12.77,;24.75,-12.66,;25.61,-13.93,;27.15,-13.83,;28.01,-15.11,;29.55,-15,;30.42,-16.27,;29.74,-17.66,;31.95,-16.16,;25.43,-11.28,;24.56,-10,;26.96,-11.16,;27.64,-9.78,;26.78,-8.5,;27.45,-7.12,;28.99,-7.01,;29.66,-5.62,;28.8,-4.35,;29.48,-2.96,;27.26,-4.45,;26.59,-5.84,;29.17,-9.67,;29.85,-8.29,;30.04,-10.95,;8.41,-6.36,;8.39,-7.88,;9.7,-8.66,;11.03,-7.91,;11.05,-6.39,;9.74,-5.62,;9.77,-4.09,;8.45,-3.31,;8.48,-1.77,;12.35,-8.69,;12.34,-10.22,;11,-10.98,;13.69,-7.94,;13.7,-6.4,)| Show InChI InChI=1S/C116H164N30O20.ClH/c1-9-143(10-2)73-37-47-81-95(65-73)166-96-66-74(144(11-3)12-4)38-48-82(96)99(81)79-21-13-14-22-80(79)112(165)146-57-55-145(56-58-146)98(152)50-49-97(151)132-84(103(156)142-94(64-72-35-45-78(150)46-36-72)111(164)136-88(28-20-54-131-116(126)127)107(160)141-92(60-68(7)8)109(162)134-86(26-18-52-129-114(122)123)105(158)138-90(101(119)154)62-70-31-41-76(148)42-32-70)24-16-15-23-83(117)102(155)139-93(63-71-33-43-77(149)44-34-71)110(163)135-87(27-19-53-130-115(124)125)106(159)140-91(59-67(5)6)108(161)133-85(25-17-51-128-113(120)121)104(157)137-89(100(118)153)61-69-29-39-75(147)40-30-69;/h13-14,21-22,29-48,65-68,83-94H,9-12,15-20,23-28,49-64,117H2,1-8H3,(H34-,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,147,148,149,150,151,153,154,155,156,157,158,159,160,161,162,163,164);1H/t83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-;/m0./s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532413
(CHEMBL4546224)Show SMILES [Cl-].CCN(CC)c1ccc2c(-c3ccccc3C(=O)N3CCN(CC3)C(=O)CCC(=O)N[C@H](C\C=C/C[C@@H](N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:42.43,65.67,84.86,99.102,122.126,141.145,32.33,wD:54.56,73.75,111.115,130.134,37.37,(18.79,-12.44,;12.91,-.41,;12.89,-1.94,;11.55,-2.69,;10.23,-1.91,;10.25,-.37,;11.53,-4.22,;10.18,-4.98,;10.16,-6.52,;11.48,-7.3,;11.47,-8.83,;10.14,-9.58,;8.81,-8.8,;7.48,-9.56,;7.48,-11.1,;8.8,-11.87,;10.12,-11.1,;11.44,-11.88,;12.1,-10.37,;11.43,-13.41,;12.76,-14.19,;12.75,-15.71,;11.42,-16.46,;10.09,-15.71,;10.1,-14.17,;11.41,-18,;10.08,-18.76,;12.74,-18.77,;12.74,-20.3,;14.06,-21.07,;15.39,-20.3,;14.06,-22.6,;15.39,-23.37,;15.39,-24.91,;14.06,-25.68,;14.06,-27.22,;15.39,-27.99,;15.39,-29.53,;14.06,-30.3,;16.73,-30.3,;16.73,-31.84,;18.06,-29.53,;19.43,-30.23,;20.72,-29.39,;22.1,-30.08,;22.18,-31.62,;23.56,-32.32,;24.85,-31.47,;26.23,-32.16,;24.76,-29.93,;23.38,-29.24,;19.52,-31.77,;18.23,-32.61,;20.89,-32.47,;20.98,-34.01,;19.7,-34.85,;19.78,-36.39,;18.49,-37.23,;18.57,-38.77,;19.94,-39.46,;20.03,-40.99,;21.22,-38.63,;22.35,-34.7,;23.64,-33.86,;22.45,-36.24,;23.81,-36.93,;25.1,-36.09,;26.48,-36.78,;27.77,-35.94,;26.57,-38.32,;23.91,-38.47,;22.62,-39.31,;25.28,-39.16,;25.37,-40.7,;24.08,-41.55,;24.16,-43.08,;22.87,-43.93,;22.96,-45.47,;21.67,-46.31,;20.29,-45.61,;21.76,-47.85,;26.74,-41.4,;28.03,-40.55,;26.83,-42.94,;28.2,-43.64,;29.49,-42.79,;30.87,-43.48,;30.95,-45.02,;32.33,-45.71,;33.62,-44.87,;35,-45.57,;33.54,-43.33,;32.16,-42.64,;28.29,-45.17,;29.67,-45.87,;27,-46.01,;16.73,-22.6,;16.73,-21.06,;18.06,-23.37,;18.74,-21.99,;17.88,-20.71,;18.55,-19.32,;20.09,-19.22,;20.77,-17.83,;19.91,-16.55,;20.57,-15.16,;18.36,-16.66,;17.69,-18.05,;20.27,-21.88,;21.14,-23.15,;20.95,-20.49,;22.49,-20.38,;23.35,-21.66,;24.89,-21.55,;25.75,-22.83,;27.29,-22.72,;28.16,-24,;27.48,-25.38,;29.69,-23.89,;23.16,-19,;22.3,-17.72,;24.7,-18.89,;25.38,-17.51,;24.51,-16.23,;25.19,-14.84,;24.33,-13.56,;26.73,-14.74,;26.91,-17.39,;27.78,-18.67,;27.59,-16.01,;29.13,-15.9,;29.99,-17.18,;31.52,-17.07,;32.38,-18.35,;33.93,-18.24,;34.79,-19.52,;34.11,-20.9,;36.33,-19.4,;29.8,-14.52,;28.94,-13.24,;31.34,-14.41,;32.02,-13.02,;31.15,-11.75,;31.82,-10.36,;33.37,-10.25,;34.03,-8.87,;33.17,-7.59,;33.85,-6.2,;31.64,-7.69,;30.96,-9.08,;33.55,-12.91,;34.23,-11.53,;34.41,-14.19,;12.79,-9.6,;12.76,-11.12,;14.07,-11.9,;15.41,-11.15,;15.42,-9.64,;14.12,-8.86,;14.14,-7.33,;12.82,-6.55,;12.85,-5.01,;16.72,-11.93,;16.71,-13.47,;15.38,-14.22,;18.06,-11.18,;18.07,-9.65,)| Show InChI InChI=1S/C116H162N30O20.ClH/c1-9-143(10-2)73-37-47-81-95(65-73)166-96-66-74(144(11-3)12-4)38-48-82(96)99(81)79-21-13-14-22-80(79)112(165)146-57-55-145(56-58-146)98(152)50-49-97(151)132-84(103(156)142-94(64-72-35-45-78(150)46-36-72)111(164)136-88(28-20-54-131-116(126)127)107(160)141-92(60-68(7)8)109(162)134-86(26-18-52-129-114(122)123)105(158)138-90(101(119)154)62-70-31-41-76(148)42-32-70)24-16-15-23-83(117)102(155)139-93(63-71-33-43-77(149)44-34-71)110(163)135-87(27-19-53-130-115(124)125)106(159)140-91(59-67(5)6)108(161)133-85(25-17-51-128-113(120)121)104(157)137-89(100(118)153)61-69-29-39-75(147)40-30-69;/h13-16,21-22,29-48,65-68,83-94H,9-12,17-20,23-28,49-64,117H2,1-8H3,(H34-,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,147,148,149,150,151,153,154,155,156,157,158,159,160,161,162,163,164);1H/b16-15-;/t83-,84-,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+;/m1./s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532418
(CHEMBL4466594)Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C81H125N25O17/c1-44(2)38-61(73(118)97-56(14-8-34-93-78(85)86)69(114)101-60(66(84)111)40-46-18-26-50(107)27-19-46)104-70(115)57(15-9-35-94-79(87)88)99-75(120)63(41-47-20-28-51(108)29-21-47)102-67(112)54(82)12-6-7-13-55(83)68(113)103-64(42-48-22-30-52(109)31-23-48)76(121)100-58(16-10-36-95-80(89)90)71(116)105-62(39-45(3)4)74(119)98-59(17-11-37-96-81(91)92)72(117)106-65(77(122)123-5)43-49-24-32-53(110)33-25-49/h18-33,44-45,54-65,107-110H,6-17,34-43,82-83H2,1-5H3,(H2,84,111)(H,97,118)(H,98,119)(H,99,120)(H,100,121)(H,101,114)(H,102,112)(H,103,113)(H,104,115)(H,105,116)(H,106,117)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532418
(CHEMBL4466594)Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C81H125N25O17/c1-44(2)38-61(73(118)97-56(14-8-34-93-78(85)86)69(114)101-60(66(84)111)40-46-18-26-50(107)27-19-46)104-70(115)57(15-9-35-94-79(87)88)99-75(120)63(41-47-20-28-51(108)29-21-47)102-67(112)54(82)12-6-7-13-55(83)68(113)103-64(42-48-22-30-52(109)31-23-48)76(121)100-58(16-10-36-95-80(89)90)71(116)105-62(39-45(3)4)74(119)98-59(17-11-37-96-81(91)92)72(117)106-65(77(122)123-5)43-49-24-32-53(110)33-25-49/h18-33,44-45,54-65,107-110H,6-17,34-43,82-83H2,1-5H3,(H2,84,111)(H,97,118)(H,98,119)(H,99,120)(H,100,121)(H,101,114)(H,102,112)(H,103,113)(H,104,115)(H,105,116)(H,106,117)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532409
(CHEMBL4445077)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C\C=C/C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H122N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h5-6,17-32,43-44,53-64,107-110H,7-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/b6-5-/t53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532409
(CHEMBL4445077)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C\C=C/C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C80H122N26O16/c1-43(2)37-61(73(119)97-55(13-7-33-93-77(85)86)69(115)101-59(65(83)111)39-45-17-25-49(107)26-18-45)105-71(117)57(15-9-35-95-79(89)90)99-75(121)63(41-47-21-29-51(109)30-22-47)103-67(113)53(81)11-5-6-12-54(82)68(114)104-64(42-48-23-31-52(110)32-24-48)76(122)100-58(16-10-36-96-80(91)92)72(118)106-62(38-44(3)4)74(120)98-56(14-8-34-94-78(87)88)70(116)102-60(66(84)112)40-46-19-27-50(108)28-20-46/h5-6,17-32,43-44,53-64,107-110H,7-16,33-42,81-82H2,1-4H3,(H2,83,111)(H2,84,112)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,115)(H,102,116)(H,103,113)(H,104,114)(H,105,117)(H,106,118)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/b6-5-/t53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532415
(CHEMBL4436741)Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC |r| Show InChI InChI=1S/C82H126N24O18/c1-45(2)39-61(73(117)97-59(17-11-37-95-81(89)90)71(115)105-65(77(121)123-5)43-49-23-31-53(109)32-24-49)103-69(113)57(15-9-35-93-79(85)86)99-75(119)63(41-47-19-27-51(107)28-20-47)101-67(111)55(83)13-7-8-14-56(84)68(112)102-64(42-48-21-29-52(108)30-22-48)76(120)100-58(16-10-36-94-80(87)88)70(114)104-62(40-46(3)4)74(118)98-60(18-12-38-96-82(91)92)72(116)106-66(78(122)124-6)44-50-25-33-54(110)34-26-50/h19-34,45-46,55-66,107-110H,7-18,35-44,83-84H2,1-6H3,(H,97,117)(H,98,118)(H,99,119)(H,100,120)(H,101,111)(H,102,112)(H,103,113)(H,104,114)(H,105,115)(H,106,116)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 617 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50532415
(CHEMBL4436741)Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC |r| Show InChI InChI=1S/C82H126N24O18/c1-45(2)39-61(73(117)97-59(17-11-37-95-81(89)90)71(115)105-65(77(121)123-5)43-49-23-31-53(109)32-24-49)103-69(113)57(15-9-35-93-79(85)86)99-75(119)63(41-47-19-27-51(107)28-20-47)101-67(111)55(83)13-7-8-14-56(84)68(112)102-64(42-48-21-29-52(108)30-22-48)76(120)100-58(16-10-36-94-80(87)88)70(114)104-62(40-46(3)4)74(118)98-60(18-12-38-96-82(91)92)72(116)106-66(78(122)124-6)44-50-25-33-54(110)34-26-50/h19-34,45-46,55-66,107-110H,7-18,35-44,83-84H2,1-6H3,(H,97,117)(H,98,118)(H,99,119)(H,100,120)(H,101,111)(H,102,112)(H,103,113)(H,104,114)(H,105,115)(H,106,116)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)(H4,91,92,96)/t55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 617 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description
Displacement of [Lys2(sCy5),Arg4]-BVD-15 from C-terminal GFP-tagged neuropeptide Y4R (unknown origin) expressed in human 293TR cells measured after 3... |
J Med Chem 59: 6059-69 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00310
BindingDB Entry DOI: 10.7270/Q2ZG6WP4 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50354072
(CHEMBL1836317)Show SMILES CS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc-2c(CCSc3ccccc-23)s1 |r,wU:6.5,wD:9.12,(30.35,-14.16,;30.37,-12.61,;31.92,-12.63,;31.16,-11.28,;29.04,-11.82,;29.06,-10.28,;27.73,-9.49,;26.38,-10.24,;25.06,-9.46,;25.08,-7.91,;26.42,-7.14,;27.75,-7.94,;23.75,-7.13,;22.4,-7.89,;21.04,-7.26,;20.02,-8.37,;20.76,-9.68,;20.14,-11.16,;18.63,-11.54,;17.42,-10.61,;17.38,-9,;15.99,-8.49,;15.74,-7.02,;16.89,-6.07,;18.29,-6.59,;18.53,-8.06,;22.23,-9.38,)| Show InChI InChI=1S/C19H25N3O2S3/c1-27(23,24)20-12-13-6-8-14(9-7-13)21-19-22-18-15-4-2-3-5-16(15)25-11-10-17(18)26-19/h2-5,13-14,20H,6-12H2,1H3,(H,21,22)/t13-,14- | PDB
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Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NPY4 receptor assessed as calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 21: 5436-41 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.124
BindingDB Entry DOI: 10.7270/Q2RN387K |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50354073
(CHEMBL1836316)Show SMILES O=S(=O)(NC[C@H]1CC[C@@H](CC1)Nc1nc-2c(CCSc3ccccc-23)s1)c1cccs1 |r,wU:5.4,wD:8.11,(42.05,-18.71,;40.51,-18.69,;41.3,-17.37,;39.18,-17.9,;39.2,-16.36,;37.88,-15.57,;36.53,-16.33,;35.21,-15.54,;35.23,-14,;36.57,-13.24,;37.9,-14.03,;33.9,-13.22,;32.56,-13.98,;31.2,-13.36,;30.19,-14.46,;30.93,-15.76,;30.31,-17.24,;28.81,-17.62,;27.6,-16.69,;27.56,-15.09,;26.18,-14.58,;25.93,-13.12,;27.07,-12.17,;28.47,-12.69,;28.71,-14.15,;32.39,-15.46,;40.49,-20.23,;41.73,-21.16,;41.24,-22.62,;39.69,-22.6,;39.24,-21.12,)| Show InChI InChI=1S/C22H25N3O2S4/c26-31(27,20-6-3-12-29-20)23-14-15-7-9-16(10-8-15)24-22-25-21-17-4-1-2-5-18(17)28-13-11-19(21)30-22/h1-6,12,15-16,23H,7-11,13-14H2,(H,24,25)/t15-,16- | PDB
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Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NPY4 receptor assessed as calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 21: 5436-41 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.124
BindingDB Entry DOI: 10.7270/Q2RN387K |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50354076
(CHEMBL1836103)Show SMILES COc1ccc(C)cc1S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc-2c(CCSc3ccccc-23)s1 |r,wU:14.14,wD:17.21,(38.95,-3.6,;37.61,-2.84,;36.28,-3.62,;36.3,-5.16,;34.96,-5.95,;33.62,-5.18,;32.29,-5.96,;33.61,-3.64,;34.95,-2.87,;34.94,-1.33,;36.48,-1.32,;35.7,.01,;33.6,-.57,;33.59,.98,;32.25,1.74,;30.92,.96,;29.58,1.72,;29.58,3.26,;30.9,4.05,;32.24,3.28,;28.23,4.02,;26.91,3.24,;25.54,3.83,;24.55,2.71,;25.3,1.43,;24.71,-.06,;23.22,-.47,;21.99,.44,;21.93,2.03,;20.53,2.52,;20.26,3.98,;21.39,4.95,;22.79,4.45,;23.06,3,;26.76,1.75,)| Show InChI InChI=1S/C26H31N3O3S3/c1-17-7-12-21(32-2)24(15-17)35(30,31)27-16-18-8-10-19(11-9-18)28-26-29-25-20-5-3-4-6-22(20)33-14-13-23(25)34-26/h3-7,12,15,18-19,27H,8-11,13-14,16H2,1-2H3,(H,28,29)/t18-,19- | PDB
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Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NPY4 receptor assessed as calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 21: 5436-41 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.124
BindingDB Entry DOI: 10.7270/Q2RN387K |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50343728
(3-((R)-9-Amino-4-(2,2-diphenylacetamido)-1-(4-hydr...)Show SMILES CN(C)c1ccc(C=CC=Cc2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)NC(N)=NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 |r,w:8.8,36.38,10.10| Show InChI InChI=1S/C55H63N9O5S/c1-63(2)44-31-27-40(28-32-44)17-9-12-26-50-64(47-23-10-11-24-48(47)70-50)38-16-25-49(66)57-35-13-14-36-59-55(69)62-54(56)58-37-15-22-46(52(67)60-39-41-29-33-45(65)34-30-41)61-53(68)51(42-18-5-3-6-19-42)43-20-7-4-8-21-43/h3-12,17-21,23-24,26-34,46,51H,13-16,22,25,35-39H2,1-2H3,(H7-,56,57,58,59,60,61,62,65,66,67,68,69)/p+1/t46-/m1/s1 | PDB
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Universit£t Regensburg
Curated by ChEMBL
| Assay Description
Displacement of Cy5-[K4]-hpp from human Y4R expressed in CHO cells by flowcytometry |
Bioorg Med Chem 19: 2859-78 (2011)
Article DOI: 10.1016/j.bmc.2011.03.045
BindingDB Entry DOI: 10.7270/Q2F47PG7 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50354071
(CHEMBL1836318)Show SMILES CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc-2c(CCSc3ccccc-23)s1 |r,wU:7.6,wD:10.13,(6.6,-30,;5.27,-29.21,;5.29,-27.67,;6.84,-27.69,;6.08,-26.34,;3.97,-26.88,;3.99,-25.34,;2.66,-24.55,;1.31,-25.3,;-.01,-24.52,;.01,-22.97,;1.35,-22.21,;2.68,-23,;-1.32,-22.19,;-2.66,-22.95,;-4.03,-22.33,;-5.04,-23.43,;-4.3,-24.74,;-4.92,-26.21,;-6.42,-26.6,;-7.64,-25.66,;-7.67,-24.07,;-9.06,-23.55,;-9.31,-22.09,;-8.16,-21.14,;-6.77,-21.66,;-6.52,-23.12,;-2.83,-24.44,)| Show InChI InChI=1S/C20H27N3O2S3/c1-2-28(24,25)21-13-14-7-9-15(10-8-14)22-20-23-19-16-5-3-4-6-17(16)26-12-11-18(19)27-20/h3-6,14-15,21H,2,7-13H2,1H3,(H,22,23)/t14-,15- | PDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck Research USA, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human NPY4 receptor assessed as calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 21: 5436-41 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.124
BindingDB Entry DOI: 10.7270/Q2RN387K |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50563421
(CHEMBL4745232)Show SMILES CS(=O)(=O)N1CCCC[C@H]1C(=O)Nc1nc2cc3OCCOc3cc2s1 |r| | PDB
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| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Allosteric antagonist activity at eFYP-tagged human NPY4R expressed in COS7 cells co-expressing Gqi5-alpha assessed as inhibition of PP-induced Ca2+ ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02000
BindingDB Entry DOI: 10.7270/Q24F1VGB |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50563421
(CHEMBL4745232)Show SMILES CS(=O)(=O)N1CCCC[C@H]1C(=O)Nc1nc2cc3OCCOc3cc2s1 |r| | PDB
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| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Allosteric antagonist activity at eFYP-tagged human NPY4R expressed in COS7 cells co-expressing Gqi5-alpha assessed as inhibition of PP-induced Ca2+ ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02000
BindingDB Entry DOI: 10.7270/Q24F1VGB |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50563420
(CHEMBL4780125)Show SMILES CS(=O)(=O)N1CCCCC1C(=O)Nc1nc2cc3OCCOc3cc2s1 | PDB
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| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Allosteric antagonist activity at eFYP-tagged human NPY4R expressed in COS7 cells co-expressing Gqi5-alpha assessed as inhibition of PP-induced Ca2+ ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02000
BindingDB Entry DOI: 10.7270/Q24F1VGB |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50563420
(CHEMBL4780125)Show SMILES CS(=O)(=O)N1CCCCC1C(=O)Nc1nc2cc3OCCOc3cc2s1 | PDB
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| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Allosteric antagonist activity at eFYP-tagged human NPY4R expressed in COS7 cells co-expressing Gqi5-alpha assessed as inhibition of PP-induced Ca2+ ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02000
BindingDB Entry DOI: 10.7270/Q24F1VGB |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50089038
(CGP 71683 | CGP-71683A | CHEMBL17645 | N-{[(1r,4r)...)Show SMILES Nc1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12 |wU:6.5,wD:9.9,(2.92,.42,;2.94,-1.13,;4.28,-1.89,;4.29,-3.44,;5.63,-4.22,;6.96,-3.45,;8.29,-4.21,;9.63,-3.44,;10.96,-4.22,;10.95,-5.76,;12.28,-6.54,;13.77,-6.13,;14.86,-7.21,;13.98,-8.47,;15.7,-5.91,;16.12,-8.05,;17.24,-7,;18.73,-7.45,;19.09,-8.94,;17.97,-9.99,;18.33,-11.48,;17.22,-12.56,;15.73,-12.11,;15.38,-10.62,;16.49,-9.56,;9.62,-6.51,;8.29,-5.75,;2.95,-4.23,;1.61,-3.45,;.26,-4.23,;-1.07,-3.46,;-1.07,-1.9,;.26,-1.13,;1.61,-1.9,)| Show InChI InChI=1S/C26H29N5O2S/c27-25-22-9-3-4-10-23(22)30-26(31-25)28-16-18-12-14-19(15-13-18)17-29-34(32,33)24-11-5-7-20-6-1-2-8-21(20)24/h1-11,18-19,29H,12-17H2,(H3,27,28,30,31)/t18-,19- | PDB
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| n/a | n/a | 5.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Compound was tested for human Neuropeptide Y receptor type 4 |
Bioorg Med Chem Lett 10: 1175-9 (2000)
BindingDB Entry DOI: 10.7270/Q2KH0MJP |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50346228
(1-(Difluoromethyl)-5-[(4S,5S)-4-(4-fluorophenyl)-4...)Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1ccc(=O)n(c1)C(F)F |r,c:3| Show InChI InChI=1S/C21H16F4N4O/c1-12-21(14-3-6-16(22)7-4-14,15-5-8-17(23)26-10-15)28-19(27-12)13-2-9-18(30)29(11-13)20(24)25/h2-12,20H,1H3,(H,27,28)/t12-,21-/m0/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human NPYY4 |
Bioorg Med Chem 17: 6106-22 (2009)
Article DOI: 10.1016/j.bmc.2009.05.069
BindingDB Entry DOI: 10.7270/Q2513ZHZ |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50301193
(6-((5-ethyl-4-(fluoromethyl)thiazol-2-ylthio)methy...)Show SMILES CCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF Show InChI InChI=1S/C23H28FN5OS2/c1-3-21-20(13-24)28-23(32-21)31-15-18-11-19(29-7-9-30-10-8-29)12-22(27-18)25-14-17-6-4-5-16(2)26-17/h4-6,11-12H,3,7-10,13-15H2,1-2H3,(H,25,27) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY from human NPYY4 receptor |
Bioorg Med Chem Lett 19: 5124-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50301192
(6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)meth...)Show SMILES Cc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(26-21)14-30-22-27-20(12-23)16(2)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,26) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-PYY from human NPYY4 receptor |
Bioorg Med Chem Lett 19: 5124-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50296881
((1-((1R,4R)-4-((S)-2,2-difluoro-1-(4-methoxyphenyl...)Show SMILES COc1ccc(cc1)[C@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(CC2)(C(=O)N2CCCC2)c2ccccc2)C(C)(C)C1)C(F)F |r| Show InChI InChI=1S/C34H45F2N3O3/c1-33(2)23-26(37-29(30(35)36)24-11-14-27(42-3)15-12-24)13-16-28(33)31(40)38-21-17-34(18-22-38,25-9-5-4-6-10-25)32(41)39-19-7-8-20-39/h4-6,9-12,14-15,26,28-30,37H,7-8,13,16-23H2,1-3H3/t26-,28+,29+/m1/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human neuropeptide Y4 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 19: 4781-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.050
BindingDB Entry DOI: 10.7270/Q2319VXR |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50249869
(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)N1CCC2(CC1)OC(=O)c1ccccc21 Show InChI InChI=1S/C23H20N4O3/c28-21-17-8-4-5-9-18(17)23(30-21)10-12-27(13-11-23)22(29)26-20-15-24-19(14-25-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2,(H,25,26,29) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human NPY Y4 receptor |
Bioorg Med Chem Lett 19: 3511-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.013
BindingDB Entry DOI: 10.7270/Q21C1WS5 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50249758
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(ccn1)C#N |r,c:3| Show InChI InChI=1S/C21H15F2N5/c1-13-21(15-2-5-17(22)6-3-15,16-4-7-19(23)26-12-16)28-20(27-13)18-10-14(11-24)8-9-25-18/h2-10,12-13H,1H3,(H,27,28)/t13-,21-/m0/s1 | PDB
Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human neuropeptide Y4 receptor |
J Med Chem 52: 3385-96 (2009)
Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50264492
(CHEMBL522589 | trans-4-[5-(5-Methyl-[1,2,4]oxadiaz...)Show SMILES Cc1nc(no1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(20.48,-8.99,;19.93,-10.43,;18.44,-10.83,;18.37,-12.37,;19.8,-12.91,;20.77,-11.72,;17.08,-13.21,;17.16,-14.75,;15.88,-15.58,;14.52,-14.88,;13.08,-15.44,;12.11,-14.24,;12.96,-12.95,;14.44,-13.35,;15.72,-12.52,;10.58,-14.32,;9.74,-13.01,;8.2,-13.1,;7.49,-14.47,;8.33,-15.77,;9.88,-15.69,;6.79,-15.85,;5.26,-15.61,;4.18,-16.7,;5.02,-14.08,;3.73,-13.24,;3.81,-11.7,;5.2,-10.99,;6.49,-11.84,;6.41,-13.38,)| Show InChI InChI=1S/C23H20N4O3/c1-13-24-21(27-30-13)15-6-7-18-19(12-15)26-20(25-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)29-23/h2-7,12,14H,8-11H2,1H3,(H,25,26)/t14-,23- | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50264494
(CHEMBL521750 | trans-4-[5-(2-Methyl-2H-tetrazol-5-...)Show SMILES Cn1nnc(n1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(29.77,-38.49,;29.22,-39.92,;30.06,-41.21,;29.1,-42.41,;27.66,-41.87,;27.74,-40.33,;26.37,-42.71,;26.46,-44.24,;25.17,-45.08,;23.81,-44.38,;22.38,-44.93,;21.41,-43.73,;22.25,-42.45,;23.73,-42.85,;25.01,-42.02,;19.87,-43.81,;19.03,-42.51,;17.49,-42.6,;16.79,-43.97,;17.63,-45.26,;19.17,-45.19,;16.08,-45.34,;14.56,-45.1,;13.47,-46.19,;14.32,-43.57,;13.03,-42.73,;13.1,-41.19,;14.49,-40.49,;15.78,-41.34,;15.7,-42.88,)| Show InChI InChI=1S/C22H20N6O2/c1-28-26-20(25-27-28)14-6-7-17-18(12-14)24-19(23-17)13-8-10-22(11-9-13)16-5-3-2-4-15(16)21(29)30-22/h2-7,12-13H,8-11H2,1H3,(H,23,24)/t13-,22- | PDB
Reactome pathway
KEGG
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| CHEMBL
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UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50264444
(CHEMBL490427 | trans-4-[5-(5-Methyl-[1,3,4]oxadiaz...)Show SMILES Cc1nnc(o1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(6.6,-22.73,;6.06,-24.16,;6.9,-25.45,;5.93,-26.65,;4.5,-26.1,;4.57,-24.56,;3.21,-26.94,;3.29,-28.48,;2.01,-29.31,;.64,-28.62,;-.79,-29.17,;-1.76,-27.97,;-.92,-26.69,;.57,-27.08,;1.85,-26.25,;-3.29,-28.05,;-4.13,-26.75,;-5.67,-26.83,;-6.38,-28.2,;-5.54,-29.5,;-3.99,-29.42,;-7.08,-29.58,;-8.61,-29.34,;-9.69,-30.43,;-8.85,-27.81,;-10.14,-26.97,;-10.06,-25.43,;-8.67,-24.73,;-7.38,-25.57,;-7.47,-27.12,)| Show InChI InChI=1S/C23H20N4O3/c1-13-26-27-21(29-13)15-6-7-18-19(12-15)25-20(24-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)30-23/h2-7,12,14H,8-11H2,1H3,(H,24,25)/t14-,23- | PDB
Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM86733
(5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1O...)Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3ccccc23)C(=O)C1 |t:8| Show InChI InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19-20H,9-12H2,1-4H3 | PDB
Reactome pathway
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CHEMBL
MCE
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| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human neuropeptide Y4 receptor |
J Med Chem 51: 4765-70 (2008)
Article DOI: 10.1021/jm8003587
BindingDB Entry DOI: 10.7270/Q2J96664 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50264726
(1'-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-3H-spir...)Show SMILES Clc1cc2nc([nH]c2cc1Cl)N1CCC2(CC1)OC(=O)c1ccccc21 Show InChI InChI=1S/C19H15Cl2N3O2/c20-13-9-15-16(10-14(13)21)23-18(22-15)24-7-5-19(6-8-24)12-4-2-1-3-11(12)17(25)26-19/h1-4,9-10H,5-8H2,(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to NPY Y4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 5010-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.018
BindingDB Entry DOI: 10.7270/Q26D5STS |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50265298
(CHEMBL496327 | methyl 2-(3-oxo-3H-spiro[isobenzofu...)Show SMILES COC(=O)c1ccc2nc([nH]c2c1)N1CCC2(CC1)OC(=O)c1ccccc21 Show InChI InChI=1S/C21H19N3O4/c1-27-18(25)13-6-7-16-17(12-13)23-20(22-16)24-10-8-21(9-11-24)15-5-3-2-4-14(15)19(26)28-21/h2-7,12H,8-11H2,1H3,(H,22,23) | PDB
Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to NPY Y4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 5010-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.018
BindingDB Entry DOI: 10.7270/Q26D5STS |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50265267
(1'-(5-phenyl-1H-benzo[d]imidazol-2-yl)-3H-spiro[is...)Show SMILES O=C1OC2(CCN(CC2)c2nc3cc(ccc3[nH]2)-c2ccccc2)c2ccccc12 Show InChI InChI=1S/C25H21N3O2/c29-23-19-8-4-5-9-20(19)25(30-23)12-14-28(15-13-25)24-26-21-11-10-18(16-22(21)27-24)17-6-2-1-3-7-17/h1-11,16H,12-15H2,(H,26,27) | PDB
Reactome pathway
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to NPY Y4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 5010-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.018
BindingDB Entry DOI: 10.7270/Q26D5STS |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50265265
(1'-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-...)Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)N1CCC2(CC1)OC(=O)c1ccccc21 Show InChI InChI=1S/C20H16F3N3O2/c21-20(22,23)12-5-6-15-16(11-12)25-18(24-15)26-9-7-19(8-10-26)14-4-2-1-3-13(14)17(27)28-19/h1-6,11H,7-10H2,(H,24,25) | PDB
Reactome pathway
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to NPY Y4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 5010-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.018
BindingDB Entry DOI: 10.7270/Q26D5STS |
More data for this
Ligand-Target Pair | |
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