Compile Data Set for Download or QSAR

Found 3 hits of ic50 for UniProtKB: P21817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50051434 (10-epi-hydroxy-Ryanodine | CHEMBL308183 | Ryanodin...) Show SMILES CC(C)C1(O)C(OC(=O)c2ccc[nH]2)C2(O)C3(C)CC4(O)OC5(C(O)C(C)CCC35O)C2(O)C14C |TLB:33:31:29:19.21.18,14:31:21:16.29.18,20:19:31.14:29,3:33:21:16.29.18,5:14:29:19.21.18,28:29:31.33:21,28:29:31.14:19.21.18,THB:32:31:21:16.29.18,32:31:29:19.21.18,33:19:31.14:29,15:14:29:19.21.18,14:16:31.33:21,30:29:31.33:21,30:29:31.14:19.21.18,34:33:21:16.29.18| Show InChI InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibitory activity against ryanodine receptor from mouse brain preparation				J Med Chem 39: 2331-8 (1996) Article DOI: 10.1021/jm950711l BindingDB Entry DOI: 10.7270/Q24Q7T31
					More data for this Ligand-Target Pair
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50051434 (10-epi-hydroxy-Ryanodine | CHEMBL308183 | Ryanodin...) Show SMILES CC(C)C1(O)C(OC(=O)c2ccc[nH]2)C2(O)C3(C)CC4(O)OC5(C(O)C(C)CCC35O)C2(O)C14C |TLB:33:31:29:19.21.18,14:31:21:16.29.18,20:19:31.14:29,3:33:21:16.29.18,5:14:29:19.21.18,28:29:31.33:21,28:29:31.14:19.21.18,THB:32:31:21:16.29.18,32:31:29:19.21.18,33:19:31.14:29,15:14:29:19.21.18,14:16:31.33:21,30:29:31.33:21,30:29:31.14:19.21.18,34:33:21:16.29.18| Show InChI InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibitory activity against ryanodine receptor from rabbit muscle preparation				J Med Chem 39: 2331-8 (1996) Article DOI: 10.1021/jm950711l BindingDB Entry DOI: 10.7270/Q24Q7T31
					More data for this Ligand-Target Pair
Ryanodine receptor 1 (Homo sapiens (Human))	BDBM50191280 (5,21-Dibromo-4-hydroxy-2-oxa-10,14-diaza-tricyclo[...) Show SMILES Oc1c(Br)cc2CCNC(=O)CCNC(=O)CCc3ccc(Oc1c2)c(Br)c3 Show InChI InChI=1S/C20H20Br2N2O4/c21-14-9-12-1-3-16(14)28-17-11-13(10-15(22)20(17)27)5-7-23-19(26)6-8-24-18(25)4-2-12/h1,3,9-11,27H,2,4-8H2,(H,23,26)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to RYR1 channels by calcium mobilization assay				Bioorg Med Chem Lett 18: 5734-7 (2009) Article DOI: 10.1016/j.bmcl.2008.09.080 BindingDB Entry DOI: 10.7270/Q2NV9K5T
					More data for this Ligand-Target Pair