Compile Data Set for Download or QSAR

Found 7 hits of ic50 for UniProtKB: P15348   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 2 (Drosophila melanogaster)	BDBM50081427 ((4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-...) Show SMILES COC(=O)[C@]12Oc3cc(C)cc(O)c3C(=O)C1=CC=C[C@H]2O |c:18,20| Show InChI InChI=1S/C16H14O6/c1-8-6-10(17)13-11(7-8)22-16(15(20)21-2)9(14(13)19)4-3-5-12(16)18/h3-7,12,17-18H,1-2H3/t12-,16+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ajinomoto Co., Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against topoisomerase II (Topo II) by using decatenation assay				Bioorg Med Chem Lett 9: 2653-6 (1999) BindingDB Entry DOI: 10.7270/Q2X34XZ8
					More data for this Ligand-Target Pair
DNA topoisomerase 2 (Drosophila melanogaster)	BDBM50495519 (CHEMBL3109309) Show SMILES CCCCCCC[C@H]1Cc2cc(O)c(C(O)=O)c(O)c2[C@@H](O)O1 |r| Show InChI InChI=1S/C17H24O6/c1-2-3-4-5-6-7-11-8-10-9-12(18)14(16(20)21)15(19)13(10)17(22)23-11/h9,11,17-19,22H,2-8H2,1H3,(H,20,21)/t11-,17-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2020.113073 BindingDB Entry DOI: 10.7270/Q2FT8R1H
					More data for this Ligand-Target Pair
DNA topoisomerase 2 (Drosophila melanogaster)	BDBM50081428 ((4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-...) Show SMILES Cc1cc(O)c2C(=O)C3=CC=C[C@@H](O)[C@]3(Oc2c1)C(=O)NCCO |c:10,t:8| Show InChI InChI=1S/C17H17NO6/c1-9-7-11(20)14-12(8-9)24-17(16(23)18-5-6-19)10(15(14)22)3-2-4-13(17)21/h2-4,7-8,13,19-21H,5-6H2,1H3,(H,18,23)/t13-,17+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ajinomoto Co., Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against topoisomerase II (Topo II) by using decatenation assay				Bioorg Med Chem Lett 9: 2653-6 (1999) BindingDB Entry DOI: 10.7270/Q2X34XZ8
					More data for this Ligand-Target Pair
DNA topoisomerase 2 (Drosophila melanogaster)	BDBM50081429 ((4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-...) Show SMILES Cc1cc(O)c2C(=O)C3=CC=C[C@@H](O)[C@]3(Oc2c1)C(N)=O |c:10,t:8| Show InChI InChI=1S/C15H13NO5/c1-7-5-9(17)12-10(6-7)21-15(14(16)20)8(13(12)19)3-2-4-11(15)18/h2-6,11,17-18H,1H3,(H2,16,20)/t11-,15+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ajinomoto Co., Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against topoisomerase II (Topo II) by using decatenation assay				Bioorg Med Chem Lett 9: 2653-6 (1999) BindingDB Entry DOI: 10.7270/Q2X34XZ8
					More data for this Ligand-Target Pair
DNA topoisomerase 2 (Drosophila melanogaster)	BDBM50110690 (CHEMBL17377 | FOSTRIECIN | Phosphoric acid mono-{3...) Show SMILES C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)(O)=O |c:7| Show InChI InChI=1S/C19H27O9P/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26)/b3-2-,6-4+,8-5-,12-11+/t15-,16+,17+,19+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of topoisomerase IIin vitro through a novel, non-DNA-strandcleaving mechanism				Bioorg Med Chem Lett 10: 1687-90 (2000) BindingDB Entry DOI: 10.7270/Q2GQ6Z8N
					More data for this Ligand-Target Pair
DNA topoisomerase 2 (Drosophila melanogaster)	BDBM50081426 ((4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-...) Show SMILES CNC(=O)[C@]12Oc3cc(C)cc(O)c3C(=O)C1=CC=C[C@H]2O |c:18,20| Show InChI InChI=1S/C16H15NO5/c1-8-6-10(18)13-11(7-8)22-16(15(21)17-2)9(14(13)20)4-3-5-12(16)19/h3-7,12,18-19H,1-2H3,(H,17,21)/t12-,16+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.32E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ajinomoto Co., Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against topoisomerase II (Topo II) by using decatenation assay				Bioorg Med Chem Lett 9: 2653-6 (1999) BindingDB Entry DOI: 10.7270/Q2X34XZ8
					More data for this Ligand-Target Pair
DNA topoisomerase 2 (Drosophila melanogaster)	BDBM50081431 (7,16-dihydroxy-5,14-dimethyl-(1S,13S,16R)-2-oxa-14...) Show SMILES CN1C2CC=C3C(=O)c4c(O)cc(C)cc4O[C@@]3([C@@H]2O)C1=O |t:4,THB:0:1:18:5.4.3,21:20:18:5.4.3| Show InChI InChI=1S/C16H15NO5/c1-7-5-10(18)12-11(6-7)22-16-8(13(12)19)3-4-9(14(16)20)17(2)15(16)21/h3,5-6,9,14,18,20H,4H2,1-2H3/t9?,14-,16+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ajinomoto Co., Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against topoisomerase II (Topo II) by using decatenation assay				Bioorg Med Chem Lett 9: 2653-6 (1999) BindingDB Entry DOI: 10.7270/Q2X34XZ8
					More data for this Ligand-Target Pair