BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 32 hits of ic50 for UniProtKB: P51531   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469331
PNG
(CHEMBL4282980)
Show SMILES Nc1cnc(F)cc1NC(=O)Nc1cc(ns1)C(F)F
Show InChI InChI=1S/C10H8F3N5OS/c11-7-1-5(4(14)3-15-7)16-10(19)17-8-2-6(9(12)13)18-20-8/h1-3,9H,14H2,(H2,15,16,17,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a<5n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469324
PNG
(CHEMBL4286345)
Show SMILES Nc1cnc(Cl)cc1NC(=O)Nc1cc(ns1)C(F)F
Show InChI InChI=1S/C10H8ClF2N5OS/c11-7-1-5(4(14)3-15-7)16-10(19)17-8-2-6(9(12)13)18-20-8/h1-3,9H,14H2,(H2,15,16,17,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a<5n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469320
PNG
(CHEMBL4293567)
Show SMILES OCc1cnc(Cl)cc1NC(=O)Nc1cc(ns1)C(F)F
Show InChI InChI=1S/C11H9ClF2N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a<5n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469330
PNG
(CHEMBL4295096)
Show SMILES OCc1cnc(F)cc1NC(=O)Nc1cc(ns1)C(F)F
Show InChI InChI=1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a<5n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469329
PNG
(CHEMBL4278436)
Show SMILES FC(F)c1cc(NC(=O)Nc2ccnc(Cl)c2)sn1
Show InChI InChI=1S/C10H7ClF2N4OS/c11-7-3-5(1-2-14-7)15-10(18)16-8-4-6(9(12)13)17-19-8/h1-4,9H,(H2,14,15,16,18)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469325
PNG
(CHEMBL4294655)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccnc(Cl)c2)sn1
Show InChI InChI=1S/C10H6ClF3N4OS/c11-7-3-5(1-2-15-7)16-9(19)17-8-4-6(18-20-8)10(12,13)14/h1-4H,(H2,15,16,17,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469321
PNG
(CHEMBL4286757)
Show SMILES Cc1cc(NC(=O)Nc2ccnc(Cl)c2)sn1
Show InChI InChI=1S/C10H9ClN4OS/c1-6-4-9(17-15-6)14-10(16)13-7-2-3-12-8(11)5-7/h2-5H,1H3,(H2,12,13,14,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM394583
PNG
(2-(6-amino-5-phenylpyridazin-3-yl)phenol | US10308...)
Show SMILES Nc1nnc(cc1-c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C16H13N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h1-10,20H,(H2,17,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 37n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00662
BindingDB Entry DOI: 10.7270/Q2TB1BX4
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469333
PNG
(CHEMBL4290175)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccnc(Cl)c2)ccn1
Show InChI InChI=1S/C12H8ClF3N4O/c13-10-6-8(2-4-18-10)20-11(21)19-7-1-3-17-9(5-7)12(14,15)16/h1-6H,(H2,17,18,19,20,21)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646015
PNG
((2S,4R)-4-hydroxy-1-((2R)-2-(3-(2-(2-(2- hydroxyph...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(cc1)-c1scnc1C)c1cc(OCCN2CCN3C(CNc4nnc(cc34)-c3ccccc3O)C2)no1 |r,w:39.42|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a<100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646016
PNG
((2S,4R)-4-hydroxy-1-((2S)-2-(3-(2-(4-((2-(2- hydro...)
Show SMILES CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(cc1)-c1scnc1C)c1cc(OCCN2CCC(CN3CCN4C(CNc5nnc(cc45)-c4ccccc4O)C3)CC2)no1 |r,w:44.65|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a<100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646014
PNG
((2S,4R)-4-hydroxy-1-((2S)-2-(2-(4-((2-(2- hydroxyp...)
Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CN1CCC(CN2CCN3C(CNc4nnc(cc34)-c3ccccc3O)C2)CC1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a<100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646012
PNG
((2S,4R)-4-hydroxy-N-[[4-(5-methyl-1,3- thiazol-4-y...)
Show SMILES Cc1scnc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CN2CCN3C(CNc4nnc(cc34)-c3ccccc3O)C2)C(C)(C)C)cc1 |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a<100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646010
PNG
((2S,4R)-4-hydroxy-1-((2S)-2-(2-(2-(2- hydroxypheny...)
Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CN1CCN2C(CNc3nnc(cc23)-c2ccccc2O)C1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a<100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469326
PNG
(CHEMBL4279505)
Show SMILES FC(F)c1cc(NC(=O)Nc2ccnc(Cl)c2)ccn1
Show InChI InChI=1S/C12H9ClF2N4O/c13-10-6-8(2-4-17-10)19-12(20)18-7-1-3-16-9(5-7)11(14)15/h1-6,11H,(H2,16,17,18,19,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469322
PNG
(CHEMBL4281368)
Show SMILES Cc1cc(NC(=O)Nc2ccnc(Cl)c2)ccn1
Show InChI InChI=1S/C12H11ClN4O/c1-8-6-9(2-4-14-8)16-12(18)17-10-3-5-15-11(13)7-10/h2-7H,1H3,(H2,14,15,16,17,18)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM394406
PNG
(2-(6-amino-5-(piperazin- | US10308614, Example 7)
Show SMILES Nc1nnc(cc1N1CCNCC1)-c1ccccc1O
Show InChI InChI=1S/C14H17N5O/c15-14-12(19-7-5-16-6-8-19)9-11(17-18-14)10-3-1-2-4-13(10)20/h1-4,9,16,20H,5-8H2,(H2,15,18)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
n/an/a 370n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646012
PNG
((2S,4R)-4-hydroxy-N-[[4-(5-methyl-1,3- thiazol-4-y...)
Show SMILES Cc1scnc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CN2CCN3C(CNc4nnc(cc34)-c3ccccc3O)C2)C(C)(C)C)cc1 |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM646010
PNG
((2S,4R)-4-hydroxy-1-((2S)-2-(2-(2-(2- hydroxypheny...)
Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CN1CCN2C(CNc3nnc(cc23)-c2ccccc2O)C1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 550n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50481805
PNG
(CHEMBL5278697)
Show SMILES CC1CCN(CCCC(=O)NC2C=CC(C=C2)S(N)(=O)=O)CC1 |c:12,15,(26.65,-10.36,;27.42,-11.7,;28.96,-11.7,;29.72,-13.03,;28.95,-14.36,;29.72,-15.69,;31.26,-15.69,;32.03,-17.02,;33.57,-17.02,;34.34,-15.69,;34.34,-18.35,;35.88,-18.35,;36.66,-19.68,;38.2,-19.68,;38.96,-18.35,;38.2,-17.02,;36.66,-17.02,;40.5,-18.35,;41.27,-19.69,;40.09,-16.85,;41.98,-17.94,;27.41,-14.37,;26.65,-13.03,)|
Show InChI InChI=1S/C16H27N3O3S/c1-13-8-11-19(12-9-13)10-2-3-16(20)18-14-4-6-15(7-5-14)23(17,21)22/h4-7,13-15H,2-3,8-12H2,1H3,(H,18,20)(H2,17,21,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 770n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469327
PNG
(CHEMBL4282784)
Show SMILES Cc1csc(NC(=O)Nc2ccnc(Cl)c2)n1
Show InChI InChI=1S/C10H9ClN4OS/c1-6-5-17-10(13-6)15-9(16)14-7-2-3-12-8(11)4-7/h2-5H,1H3,(H2,12,13,14,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 970n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM342597
PNG
(N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindo...)
Show SMILES Cc1[nH]c(c2CCCC(=O)c12)-c1cc(NS(C)(=O)=O)ccc1Oc1ccccc1
Show InChI InChI=1S/C22H22N2O4S/c1-14-21-17(9-6-10-19(21)25)22(23-14)18-13-15(24-29(2,26)27)11-12-20(18)28-16-7-4-3-5-8-16/h3-5,7-8,11-13,23-24H,6,9-10H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL 60064, USA.

Curated by ChEMBL


Assay Description
Inhibition of human SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay

Bioorg Med Chem Lett 27: 2225-2233 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.057
BindingDB Entry DOI: 10.7270/Q20P12FJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50256397
PNG
(CHEMBL4088466)
Show SMILES Cn1cc(-c2cc(ccc2Oc2ccc(F)cc2F)S(C)(=O)=O)c2cc[nH]c(=O)c12
Show InChI InChI=1S/C21H16F2N2O4S/c1-25-11-16(14-7-8-24-21(26)20(14)25)15-10-13(30(2,27)28)4-6-18(15)29-19-5-3-12(22)9-17(19)23/h3-11H,1-2H3,(H,24,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL 60064, USA.

Curated by ChEMBL


Assay Description
Inhibition of human SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay

Bioorg Med Chem Lett 27: 2225-2233 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.057
BindingDB Entry DOI: 10.7270/Q20P12FJ
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469323
PNG
(CHEMBL4290675)
Show SMILES Clc1cc(NC(=O)Nc2ccncc2)ccn1
Show InChI InChI=1S/C11H9ClN4O/c12-10-7-9(3-6-14-10)16-11(17)15-8-1-4-13-5-2-8/h1-7H,(H2,13,14,15,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469328
PNG
(CHEMBL4292870)
Show SMILES Clc1cc(NC(=O)Nc2ccccn2)ccn1
Show InChI InChI=1S/C11H9ClN4O/c12-9-7-8(4-6-13-9)15-11(17)16-10-3-1-2-5-14-10/h1-7H,(H2,13,14,15,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.80E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50598934
PNG
(CHEMBL5183240)
Show SMILES Nc1nnc2c3ccccc3[nH]c2c1-c1ccccc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00662
BindingDB Entry DOI: 10.7270/Q2TB1BX4
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM310898
PNG
(N,N-dimethyl-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C17H17N3O2/c1-19(2)16(21)12-6-4-5-11(9-12)14-10-20(3)17(22)15-13(14)7-8-18-15/h4-10,18H,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 6.70E+3n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to human partial length SMARCA2 expressed in bacterial expression system by BROMOscan assay

J Med Chem 59: 5391-402 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM310898
PNG
(N,N-dimethyl-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C17H17N3O2/c1-19(2)16(21)12-6-4-5-11(9-12)14-10-20(3)17(22)15-13(14)7-8-18-15/h4-10,18H,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 6.70E+3n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Binding affinity to human partial length SMARCA2 expressed in bacterial expression system by BROMOscan assay

J Med Chem 59: 5391-402 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00264
BindingDB Entry DOI: 10.7270/Q2VQ3641
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469323
PNG
(CHEMBL4290675)
Show SMILES Clc1cc(NC(=O)Nc2ccncc2)ccn1
Show InChI InChI=1S/C11H9ClN4O/c12-10-7-9(3-6-14-10)16-11(17)15-8-1-4-13-5-2-8/h1-7H,(H2,13,14,15,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.10E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of full length BRM ATPase (1 to 1572 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins followed by pCMV-dR8...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50028142
PNG
(CHEMBL2177300)
Show SMILES C[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/a<3.16E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human SMARCA2 by BROMOscan assay

J Med Chem 57: 8111-31 (2014)


Article DOI: 10.1021/jm5010539
BindingDB Entry DOI: 10.7270/Q23R0VGR
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50469332
PNG
(CHEMBL4291666)
Show SMILES Cc1c[nH]c(NC(=O)Nc2ccnc(Cl)c2)n1
Show InChI InChI=1S/C10H10ClN5O/c1-6-5-13-9(14-6)16-10(17)15-7-2-3-12-8(11)4-7/h2-5H,1H3,(H3,12,13,14,15,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...

J Med Chem 61: 10155-10172 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01318
BindingDB Entry DOI: 10.7270/Q2TH8QDB
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))		BDBM50249797
PNG
(CHEMBL4059509)
Show SMILES CCc1cc2cc(NS(=O)(=O)c3ccc(cc3)C#N)ccc2n(CC)c1=O
Show InChI InChI=1S/C20H19N3O3S/c1-3-15-11-16-12-17(7-10-19(16)23(4-2)20(15)24)22-27(25,26)18-8-5-14(13-21)6-9-18/h5-12,22H,3-4H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.70E+4n/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Inhibition of human SMARCA2A expressed in Escherichia coli BL21 after 1 hr by BROMOscan assay

J Med Chem 60: 668-680 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01583
BindingDB Entry DOI: 10.7270/Q29K4DQ5
More data for this
Ligand-Target Pair