Found 8 hits of ki for UniProtKB: P29703 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Saccharomyces cerevisiae) | BDBM50298243
((2E,6E)-8-(2-diazo-3,3,3-trifluoropropanoyloxy)-3,...)Show SMILES C\C(CC\C=C(/C)COC(=O)[C-]([N+]#N)C(F)(F)F)=C/COP(O)(=O)OP(O)(O)=O Show InChI InChI=1S/C13H19F3N2O9P2/c1-9(6-7-26-29(23,24)27-28(20,21)22)4-3-5-10(2)8-25-12(19)11(18-17)13(14,15)16/h5-6H,3-4,7-8H2,1-2H3,(H,23,24)(H2,20,21,22)/b9-6+,10-5+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description
Inhibition of Saccharomyces cerevisiae protein farnesyltransferase assessed as farnsylation of N-dansyl-GCVIA |
Bioorg Med Chem 17: 4797-805 (2009)
Article DOI: 10.1016/j.bmc.2009.04.034
BindingDB Entry DOI: 10.7270/Q2HT2PCH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Saccharomyces cerevisiae (Baker's yeast)) | BDBM50289981
(Prenyl pyrophosphate analogue | {[(2E,6E)-8-[(3-be...)Show SMILES C\C(CC\C=C(/C)COC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O Show InChI InChI=1S/C24H28O10P2/c1-18(14-15-33-36(30,31)34-35(27,28)29)8-6-9-19(2)17-32-24(26)22-13-7-12-21(16-22)23(25)20-10-4-3-5-11-20/h3-5,7,9-14,16H,6,8,15,17H2,1-2H3,(H,30,31)(H2,27,28,29)/p-3/b18-14+,19-9+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of yeast Farnesyl transferase |
Bioorg Med Chem Lett 7: 2125-2130 (1997)
Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Saccharomyces cerevisiae) | BDBM50298245
(4-Benzoylbenzylphosphonic((2E,6E)-3,7,11-trimethyl...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#8]P([#8])(=O)[#8]P([#8])(=O)[#6]-c1ccc(cc1)-[#6](=O)-c1ccccc1 Show InChI InChI=1S/C29H38O7P2/c1-23(2)10-8-11-24(3)12-9-13-25(4)20-21-35-38(33,34)36-37(31,32)22-26-16-18-28(19-17-26)29(30)27-14-6-5-7-15-27/h5-7,10,12,14-20H,8-9,11,13,21-22H2,1-4H3,(H,31,32)(H,33,34)/b24-12+,25-20+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 480 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description
Inhibition of Saccharomyces cerevisiae protein farnesyltransferase assessed as farnsylation of N-dansyl-GCVIA |
Bioorg Med Chem 17: 4797-805 (2009)
Article DOI: 10.1016/j.bmc.2009.04.034
BindingDB Entry DOI: 10.7270/Q2HT2PCH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Saccharomyces cerevisiae) | BDBM50298242
((E)-4-(3-benzoylbenzyloxy)-3-methylbut-2-enyl diph...)Show SMILES C\C(COCc1cccc(c1)C(=O)c1ccccc1)=C/COP(O)(=O)OP(O)(O)=O Show InChI InChI=1S/C19H22O9P2/c1-15(10-11-27-30(24,25)28-29(21,22)23)13-26-14-16-6-5-9-18(12-16)19(20)17-7-3-2-4-8-17/h2-10,12H,11,13-14H2,1H3,(H,24,25)(H2,21,22,23)/b15-10+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description
Inhibition of Saccharomyces cerevisiae protein farnesyltransferase assessed as farnsylation of N-dansyl-GCVIA |
Bioorg Med Chem 17: 4797-805 (2009)
Article DOI: 10.1016/j.bmc.2009.04.034
BindingDB Entry DOI: 10.7270/Q2HT2PCH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Saccharomyces cerevisiae (Baker's yeast)) | BDBM50289982
(Prenyl pyrophosphate analogue)Show SMILES C\C(CC\C=C(/C)CNC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O Show InChI InChI=1S/C24H29NO9P2/c1-18(14-15-33-36(31,32)34-35(28,29)30)8-6-9-19(2)17-25-24(27)22-13-7-12-21(16-22)23(26)20-10-4-3-5-11-20/h3-5,7,9-14,16H,6,8,15,17H2,1-2H3,(H,25,27)(H,31,32)(H2,28,29,30)/p-3/b18-14+,19-9+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of yeast Farnesyl transferase |
Bioorg Med Chem Lett 7: 2125-2130 (1997)
Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Saccharomyces cerevisiae (Baker's yeast)) | BDBM50289979
(Prenyl pyrophosphate analogue | {[(2E)-4-[(3-benzo...)Show SMILES C\C(COC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O Show InChI InChI=1S/C19H20O10P2/c1-14(10-11-28-31(25,26)29-30(22,23)24)13-27-19(21)17-9-5-8-16(12-17)18(20)15-6-3-2-4-7-15/h2-10,12H,11,13H2,1H3,(H,25,26)(H2,22,23,24)/p-3/b14-10+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of yeast Farnesyl transferase |
Bioorg Med Chem Lett 7: 2125-2130 (1997)
Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Saccharomyces cerevisiae (Baker's yeast)) | BDBM50289978
(Prenyl pyrophosphate analogue | {[(2E)-4-[(3-benzo...)Show SMILES C\C(CNC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O Show InChI InChI=1S/C19H21NO9P2/c1-14(10-11-28-31(26,27)29-30(23,24)25)13-20-19(22)17-9-5-8-16(12-17)18(21)15-6-3-2-4-7-15/h2-10,12H,11,13H2,1H3,(H,20,22)(H,26,27)(H2,23,24,25)/p-3/b14-10+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of yeast Farnesyl transferase |
Bioorg Med Chem Lett 7: 2125-2130 (1997)
Article DOI: 10.1016/S0960-894X(97)00373-9
BindingDB Entry DOI: 10.7270/Q2542P3X |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Saccharomyces cerevisiae (Baker's yeast)) | BDBM50144314
((2E,4E,6E,8E)-3,7,11-trimethyldodeca-2,4,6,8,10-pe...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]=[#6]/[#6](/[#6])=[#6]/[#6]=[#6]/[#6](/[#6])=[#6]/[#6]-[#8]P([#8])(=O)[#8]P([#8])([#8])=O Show InChI InChI=1S/C15H24O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h5-11H,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b8-5+,10-6+,14-9+,15-11+ | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Utah
Curated by ChEMBL
| Assay Description
Dissociation constant against yeast farnesyltransferase |
Bioorg Med Chem Lett 14: 2137-40 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.077
BindingDB Entry DOI: 10.7270/Q2S181Z3 |
More data for this
Ligand-Target Pair | |
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