Found 769 hits of ic50 for UniProtKB: Q9R0C9 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225205
(CHEMBL540269)Show SMILES Br.[H][C@@]12Oc3c4c(CC5N(C)CC[C@@]14[C@]5(CCC2=O)OC)ccc3O |r,THB:10:9:14:5.6.7| Show InChI InChI=1S/C18H21NO4.BrH/c1-19-8-7-17-14-10-3-4-11(20)15(14)23-16(17)12(21)5-6-18(17,22-2)13(19)9-10;/h3-4,13,16,20H,5-9H2,1-2H3;1H/t13?,16-,17-,18+;/m0./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50017233
(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r,TLB:0:1:12.18.11:9| Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description 50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenate |
J Med Chem 28: 1177-80 (1985)
BindingDB Entry DOI: 10.7270/Q2X350PW |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50000788
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r| Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50000788
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r| Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.00900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50001707
(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CCC4=O)ccc5O |TLB:14:12:8.9.10:1.3.2,THB:13:12:8.9.10:1.3.2| Show InChI InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225845
(CHEMBL293967)Show SMILES Oc1ccc2CC3N(CC4CC4)CCC45C(Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\C(=O)OCCc1ccccc1 |TLB:23:22:18.4.5:7.13.12,THB:17:18:22:7.13.12,8:7:22:18.4.5| Show InChI InChI=1S/C32H36N2O6/c35-24-9-8-22-18-25-32(38)14-12-23(33-26(36)10-11-27(37)39-17-13-20-4-2-1-3-5-20)30-31(32,28(22)29(24)40-30)15-16-34(25)19-21-6-7-21/h1-5,8-11,21,23,25,30,35,38H,6-7,12-19H2,(H,33,36)/b11-10+/t23-,25?,30?,31?,32-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 0.0150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligand |
J Med Chem 29: 1868-71 (1986)
BindingDB Entry DOI: 10.7270/Q2D50Q50 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225204
(CHEMBL606711)Show SMILES [H][C@]12Cc3cccc(O)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,THB:14:13:20:9.3.2| Show InChI InChI=1S/C18H23NO3/c1-19-9-8-17-11-13(20)6-7-18(17,22-2)15(19)10-12-4-3-5-14(21)16(12)17/h3-5,15,21H,6-11H2,1-2H3/t15-,17-,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50000092
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description 50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenate |
J Med Chem 28: 1177-80 (1985)
BindingDB Entry DOI: 10.7270/Q2X350PW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50000092
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035145
(1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...)Show InChI InChI=1S/C21H31NO2/c1-2-8-19(9-3-1)23-16-6-13-22-14-11-21(12-15-22)20-10-5-4-7-18(20)17-24-21/h4-5,7,10,19H,1-3,6,8-9,11-17H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035141
(1'-(cyclohexylbutyl)-3H-spiro[2-benzofuran-1,4'-pi...)Show InChI InChI=1S/C22H33NO/c1-2-8-19(9-3-1)10-6-7-15-23-16-13-22(14-17-23)21-12-5-4-11-20(21)18-24-22/h4-5,11-12,19H,1-3,6-10,13-18H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225205
(CHEMBL540269)Show SMILES Br.[H][C@@]12Oc3c4c(CC5N(C)CC[C@@]14[C@]5(CCC2=O)OC)ccc3O |r,THB:10:9:14:5.6.7| Show InChI InChI=1S/C18H21NO4.BrH/c1-19-8-7-17-14-10-3-4-11(20)15(14)23-16(17)12(21)5-6-18(17,22-2)13(19)9-10;/h3-4,13,16,20H,5-9H2,1-2H3;1H/t13?,16-,17-,18+;/m0./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225211
(CHEMBL606767)Show SMILES [H][C@]12Cc3ccc(OC)c(OC)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,THB:17:16:23:12.3.2| Show InChI InChI=1S/C20H27NO4/c1-21-10-9-19-12-14(22)7-8-20(19,25-4)16(21)11-13-5-6-15(23-2)18(24-3)17(13)19/h5-6,16H,7-12H2,1-4H3/t16-,19-,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0850 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50054124
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)Show InChI InChI=1S/C21H33NO/c1-21(2)13-7-15-22(16-21)14-6-9-17-8-4-11-19-18(17)10-5-12-20(19)23-3/h5,10,12,17H,4,6-9,11,13-16H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0890 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bari
Curated by ChEMBL
| Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane. |
J Med Chem 41: 3940-7 (1998)
Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50054124
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)Show InChI InChI=1S/C21H33NO/c1-21(2)13-7-15-22(16-21)14-6-9-17-8-4-11-19-18(17)10-5-12-20(19)23-3/h5,10,12,17H,4,6-9,11,13-16H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0890 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bari
Curated by ChEMBL
| Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane. |
J Med Chem 41: 3940-7 (1998)
Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035105
(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccccc32)c2ccccc12 Show InChI InChI=1S/C30H31FN2O/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035133
(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)SCc2ccccc32)c2ccccc12 Show InChI InChI=1S/C30H31FN2S/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50001707
(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CCC4=O)ccc5O |TLB:14:12:8.9.10:1.3.2,THB:13:12:8.9.10:1.3.2| Show InChI InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225206
(CHEMBL606643)Show SMILES [H][C@]12Cc3cccc(O)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23O |r,THB:14:13:20:9.3.2| Show InChI InChI=1S/C17H21NO3/c1-18-8-7-16-10-12(19)5-6-17(16,21)14(18)9-11-3-2-4-13(20)15(11)16/h2-4,14,20-21H,5-10H2,1H3/t14-,16-,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035144
(1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...)Show InChI InChI=1S/C24H31NO/c1(4-10-21-11-5-3-6-12-21)2-9-17-25-18-15-24(16-19-25)23-14-8-7-13-22(23)20-26-24/h3,5-8,11-14H,1-2,4,9-10,15-20H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035122
(1'-(2-phenylpentyl)-3H-spiro[2-benzofuran-1,4'-pip...)Show InChI InChI=1S/C23H29NO/c1-3-9-20(10-4-1)11-5-2-8-16-24-17-14-23(15-18-24)22-13-7-6-12-21(22)19-25-23/h1,3-4,6-7,9-10,12-13H,2,5,8,11,14-19H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50326670
(17-methoxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyc...)Show SMILES CO[C@]12CCC(=O)[C@@H]3Oc4cccc5C[C@H]1N(C)CC[C@@]23c45 |r| Show InChI InChI=1S/C18H21NO3/c1-19-9-8-17-15-11-4-3-5-13(15)22-16(17)12(20)6-7-18(17,21-2)14(19)10-11/h3-5,14,16H,6-10H2,1-2H3/t14-,16+,17+,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225213
(CHEMBL606820)Show SMILES [H][C@]12Cc3ccccc3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,TLB:18:19:8.2.3:12.10.11,20:19:8.2.3:12.10.11,13:12:19:8.2.3,THB:7:8:19:12.10.11| Show InChI InChI=1S/C18H23NO2/c1-19-10-9-17-12-14(20)7-8-18(17,21-2)16(19)11-13-5-3-4-6-15(13)17/h3-6,16H,7-12H2,1-2H3/t16-,17-,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50027473
(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)Show SMILES CCC(=O)N(c1ccccc1)[C@]1(CCN(CCc2ccccc2)C[C@H]1C)C(=O)OC Show InChI InChI=1S/C25H32N2O3/c1-4-23(28)27(22-13-9-6-10-14-22)25(24(29)30-3)16-18-26(19-20(25)2)17-15-21-11-7-5-8-12-21/h5-14,20H,4,15-19H2,1-3H3/t20-,25+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]nalotrexone from rat-brain Opioid receptors |
J Med Chem 25: 913-9 (1982)
BindingDB Entry DOI: 10.7270/Q2CF9S9G |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035129
(1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...)Show InChI InChI=1S/C22H27NO/c1-2-8-19(9-3-1)10-6-7-15-23-16-13-22(14-17-23)21-12-5-4-11-20(21)18-24-22/h1-5,8-9,11-12H,6-7,10,13-18H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035134
(1'-(3-(cyclohexylthio)propyl)-3H-spiro[2-benzofura...)Show InChI InChI=1S/C21H31NOS/c1-2-8-19(9-3-1)24-16-6-13-22-14-11-21(12-15-22)20-10-5-4-7-18(20)17-23-21/h4-5,7,10,19H,1-3,6,8-9,11-17H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035097
(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)Show InChI InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035097
(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)Show InChI InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine |
J Med Chem 38: 1998-2008 (1995)
BindingDB Entry DOI: 10.7270/Q2SJ1M8P |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035129
(1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...)Show InChI InChI=1S/C22H27NO/c1-2-8-19(9-3-1)10-6-7-15-23-16-13-22(14-17-23)21-12-5-4-11-20(21)18-24-22/h1-5,8-9,11-12H,6-7,10,13-18H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50326659
(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)Show SMILES COc1cccc2C[C@H]3N(C)CC[C@@]4(CC(=O)CC[C@@]34OC)c12 |r| Show InChI InChI=1S/C19H25NO3/c1-20-10-9-18-12-14(21)7-8-19(18,23-3)16(20)11-13-5-4-6-15(22-2)17(13)18/h4-6,16H,7-12H2,1-3H3/t16-,18-,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50013184
(1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-1...)Show SMILES CN1C(CNC(=O)c2cc3ccccc3[nH]2)CN=C(c2ccccc2F)c2ccccc12 |t:19| Show InChI InChI=1S/C26H23FN4O/c1-31-18(16-29-26(32)23-14-17-8-2-6-12-22(17)30-23)15-28-25(19-9-3-5-11-21(19)27)20-10-4-7-13-24(20)31/h2-14,18,30H,15-16H2,1H3,(H,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]dihydromorphine (DHM) from rat brain Opioid receptors |
J Med Chem 33: 450-5 (1990)
BindingDB Entry DOI: 10.7270/Q26M35TN |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225848
(CHEMBL53563)Show SMILES Oc1ccc2CC3N(CC4CC4)CCC45C(Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\C(=O)OCc1ccccc1 |TLB:23:22:18.4.5:7.13.12,THB:17:18:22:7.13.12,8:7:22:18.4.5| Show InChI InChI=1S/C31H34N2O6/c34-23-9-8-21-16-24-31(37)13-12-22(32-25(35)10-11-26(36)38-18-20-4-2-1-3-5-20)29-30(31,27(21)28(23)39-29)14-15-33(24)17-19-6-7-19/h1-5,8-11,19,22,24,29,34,37H,6-7,12-18H2,(H,32,35)/b11-10+/t22-,24?,29?,30?,31-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligand |
J Med Chem 29: 1868-71 (1986)
BindingDB Entry DOI: 10.7270/Q2D50Q50 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225214
(CHEMBL606769)Show SMILES [H][C@]12Cc3ccccc3[C@@]3(CCN1C)CC(=O)CC[C@@]23O |r,TLB:18:19:8.2.3:12.10.11,20:19:8.2.3:12.10.11,13:12:19:8.2.3,THB:7:8:19:12.10.11| Show InChI InChI=1S/C17H21NO2/c1-18-9-8-16-11-13(19)6-7-17(16,20)15(18)10-12-4-2-3-5-14(12)16/h2-5,15,20H,6-11H2,1H3/t15-,16-,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035142
(1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[6-fluorospi...)Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccc(F)cc32)c2ccccc12 Show InChI InChI=1S/C30H30F2N2O/c31-24-10-12-26(13-11-24)34-20-22(27-6-1-2-7-29(27)34)5-3-4-16-33-17-14-30(15-18-33)28-19-25(32)9-8-23(28)21-35-30/h1-2,6-13,19-20H,3-5,14-18,21H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035135
(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)COCc2ccccc32)c2ccccc12 Show InChI InChI=1S/C31H33FN2O/c32-26-12-14-27(15-13-26)34-21-24(28-9-2-4-11-30(28)34)7-5-6-18-33-19-16-31(17-20-33)23-35-22-25-8-1-3-10-29(25)31/h1-4,8-15,21H,5-7,16-20,22-23H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.340 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035145
(1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...)Show InChI InChI=1S/C21H31NO2/c1-2-8-19(9-3-1)23-16-6-13-22-14-11-21(12-15-22)20-10-5-4-7-18(20)17-24-21/h4-5,7,10,19H,1-3,6,8-9,11-17H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224339
(CHEMBL1744167)Show SMILES OC(=O)\C=C/C(O)=O.COc1ccccc1N(CC#C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1 Show InChI InChI=1S/C26H31ClN2O3.C4H4O4/c1-4-16-29(23-11-7-8-12-24(23)32-3)25(30)20(2)26(31)14-18-28(19-15-26)17-13-21-9-5-6-10-22(21)27;5-3(6)1-2-4(7)8/h1,5-12,20,31H,13-19H2,2-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50354578
(BUPRENORPHINE | US10752592, Compound buprenorphine...)Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 |r| Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224336
(CHEMBL1744168)Show SMILES OC(=O)\C=C/C(O)=O.COc1ccccc1N(CC=C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1 Show InChI InChI=1S/C26H33ClN2O3.C4H4O4/c1-4-16-29(23-11-7-8-12-24(23)32-3)25(30)20(2)26(31)14-18-28(19-15-26)17-13-21-9-5-6-10-22(21)27;5-3(6)1-2-4(7)8/h4-12,20,31H,1,13-19H2,2-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50354578
(BUPRENORPHINE | US10752592, Compound buprenorphine...)Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 |r| Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl. |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50226933
(Naltrexonazine)Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC\C2=N/N=C1\CC[C@@]2(O)[C@@]4([H])Cc5ccc(O)c6O[C@]1([H])[C@]2(CCN4CC1CC1)c56)ccc3O |r,TLB:45:44:32.49.31:27,THB:10:9:17:6.5.4| Show InChI InChI=1S/C40H46N4O6/c45-27-7-5-23-17-29-39(47)11-9-25(35-37(39,31(23)33(27)49-35)13-15-43(29)19-21-1-2-21)41-42-26-10-12-40(48)30-18-24-6-8-28(46)34-32(24)38(40,36(26)50-34)14-16-44(30)20-22-3-4-22/h5-8,21-22,29-30,35-36,45-48H,1-4,9-20H2/b41-25+,42-26+/t29-,30-,35+,36+,37+,38+,39-,40-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptor |
J Med Chem 30: 1489-94 (1987)
BindingDB Entry DOI: 10.7270/Q2S46V6F |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50226933
(Naltrexonazine)Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC\C2=N/N=C1\CC[C@@]2(O)[C@@]4([H])Cc5ccc(O)c6O[C@]1([H])[C@]2(CCN4CC1CC1)c56)ccc3O |r,TLB:45:44:32.49.31:27,THB:10:9:17:6.5.4| Show InChI InChI=1S/C40H46N4O6/c45-27-7-5-23-17-29-39(47)11-9-25(35-37(39,31(23)33(27)49-35)13-15-43(29)19-21-1-2-21)41-42-26-10-12-40(48)30-18-24-6-8-28(46)34-32(24)38(40,36(26)50-34)14-16-44(30)20-22-3-4-22/h5-8,21-22,29-30,35-36,45-48H,1-4,9-20H2/b41-25+,42-26+/t29-,30-,35+,36+,37+,38+,39-,40-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptor |
J Med Chem 30: 1489-94 (1987)
BindingDB Entry DOI: 10.7270/Q2S46V6F |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50226933
(Naltrexonazine)Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC\C2=N/N=C1\CC[C@@]2(O)[C@@]4([H])Cc5ccc(O)c6O[C@]1([H])[C@]2(CCN4CC1CC1)c56)ccc3O |r,TLB:45:44:32.49.31:27,THB:10:9:17:6.5.4| Show InChI InChI=1S/C40H46N4O6/c45-27-7-5-23-17-29-39(47)11-9-25(35-37(39,31(23)33(27)49-35)13-15-43(29)19-21-1-2-21)41-42-26-10-12-40(48)30-18-24-6-8-28(46)34-32(24)38(40,36(26)50-34)14-16-44(30)20-22-3-4-22/h5-8,21-22,29-30,35-36,45-48H,1-4,9-20H2/b41-25+,42-26+/t29-,30-,35+,36+,37+,38+,39-,40-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptor |
J Med Chem 30: 1489-94 (1987)
BindingDB Entry DOI: 10.7270/Q2S46V6F |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50013209
(4-Chloro-N-[5-(2-fluoro-phenyl)-1-methyl-2,3-dihyd...)Show SMILES CN1C(CNC(=O)c2ccc(Cl)cc2)CN=C(c2ccccc2F)c2ccccc12 |t:16| Show InChI InChI=1S/C24H21ClFN3O/c1-29-18(15-28-24(30)16-10-12-17(25)13-11-16)14-27-23(19-6-2-4-8-21(19)26)20-7-3-5-9-22(20)29/h2-13,18H,14-15H2,1H3,(H,28,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of binding of [125I]-CCK-8 to Cholecystokinin type A receptor in rat pancreas |
J Med Chem 33: 450-5 (1990)
BindingDB Entry DOI: 10.7270/Q26M35TN |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225232
(CHEMBL606768)Show SMILES [H][C@]12Cc3ccc(OC)c(OC)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23O |r,THB:17:16:23:12.3.2| Show InChI InChI=1S/C19H25NO4/c1-20-9-8-18-11-13(21)6-7-19(18,22)15(20)10-12-4-5-14(23-2)17(24-3)16(12)18/h4-5,15,22H,6-11H2,1-3H3/t15-,18-,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM60212
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck
Curated by ChEMBL
| Assay Description Inhibition of [3H]naloxone binding to opioid receptor in presence of NaCl |
J Med Chem 32: 418-21 (1989)
BindingDB Entry DOI: 10.7270/Q2ZG6VG1 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225212
(CHEMBL606707)Show SMILES [H][C@]12Cc3ccc(OC)c(O)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,THB:16:15:22:11.3.2| Show InChI InChI=1S/C19H25NO4/c1-20-9-8-18-11-13(21)6-7-19(18,24-3)15(20)10-12-4-5-14(23-2)17(22)16(12)18/h4-5,15,22H,6-11H2,1-3H3/t15-,18-,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224323
(CHEMBL1794881)Show SMILES OC(=O)\C=C\C(O)=O.CCCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OC Show InChI InChI=1S/C26H35ClN2O3.C4H4O4/c1-4-16-29(23-11-7-8-12-24(23)32-3)25(30)20(2)26(31)14-18-28(19-15-26)17-13-21-9-5-6-10-22(21)27;5-3(6)1-2-4(7)8/h5-12,20,31H,4,13-19H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50035144
(1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...)Show InChI InChI=1S/C24H31NO/c1(4-10-21-11-5-3-6-12-21)2-9-17-25-18-15-24(16-19-25)23-14-8-7-13-22(23)20-26-24/h3,5-8,11-14H,1-2,4,9-10,15-20H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S
Curated by ChEMBL
| Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. |
J Med Chem 38: 2009-17 (1995)
BindingDB Entry DOI: 10.7270/Q2NS0VKD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224340
(CHEMBL147150)Show SMILES CCOc1ccccc1N(CC)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1 Show InChI InChI=1S/C26H35ClN2O3/c1-4-29(23-12-8-9-13-24(23)32-5-2)25(30)20(3)26(31)15-18-28(19-16-26)17-14-21-10-6-7-11-22(21)27/h6-13,20,31H,4-5,14-19H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |