Found 53 hits of ki for UniProtKB: P32307 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020671
(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CCN)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@H](CCCNC(N)=N)C(N)=O)cc1 Show InChI InChI=1S/C46H69N11O8S2/c1-4-65-31-17-15-30(16-18-31)25-34-41(61)55-35(24-29-12-7-5-8-13-29)42(62)57-38(28(2)3)44(64)54-33(19-22-47)40(60)56-36(43(63)53-32(39(48)59)14-11-23-51-45(49)50)27-66-67-46(26-37(58)52-34)20-9-6-10-21-46/h5,7-8,12-13,15-18,28,32-36,38H,4,6,9-11,14,19-27,47H2,1-3H3,(H2,48,59)(H,52,58)(H,53,63)(H,54,64)(H,55,61)(H,56,60)(H,57,62)(H4,49,50,51)/t32-,33-,34+,35-,36-,38+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane |
J Med Chem 29: 984-8 (1986)
BindingDB Entry DOI: 10.7270/Q27M06W4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020669
(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CCN)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)cc1 Show InChI InChI=1S/C46H69N11O8S2/c1-4-65-31-17-15-30(16-18-31)25-34-41(61)55-35(24-29-12-7-5-8-13-29)42(62)57-38(28(2)3)44(64)54-33(19-22-47)40(60)56-36(43(63)53-32(39(48)59)14-11-23-51-45(49)50)27-66-67-46(26-37(58)52-34)20-9-6-10-21-46/h5,7-8,12-13,15-18,28,32-36,38H,4,6,9-11,14,19-27,47H2,1-3H3,(H2,48,59)(H,52,58)(H,53,63)(H,54,64)(H,55,61)(H,56,60)(H,57,62)(H4,49,50,51)/t32-,33+,34-,35+,36+,38-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane |
J Med Chem 29: 984-8 (1986)
BindingDB Entry DOI: 10.7270/Q27M06W4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020665
(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CCN)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1 Show InChI InChI=1S/C48H72N12O9S2/c1-4-69-32-17-15-31(16-18-32)25-35-43(65)58-36(24-30-12-7-5-8-13-30)44(66)60-40(29(2)3)46(68)57-34(19-22-49)42(64)59-37(28-70-71-48(26-39(62)55-35)20-9-6-10-21-48)45(67)56-33(14-11-23-53-47(51)52)41(63)54-27-38(50)61/h5,7-8,12-13,15-18,29,33-37,40H,4,6,9-11,14,19-28,49H2,1-3H3,(H2,50,61)(H,54,63)(H,55,62)(H,56,67)(H,57,68)(H,58,65)(H,59,64)(H,60,66)(H4,51,52,53)/t33-,34+,35-,36+,37+,40-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane |
J Med Chem 29: 984-8 (1986)
BindingDB Entry DOI: 10.7270/Q27M06W4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016752
(CHEMBL339943 | N*1*-[1-(1-Carbamoyl-4-guanidino-bu...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@H](CCCNC(N)=N)C(N)=O)cc1 Show InChI InChI=1S/C47H69N11O9S2/c1-4-67-31-17-15-30(16-18-31)23-33-41(62)55-34(22-29-12-7-5-8-13-29)43(64)58-39(28(2)3)45(66)56-35(24-37(48)59)42(63)57-36(44(65)54-32(40(49)61)14-11-21-52-46(50)51)26-68-27-69-47(25-38(60)53-33)19-9-6-10-20-47/h5,7-8,12-13,15-18,28,32-36,39H,4,6,9-11,14,19-27H2,1-3H3,(H2,48,59)(H2,49,61)(H,53,60)(H,54,65)(H,55,62)(H,56,66)(H,57,63)(H,58,64)(H4,50,51,52)/t32-,33-,34-,35-,36-,39+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor) |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50452524
(CHEMBL2372291)Show SMILES [#6]-[#6]-[#8]-c1ccc(-[#6]-[#6@H]-2-[#7]-[#6](=O)-[#6]C3([#6]-[#6]-[#6]-[#6]-[#6]3)[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c3ccccc3)-[#7]-[#6]-2=O)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-2-[#6]-[#6]-[#6]-[#6@@H]-2-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](-[#7])=O)cc1 Show InChI InChI=1S/C51H74N12O10S2/c1-4-73-33-19-17-32(18-20-33)26-35-44(67)59-36(25-31-13-7-5-8-14-31)46(69)62-42(30(2)3)48(71)60-37(27-40(52)64)45(68)61-38(29-74-75-51(28-41(65)57-35)21-9-6-10-22-51)49(72)63-24-12-16-39(63)47(70)58-34(43(53)66)15-11-23-56-50(54)55/h5,7-8,13-14,17-20,30,34-39,42H,4,6,9-12,15-16,21-29H2,1-3H3,(H2,52,64)(H2,53,66)(H,57,65)(H,58,70)(H,59,67)(H,60,71)(H,61,68)(H,62,69)(H4,54,55,56)/t34-,35+,36-,37-,38?,39+,42-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
In vitro antagonist activity of the compound was measured by inhibition of vasopressin-stimulated adenylate cyclase in renal medullary preparation in... |
J Med Chem 31: 1487-9 (1988)
BindingDB Entry DOI: 10.7270/Q2S46QZN |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020654
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(N)=N)C(N)=O)cc1 Show InChI InChI=1S/C51H74N12O10S2/c1-4-73-33-19-17-32(18-20-33)26-35-44(67)59-36(25-31-13-7-5-8-14-31)46(69)62-42(30(2)3)48(71)60-37(27-40(52)64)45(68)61-38(29-74-75-51(28-41(65)57-35)21-9-6-10-22-51)49(72)63-24-12-16-39(63)47(70)58-34(43(53)66)15-11-23-56-50(54)55/h5,7-8,13-14,17-20,30,34-39,42H,4,6,9-12,15-16,21-29H2,1-3H3,(H2,52,64)(H2,53,66)(H,57,65)(H,58,70)(H,59,67)(H,60,71)(H,61,68)(H,62,69)(H4,54,55,56)/t34-,35-,36-,37-,38-,39+,42+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations. |
J Med Chem 29: 2425-6 (1987)
BindingDB Entry DOI: 10.7270/Q23T9G6Q |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020667
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)cc1 Show InChI InChI=1S/C51H74N12O10S2/c1-4-73-33-19-17-32(18-20-33)26-35-44(67)59-36(25-31-13-7-5-8-14-31)46(69)62-42(30(2)3)48(71)60-37(27-40(52)64)45(68)61-38(29-74-75-51(28-41(65)57-35)21-9-6-10-22-51)49(72)63-24-12-16-39(63)47(70)58-34(43(53)66)15-11-23-56-50(54)55/h5,7-8,13-14,17-20,30,34-39,42H,4,6,9-12,15-16,21-29H2,1-3H3,(H2,52,64)(H2,53,66)(H,57,65)(H,58,70)(H,59,67)(H,60,71)(H,61,68)(H,62,69)(H4,54,55,56)/t34-,35-,36+,37+,38+,39-,42-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane |
J Med Chem 29: 984-8 (1986)
BindingDB Entry DOI: 10.7270/Q27M06W4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016753
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES [#6]-[#6]-[#8]-c1ccc(-[#6]-[#6@H]-2-[#7]-[#6](=O)-[#6]C3([#6]-[#6]-[#6]-[#6]-[#6]3)[#16]-[#6]-[#16]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-c3ccccc3)-[#7]-[#6]-2=O)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](-[#7])=O)cc1 Show InChI InChI=1S/C54H79N13O11S2/c1-4-78-35-19-17-34(18-20-35)26-37-47(72)63-38(25-33-13-7-5-8-14-33)49(74)66-45(32(2)3)51(76)64-39(27-42(55)68)48(73)65-40(30-79-31-80-54(28-44(70)61-37)21-9-6-10-22-54)52(77)67-24-12-16-41(67)50(75)62-36(15-11-23-59-53(57)58)46(71)60-29-43(56)69/h5,7-8,13-14,17-20,32,36-41,45H,4,6,9-12,15-16,21-31H2,1-3H3,(H2,55,68)(H2,56,69)(H,60,71)(H,61,70)(H,62,75)(H,63,72)(H,64,76)(H,65,73)(H,66,74)(H4,57,58,59)/t36-,37+,38+,39+,40+,41-,45-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016757
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES [#6]-[#6]-[#8]-c1ccc(-[#6]-[#6@H]-2-[#7]-[#6](=O)-[#6]C3([#6]-[#6]-[#6]-[#6]-[#6]3)[#16]-[#6]-[#16]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-c3ccccc3)-[#7]-[#6]-2=O)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#7])=O)cc1 Show InChI InChI=1S/C52H76N12O10S2/c1-4-74-34-19-17-33(18-20-34)26-36-45(68)60-37(25-32-13-7-5-8-14-32)47(70)63-43(31(2)3)49(72)61-38(27-41(53)65)46(69)62-39(29-75-30-76-52(28-42(66)58-36)21-9-6-10-22-52)50(73)64-24-12-16-40(64)48(71)59-35(44(54)67)15-11-23-57-51(55)56/h5,7-8,13-14,17-20,31,35-40,43H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,53,65)(H2,54,67)(H,58,66)(H,59,71)(H,60,68)(H,61,72)(H,62,69)(H,63,70)(H4,55,56,57)/t35-,36+,37+,38+,39+,40-,43-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020655
(CHEMBL408474 | [6-Amino-2-({1-[19-amino-13-benzyl-...)Show SMILES NCCCC[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(O)=O Show InChI InChI=1S/C46H64N12O13S2/c47-17-5-4-9-29(40(65)51-22-38(62)63)53-45(70)35-10-6-18-58(35)46(71)34-24-73-72-23-28(48)39(64)54-31(20-26-11-13-27(59)14-12-26)43(68)55-32(19-25-7-2-1-3-8-25)42(67)52-30(15-16-36(49)60)41(66)56-33(21-37(50)61)44(69)57-34/h1-3,7-8,11-14,28-35,59H,4-6,9-10,15-24,47-48H2,(H2,49,60)(H2,50,61)(H,51,65)(H,52,67)(H,53,70)(H,54,64)(H,55,68)(H,56,66)(H,57,69)(H,62,63)/t28-,29+,30-,31-,32+,33+,34+,35-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition of hog kidney renin |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020655
(CHEMBL408474 | [6-Amino-2-({1-[19-amino-13-benzyl-...)Show SMILES NCCCC[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(O)=O Show InChI InChI=1S/C46H64N12O13S2/c47-17-5-4-9-29(40(65)51-22-38(62)63)53-45(70)35-10-6-18-58(35)46(71)34-24-73-72-23-28(48)39(64)54-31(20-26-11-13-27(59)14-12-26)43(68)55-32(19-25-7-2-1-3-8-25)42(67)52-30(15-16-36(49)60)41(66)56-33(21-37(50)61)44(69)57-34/h1-3,7-8,11-14,28-35,59H,4-6,9-10,15-24,47-48H2,(H2,49,60)(H2,50,61)(H,51,65)(H,52,67)(H,53,70)(H,54,64)(H,55,68)(H,56,66)(H,57,69)(H,62,63)/t28-,29+,30-,31-,32+,33+,34+,35-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016747
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)NCCN)cc1 Show InChI InChI=1S/C48H69N9O9S2/c1-4-66-33-17-15-32(16-18-33)25-34-42(60)53-35(24-31-12-7-5-8-13-31)44(62)56-41(30(2)3)46(64)54-36(26-39(50)58)43(61)55-37(47(65)57-23-11-14-38(57)45(63)51-22-21-49)28-67-29-68-48(27-40(59)52-34)19-9-6-10-20-48/h5,7-8,12-13,15-18,30,34-38,41H,4,6,9-11,14,19-29,49H2,1-3H3,(H2,50,58)(H,51,63)(H,52,59)(H,53,60)(H,54,64)(H,55,61)(H,56,62)/t34-,35-,36-,37-,38+,41+/m1/s1 | Reactome pathway
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| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020675
(1-[13-Benzyl-7-carbamoylmethyl-16-(4-ethoxy-benzyl...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC(CC)(CC)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1 Show InChI InChI=1S/C52H77N13O11S2/c1-6-52(7-2)27-42(68)59-35(25-32-18-20-33(21-19-32)76-8-3)45(70)61-36(24-31-14-10-9-11-15-31)47(72)64-43(30(4)5)49(74)62-37(26-40(53)66)46(71)63-38(29-77-78-52)50(75)65-23-13-17-39(65)48(73)60-34(16-12-22-57-51(55)56)44(69)58-28-41(54)67/h9-11,14-15,18-21,30,34-39,43H,6-8,12-13,16-17,22-29H2,1-5H3,(H2,53,66)(H2,54,67)(H,58,69)(H,59,68)(H,60,73)(H,61,70)(H,62,74)(H,63,71)(H,64,72)(H4,55,56,57)/t34-,35-,36-,37-,38-,39+,43+/m1/s1 | Reactome pathway
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| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations. |
J Med Chem 29: 2425-6 (1987)
BindingDB Entry DOI: 10.7270/Q23T9G6Q |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016760
(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@H](CCCCN)C(N)=O)cc1 Show InChI InChI=1S/C46H67N9O9S2/c1-4-64-31-18-16-30(17-19-31)24-33-41(59)52-34(23-29-13-7-5-8-14-29)43(61)55-39(28(2)3)45(63)53-35(25-37(48)56)42(60)54-36(44(62)51-32(40(49)58)15-9-12-22-47)27-65-66-46(26-38(57)50-33)20-10-6-11-21-46/h5,7-8,13-14,16-19,28,32-36,39H,4,6,9-12,15,20-27,47H2,1-3H3,(H2,48,56)(H2,49,58)(H,50,57)(H,51,62)(H,52,59)(H,53,63)(H,54,60)(H,55,61)/t32-,33-,34-,35-,36-,39+/m1/s1 | Reactome pathway
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| 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016760
(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@H](CCCCN)C(N)=O)cc1 Show InChI InChI=1S/C46H67N9O9S2/c1-4-64-31-18-16-30(17-19-31)24-33-41(59)52-34(23-29-13-7-5-8-14-29)43(61)55-39(28(2)3)45(63)53-35(25-37(48)56)42(60)54-36(44(62)51-32(40(49)58)15-9-12-22-47)27-65-66-46(26-38(57)50-33)20-10-6-11-21-46/h5,7-8,13-14,16-19,28,32-36,39H,4,6,9-12,15,20-27,47H2,1-3H3,(H2,48,56)(H2,49,58)(H,50,57)(H,51,62)(H,52,59)(H,53,63)(H,54,60)(H,55,61)/t32-,33-,34-,35-,36-,39+/m1/s1 | Reactome pathway
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| 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020666
(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CCN)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@@H](CCCCN)C(N)=O)cc1 Show InChI InChI=1S/C46H69N9O8S2/c1-4-63-32-18-16-31(17-19-32)26-35-42(59)53-36(25-30-13-7-5-8-14-30)43(60)55-39(29(2)3)45(62)52-34(20-24-48)41(58)54-37(44(61)51-33(40(49)57)15-9-12-23-47)28-64-65-46(27-38(56)50-35)21-10-6-11-22-46/h5,7-8,13-14,16-19,29,33-37,39H,4,6,9-12,15,20-28,47-48H2,1-3H3,(H2,49,57)(H,50,56)(H,51,61)(H,52,62)(H,53,59)(H,54,58)(H,55,60)/t33-,34+,35-,36+,37+,39-/m0/s1 | Reactome pathway
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| 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane |
J Med Chem 29: 984-8 (1986)
BindingDB Entry DOI: 10.7270/Q27M06W4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016756
(CHEMBL265591 | c(Pmp-D-Tyr(Et)-Phe-Val-Asn-Cys)-Pr...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCCC2C(=O)NCCCCNC(N)=N)cc1 Show InChI InChI=1S/C51H75N11O9S2/c1-4-71-35-19-17-34(18-20-35)27-36-44(65)58-37(26-33-14-7-5-8-15-33)46(67)61-43(32(2)3)48(69)59-38(28-41(52)63)45(66)60-39(30-72-31-73-51(29-42(64)57-36)21-9-6-10-22-51)49(70)62-25-13-16-40(62)47(68)55-23-11-12-24-56-50(53)54/h5,7-8,14-15,17-20,32,36-40,43H,4,6,9-13,16,21-31H2,1-3H3,(H2,52,63)(H,55,68)(H,57,64)(H,58,65)(H,59,69)(H,60,66)(H,61,67)(H4,53,54,56)/t36-,37-,38-,39-,40?,43+/m1/s1 | Reactome pathway
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| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020673
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1 Show InChI InChI=1S/C53H77N13O11S2/c1-4-77-34-19-17-33(18-20-34)26-36-46(71)62-37(25-32-13-7-5-8-14-32)48(73)65-44(31(2)3)50(75)63-38(27-41(54)67)47(72)64-39(30-78-79-53(28-43(69)60-36)21-9-6-10-22-53)51(76)66-24-12-16-40(66)49(74)61-35(15-11-23-58-52(56)57)45(70)59-29-42(55)68/h5,7-8,13-14,17-20,31,35-40,44H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,54,67)(H2,55,68)(H,59,70)(H,60,69)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H4,56,57,58)/t35-,36-,37+,38+,39+,40-,44-/m0/s1 | Reactome pathway
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| 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane |
J Med Chem 29: 984-8 (1986)
BindingDB Entry DOI: 10.7270/Q27M06W4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020653
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1 Show InChI InChI=1S/C53H77N13O11S2/c1-4-77-34-19-17-33(18-20-34)26-36-46(71)62-37(25-32-13-7-5-8-14-32)48(73)65-44(31(2)3)50(75)63-38(27-41(54)67)47(72)64-39(30-78-79-53(28-43(69)60-36)21-9-6-10-22-53)51(76)66-24-12-16-40(66)49(74)61-35(15-11-23-58-52(56)57)45(70)59-29-42(55)68/h5,7-8,13-14,17-20,31,35-40,44H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,54,67)(H2,55,68)(H,59,70)(H,60,69)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H4,56,57,58)/t35-,36-,37-,38-,39-,40+,44+/m1/s1 | Reactome pathway
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| 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020653
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1 Show InChI InChI=1S/C53H77N13O11S2/c1-4-77-34-19-17-33(18-20-34)26-36-46(71)62-37(25-32-13-7-5-8-14-32)48(73)65-44(31(2)3)50(75)63-38(27-41(54)67)47(72)64-39(30-78-79-53(28-43(69)60-36)21-9-6-10-22-53)51(76)66-24-12-16-40(66)49(74)61-35(15-11-23-58-52(56)57)45(70)59-29-42(55)68/h5,7-8,13-14,17-20,31,35-40,44H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,54,67)(H2,55,68)(H,59,70)(H,60,69)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H4,56,57,58)/t35-,36-,37-,38-,39-,40+,44+/m1/s1 | Reactome pathway
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| 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations. |
J Med Chem 29: 2425-6 (1987)
BindingDB Entry DOI: 10.7270/Q23T9G6Q |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016755
(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)NCCCCCN)cc1 Show InChI InChI=1S/C46H68N8O8S2/c1-4-62-33-18-16-32(17-19-33)25-34-42(58)51-35(24-31-14-8-5-9-15-31)44(60)54-40(30(2)3)45(61)52-36(26-38(48)55)43(59)53-37(41(57)49-23-13-7-12-22-47)28-63-29-64-46(27-39(56)50-34)20-10-6-11-21-46/h5,8-9,14-19,30,34-37,40H,4,6-7,10-13,20-29,47H2,1-3H3,(H2,48,55)(H,49,57)(H,50,56)(H,51,58)(H,52,61)(H,53,59)(H,54,60)/t34-,35-,36-,37-,40+/m1/s1 | Reactome pathway
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| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor) |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016763
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)NCCCCN)cc1 Show InChI InChI=1S/C50H73N9O9S2/c1-4-68-35-19-17-34(18-20-35)27-36-44(62)55-37(26-33-14-7-5-8-15-33)46(64)58-43(32(2)3)48(66)56-38(28-41(52)60)45(63)57-39(30-69-31-70-50(29-42(61)54-36)21-9-6-10-22-50)49(67)59-25-13-16-40(59)47(65)53-24-12-11-23-51/h5,7-8,14-15,17-20,32,36-40,43H,4,6,9-13,16,21-31,51H2,1-3H3,(H2,52,60)(H,53,65)(H,54,61)(H,55,62)(H,56,66)(H,57,63)(H,58,64)/t36-,37-,38-,39-,40+,43+/m1/s1 | Reactome pathway
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| 7.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016754
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCCC2C(=O)NCCCCCN)cc1 Show InChI InChI=1S/C51H75N9O9S2/c1-4-69-36-20-18-35(19-21-36)28-37-45(63)56-38(27-34-15-8-5-9-16-34)47(65)59-44(33(2)3)49(67)57-39(29-42(53)61)46(64)58-40(31-70-32-71-51(30-43(62)55-37)22-10-6-11-23-51)50(68)60-26-14-17-41(60)48(66)54-25-13-7-12-24-52/h5,8-9,15-16,18-21,33,37-41,44H,4,6-7,10-14,17,22-32,52H2,1-3H3,(H2,53,61)(H,54,66)(H,55,62)(H,56,63)(H,57,67)(H,58,64)(H,59,65)/t37-,38-,39-,40-,41?,44+/m1/s1 | Reactome pathway
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| 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020674
(1-[13-Benzyl-7-carbamoylmethyl-16-(4-ethoxy-benzyl...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC(CC)(CC)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(N)=N)C(N)=O)cc1 Show InChI InChI=1S/C50H74N12O10S2/c1-6-50(7-2)27-40(64)56-34(25-31-18-20-32(21-19-31)72-8-3)43(66)58-35(24-30-14-10-9-11-15-30)45(68)61-41(29(4)5)47(70)59-36(26-39(51)63)44(67)60-37(28-73-74-50)48(71)62-23-13-17-38(62)46(69)57-33(42(52)65)16-12-22-55-49(53)54/h9-11,14-15,18-21,29,33-38,41H,6-8,12-13,16-17,22-28H2,1-5H3,(H2,51,63)(H2,52,65)(H,56,64)(H,57,69)(H,58,66)(H,59,70)(H,60,67)(H,61,68)(H4,53,54,55)/t33-,34-,35-,36-,37-,38+,41+/m1/s1 | Reactome pathway
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| 8.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations. |
J Med Chem 29: 2425-6 (1987)
BindingDB Entry DOI: 10.7270/Q23T9G6Q |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020656
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCCN)C(N)=O)cc1 Show InChI InChI=1S/C51H74N10O10S2/c1-4-71-34-20-18-33(19-21-34)27-36-45(65)57-37(26-32-14-7-5-8-15-32)47(67)60-43(31(2)3)49(69)58-38(28-41(53)62)46(66)59-39(30-72-73-51(29-42(63)55-36)22-10-6-11-23-51)50(70)61-25-13-17-40(61)48(68)56-35(44(54)64)16-9-12-24-52/h5,7-8,14-15,18-21,31,35-40,43H,4,6,9-13,16-17,22-30,52H2,1-3H3,(H2,53,62)(H2,54,64)(H,55,63)(H,56,68)(H,57,65)(H,58,69)(H,59,66)(H,60,67)/t35-,36-,37-,38-,39-,40+,43+/m1/s1 | Reactome pathway
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| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020656
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCCN)C(N)=O)cc1 Show InChI InChI=1S/C51H74N10O10S2/c1-4-71-34-20-18-33(19-21-34)27-36-45(65)57-37(26-32-14-7-5-8-15-32)47(67)60-43(31(2)3)49(69)58-38(28-41(53)62)46(66)59-39(30-72-73-51(29-42(63)55-36)22-10-6-11-23-51)50(70)61-25-13-17-40(61)48(68)56-35(44(54)64)16-9-12-24-52/h5,7-8,14-15,18-21,31,35-40,43H,4,6,9-13,16-17,22-30,52H2,1-3H3,(H2,53,62)(H2,54,64)(H,55,63)(H,56,68)(H,57,65)(H,58,69)(H,59,66)(H,60,67)/t35-,36-,37-,38-,39-,40+,43+/m1/s1 | Reactome pathway
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| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016761
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(N)=O)cc1 Show InChI InChI=1S/C52H76N10O10S2/c1-4-72-35-20-18-34(19-21-35)27-37-46(66)58-38(26-33-14-7-5-8-15-33)48(68)61-44(32(2)3)50(70)59-39(28-42(54)63)47(67)60-40(30-73-31-74-52(29-43(64)56-37)22-10-6-11-23-52)51(71)62-25-13-17-41(62)49(69)57-36(45(55)65)16-9-12-24-53/h5,7-8,14-15,18-21,32,36-41,44H,4,6,9-13,16-17,22-31,53H2,1-3H3,(H2,54,63)(H2,55,65)(H,56,64)(H,57,69)(H,58,66)(H,59,70)(H,60,67)(H,61,68)/t36-,37+,38-,39-,40+,41-,44-/m0/s1 | Reactome pathway
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| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020701
(1-(13,16-Dibenzyl-7-carbamoylmethyl-10-isopropyl-6...)Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O Show InChI InChI=1S/C46H65N13O10S2/c1-26(2)38-44(68)56-32(23-35(47)60)41(65)57-33(45(69)59-19-10-16-34(59)43(67)54-29(15-9-18-51-46(49)50)39(63)52-24-36(48)61)25-71-70-20-17-37(62)53-30(21-27-11-5-3-6-12-27)40(64)55-31(42(66)58-38)22-28-13-7-4-8-14-28/h3-8,11-14,26,29-34,38H,9-10,15-25H2,1-2H3,(H2,47,60)(H2,48,61)(H,52,63)(H,53,62)(H,54,67)(H,55,64)(H,56,68)(H,57,65)(H,58,66)(H4,49,50,51)/t29-,30-,31-,32-,33-,34-,38-/m0/s1 | Reactome pathway
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline and French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of LVP-sensitive adenylate cyclase in a pig renal medullary preparation |
J Med Chem 31: 742-4 (1988)
BindingDB Entry DOI: 10.7270/Q2VD6XFS |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016762
(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)NCCCCCN=C(N)CN)cc1 |w:61.63| Show InChI InChI=1S/C48H72N10O8S2/c1-4-66-34-18-16-33(17-19-34)25-35-44(62)55-36(24-32-14-8-5-9-15-32)46(64)58-42(31(2)3)47(65)56-37(26-40(51)59)45(63)57-38(43(61)53-23-13-7-12-22-52-39(50)28-49)29-67-30-68-48(27-41(60)54-35)20-10-6-11-21-48/h5,8-9,14-19,31,35-38,42H,4,6-7,10-13,20-30,49H2,1-3H3,(H2,50,52)(H2,51,59)(H,53,61)(H,54,60)(H,55,62)(H,56,65)(H,57,63)(H,58,64)/t35-,36-,37-,38-,42+/m1/s1 | Reactome pathway
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor) |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016750
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCCC2C(=O)NCc2cccc(CN)c2)cc1 Show InChI InChI=1S/C54H73N9O9S2/c1-4-72-39-20-18-36(19-21-39)27-40-48(66)59-41(26-35-13-7-5-8-14-35)50(68)62-47(34(2)3)52(70)60-42(28-45(56)64)49(67)61-43(32-73-33-74-54(29-46(65)58-40)22-9-6-10-23-54)53(71)63-24-12-17-44(63)51(69)57-31-38-16-11-15-37(25-38)30-55/h5,7-8,11,13-16,18-21,25,34,40-44,47H,4,6,9-10,12,17,22-24,26-33,55H2,1-3H3,(H2,56,64)(H,57,69)(H,58,65)(H,59,66)(H,60,70)(H,61,67)(H,62,68)/t40-,41-,42-,43-,44?,47+/m1/s1 | Reactome pathway
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor) |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020654
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(N)=N)C(N)=O)cc1 Show InChI InChI=1S/C51H74N12O10S2/c1-4-73-33-19-17-32(18-20-33)26-35-44(67)59-36(25-31-13-7-5-8-14-31)46(69)62-42(30(2)3)48(71)60-37(27-40(52)64)45(68)61-38(29-74-75-51(28-41(65)57-35)21-9-6-10-22-51)49(72)63-24-12-16-39(63)47(70)58-34(43(53)66)15-11-23-56-50(54)55/h5,7-8,13-14,17-20,30,34-39,42H,4,6,9-12,15-16,21-29H2,1-3H3,(H2,52,64)(H2,53,66)(H,57,65)(H,58,70)(H,59,67)(H,60,71)(H,61,68)(H,62,69)(H4,54,55,56)/t34-,35-,36-,37-,38-,39+,42+/m1/s1 | Reactome pathway
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020653
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1 Show InChI InChI=1S/C53H77N13O11S2/c1-4-77-34-19-17-33(18-20-34)26-36-46(71)62-37(25-32-13-7-5-8-14-32)48(73)65-44(31(2)3)50(75)63-38(27-41(54)67)47(72)64-39(30-78-79-53(28-43(69)60-36)21-9-6-10-22-53)51(76)66-24-12-16-40(66)49(74)61-35(15-11-23-58-52(56)57)45(70)59-29-42(55)68/h5,7-8,13-14,17-20,31,35-40,44H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,54,67)(H2,55,68)(H,59,70)(H,60,69)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H4,56,57,58)/t35-,36-,37-,38-,39-,40+,44+/m1/s1 | Reactome pathway
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020654
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(N)=N)C(N)=O)cc1 Show InChI InChI=1S/C51H74N12O10S2/c1-4-73-33-19-17-32(18-20-33)26-35-44(67)59-36(25-31-13-7-5-8-14-31)46(69)62-42(30(2)3)48(71)60-37(27-40(52)64)45(68)61-38(29-74-75-51(28-41(65)57-35)21-9-6-10-22-51)49(72)63-24-12-16-39(63)47(70)58-34(43(53)66)15-11-23-56-50(54)55/h5,7-8,13-14,17-20,30,34-39,42H,4,6,9-12,15-16,21-29H2,1-3H3,(H2,52,64)(H2,53,66)(H,57,65)(H,58,70)(H,59,67)(H,60,71)(H,61,68)(H,62,69)(H4,54,55,56)/t34-,35-,36-,37-,38-,39+,42+/m1/s1 | Reactome pathway
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020672
(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CCN)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@@H](CCCCNC(N)=N)C(N)=O)cc1 Show InChI InChI=1S/C47H71N11O8S2/c1-4-66-32-18-16-31(17-19-32)26-35-42(62)56-36(25-30-13-7-5-8-14-30)43(63)58-39(29(2)3)45(65)55-34(20-23-48)41(61)57-37(28-67-68-47(27-38(59)53-35)21-10-6-11-22-47)44(64)54-33(40(49)60)15-9-12-24-52-46(50)51/h5,7-8,13-14,16-19,29,33-37,39H,4,6,9-12,15,20-28,48H2,1-3H3,(H2,49,60)(H,53,59)(H,54,64)(H,55,65)(H,56,62)(H,57,61)(H,58,63)(H4,50,51,52)/t33-,34+,35-,36+,37+,39-/m0/s1 | Reactome pathway
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane |
J Med Chem 29: 984-8 (1986)
BindingDB Entry DOI: 10.7270/Q27M06W4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020651
(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)NCCCCCN)cc1 Show InChI InChI=1S/C45H66N8O8S2/c1-4-61-32-18-16-31(17-19-32)25-33-41(57)50-34(24-30-14-8-5-9-15-30)43(59)53-39(29(2)3)44(60)51-35(26-37(47)54)42(58)52-36(40(56)48-23-13-7-12-22-46)28-62-63-45(27-38(55)49-33)20-10-6-11-21-45/h5,8-9,14-19,29,33-36,39H,4,6-7,10-13,20-28,46H2,1-3H3,(H2,47,54)(H,48,56)(H,49,55)(H,50,57)(H,51,60)(H,52,58)(H,53,59)/t33-,34-,35-,36-,39+/m1/s1 | Reactome pathway
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020651
(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)NCCCCCN)cc1 Show InChI InChI=1S/C45H66N8O8S2/c1-4-61-32-18-16-31(17-19-32)25-33-41(57)50-34(24-30-14-8-5-9-15-30)43(59)53-39(29(2)3)44(60)51-35(26-37(47)54)42(58)52-36(40(56)48-23-13-7-12-22-46)28-62-63-45(27-38(55)49-33)20-10-6-11-21-45/h5,8-9,14-19,29,33-36,39H,4,6-7,10-13,20-28,46H2,1-3H3,(H2,47,54)(H,48,56)(H,49,55)(H,50,57)(H,51,60)(H,52,58)(H,53,59)/t33-,34-,35-,36-,39+/m1/s1 | Reactome pathway
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020668
(2-{[13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benz...)Show SMILES CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CCN)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)cc1 Show InChI InChI=1S/C46H68N10O9S2/c1-4-65-31-17-15-30(16-18-31)25-34-40(59)54-35(24-29-12-7-5-8-13-29)41(60)56-38(28(2)3)43(62)52-32(19-22-47)39(58)55-36(42(61)53-33(44(63)64)14-11-23-50-45(48)49)27-66-67-46(26-37(57)51-34)20-9-6-10-21-46/h5,7-8,12-13,15-18,28,32-36,38H,4,6,9-11,14,19-27,47H2,1-3H3,(H,51,57)(H,52,62)(H,53,61)(H,54,59)(H,55,58)(H,56,60)(H,63,64)(H4,48,49,50)/t32-,33+,34+,35-,36-,38+/m1/s1 | Reactome pathway
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane |
J Med Chem 29: 984-8 (1986)
BindingDB Entry DOI: 10.7270/Q27M06W4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016760
(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@H](CCCCN)C(N)=O)cc1 Show InChI InChI=1S/C46H67N9O9S2/c1-4-64-31-18-16-30(17-19-31)24-33-41(59)52-34(23-29-13-7-5-8-14-29)43(61)55-39(28(2)3)45(63)53-35(25-37(48)56)42(60)54-36(44(62)51-32(40(49)58)15-9-12-22-47)27-65-66-46(26-38(57)50-33)20-10-6-11-21-46/h5,7-8,13-14,16-19,28,32-36,39H,4,6,9-12,15,20-27,47H2,1-3H3,(H2,48,56)(H2,49,58)(H,50,57)(H,51,62)(H,52,59)(H,53,63)(H,54,60)(H,55,61)/t32-,33-,34-,35-,36-,39+/m1/s1 | Reactome pathway
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016749
(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)NCCCCN)cc1 Show InChI InChI=1S/C45H66N8O8S2/c1-4-61-32-17-15-31(16-18-32)24-33-41(57)50-34(23-30-13-7-5-8-14-30)43(59)53-39(29(2)3)44(60)51-35(25-37(47)54)42(58)52-36(40(56)48-22-12-11-21-46)27-62-28-63-45(26-38(55)49-33)19-9-6-10-20-45/h5,7-8,13-18,29,33-36,39H,4,6,9-12,19-28,46H2,1-3H3,(H2,47,54)(H,48,56)(H,49,55)(H,50,57)(H,51,60)(H,52,58)(H,53,59)/t33-,34-,35-,36-,39+/m1/s1 | Reactome pathway
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor) |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016759
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCCC2C(=O)NCc2ccc(CN)cc2)cc1 Show InChI InChI=1S/C54H73N9O9S2/c1-4-72-39-21-19-36(20-22-39)27-40-48(66)59-41(26-35-12-7-5-8-13-35)50(68)62-47(34(2)3)52(70)60-42(28-45(56)64)49(67)61-43(32-73-33-74-54(29-46(65)58-40)23-9-6-10-24-54)53(71)63-25-11-14-44(63)51(69)57-31-38-17-15-37(30-55)16-18-38/h5,7-8,12-13,15-22,34,40-44,47H,4,6,9-11,14,23-33,55H2,1-3H3,(H2,56,64)(H,57,69)(H,58,65)(H,59,66)(H,60,70)(H,61,67)(H,62,68)/t40-,41-,42-,43-,44?,47+/m1/s1 | Reactome pathway
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| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor) |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016746
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCCC2C(=O)NCCCCCCN)cc1 Show InChI InChI=1S/C52H77N9O9S2/c1-4-70-37-21-19-36(20-22-37)29-38-46(64)57-39(28-35-16-9-7-10-17-35)48(66)60-45(34(2)3)50(68)58-40(30-43(54)62)47(65)59-41(32-71-33-72-52(31-44(63)56-38)23-11-8-12-24-52)51(69)61-27-15-18-42(61)49(67)55-26-14-6-5-13-25-53/h7,9-10,16-17,19-22,34,38-42,45H,4-6,8,11-15,18,23-33,53H2,1-3H3,(H2,54,62)(H,55,67)(H,56,63)(H,57,64)(H,58,68)(H,59,65)(H,60,66)/t38-,39-,40-,41-,42?,45+/m1/s1 | Reactome pathway
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| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020652
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@@H]2C(=O)NCCCCCN)cc1 Show InChI InChI=1S/C50H73N9O9S2/c1-4-68-35-20-18-34(19-21-35)28-36-44(62)55-37(27-33-15-8-5-9-16-33)46(64)58-43(32(2)3)48(66)56-38(29-41(52)60)45(63)57-39(31-69-70-50(30-42(61)54-36)22-10-6-11-23-50)49(67)59-26-14-17-40(59)47(65)53-25-13-7-12-24-51/h5,8-9,15-16,18-21,32,36-40,43H,4,6-7,10-14,17,22-31,51H2,1-3H3,(H2,52,60)(H,53,65)(H,54,61)(H,55,62)(H,56,66)(H,57,63)(H,58,64)/t36-,37-,38-,39-,40-,43+/m1/s1 | Reactome pathway
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020652
(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@@H]2C(=O)NCCCCCN)cc1 Show InChI InChI=1S/C50H73N9O9S2/c1-4-68-35-20-18-34(19-21-35)28-36-44(62)55-37(27-33-15-8-5-9-16-33)46(64)58-43(32(2)3)48(66)56-38(29-41(52)60)45(63)57-39(31-69-70-50(30-42(61)54-36)22-10-6-11-23-50)49(67)59-26-14-17-40(59)47(65)53-25-13-7-12-24-51/h5,8-9,15-16,18-21,32,36-40,43H,4,6-7,10-14,17,22-31,51H2,1-3H3,(H2,52,60)(H,53,65)(H,54,61)(H,55,62)(H,56,66)(H,57,63)(H,58,64)/t36-,37-,38-,39-,40-,43+/m1/s1 | Reactome pathway
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney. |
J Med Chem 28: 1759-60 (1986)
BindingDB Entry DOI: 10.7270/Q2CC0ZNX |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020670
((2-{[13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-ben...)Show SMILES CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](NC(=O)[C@@H](CCN)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)cc1 Show InChI InChI=1S/C48H71N11O10S2/c1-4-69-32-17-15-31(16-18-32)25-35-43(65)57-36(24-30-12-7-5-8-13-30)44(66)59-40(29(2)3)46(68)56-34(19-22-49)42(64)58-37(28-70-71-48(26-38(60)54-35)20-9-6-10-21-48)45(67)55-33(14-11-23-52-47(50)51)41(63)53-27-39(61)62/h5,7-8,12-13,15-18,29,33-37,40H,4,6,9-11,14,19-28,49H2,1-3H3,(H,53,63)(H,54,60)(H,55,67)(H,56,68)(H,57,65)(H,58,64)(H,59,66)(H,61,62)(H4,50,51,52)/t33-,34+,35-,36+,37+,40-/m0/s1 | Reactome pathway
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| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane |
J Med Chem 29: 984-8 (1986)
BindingDB Entry DOI: 10.7270/Q27M06W4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016748
(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCCC2C(=O)NCCCCCCCN)cc1 Show InChI InChI=1S/C53H79N9O9S2/c1-4-71-38-22-20-37(21-23-38)30-39-47(65)58-40(29-36-17-10-8-11-18-36)49(67)61-46(35(2)3)51(69)59-41(31-44(55)63)48(66)60-42(33-72-34-73-53(32-45(64)57-39)24-12-9-13-25-53)52(70)62-28-16-19-43(62)50(68)56-27-15-7-5-6-14-26-54/h8,10-11,17-18,20-23,35,39-43,46H,4-7,9,12-16,19,24-34,54H2,1-3H3,(H2,55,63)(H,56,68)(H,57,64)(H,58,65)(H,59,69)(H,60,66)(H,61,67)/t39-,40-,41-,42-,43?,46+/m1/s1 | Reactome pathway
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| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor) |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020698
(1-(13,16-Dibenzyl-7-carbamoylmethyl-20-cyclopentyl...)Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CC(SSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1CCCC1 Show InChI InChI=1S/C51H73N13O10S2/c1-29(2)43-49(73)61-36(25-40(52)65)46(70)62-37(50(74)64-22-12-20-38(64)48(72)59-33(19-11-21-56-51(54)55)44(68)57-27-41(53)66)28-75-76-39(32-17-9-10-18-32)26-42(67)58-34(23-30-13-5-3-6-14-30)45(69)60-35(47(71)63-43)24-31-15-7-4-8-16-31/h3-8,13-16,29,32-39,43H,9-12,17-28H2,1-2H3,(H2,52,65)(H2,53,66)(H,57,68)(H,58,67)(H,59,72)(H,60,69)(H,61,73)(H,62,70)(H,63,71)(H4,54,55,56)/t33-,34-,35-,36-,37-,38-,39?,43-/m0/s1 | Reactome pathway
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| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline and French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of LVP-sensitive adenylate cyclase in a pig renal medullary preparation |
J Med Chem 31: 742-4 (1988)
BindingDB Entry DOI: 10.7270/Q2VD6XFS |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016758
(2-[20-Benzyl-23-(4-ethoxy-benzyl)-11-(2-hydroxy-py...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCCC2O)cc1 Show InChI InChI=1S/C45H63N7O9S2/c1-4-61-31-17-15-30(16-18-31)23-32-40(56)48-33(22-29-12-7-5-8-13-29)42(58)51-39(28(2)3)43(59)49-34(24-36(46)53)41(57)50-35(44(60)52-21-11-14-38(52)55)26-62-27-63-45(25-37(54)47-32)19-9-6-10-20-45/h5,7-8,12-13,15-18,28,32-35,38-39,55H,4,6,9-11,14,19-27H2,1-3H3,(H2,46,53)(H,47,54)(H,48,56)(H,49,59)(H,50,57)(H,51,58)/t32-,33-,34-,35-,38?,39+/m1/s1 | Reactome pathway
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| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor) |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50016751
(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)Show SMILES CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SCSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(O)=O)cc1 Show InChI InChI=1S/C41H56N6O9S2/c1-4-56-28-15-13-27(14-16-28)20-29-36(50)44-30(19-26-11-7-5-8-12-26)38(52)47-35(25(2)3)39(53)45-31(21-33(42)48)37(51)46-32(40(54)55)23-57-24-58-41(22-34(49)43-29)17-9-6-10-18-41/h5,7-8,11-16,25,29-32,35H,4,6,9-10,17-24H2,1-3H3,(H2,42,48)(H,43,49)(H,44,50)(H,45,53)(H,46,51)(H,47,52)(H,54,55)/t29-,30-,31-,32-,35+/m1/s1 | Reactome pathway
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| 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline & French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor) |
J Med Chem 32: 391-6 (1989)
BindingDB Entry DOI: 10.7270/Q2GM8688 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020700
(1-(2,5-Dibenzyl-11-carbamoylmethyl-8-isopropyl-3,6...)Show SMILES [H][C@@]([#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])([#7]-[#6](=O)[C@]1([H])[#6]-[#6]-[#6]-[#7]1-[#6](=O)[C@]1([H])[#6]-[#6]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7][C@@]([H])([#6]-[#6](-[#7])=O)[#6](=O)-[#7]1)[#6](=O)-[#7]-[#6]-[#6](-[#7])=O Show InChI InChI=1S/C46H65N13O10/c1-26(2)38-44(68)57-33(24-35(47)60)41(65)55-30(45(69)59-21-11-18-34(59)43(67)54-29(17-10-20-51-46(49)50)39(63)52-25-36(48)61)16-9-19-37(62)53-31(22-27-12-5-3-6-13-27)40(64)56-32(42(66)58-38)23-28-14-7-4-8-15-28/h3-8,12-15,26,29-34,38H,9-11,16-25H2,1-2H3,(H2,47,60)(H2,48,61)(H,52,63)(H,53,62)(H,54,67)(H,55,65)(H,56,64)(H,57,68)(H,58,66)(H4,49,50,51)/t29-,30-,31-,32-,33-,34-,38-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline and French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of LVP-sensitive adenylate cyclase in a pig renal medullary preparation |
J Med Chem 31: 742-4 (1988)
BindingDB Entry DOI: 10.7270/Q2VD6XFS |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Sus scrofa) | BDBM50020699
(1-(2,5-Dibenzyl-11-carbamoylmethyl-8-isopropyl-3,6...)Show SMILES CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O Show InChI InChI=1S/C46H65N13O10/c1-26(2)38-44(68)57-33(24-35(47)60)41(65)55-30(45(69)59-21-11-18-34(59)43(67)54-29(17-10-20-51-46(49)50)39(63)52-25-36(48)61)16-9-19-37(62)53-31(22-27-12-5-3-6-13-27)40(64)56-32(42(66)58-38)23-28-14-7-4-8-15-28/h3-8,12-15,26,29-34,38H,9-11,16-25H2,1-2H3,(H2,47,60)(H2,48,61)(H,52,63)(H,53,62)(H,54,67)(H,55,65)(H,56,64)(H,57,68)(H,58,66)(H4,49,50,51)/t29-,30+,31-,32-,33-,34-,38-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Smith Kline and French Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of LVP-sensitive adenylate cyclase in a pig renal medullary preparation |
J Med Chem 31: 742-4 (1988)
BindingDB Entry DOI: 10.7270/Q2VD6XFS |
More data for this
Ligand-Target Pair | |
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