Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50110227 (3-{2-[4-(4-Methyl-pyridin-2-ylamino)-butyrylamino]...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham Curated by ChEMBL | Assay Description Inhibition of integrin alphavbeta6 (unknown origin) by Merck binding assay | ACS Med Chem Lett 5: 1207-12 (2014) Article DOI: 10.1021/ml5002079 BindingDB Entry DOI: 10.7270/Q2K07781 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50110227 (3-{2-[4-(4-Methyl-pyridin-2-ylamino)-butyrylamino]...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrin | J Med Chem 45: 1045-51 (2002) BindingDB Entry DOI: 10.7270/Q2RR1XJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6/beta-8 (Homo sapiens (Human)) | BDBM297773 (US10118929, Compound A1) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
SciFluor Life Sciences, Inc. US Patent | Assay Description The optimized protocol was validated by employing reference compounds such as Cilengitide (+Vβ3/αVβ5−VN interaction) and CWHM12 ... | US Patent US10118929 (2018) BindingDB Entry DOI: 10.7270/Q2V126WM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50110228 (3-{2-[4-(4-Methyl-pyridin-2-ylamino)-butyrylamino]...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrin | J Med Chem 45: 1045-51 (2002) BindingDB Entry DOI: 10.7270/Q2RR1XJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279573 ((3S)-3-(3,5-dibromophenyl)-3-[[2-[[5-[(5-hydroxy-1...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279573 ((3S)-3-(3,5-dibromophenyl)-3-[[2-[[5-[(5-hydroxy-1...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50530099 (CHEMBL4441624) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t M£nchen Curated by ChEMBL | Assay Description Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assay | J Med Chem 62: 2024-2037 (2019) Article DOI: 10.1021/acs.jmedchem.8b01588 BindingDB Entry DOI: 10.7270/Q26T0R53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50530099 (CHEMBL4441624) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t M£nchen Curated by ChEMBL | Assay Description Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assay | J Med Chem 62: 2024-2037 (2019) Article DOI: 10.1021/acs.jmedchem.8b01588 BindingDB Entry DOI: 10.7270/Q26T0R53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50565948 (CHEMBL4780301) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human integrin alphaVbeta6 incubated for 1 hr by ELISA based solid phase integrin binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01536 BindingDB Entry DOI: 10.7270/Q2FX7F74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279561 ((3S)-3-(3-bromo-5-(trifluoromethyl)phenyl)-3-(2-(3...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279569 ((3S)-3-[3,5-bis(trifluoromethyl)phenyl)-3-(2-(3-hy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279568 ((3S)-3-[3-bromo-5-(trifluoromethyl)phenyl]-3-[[2-[...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279566 ((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl]3-[[2-[...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279561 ((3S)-3-(3-bromo-5-(trifluoromethyl)phenyl)-3-(2-(3...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279569 ((3S)-3-[3,5-bis(trifluoromethyl)phenyl)-3-(2-(3-hy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279568 ((3S)-3-[3-bromo-5-(trifluoromethyl)phenyl]-3-[[2-[...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279566 ((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl]3-[[2-[...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279572 ((3S)-3-[3-bromo-5-fluoro-phenyl)-3-(2-(3-hydroxy-5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279567 ((3S)-3-(3-bromo-5-chloro-phenyl)-3-[[2-[[5-[(5-hyd...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279565 ((3S)-3-[3-bromo-5-chloro-phenyl)-3-(2-(3-hydroxy-5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279565 ((3S)-3-[3-bromo-5-chloro-phenyl)-3-(2-(3-hydroxy-5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279560 ((3S)-3-(3,5-dibromophenyl)-3-(2-(3-hydroxy-5-((5-h...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279563 ((3S)-3-[3-bromo-5-(difluoromethyl)phenyl)-3-(2-(3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279562 ((3S)-3-[3-chloro-5-(difluoromethyl)phenyl)-3-(2-(3...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279567 ((3S)-3-(3-bromo-5-chloro-phenyl)-3-[[2-[[5-[(5-hyd...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279560 ((3S)-3-(3,5-dibromophenyl)-3-(2-(3-hydroxy-5-((5-h...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279572 ((3S)-3-[3-bromo-5-fluoro-phenyl)-3-(2-(3-hydroxy-5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279562 ((3S)-3-[3-chloro-5-(difluoromethyl)phenyl)-3-(2-(3...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279563 ((3S)-3-[3-bromo-5-(difluoromethyl)phenyl)-3-(2-(3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50110236 (3-(3,5-Dichloro-phenyl)-3-{2-[5-(4-methyl-pyridin-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrin | J Med Chem 45: 1045-51 (2002) BindingDB Entry DOI: 10.7270/Q2RR1XJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279570 ((3S)-3-[3-bromo-5-methyl-phenyl)-3-(2-(3-hydroxy-5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279564 ((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl)-3-(2-(...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279575 ((3S)-3-[3-chloro-5-(trifluoromethoxy)phenyl)-3-(2-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279564 ((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl)-3-(2-(...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279575 ((3S)-3-[3-chloro-5-(trifluoromethoxy)phenyl)-3-(2-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279570 ((3S)-3-[3-bromo-5-methyl-phenyl)-3-(2-(3-hydroxy-5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM606867 (US11685738, Compound A3) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q20Z77CR | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279571 ((3S)-3-[3-chloro-5-methyl-phenyl)-3-(2-(3-hydroxy-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279571 ((3S)-3-[3-chloro-5-methyl-phenyl)-3-(2-(3-hydroxy-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50110232 (3-Biphenyl-4-yl-3-{2-[5-(pyridin-2-ylamino)-pentan...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrin | J Med Chem 45: 1045-51 (2002) BindingDB Entry DOI: 10.7270/Q2RR1XJR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50110232 (3-Biphenyl-4-yl-3-{2-[5-(pyridin-2-ylamino)-pentan...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bradford Curated by ChEMBL | Assay Description Antagonist activity at alphavbeta6 integrin receptor (unknown origin) by cell-free ELISA | J Med Chem 57: 6301-15 (2014) Article DOI: 10.1021/jm5000547 BindingDB Entry DOI: 10.7270/Q2NS0XW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279574 ((3S)-3-[3,5-dichloro-phenyl)-3-(2-(3-hydroxy-5-((5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279574 ((3S)-3-[3,5-dichloro-phenyl)-3-(2-(3-hydroxy-5-((5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50530110 (CHEMBL4575627) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t M£nchen Curated by ChEMBL | Assay Description Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assay | J Med Chem 62: 2024-2037 (2019) Article DOI: 10.1021/acs.jmedchem.8b01588 BindingDB Entry DOI: 10.7270/Q26T0R53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50530110 (CHEMBL4575627) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t M£nchen Curated by ChEMBL | Assay Description Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assay | J Med Chem 62: 2024-2037 (2019) Article DOI: 10.1021/acs.jmedchem.8b01588 BindingDB Entry DOI: 10.7270/Q26T0R53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM279576 ((3S)-3-(3-bromo-5-(trifluoromethoxy)phenyl)-3-(2-(...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M... | US Patent US10035778 (2018) BindingDB Entry DOI: 10.7270/Q24M96KK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM279576 ((3S)-3-(3-bromo-5-(trifluoromethoxy)phenyl)-3-(2-(...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM432097 (US10577330, Comparison Compound C6) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-5/beta-6 (Homo sapiens (Human)) | BDBM432094 (US10577330, Comparison Compound C3) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Saint Louis University US Patent | Assay Description Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2, ... | US Patent US10577330 (2020) BindingDB Entry DOI: 10.7270/Q2862JVR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-6 (Homo sapiens (Human)) | BDBM50464106 (CHEMBL4237498) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Strathclyde Curated by ChEMBL | Assay Description Antagonist activity at human integrin alphaVbeta6 expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BC... | J Med Chem 61: 8417-8443 (2018) Article DOI: 10.1021/acs.jmedchem.8b00959 BindingDB Entry DOI: 10.7270/Q24T6N25 | |||||||||||
More data for this Ligand-Target Pair |
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