Found 32 hits of ec50 for UniProtKB: P48546 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275595
(CHEMBL4127525)Show SMILES CCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C210H334N54O61/c1-17-19-20-21-22-23-24-25-26-27-28-29-30-31-32-39-70-161(276)233-139(207(323)324)74-80-160(275)222-86-49-45-64-132(235-184(300)135(72-78-158(216)273)239-181(297)131(63-44-48-85-213)238-196(312)150(109-267)253-190(306)142(94-115(7)8)245-193(309)147(100-169(287)288)249-197(313)152(111-269)255-203(319)172(121(14)271)259-195(311)144(96-123-57-37-34-38-58-123)250-202(318)171(120(13)270)257-164(279)105-227-177(293)134(71-77-157(215)272)256-208(325)210(15,16)260-176(292)127(214)98-125-102-221-112-229-125)183(299)248-146(99-168(285)286)192(308)241-137(75-81-166(281)282)186(302)240-136(73-79-159(217)274)185(301)236-133(65-50-87-223-209(219)220)180(296)232-118(11)175(291)234-130(62-43-47-84-212)182(298)243-141(93-114(5)6)189(305)246-143(95-122-55-35-33-36-56-122)194(310)258-170(116(9)18-2)201(317)242-138(76-82-167(283)284)187(303)247-145(97-124-101-224-128-60-41-40-59-126(124)128)191(307)244-140(92-113(3)4)188(304)237-129(61-42-46-83-211)179(295)231-117(10)174(290)226-103-162(277)225-106-165(280)261-88-51-66-153(261)199(315)254-151(110-268)198(314)252-149(108-266)178(294)228-104-163(278)230-119(12)204(320)263-90-53-68-155(263)206(322)264-91-54-69-156(264)205(321)262-89-52-67-154(262)200(316)251-148(107-265)173(218)289/h33-38,40-41,55-60,101-102,112-121,127,129-156,170-172,224,265-271H,17-32,39,42-54,61-100,103-111,211-214H2,1-16H3,(H2,215,272)(H2,216,273)(H2,217,274)(H2,218,289)(H,221,229)(H,222,275)(H,225,277)(H,226,290)(H,227,293)(H,228,294)(H,230,278)(H,231,295)(H,232,296)(H,233,276)(H,234,291)(H,235,300)(H,236,301)(H,237,304)(H,238,312)(H,239,297)(H,240,302)(H,241,308)(H,242,317)(H,243,298)(H,244,307)(H,245,309)(H,246,305)(H,247,303)(H,248,299)(H,249,313)(H,250,318)(H,251,316)(H,252,314)(H,253,306)(H,254,315)(H,255,319)(H,256,325)(H,257,279)(H,258,310)(H,259,311)(H,260,292)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,323,324)(H4,219,220,223)/t116-,117-,118-,119-,120+,121+,127-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,170-,171-,172-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0397 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275593
(CHEMBL4126812)Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C213H336N54O64/c1-19-22-23-24-25-26-27-28-29-30-31-32-33-40-68-161(279)235-139(210(329)330)73-80-162(280)236-138(209(327)328)72-79-160(278)224-85-48-45-62-131(238-185(303)134(70-77-158(218)276)241-182(300)130(61-44-47-84-215)240-197(315)150(108-270)255-190(308)141(92-113(6)7)246-193(311)147(99-170(291)292)251-198(316)152(110-272)257-205(323)174(121(16)274)262-196(314)144(95-123-56-38-35-39-57-123)252-204(322)173(120(15)273)259-165(283)104-229-179(297)133(69-76-157(217)275)258-211(331)213(17,18)263-178(296)127(216)97-125-101-223-111-231-125)184(302)250-146(98-169(289)290)192(310)243-136(74-81-167(285)286)187(305)242-135(71-78-159(219)277)186(304)239-132(63-49-86-225-212(221)222)181(299)233-118(13)177(295)237-129(60-43-46-83-214)183(301)245-140(91-112(4)5)189(307)248-143(94-122-54-36-34-37-55-122)195(313)261-172(116(11)21-3)203(321)244-137(75-82-168(287)288)188(306)249-145(96-124-100-226-128-59-42-41-58-126(124)128)191(309)247-142(93-114(8)9)194(312)260-171(115(10)20-2)202(320)234-117(12)176(294)228-102-163(281)227-105-166(284)264-87-50-64-153(264)200(318)256-151(109-271)199(317)254-149(107-269)180(298)230-103-164(282)232-119(14)206(324)266-89-52-66-155(266)208(326)267-90-53-67-156(267)207(325)265-88-51-65-154(265)201(319)253-148(106-268)175(220)293/h34-39,41-42,54-59,100-101,111-121,127,129-156,171-174,226,268-274H,19-33,40,43-53,60-99,102-110,214-216H2,1-18H3,(H2,217,275)(H2,218,276)(H2,219,277)(H2,220,293)(H,223,231)(H,224,278)(H,227,281)(H,228,294)(H,229,297)(H,230,298)(H,232,282)(H,233,299)(H,234,320)(H,235,279)(H,236,280)(H,237,295)(H,238,303)(H,239,304)(H,240,315)(H,241,300)(H,242,305)(H,243,310)(H,244,321)(H,245,301)(H,246,311)(H,247,309)(H,248,307)(H,249,306)(H,250,302)(H,251,316)(H,252,322)(H,253,319)(H,254,317)(H,255,308)(H,256,318)(H,257,323)(H,258,331)(H,259,283)(H,260,312)(H,261,313)(H,262,314)(H,263,296)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H,327,328)(H,329,330)(H4,221,222,225)/t115-,116-,117-,118-,119-,120+,121+,127-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,171-,172-,173-,174-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0582 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275596
(CHEMBL4129347)Show SMILES CCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C208H329N53O61/c1-19-21-22-23-24-25-26-27-28-29-30-31-32-33-34-41-69-158(273)230-136(203(319)320)73-79-157(272)219-84-49-46-63-129(232-180(296)132(71-77-155(213)270)235-177(293)128(62-45-48-83-210)234-191(307)147(107-264)249-185(301)138(91-112(5)6)240-188(304)144(98-166(284)285)245-192(308)149(109-266)251-199(315)169(119(14)268)255-190(306)141(94-121-57-39-36-40-58-121)246-198(314)168(118(13)267)253-161(276)103-224-174(290)131(70-76-154(212)269)252-205(322)208(17,18)256-173(289)125(211)96-123-100-218-110-226-123)179(295)244-143(97-165(282)283)187(303)237-134(74-80-163(278)279)182(298)236-133(72-78-156(214)271)181(297)233-130(64-50-85-220-206(216)217)176(292)228-116(11)172(288)231-127(61-44-47-82-209)178(294)239-137(90-111(3)4)184(300)242-140(93-120-55-37-35-38-56-120)189(305)254-167(114(9)20-2)197(313)238-135(75-81-164(280)281)183(299)243-142(95-122-99-221-126-60-43-42-59-124(122)126)186(302)241-139(92-113(7)8)194(310)257-207(15,16)204(321)229-115(10)171(287)223-101-159(274)222-104-162(277)258-86-51-65-150(258)195(311)250-148(108-265)193(309)248-146(106-263)175(291)225-102-160(275)227-117(12)200(316)260-88-53-67-152(260)202(318)261-89-54-68-153(261)201(317)259-87-52-66-151(259)196(312)247-145(105-262)170(215)286/h35-40,42-43,55-60,99-100,110-119,125,127-153,167-169,221,262-268H,19-34,41,44-54,61-98,101-109,209-211H2,1-18H3,(H2,212,269)(H2,213,270)(H2,214,271)(H2,215,286)(H,218,226)(H,219,272)(H,222,274)(H,223,287)(H,224,290)(H,225,291)(H,227,275)(H,228,292)(H,229,321)(H,230,273)(H,231,288)(H,232,296)(H,233,297)(H,234,307)(H,235,293)(H,236,298)(H,237,303)(H,238,313)(H,239,294)(H,240,304)(H,241,302)(H,242,300)(H,243,299)(H,244,295)(H,245,308)(H,246,314)(H,247,312)(H,248,309)(H,249,301)(H,250,311)(H,251,315)(H,252,322)(H,253,276)(H,254,305)(H,255,306)(H,256,289)(H,257,310)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,319,320)(H4,216,217,220)/t114-,115-,116-,117-,118+,119+,125-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,167-,168-,169-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.102 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459986
(CHEMBL4226634)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)C(O)=O |r| Show InChI InChI=1S/C178H275N47O53/c1-16-17-18-19-20-21-22-23-24-25-26-27-34-53-136(236)201-117(174(276)277)61-66-135(235)190-69-40-38-50-111(204-164(266)127(82-142(245)246)217-170(272)130(90-227)220-173(275)146(99(13)229)224-168(270)123(76-101-45-32-29-33-46-101)218-172(274)145(98(12)228)222-138(238)88-195-151(253)113(58-63-131(181)231)221-175(278)178(14,15)225-149(251)107(180)79-104-85-189-91-197-104)155(257)219-129(89-226)169(271)205-110(49-37-39-68-179)154(256)211-121(77-102-54-56-105(230)57-55-102)162(264)209-120(74-94(6)7)161(263)216-126(81-141(243)244)165(267)206-116(62-67-139(239)240)156(258)203-112(52-42-71-192-177(187)188)153(255)199-96(10)147(249)198-97(11)148(250)202-114(59-64-132(182)232)157(259)215-128(83-143(247)248)166(268)212-122(75-100-43-30-28-31-44-100)167(269)223-144(95(8)9)171(273)207-115(60-65-133(183)233)158(260)213-124(78-103-84-193-108-48-36-35-47-106(103)108)163(265)210-118(72-92(2)3)159(261)208-119(73-93(4)5)160(262)214-125(80-140(241)242)152(254)196-87-137(237)200-109(51-41-70-191-176(185)186)150(252)194-86-134(184)234/h28-33,35-36,43-48,54-57,84-85,91-99,107,109-130,144-146,193,226-230H,16-27,34,37-42,49-53,58-83,86-90,179-180H2,1-15H3,(H2,181,231)(H2,182,232)(H2,183,233)(H2,184,234)(H,189,197)(H,190,235)(H,194,252)(H,195,253)(H,196,254)(H,198,249)(H,199,255)(H,200,237)(H,201,236)(H,202,250)(H,203,258)(H,204,266)(H,205,271)(H,206,267)(H,207,273)(H,208,261)(H,209,264)(H,210,265)(H,211,256)(H,212,268)(H,213,260)(H,214,262)(H,215,259)(H,216,263)(H,217,272)(H,218,274)(H,219,257)(H,220,275)(H,221,278)(H,222,238)(H,223,269)(H,224,270)(H,225,251)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,276,277)(H4,185,186,191)(H4,187,188,192)/t96-,97-,98+,99+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,144-,145-,146-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.133 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275567
(CHEMBL4128194)Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C213H336N54O64/c1-19-21-22-23-24-25-26-27-28-29-30-31-32-39-67-162(279)235-139(210(329)330)72-79-163(280)236-138(209(327)328)71-78-161(278)224-84-47-44-61-131(238-185(303)134(69-76-159(218)276)241-182(300)130(60-43-46-83-215)240-198(316)151(108-270)256-192(310)143(93-115(9)10)248-195(313)148(99-171(291)292)252-199(317)153(110-272)258-205(323)174(121(16)274)262-197(315)145(95-123-55-37-34-38-56-123)253-204(322)173(120(15)273)260-166(283)104-229-179(297)133(68-75-158(217)275)259-211(331)213(17,18)263-178(296)127(216)97-125-101-223-111-231-125)184(302)251-147(98-170(289)290)194(312)243-136(73-80-168(285)286)187(305)242-135(70-77-160(219)277)186(304)239-132(62-48-85-225-212(221)222)181(299)234-118(13)177(295)237-129(59-42-45-82-214)183(301)245-141(91-113(5)6)191(309)249-144(94-122-53-35-33-36-54-122)196(314)261-172(116(11)20-2)203(321)244-137(74-81-169(287)288)188(306)250-146(96-124-100-226-128-58-41-40-57-126(124)128)193(311)247-142(92-114(7)8)190(308)246-140(90-112(3)4)189(307)233-117(12)176(294)228-102-164(281)227-105-167(284)264-86-49-63-154(264)201(319)257-152(109-271)200(318)255-150(107-269)180(298)230-103-165(282)232-119(14)206(324)266-88-51-65-156(266)208(326)267-89-52-66-157(267)207(325)265-87-50-64-155(265)202(320)254-149(106-268)175(220)293/h33-38,40-41,53-58,100-101,111-121,127,129-157,172-174,226,268-274H,19-32,39,42-52,59-99,102-110,214-216H2,1-18H3,(H2,217,275)(H2,218,276)(H2,219,277)(H2,220,293)(H,223,231)(H,224,278)(H,227,281)(H,228,294)(H,229,297)(H,230,298)(H,232,282)(H,233,307)(H,234,299)(H,235,279)(H,236,280)(H,237,295)(H,238,303)(H,239,304)(H,240,316)(H,241,300)(H,242,305)(H,243,312)(H,244,321)(H,245,301)(H,246,308)(H,247,311)(H,248,313)(H,249,309)(H,250,306)(H,251,302)(H,252,317)(H,253,322)(H,254,320)(H,255,318)(H,256,310)(H,257,319)(H,258,323)(H,259,331)(H,260,283)(H,261,314)(H,262,315)(H,263,296)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H,327,328)(H,329,330)(H4,221,222,225)/t116-,117-,118-,119-,120+,121+,127-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,172-,173-,174-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.189 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275594
(CHEMBL4130225)Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C213H337N55O64/c1-17-19-20-21-22-23-24-25-26-27-28-29-30-37-68-162(280)236-140(210(330)331)73-80-163(281)237-139(209(328)329)72-79-161(279)225-86-47-43-62-132(239-186(305)135(70-77-159(219)277)243-183(302)131(61-42-46-85-216)242-198(317)151(109-271)257-192(311)143(94-115(7)8)249-195(314)148(100-171(292)293)253-199(318)153(111-273)259-205(324)174(121(14)275)263-197(316)145(96-123-55-35-32-36-56-123)254-204(323)173(120(13)274)261-166(284)105-230-179(298)134(69-76-158(218)276)260-211(332)213(15,16)264-178(297)127(217)98-125-102-224-112-232-125)185(304)252-147(99-170(290)291)194(313)245-137(74-81-168(286)287)188(307)244-136(71-78-160(220)278)187(306)240-133(63-48-87-226-212(222)223)182(301)235-118(11)177(296)238-130(60-41-45-84-215)184(303)247-142(93-114(5)6)191(310)250-144(95-122-53-33-31-34-54-122)196(315)262-172(116(9)18-2)203(322)246-138(75-82-169(288)289)189(308)251-146(97-124-101-227-128-58-39-38-57-126(124)128)193(312)248-141(92-113(3)4)190(309)241-129(59-40-44-83-214)181(300)234-117(10)176(295)229-103-164(282)228-106-167(285)265-88-49-64-154(265)201(320)258-152(110-272)200(319)256-150(108-270)180(299)231-104-165(283)233-119(12)206(325)267-90-51-66-156(267)208(327)268-91-52-67-157(268)207(326)266-89-50-65-155(266)202(321)255-149(107-269)175(221)294/h31-36,38-39,53-58,101-102,112-121,127,129-157,172-174,227,269-275H,17-30,37,40-52,59-100,103-111,214-217H2,1-16H3,(H2,218,276)(H2,219,277)(H2,220,278)(H2,221,294)(H,224,232)(H,225,279)(H,228,282)(H,229,295)(H,230,298)(H,231,299)(H,233,283)(H,234,300)(H,235,301)(H,236,280)(H,237,281)(H,238,296)(H,239,305)(H,240,306)(H,241,309)(H,242,317)(H,243,302)(H,244,307)(H,245,313)(H,246,322)(H,247,303)(H,248,312)(H,249,314)(H,250,310)(H,251,308)(H,252,304)(H,253,318)(H,254,323)(H,255,321)(H,256,319)(H,257,311)(H,258,320)(H,259,324)(H,260,332)(H,261,284)(H,262,315)(H,263,316)(H,264,297)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,328,329)(H,330,331)(H4,222,223,226)/t116-,117-,118-,119-,120+,121+,127-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,172-,173-,174-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.224 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459992
(CHEMBL4227180)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)C(O)=O |r| Show InChI InChI=1S/C177H273N47O54/c1-14-15-16-17-18-19-20-21-22-23-24-25-32-51-136(236)200-116(175(277)278)59-64-135(235)189-67-38-36-48-110(203-164(266)126(80-142(245)246)217-171(273)130(89-227)221-174(276)146(98(13)229)224-168(270)122(74-100-43-30-27-31-44-100)218-173(275)145(97(12)228)222-138(238)86-194-151(253)112(56-61-131(180)231)205-169(271)128(87-225)219-149(251)106(179)77-103-83-188-90-196-103)155(257)220-129(88-226)170(272)204-109(47-35-37-66-178)154(256)211-120(75-101-52-54-104(230)55-53-101)162(264)209-119(72-93(6)7)161(263)216-125(79-141(243)244)165(267)206-115(60-65-139(239)240)156(258)202-111(50-40-69-191-177(186)187)153(255)198-95(10)147(249)197-96(11)148(250)201-113(57-62-132(181)232)157(259)215-127(81-143(247)248)166(268)212-121(73-99-41-28-26-29-42-99)167(269)223-144(94(8)9)172(274)207-114(58-63-133(182)233)158(260)213-123(76-102-82-192-107-46-34-33-45-105(102)107)163(265)210-117(70-91(2)3)159(261)208-118(71-92(4)5)160(262)214-124(78-140(241)242)152(254)195-85-137(237)199-108(49-39-68-190-176(184)185)150(252)193-84-134(183)234/h26-31,33-34,41-46,52-55,82-83,90-98,106,108-130,144-146,192,225-230H,14-25,32,35-40,47-51,56-81,84-89,178-179H2,1-13H3,(H2,180,231)(H2,181,232)(H2,182,233)(H2,183,234)(H,188,196)(H,189,235)(H,193,252)(H,194,253)(H,195,254)(H,197,249)(H,198,255)(H,199,237)(H,200,236)(H,201,250)(H,202,258)(H,203,266)(H,204,272)(H,205,271)(H,206,267)(H,207,274)(H,208,261)(H,209,264)(H,210,265)(H,211,256)(H,212,268)(H,213,260)(H,214,262)(H,215,259)(H,216,263)(H,217,273)(H,218,275)(H,219,251)(H,220,257)(H,221,276)(H,222,238)(H,223,269)(H,224,270)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,277,278)(H4,184,185,190)(H4,186,187,191)/t95-,96-,97+,98+,106-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128+,129-,130-,144-,145-,146-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.812 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459981
(CHEMBL4225594)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r| Show InChI InChI=1S/C152H221N37O49S/c1-14-75(6)121(150(236)165-78(9)128(214)173-106(61-86-66-160-92-32-22-21-31-90(86)92)141(227)175-100(55-73(2)3)137(223)172-99(51-54-239-13)136(222)179-107(63-114(157)199)146(232)188-122(79(10)193)125(158)211)187-144(230)104(57-82-27-17-15-18-28-82)177-135(221)98(46-50-118(205)206)170-132(218)93(33-23-25-52-153)166-127(213)77(8)163-126(212)76(7)164-131(217)96(43-47-113(156)198)169-134(220)97(45-49-117(203)204)171-142(228)108(64-119(207)208)180-138(224)101(56-74(4)5)174-139(225)102(59-84-35-39-88(196)40-36-84)176-133(219)94(34-24-26-53-154)167-148(234)111(70-191)184-140(226)103(60-85-37-41-89(197)42-38-85)178-143(229)109(65-120(209)210)181-149(235)112(71-192)185-152(238)124(81(12)195)189-145(231)105(58-83-29-19-16-20-30-83)182-151(237)123(80(11)194)186-115(200)68-161-130(216)95(44-48-116(201)202)168-147(233)110(69-190)183-129(215)91(155)62-87-67-159-72-162-87/h15-22,27-32,35-42,66-67,72-81,91,93-112,121-124,160,190-197H,14,23-26,33-34,43-65,68-71,153-155H2,1-13H3,(H2,156,198)(H2,157,199)(H2,158,211)(H,159,162)(H,161,216)(H,163,212)(H,164,217)(H,165,236)(H,166,213)(H,167,234)(H,168,233)(H,169,220)(H,170,218)(H,171,228)(H,172,223)(H,173,214)(H,174,225)(H,175,227)(H,176,219)(H,177,221)(H,178,229)(H,179,222)(H,180,224)(H,181,235)(H,182,237)(H,183,215)(H,184,226)(H,185,238)(H,186,200)(H,187,230)(H,188,232)(H,189,231)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,209,210)/t75-,76-,77-,78-,79+,80+,81+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.867 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459990
(CHEMBL4224968)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C170H260N42O52/c1-15-16-17-18-19-20-21-22-23-24-25-26-33-50-130(223)189-112(169(263)264)58-63-129(222)180-66-39-37-48-106(192-158(252)121(77-135(230)231)205-165(259)125(85-214)208-168(262)141(95(14)217)212-162(256)118(72-97-43-31-28-32-44-97)206-167(261)140(94(13)216)209-132(225)83-184-146(240)108(55-60-126(173)219)188-131(224)82-183-145(239)103(172)75-100-81-179-86-185-100)149(243)207-124(84-213)164(258)193-105(47-36-38-65-171)148(242)199-116(73-98-51-53-101(218)54-52-98)156(250)197-115(70-89(6)7)154(248)203-120(76-134(228)229)159(253)194-111(59-64-133(226)227)150(244)191-107(49-40-67-181-170(177)178)147(241)187-91(10)143(237)186-92(11)144(238)190-109(56-61-127(174)220)151(245)202-122(78-136(232)233)160(254)200-117(71-96-41-29-27-30-42-96)161(255)210-138(90(8)9)166(260)195-110(57-62-128(175)221)152(246)201-119(74-99-80-182-104-46-35-34-45-102(99)104)157(251)198-113(68-87(2)3)153(247)196-114(69-88(4)5)155(249)204-123(79-137(234)235)163(257)211-139(93(12)215)142(176)236/h27-32,34-35,41-46,51-54,80-81,86-95,103,105-125,138-141,182,213-218H,15-26,33,36-40,47-50,55-79,82-85,171-172H2,1-14H3,(H2,173,219)(H2,174,220)(H2,175,221)(H2,176,236)(H,179,185)(H,180,222)(H,183,239)(H,184,240)(H,186,237)(H,187,241)(H,188,224)(H,189,223)(H,190,238)(H,191,244)(H,192,252)(H,193,258)(H,194,253)(H,195,260)(H,196,247)(H,197,250)(H,198,251)(H,199,242)(H,200,254)(H,201,246)(H,202,245)(H,203,248)(H,204,249)(H,205,259)(H,206,261)(H,207,243)(H,208,262)(H,209,225)(H,210,255)(H,211,257)(H,212,256)(H,226,227)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H,263,264)(H4,177,178,181)/t91-,92-,93+,94+,95+,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,138-,139-,140-,141-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275598
(CHEMBL4126027)Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C206H325N53O61/c1-19-21-22-23-24-25-26-27-28-29-30-31-32-39-67-156(271)228-134(201(317)318)71-77-155(270)217-82-47-44-61-127(230-178(294)130(69-75-153(211)268)233-175(291)126(60-43-46-81-208)232-189(305)145(105-262)247-183(299)136(89-110(5)6)238-186(302)142(96-164(282)283)243-190(306)147(107-264)249-197(313)167(117(14)266)253-188(304)139(92-119-55-37-34-38-56-119)244-196(312)166(116(13)265)251-159(274)101-222-172(288)129(68-74-152(210)267)250-203(320)206(17,18)254-171(287)123(209)94-121-98-216-108-224-121)177(293)242-141(95-163(280)281)185(301)235-132(72-78-161(276)277)180(296)234-131(70-76-154(212)269)179(295)231-128(62-48-83-218-204(214)215)174(290)226-114(11)170(286)229-125(59-42-45-80-207)176(292)237-135(88-109(3)4)182(298)240-138(91-118-53-35-33-36-54-118)187(303)252-165(112(9)20-2)195(311)236-133(73-79-162(278)279)181(297)241-140(93-120-97-219-124-58-41-40-57-122(120)124)184(300)239-137(90-111(7)8)192(308)255-205(15,16)202(319)227-113(10)169(285)221-99-157(272)220-102-160(275)256-84-49-63-148(256)193(309)248-146(106-263)191(307)246-144(104-261)173(289)223-100-158(273)225-115(12)198(314)258-86-51-65-150(258)200(316)259-87-52-66-151(259)199(315)257-85-50-64-149(257)194(310)245-143(103-260)168(213)284/h33-38,40-41,53-58,97-98,108-117,123,125-151,165-167,219,260-266H,19-32,39,42-52,59-96,99-107,207-209H2,1-18H3,(H2,210,267)(H2,211,268)(H2,212,269)(H2,213,284)(H,216,224)(H,217,270)(H,220,272)(H,221,285)(H,222,288)(H,223,289)(H,225,273)(H,226,290)(H,227,319)(H,228,271)(H,229,286)(H,230,294)(H,231,295)(H,232,305)(H,233,291)(H,234,296)(H,235,301)(H,236,311)(H,237,292)(H,238,302)(H,239,300)(H,240,298)(H,241,297)(H,242,293)(H,243,306)(H,244,312)(H,245,310)(H,246,307)(H,247,299)(H,248,309)(H,249,313)(H,250,320)(H,251,274)(H,252,303)(H,253,304)(H,254,287)(H,255,308)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,317,318)(H4,214,215,218)/t112-,113-,114-,115-,116+,117+,123-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,165-,166-,167-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.16 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275564
(CHEMBL4128125)Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C204H320N56O65/c1-12-14-15-16-17-18-19-20-21-22-23-24-25-32-62-155(275)228-129(201(322)323)66-71-154(274)217-75-40-37-55-122(230-177(298)127(65-70-152(210)272)236-173(294)120(53-35-38-73-205)233-189(310)141(100-263)249-181(302)131(83-107(5)6)239-183(304)137(90-162(284)285)245-191(312)144(103-266)252-197(318)166(112(11)269)256-187(308)133(85-114-49-30-27-31-50-114)246-196(317)165(111(10)268)254-158(278)96-223-169(290)125(63-68-150(208)270)235-188(309)140(99-262)247-168(289)118(207)87-116-93-216-105-225-116)176(297)243-138(91-163(286)287)185(306)250-142(101-264)190(311)234-124(57-42-77-219-204(214)215)174(295)231-123(56-41-76-218-203(212)213)172(293)227-109(8)167(288)229-126(64-69-151(209)271)178(299)244-136(89-161(282)283)184(305)240-132(84-113-47-28-26-29-48-113)186(307)255-164(108(7)13-2)195(316)237-128(67-72-160(280)281)179(300)241-134(86-115-92-220-119-52-34-33-51-117(115)119)182(303)238-130(82-106(3)4)180(301)232-121(54-36-39-74-206)175(296)242-135(88-153(211)273)170(291)222-94-156(276)221-97-159(279)257-78-43-58-146(257)193(314)251-143(102-265)192(313)248-139(98-261)171(292)224-95-157(277)226-110(9)198(319)259-80-45-60-148(259)200(321)260-81-46-61-149(260)199(320)258-79-44-59-147(258)194(315)253-145(104-267)202(324)325/h26-31,33-34,47-52,92-93,105-112,118,120-149,164-166,220,261-269H,12-25,32,35-46,53-91,94-104,205-207H2,1-11H3,(H2,208,270)(H2,209,271)(H2,210,272)(H2,211,273)(H,216,225)(H,217,274)(H,221,276)(H,222,291)(H,223,290)(H,224,292)(H,226,277)(H,227,293)(H,228,275)(H,229,288)(H,230,298)(H,231,295)(H,232,301)(H,233,310)(H,234,311)(H,235,309)(H,236,294)(H,237,316)(H,238,303)(H,239,304)(H,240,305)(H,241,300)(H,242,296)(H,243,297)(H,244,299)(H,245,312)(H,246,317)(H,247,289)(H,248,313)(H,249,302)(H,250,306)(H,251,314)(H,252,318)(H,253,315)(H,254,278)(H,255,307)(H,256,308)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,322,323)(H,324,325)(H4,212,213,218)(H4,214,215,219)/t108-,109-,110-,111+,112+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,164-,165-,166-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.21 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459991
(CHEMBL4226185)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C171H262N42O52/c1-16-17-18-19-20-21-22-23-24-25-26-27-34-51-131(224)189-113(170(264)265)59-64-130(223)181-67-40-38-49-107(193-159(253)122(78-135(230)231)206-166(260)126(85-215)209-169(263)141(96(15)218)213-163(257)119(73-98-44-32-29-33-45-98)207-168(262)140(95(14)217)210-132(225)83-184-147(241)109(56-61-127(174)220)190-145(239)93(12)187-146(240)104(173)76-101-82-180-86-185-101)150(244)208-125(84-214)165(259)194-106(48-37-39-66-172)149(243)200-117(74-99-52-54-102(219)55-53-99)157(251)198-116(71-89(6)7)155(249)204-121(77-134(228)229)160(254)195-112(60-65-133(226)227)151(245)192-108(50-41-68-182-171(178)179)148(242)188-91(10)143(237)186-92(11)144(238)191-110(57-62-128(175)221)152(246)203-123(79-136(232)233)161(255)201-118(72-97-42-30-28-31-43-97)162(256)211-138(90(8)9)167(261)196-111(58-63-129(176)222)153(247)202-120(75-100-81-183-105-47-36-35-46-103(100)105)158(252)199-114(69-87(2)3)154(248)197-115(70-88(4)5)156(250)205-124(80-137(234)235)164(258)212-139(94(13)216)142(177)236/h28-33,35-36,42-47,52-55,81-82,86-96,104,106-126,138-141,183,214-219H,16-27,34,37-41,48-51,56-80,83-85,172-173H2,1-15H3,(H2,174,220)(H2,175,221)(H2,176,222)(H2,177,236)(H,180,185)(H,181,223)(H,184,241)(H,186,237)(H,187,240)(H,188,242)(H,189,224)(H,190,239)(H,191,238)(H,192,245)(H,193,253)(H,194,259)(H,195,254)(H,196,261)(H,197,248)(H,198,251)(H,199,252)(H,200,243)(H,201,255)(H,202,247)(H,203,246)(H,204,249)(H,205,250)(H,206,260)(H,207,262)(H,208,244)(H,209,263)(H,210,225)(H,211,256)(H,212,258)(H,213,257)(H,226,227)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H,264,265)(H4,178,179,182)/t91-,92-,93+,94+,95+,96+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,138-,139-,140-,141-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459984
(CHEMBL4225795)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C171H262N42O53/c1-15-16-17-18-19-20-21-22-23-24-25-26-33-50-131(225)188-112(170(265)266)58-63-130(224)181-66-39-37-48-106(191-158(253)121(77-135(231)232)205-166(261)126(85-216)209-169(264)141(95(14)219)213-162(257)118(72-97-43-31-28-32-44-97)206-168(263)140(94(13)218)210-132(226)82-184-146(241)108(55-60-127(174)221)193-164(259)124(83-214)207-145(240)103(173)75-100-81-180-86-185-100)149(244)208-125(84-215)165(260)192-105(47-36-38-65-172)148(243)199-116(73-98-51-53-101(220)54-52-98)156(251)197-115(70-89(6)7)154(249)203-120(76-134(229)230)159(254)194-111(59-64-133(227)228)150(245)190-107(49-40-67-182-171(178)179)147(242)187-91(10)143(238)186-92(11)144(239)189-109(56-61-128(175)222)151(246)202-122(78-136(233)234)160(255)200-117(71-96-41-29-27-30-42-96)161(256)211-138(90(8)9)167(262)195-110(57-62-129(176)223)152(247)201-119(74-99-80-183-104-46-35-34-45-102(99)104)157(252)198-113(68-87(2)3)153(248)196-114(69-88(4)5)155(250)204-123(79-137(235)236)163(258)212-139(93(12)217)142(177)237/h27-32,34-35,41-46,51-54,80-81,86-95,103,105-126,138-141,183,214-220H,15-26,33,36-40,47-50,55-79,82-85,172-173H2,1-14H3,(H2,174,221)(H2,175,222)(H2,176,223)(H2,177,237)(H,180,185)(H,181,224)(H,184,241)(H,186,238)(H,187,242)(H,188,225)(H,189,239)(H,190,245)(H,191,253)(H,192,260)(H,193,259)(H,194,254)(H,195,262)(H,196,248)(H,197,251)(H,198,252)(H,199,243)(H,200,255)(H,201,247)(H,202,246)(H,203,249)(H,204,250)(H,205,261)(H,206,263)(H,207,240)(H,208,244)(H,209,264)(H,210,226)(H,211,256)(H,212,258)(H,213,257)(H,227,228)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H,265,266)(H4,178,179,182)/t91-,92-,93+,94+,95+,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124+,125-,126-,138-,139-,140-,141-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459983
(CHEMBL4224701)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C172H264N42O52/c1-17-18-19-20-21-22-23-24-25-26-27-28-35-52-131(225)189-113(169(264)265)60-65-130(224)182-68-41-39-50-107(192-158(253)122(79-135(231)232)205-165(260)126(86-216)208-168(263)141(96(14)219)213-162(257)119(74-98-45-33-30-34-46-98)206-167(262)140(95(13)218)210-132(226)84-185-146(241)109(57-62-127(175)221)209-170(266)172(15,16)214-145(240)104(174)77-101-83-181-87-186-101)149(244)207-125(85-215)164(259)193-106(49-38-40-67-173)148(243)199-117(75-99-53-55-102(220)56-54-99)156(251)197-116(72-90(6)7)154(249)203-121(78-134(229)230)159(254)194-112(61-66-133(227)228)150(245)191-108(51-42-69-183-171(179)180)147(242)188-92(10)143(238)187-93(11)144(239)190-110(58-63-128(176)222)151(246)202-123(80-136(233)234)160(255)200-118(73-97-43-31-29-32-44-97)161(256)211-138(91(8)9)166(261)195-111(59-64-129(177)223)152(247)201-120(76-100-82-184-105-48-37-36-47-103(100)105)157(252)198-114(70-88(2)3)153(248)196-115(71-89(4)5)155(250)204-124(81-137(235)236)163(258)212-139(94(12)217)142(178)237/h29-34,36-37,43-48,53-56,82-83,87-96,104,106-126,138-141,184,215-220H,17-28,35,38-42,49-52,57-81,84-86,173-174H2,1-16H3,(H2,175,221)(H2,176,222)(H2,177,223)(H2,178,237)(H,181,186)(H,182,224)(H,185,241)(H,187,238)(H,188,242)(H,189,225)(H,190,239)(H,191,245)(H,192,253)(H,193,259)(H,194,254)(H,195,261)(H,196,248)(H,197,251)(H,198,252)(H,199,243)(H,200,255)(H,201,247)(H,202,246)(H,203,249)(H,204,250)(H,205,260)(H,206,262)(H,207,244)(H,208,263)(H,209,266)(H,210,226)(H,211,256)(H,212,258)(H,213,257)(H,214,240)(H,227,228)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H,264,265)(H4,179,180,183)/t92-,93-,94+,95+,96+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,138-,139-,140-,141-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275545
(CHEMBL4126953)Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C211H332N54O64/c1-19-21-22-23-24-25-26-27-28-29-30-31-32-39-67-159(277)233-137(206(326)327)72-79-160(278)234-136(205(324)325)71-78-158(276)222-84-47-44-61-129(236-182(301)132(69-76-156(216)274)239-179(298)128(60-43-46-83-213)238-193(312)148(107-268)253-187(306)139(91-112(5)6)244-190(309)145(98-168(289)290)249-194(313)150(109-270)255-201(320)171(119(14)272)259-192(311)142(94-121-55-37-34-38-56-121)250-200(319)170(118(13)271)257-163(281)103-227-176(295)131(68-75-155(215)273)256-208(329)211(17,18)260-175(294)125(214)96-123-100-221-110-229-123)181(300)248-144(97-167(287)288)189(308)241-134(73-80-165(283)284)184(303)240-133(70-77-157(217)275)183(302)237-130(62-48-85-223-209(219)220)178(297)231-116(11)174(293)235-127(59-42-45-82-212)180(299)243-138(90-111(3)4)186(305)246-141(93-120-53-35-33-36-54-120)191(310)258-169(114(9)20-2)199(318)242-135(74-81-166(285)286)185(304)247-143(95-122-99-224-126-58-41-40-57-124(122)126)188(307)245-140(92-113(7)8)196(315)261-210(15,16)207(328)232-115(10)173(292)226-101-161(279)225-104-164(282)262-86-49-63-151(262)197(316)254-149(108-269)195(314)252-147(106-267)177(296)228-102-162(280)230-117(12)202(321)264-88-51-65-153(264)204(323)265-89-52-66-154(265)203(322)263-87-50-64-152(263)198(317)251-146(105-266)172(218)291/h33-38,40-41,53-58,99-100,110-119,125,127-154,169-171,224,266-272H,19-32,39,42-52,59-98,101-109,212-214H2,1-18H3,(H2,215,273)(H2,216,274)(H2,217,275)(H2,218,291)(H,221,229)(H,222,276)(H,225,279)(H,226,292)(H,227,295)(H,228,296)(H,230,280)(H,231,297)(H,232,328)(H,233,277)(H,234,278)(H,235,293)(H,236,301)(H,237,302)(H,238,312)(H,239,298)(H,240,303)(H,241,308)(H,242,318)(H,243,299)(H,244,309)(H,245,307)(H,246,305)(H,247,304)(H,248,300)(H,249,313)(H,250,319)(H,251,317)(H,252,314)(H,253,306)(H,254,316)(H,255,320)(H,256,329)(H,257,281)(H,258,310)(H,259,311)(H,260,294)(H,261,315)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,324,325)(H,326,327)(H4,219,220,223)/t114-,115-,116-,117-,118+,119+,125-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,169-,170-,171-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.03 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275568
(CHEMBL4126738)Show SMILES CCCCCCCCCCCCCCCCC(=O)[C@H](CCN[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(N)=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C219H349N55O61/c1-19-21-22-23-24-25-26-27-28-29-30-31-32-39-75-164(280)133(213(330)331)88-95-232-147(214(332)333)79-85-168(284)233-93-51-46-67-139(245-189(306)142(77-83-166(226)282)248-186(303)138(66-44-49-91-222)247-201(318)157(116-276)261-194(311)149(102-120(5)6)254-197(314)155(109-175(294)295)259-202(319)158(117-277)263-208(325)178(127(14)279)267-199(316)152(105-129-60-37-34-38-61-129)260-207(324)177(126(13)278)265-170(286)113-238-184(301)141(76-82-165(225)281)264-216(335)219(17,18)268-183(300)134(224)107-131-111-231-118-239-131)188(305)258-154(108-174(292)293)196(313)250-144(80-86-172(288)289)191(308)249-143(78-84-167(227)283)190(307)246-140(69-52-94-234-217(229)230)185(302)240-124(11)181(298)244-137(65-43-48-90-221)187(304)253-148(101-119(3)4)193(310)256-151(104-128-58-35-33-36-59-128)198(315)266-176(122(9)20-2)206(323)251-145(81-87-173(290)291)192(309)257-153(106-130-110-235-135-63-41-40-62-132(130)135)195(312)255-150(103-121(7)8)203(320)269-218(15,16)215(334)242-123(10)180(297)237-112-169(285)236-114-171(287)270-96-55-72-161(270)210(327)271-97-54-71-160(271)205(322)262-156(115-275)200(317)241-125(12)182(299)252-146(68-45-50-92-223)209(326)273-99-56-73-162(273)212(329)274-100-57-74-163(274)211(328)272-98-53-70-159(272)204(321)243-136(179(228)296)64-42-47-89-220/h33-38,40-41,58-63,110-111,118-127,133-134,136-163,176-178,232,235,275-279H,19-32,39,42-57,64-109,112-117,220-224H2,1-18H3,(H2,225,281)(H2,226,282)(H2,227,283)(H2,228,296)(H,231,239)(H,233,284)(H,236,285)(H,237,297)(H,238,301)(H,240,302)(H,241,317)(H,242,334)(H,243,321)(H,244,298)(H,245,306)(H,246,307)(H,247,318)(H,248,303)(H,249,308)(H,250,313)(H,251,323)(H,252,299)(H,253,304)(H,254,314)(H,255,312)(H,256,310)(H,257,309)(H,258,305)(H,259,319)(H,260,324)(H,261,311)(H,262,322)(H,263,325)(H,264,335)(H,265,286)(H,266,315)(H,267,316)(H,268,300)(H,269,320)(H,288,289)(H,290,291)(H,292,293)(H,294,295)(H,330,331)(H,332,333)(H4,229,230,234)/t122-,123-,124-,125-,126+,127+,133-,134-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,176-,177-,178-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.03 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459982
(CHEMBL4226514)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C170H262N42O50S/c1-18-19-20-21-22-23-24-25-26-27-28-29-36-53-129(223)187-112(165(259)260)61-65-128(222)180-68-42-40-51-106(189-154(248)119(78-131(225)226)200-160(254)124(86-214)204-164(258)138(95(12)217)210-157(251)117(74-97-46-34-31-35-47-97)202-163(257)137(94(11)216)207-130(224)84-183-143(237)108(58-62-125(173)219)206-166(261)169(13,14)211-142(236)103(172)77-100-83-179-87-184-100)146(240)203-123(85-213)159(253)190-105(50-39-41-67-171)145(239)195-115(75-98-54-56-101(218)57-55-98)152(246)193-114(72-89(4)5)151(245)201-122(81-134(231)232)161(255)212-170(15,16)167(262)205-107(52-43-69-181-168(177)178)144(238)186-91(8)140(234)185-92(9)141(235)188-109(59-63-126(174)220)147(241)198-120(79-132(227)228)155(249)196-116(73-96-44-32-30-33-45-96)156(250)208-135(90(6)7)162(256)192-110(60-64-127(175)221)148(242)197-118(76-99-82-182-104-49-38-37-48-102(99)104)153(247)194-113(71-88(2)3)150(244)191-111(66-70-263-17)149(243)199-121(80-133(229)230)158(252)209-136(93(10)215)139(176)233/h30-35,37-38,44-49,54-57,82-83,87-95,103,105-124,135-138,182,213-218H,18-29,36,39-43,50-53,58-81,84-86,171-172H2,1-17H3,(H2,173,219)(H2,174,220)(H2,175,221)(H2,176,233)(H,179,184)(H,180,222)(H,183,237)(H,185,234)(H,186,238)(H,187,223)(H,188,235)(H,189,248)(H,190,253)(H,191,244)(H,192,256)(H,193,246)(H,194,247)(H,195,239)(H,196,249)(H,197,242)(H,198,241)(H,199,243)(H,200,254)(H,201,245)(H,202,257)(H,203,240)(H,204,258)(H,205,262)(H,206,261)(H,207,224)(H,208,250)(H,209,252)(H,210,251)(H,211,236)(H,212,255)(H,225,226)(H,227,228)(H,229,230)(H,231,232)(H,259,260)(H4,177,178,181)/t91-,92-,93+,94+,95+,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,135-,136-,137-,138-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459989
(CHEMBL4225340)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C170H262N40O51S/c1-15-17-18-19-20-21-22-23-24-25-26-27-34-52-132(222)186-115(170(260)261)59-64-131(221)179-70-42-39-51-109(188-159(249)124(81-137(230)231)202-166(256)127(87-213)206-169(259)141(97(13)216)210-162(252)120(75-99-45-32-29-33-46-99)203-168(258)140(96(12)215)207-133(223)84-181-147(237)110(57-62-128(174)218)190-164(254)125(85-211)204-146(236)105(173)78-102-83-178-88-182-102)151(241)205-126(86-212)165(255)189-108(50-38-41-69-172)150(240)198-118(76-100-53-55-103(217)56-54-100)157(247)196-117(73-90(5)6)156(246)201-123(80-136(228)229)160(250)193-112(60-65-134(224)225)152(242)191-111(58-63-129(175)219)148(238)184-92(8)143(233)183-93(9)144(234)187-107(49-37-40-68-171)149(239)192-113(61-66-135(226)227)153(243)199-119(74-98-43-30-28-31-44-98)161(251)208-138(91(7)16-2)167(257)185-94(10)145(235)195-121(77-101-82-180-106-48-36-35-47-104(101)106)158(248)197-116(72-89(3)4)155(245)194-114(67-71-262-14)154(244)200-122(79-130(176)220)163(253)209-139(95(11)214)142(177)232/h28-33,35-36,43-48,53-56,82-83,88-97,105,107-127,138-141,180,211-217H,15-27,34,37-42,49-52,57-81,84-87,171-173H2,1-14H3,(H2,174,218)(H2,175,219)(H2,176,220)(H2,177,232)(H,178,182)(H,179,221)(H,181,237)(H,183,233)(H,184,238)(H,185,257)(H,186,222)(H,187,234)(H,188,249)(H,189,255)(H,190,254)(H,191,242)(H,192,239)(H,193,250)(H,194,245)(H,195,235)(H,196,247)(H,197,248)(H,198,240)(H,199,243)(H,200,244)(H,201,246)(H,202,256)(H,203,258)(H,204,236)(H,205,241)(H,206,259)(H,207,223)(H,208,251)(H,209,253)(H,210,252)(H,224,225)(H,226,227)(H,228,229)(H,230,231)(H,260,261)/t91-,92-,93-,94-,95+,96+,97+,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125+,126-,127-,138-,139-,140-,141-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459993
(CHEMBL4229251)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C172H265N39O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-37-55-132(221)187-116(170(260)261)62-67-131(220)180-72-45-42-54-111(189-160(250)125(82-137(229)230)202-166(256)128(88-213)205-169(259)142(99(15)216)210-163(253)122(77-101-48-35-32-36-49-101)203-168(258)141(98(14)215)207-133(222)86-182-148(238)112(60-65-129(176)218)206-171(262)172(16,17)211-147(237)107(175)80-104-85-179-89-183-104)152(242)204-127(87-212)165(255)190-110(53-41-44-71-174)151(241)198-120(78-102-56-58-105(217)59-57-102)158(248)196-119(75-92(7)8)156(246)200-124(81-136(227)228)161(251)193-114(63-68-134(223)224)153(243)191-113(61-66-130(177)219)149(239)185-94(10)144(234)184-95(11)145(235)188-109(52-40-43-70-173)150(240)192-115(64-69-135(225)226)154(244)199-121(76-100-46-33-31-34-47-100)162(252)208-139(93(9)19-2)167(257)186-96(12)146(236)194-123(79-103-84-181-108-51-39-38-50-106(103)108)159(249)197-117(73-90(3)4)155(245)195-118(74-91(5)6)157(247)201-126(83-138(231)232)164(254)209-140(97(13)214)143(178)233/h31-36,38-39,46-51,56-59,84-85,89-99,107,109-128,139-142,181,212-217H,18-30,37,40-45,52-55,60-83,86-88,173-175H2,1-17H3,(H2,176,218)(H2,177,219)(H2,178,233)(H,179,183)(H,180,220)(H,182,238)(H,184,234)(H,185,239)(H,186,257)(H,187,221)(H,188,235)(H,189,250)(H,190,255)(H,191,243)(H,192,240)(H,193,251)(H,194,236)(H,195,245)(H,196,248)(H,197,249)(H,198,241)(H,199,244)(H,200,246)(H,201,247)(H,202,256)(H,203,258)(H,204,242)(H,205,259)(H,206,262)(H,207,222)(H,208,252)(H,209,254)(H,210,253)(H,211,237)(H,223,224)(H,225,226)(H,227,228)(H,229,230)(H,231,232)(H,260,261)/t93-,94-,95-,96-,97+,98+,99+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,139-,140-,141-,142-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459980
(CHEMBL4227861)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r| Show InChI InChI=1S/C158H228N40O47S/c1-14-79(7)126(155(242)172-81(9)132(219)180-110(62-89-68-168-96-33-23-22-32-94(89)96)145(232)182-104(56-77(3)4)141(228)179-103(52-55-246-13)139(226)186-112(65-120(163)209)151(238)197-128(82(10)202)131(164)218)196-149(236)108(58-85-28-18-16-19-29-85)184-138(225)102(47-51-123(212)213)176-135(222)98-35-25-27-54-167-121(210)50-46-101(140(227)195-127(80(8)15-2)156(243)190-111(64-91-70-166-76-171-91)146(233)177-100(137(224)173-98)45-49-119(162)208)178-147(234)113(66-124(214)215)187-142(229)105(57-78(5)6)181-143(230)106(60-87-36-40-92(205)41-37-87)183-136(223)97(34-24-26-53-159)174-153(240)116(73-200)192-144(231)107(61-88-38-42-93(206)43-39-88)185-148(235)114(67-125(216)217)188-154(241)117(74-201)193-158(245)130(84(12)204)198-150(237)109(59-86-30-20-17-21-31-86)189-157(244)129(83(11)203)194-122(211)71-169-134(221)99(44-48-118(161)207)175-152(239)115(72-199)191-133(220)95(160)63-90-69-165-75-170-90/h16-23,28-33,36-43,68-70,75-84,95,97-117,126-130,168,199-206H,14-15,24-27,34-35,44-67,71-74,159-160H2,1-13H3,(H2,161,207)(H2,162,208)(H2,163,209)(H2,164,218)(H,165,170)(H,166,171)(H,167,210)(H,169,221)(H,172,242)(H,173,224)(H,174,240)(H,175,239)(H,176,222)(H,177,233)(H,178,234)(H,179,228)(H,180,219)(H,181,230)(H,182,232)(H,183,223)(H,184,225)(H,185,235)(H,186,226)(H,187,229)(H,188,241)(H,189,244)(H,190,243)(H,191,220)(H,192,231)(H,193,245)(H,194,211)(H,195,227)(H,196,236)(H,197,238)(H,198,237)(H,212,213)(H,214,215)(H,216,217)/t79-,80-,81-,82+,83+,84+,95-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-,129-,130-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459985
(CHEMBL4226451)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)CN(C)C(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C171H262N42O52/c1-16-17-18-19-20-21-22-23-24-25-26-27-34-51-131(224)189-113(170(264)265)59-64-130(223)181-67-40-38-49-107(192-158(252)122(78-136(231)232)205-165(259)126(86-215)208-168(262)142(96(14)218)212-162(256)119(73-98-44-32-29-33-45-98)206-167(261)141(95(13)217)209-132(225)83-184-146(240)109(56-61-127(174)220)188-133(226)84-213(15)169(263)104(173)76-101-82-180-87-185-101)149(243)207-125(85-214)164(258)193-106(48-37-39-66-172)148(242)199-117(74-99-52-54-102(219)55-53-99)156(250)197-116(71-90(6)7)154(248)203-121(77-135(229)230)159(253)194-112(60-65-134(227)228)150(244)191-108(50-41-68-182-171(178)179)147(241)187-92(10)144(238)186-93(11)145(239)190-110(57-62-128(175)221)151(245)202-123(79-137(233)234)160(254)200-118(72-97-42-30-28-31-43-97)161(255)210-139(91(8)9)166(260)195-111(58-63-129(176)222)152(246)201-120(75-100-81-183-105-47-36-35-46-103(100)105)157(251)198-114(69-88(2)3)153(247)196-115(70-89(4)5)155(249)204-124(80-138(235)236)163(257)211-140(94(12)216)143(177)237/h28-33,35-36,42-47,52-55,81-82,87-96,104,106-126,139-142,183,214-219H,16-27,34,37-41,48-51,56-80,83-86,172-173H2,1-15H3,(H2,174,220)(H2,175,221)(H2,176,222)(H2,177,237)(H,180,185)(H,181,223)(H,184,240)(H,186,238)(H,187,241)(H,188,226)(H,189,224)(H,190,239)(H,191,244)(H,192,252)(H,193,258)(H,194,253)(H,195,260)(H,196,247)(H,197,250)(H,198,251)(H,199,242)(H,200,254)(H,201,246)(H,202,245)(H,203,248)(H,204,249)(H,205,259)(H,206,261)(H,207,243)(H,208,262)(H,209,225)(H,210,255)(H,211,257)(H,212,256)(H,227,228)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H,264,265)(H4,178,179,182)/t92-,93-,94+,95+,96+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,139-,140-,141-,142-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459988
(CHEMBL4227045)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r| Show InChI InChI=1S/C152H220N38O47S/c1-14-75(6)121(150(235)166-78(9)128(213)174-106(61-86-66-161-92-32-22-21-31-90(86)92)141(226)176-100(55-73(2)3)137(222)173-99(51-54-238-13)136(221)180-107(63-115(157)201)146(231)189-122(79(10)194)125(158)210)188-144(229)104(57-82-27-17-15-18-28-82)178-135(220)98(46-50-118(204)205)171-132(217)93-34-24-26-53-160-116(202)49-45-97(134(219)170-96(44-48-114(156)200)131(216)165-76(7)126(211)164-77(8)127(212)167-93)172-142(227)108(64-119(206)207)181-138(223)101(56-74(4)5)175-139(224)102(59-84-35-39-88(197)40-36-84)177-133(218)94(33-23-25-52-153)168-148(233)111(70-192)185-140(225)103(60-85-37-41-89(198)42-38-85)179-143(228)109(65-120(208)209)182-149(234)112(71-193)186-152(237)124(81(12)196)190-145(230)105(58-83-29-19-16-20-30-83)183-151(236)123(80(11)195)187-117(203)68-162-130(215)95(43-47-113(155)199)169-147(232)110(69-191)184-129(214)91(154)62-87-67-159-72-163-87/h15-22,27-32,35-42,66-67,72-81,91,93-112,121-124,161,191-198H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,199)(H2,156,200)(H2,157,201)(H2,158,210)(H,159,163)(H,160,202)(H,162,215)(H,164,211)(H,165,216)(H,166,235)(H,167,212)(H,168,233)(H,169,232)(H,170,219)(H,171,217)(H,172,227)(H,173,222)(H,174,213)(H,175,224)(H,176,226)(H,177,218)(H,178,220)(H,179,228)(H,180,221)(H,181,223)(H,182,234)(H,183,236)(H,184,214)(H,185,225)(H,186,237)(H,187,203)(H,188,229)(H,189,231)(H,190,230)(H,204,205)(H,206,207)(H,208,209)/t75-,76-,77-,78-,79+,80+,81+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50459987
(CHEMBL4226613)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r| Show InChI InChI=1S/C152H222N38O48S/c1-14-75(6)121(150(236)166-78(9)128(214)174-106(61-86-66-161-92-32-22-21-31-90(86)92)141(227)176-100(55-73(2)3)137(223)173-99(51-54-239-13)136(222)180-107(63-115(158)201)146(232)189-122(79(10)194)125(159)211)188-144(230)104(57-82-27-17-15-18-28-82)178-135(221)98(46-50-118(205)206)171-132(218)93(33-23-25-52-153)167-127(213)77(8)164-126(212)76(7)165-131(217)96(44-48-114(157)200)170-134(220)97(45-49-117(203)204)172-142(228)108(64-119(207)208)181-138(224)101(56-74(4)5)175-139(225)102(59-84-35-39-88(197)40-36-84)177-133(219)94(34-24-26-53-154)168-148(234)111(70-192)185-140(226)103(60-85-37-41-89(198)42-38-85)179-143(229)109(65-120(209)210)182-149(235)112(71-193)186-152(238)124(81(12)196)190-145(231)105(58-83-29-19-16-20-30-83)183-151(237)123(80(11)195)187-116(202)68-162-130(216)95(43-47-113(156)199)169-147(233)110(69-191)184-129(215)91(155)62-87-67-160-72-163-87/h15-22,27-32,35-42,66-67,72-81,91,93-112,121-124,161,191-198H,14,23-26,33-34,43-65,68-71,153-155H2,1-13H3,(H2,156,199)(H2,157,200)(H2,158,201)(H2,159,211)(H,160,163)(H,162,216)(H,164,212)(H,165,217)(H,166,236)(H,167,213)(H,168,234)(H,169,233)(H,170,220)(H,171,218)(H,172,228)(H,173,223)(H,174,214)(H,175,225)(H,176,227)(H,177,219)(H,178,221)(H,179,229)(H,180,222)(H,181,224)(H,182,235)(H,183,237)(H,184,215)(H,185,226)(H,186,238)(H,187,202)(H,188,230)(H,189,232)(H,190,231)(H,203,204)(H,205,206)(H,207,208)(H,209,210)/t75-,76-,77-,78-,79+,80+,81+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a |
Novo Nordisk Research Center Indianapolis
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as increase in cAMP level after 5 hrs by CRE driven luciferase reporter gen... |
Bioorg Med Chem 26: 2873-2881 (2018)
Article DOI: 10.1016/j.bmc.2017.10.047
BindingDB Entry DOI: 10.7270/Q2FN18TN |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50597204
(CHEMBL5196841)Show SMILES Cl.Cl.COc1ccc2[C@@H](C)N(CCc2c1-c1cc(F)c(O)c(NCC(C)C)c1)C(C)c1ccc(cc1)C(C)C |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00220
BindingDB Entry DOI: 10.7270/Q2M90DQP |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50597205
(CHEMBL5184469)Show SMILES COc1ccc2[C@@H](C)N(CCc2c1-c1cc(C)c(O)c(F)c1)C(C)c1ccc(cc1)C(C)C |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00220
BindingDB Entry DOI: 10.7270/Q2M90DQP |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275569
(CHEMBL4130148)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C184H285N51O57/c1-20-94(10)144(174(285)211-114(55-60-141(252)253)159(270)217-121(74-102-78-196-106-43-28-27-42-104(102)106)163(274)215-118(71-93(8)9)171(282)231-183(16,17)180(291)204-95(11)148(259)198-80-136(246)197-83-139(249)232-64-34-47-129(232)172(283)224-127(87-239)170(281)222-125(85-237)152(263)200-81-137(247)202-97(13)177(288)234-66-36-49-131(234)179(290)235-67-37-50-132(235)178(289)233-65-35-48-130(233)173(284)221-124(84-236)147(191)258)228-166(277)119(72-100-38-23-21-24-39-100)216-160(271)115(68-90(2)3)212-155(266)107(44-29-31-61-185)205-149(260)96(12)203-153(264)109(46-33-63-195-182(192)193)206-156(267)111(52-57-134(189)244)209-157(268)113(54-59-140(250)251)210-164(275)122(76-142(254)255)218-161(272)116(69-91(4)5)213-158(269)112(53-58-135(190)245)208-154(265)108(45-30-32-62-186)207-168(279)126(86-238)223-162(273)117(70-92(6)7)214-165(276)123(77-143(256)257)219-169(280)128(88-240)225-176(287)146(99(15)242)229-167(278)120(73-101-40-25-22-26-41-101)220-175(286)145(98(14)241)227-138(248)82-199-151(262)110(51-56-133(188)243)226-181(292)184(18,19)230-150(261)105(187)75-103-79-194-89-201-103/h21-28,38-43,78-79,89-99,105,107-132,144-146,196,236-242H,20,29-37,44-77,80-88,185-187H2,1-19H3,(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,258)(H,194,201)(H,197,246)(H,198,259)(H,199,262)(H,200,263)(H,202,247)(H,203,264)(H,204,291)(H,205,260)(H,206,267)(H,207,279)(H,208,265)(H,209,268)(H,210,275)(H,211,285)(H,212,266)(H,213,269)(H,214,276)(H,215,274)(H,216,271)(H,217,270)(H,218,272)(H,219,280)(H,220,286)(H,221,284)(H,222,281)(H,223,273)(H,224,283)(H,225,287)(H,226,292)(H,227,248)(H,228,277)(H,229,278)(H,230,261)(H,231,282)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H4,192,193,195)/t94-,95-,96-,97-,98+,99+,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,144-,145-,146-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 114 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275546
(CHEMBL4130044)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C184H286N52O57/c1-18-94(8)144(174(286)213-115(56-61-141(253)254)160(272)218-121(75-102-79-197-106-43-26-25-42-104(102)106)163(275)216-118(72-93(6)7)171(283)232-183(14,15)180(292)205-95(9)148(260)199-81-136(247)198-84-139(250)233-66-34-48-129(233)172(284)225-127(88-240)170(282)223-125(86-238)152(264)201-82-137(248)203-97(11)177(289)235-68-36-50-131(235)179(291)236-69-37-51-132(236)178(290)234-67-35-49-130(234)173(285)222-124(85-237)147(192)259)229-166(278)119(73-100-38-21-19-22-39-100)217-161(273)116(70-91(2)3)214-155(267)107(44-27-30-62-185)206-149(261)96(10)204-153(265)110(47-33-65-196-182(193)194)208-158(270)113(54-59-135(191)246)211-159(271)114(55-60-140(251)252)212-164(276)122(77-142(255)256)219-156(268)109(46-29-32-64-187)207-157(269)112(53-58-134(190)245)210-154(266)108(45-28-31-63-186)209-168(280)126(87-239)224-162(274)117(71-92(4)5)215-165(277)123(78-143(257)258)220-169(281)128(89-241)226-176(288)146(99(13)243)230-167(279)120(74-101-40-23-20-24-41-101)221-175(287)145(98(12)242)228-138(249)83-200-151(263)111(52-57-133(189)244)227-181(293)184(16,17)231-150(262)105(188)76-103-80-195-90-202-103/h19-26,38-43,79-80,90-99,105,107-132,144-146,197,237-243H,18,27-37,44-78,81-89,185-188H2,1-17H3,(H2,189,244)(H2,190,245)(H2,191,246)(H2,192,259)(H,195,202)(H,198,247)(H,199,260)(H,200,263)(H,201,264)(H,203,248)(H,204,265)(H,205,292)(H,206,261)(H,207,269)(H,208,270)(H,209,280)(H,210,266)(H,211,271)(H,212,276)(H,213,286)(H,214,267)(H,215,277)(H,216,275)(H,217,273)(H,218,272)(H,219,268)(H,220,281)(H,221,287)(H,222,285)(H,223,282)(H,224,274)(H,225,284)(H,226,288)(H,227,293)(H,228,249)(H,229,278)(H,230,279)(H,231,262)(H,232,283)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H4,193,194,196)/t94-,95-,96-,97-,98+,99+,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,144-,145-,146-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 177 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50241203
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)Show SMILES [H][C@](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275566
(CHEMBL4128276)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C149H225N39O46/c1-17-76(10)119(145(230)166-80(14)125(210)174-104(60-86-63-158-91-36-25-24-35-89(86)91)135(220)176-100(56-73(4)5)136(221)185-117(74(6)7)143(228)173-92(37-26-28-52-150)127(212)159-66-111(197)168-98(148(233)234)39-30-54-157-149(154)155)187-137(222)102(57-83-31-20-18-21-32-83)177-132(217)97(47-51-115(203)204)172-131(216)93(38-27-29-53-151)169-123(208)78(12)163-122(207)77(11)165-130(215)96(44-48-109(153)195)167-110(196)65-160-129(214)95(46-50-114(201)202)171-133(218)99(55-72(2)3)175-134(219)101(59-85-40-42-88(194)43-41-85)178-140(225)106(68-189)181-142(227)108(70-191)182-144(229)118(75(8)9)186-139(224)105(62-116(205)206)179-141(226)107(69-190)183-147(232)121(82(16)193)188-138(223)103(58-84-33-22-19-23-34-84)180-146(231)120(81(15)192)184-112(198)67-161-128(213)94(45-49-113(199)200)170-124(209)79(13)164-126(211)90(152)61-87-64-156-71-162-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,158,189-194H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,195)(H,156,162)(H,159,212)(H,160,214)(H,161,213)(H,163,207)(H,164,211)(H,165,215)(H,166,230)(H,167,196)(H,168,197)(H,169,208)(H,170,209)(H,171,218)(H,172,216)(H,173,228)(H,174,210)(H,175,219)(H,176,220)(H,177,217)(H,178,225)(H,179,226)(H,180,231)(H,181,227)(H,182,229)(H,183,232)(H,184,198)(H,185,221)(H,186,224)(H,187,222)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,233,234)(H4,154,155,157)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275565
(CHEMBL4125912)Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C173H267N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-31-38-54-130(225)196-117(171(266)267)60-65-129(224)181-69-42-41-51-112(154(249)200-116(63-68-136(233)234)155(250)205-121(74-101-45-34-32-35-46-101)160(255)215-141(94(11)19-2)168(263)193-98(15)147(242)202-123(77-104-80-184-109-50-40-39-49-107(104)109)158(253)204-119(73-91(5)6)159(254)213-139(92(7)8)166(261)201-111(53-44-71-183-173(178)179)150(245)185-82-131(226)194-110(52-43-70-182-172(176)177)149(244)188-85-138(237)238)197-145(240)96(13)190-144(239)95(12)192-153(248)115(59-64-128(175)223)195-132(227)83-186-152(247)114(62-67-135(231)232)199-156(251)118(72-90(3)4)203-157(252)120(76-103-55-57-106(222)58-56-103)206-163(258)125(86-217)209-165(260)127(88-219)210-167(262)140(93(9)10)214-162(257)124(79-137(235)236)207-164(259)126(87-218)211-170(265)143(100(17)221)216-161(256)122(75-102-47-36-33-37-48-102)208-169(264)142(99(16)220)212-133(228)84-187-151(246)113(61-66-134(229)230)198-146(241)97(14)191-148(243)108(174)78-105-81-180-89-189-105/h32-37,39-40,45-50,55-58,80-81,89-100,108,110-127,139-143,184,217-222H,18-31,38,41-44,51-54,59-79,82-88,174H2,1-17H3,(H2,175,223)(H,180,189)(H,181,224)(H,185,245)(H,186,247)(H,187,246)(H,188,244)(H,190,239)(H,191,243)(H,192,248)(H,193,263)(H,194,226)(H,195,227)(H,196,225)(H,197,240)(H,198,241)(H,199,251)(H,200,249)(H,201,261)(H,202,242)(H,203,252)(H,204,253)(H,205,250)(H,206,258)(H,207,259)(H,208,264)(H,209,260)(H,210,262)(H,211,265)(H,212,228)(H,213,254)(H,214,257)(H,215,255)(H,216,256)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H,237,238)(H,266,267)(H4,176,177,182)(H4,178,179,183)/t94-,95-,96-,97-,98-,99+,100+,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,139-,140-,141-,142-,143-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50275578
(CHEMBL4128112)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(N)=O |r| Show InChI InChI=1S/C143H223N37O44S2/c1-15-74(10)115(140(221)163-89(42-46-112(191)192)126(207)169-95(58-80-61-150-83-32-20-19-31-81(80)83)132(213)167-90(53-70(2)3)128(209)156-76(12)118(199)155-75(11)117(198)152-62-108(186)151-64-110(188)177-49-25-35-102(177)138(219)173-99(67-183)136(217)171-97(65-181)121(202)153-63-109(187)154-78(14)141(222)179-51-27-37-104(179)143(224)180-52-28-38-105(180)142(223)178-50-26-36-103(178)139(220)174-100(68-225)116(149)197)176-134(215)94(57-79-29-17-16-18-30-79)168-129(210)92(55-72(6)7)165-123(204)84(33-21-23-47-144)158-119(200)77(13)157-137(218)101(69-226)175-127(208)87(40-44-107(148)185)161-124(205)88(41-45-111(189)190)162-133(214)96(60-114(195)196)170-130(211)93(56-73(8)9)166-125(206)86(39-43-106(147)184)160-122(203)85(34-22-24-48-145)159-135(216)98(66-182)172-131(212)91(54-71(4)5)164-120(201)82(146)59-113(193)194/h16-20,29-32,61,70-78,82,84-105,115,150,181-183,225-226H,15,21-28,33-60,62-69,144-146H2,1-14H3,(H2,147,184)(H2,148,185)(H2,149,197)(H,151,186)(H,152,198)(H,153,202)(H,154,187)(H,155,199)(H,156,209)(H,157,218)(H,158,200)(H,159,216)(H,160,203)(H,161,205)(H,162,214)(H,163,221)(H,164,201)(H,165,204)(H,166,206)(H,167,213)(H,168,210)(H,169,207)(H,170,211)(H,171,217)(H,172,212)(H,173,219)(H,174,220)(H,175,208)(H,176,215)(H,189,190)(H,191,192)(H,193,194)(H,195,196)/t74-,75-,76-,77-,78-,82-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,115-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
Gastric inhibitory polypeptide receptor
(Homo sapiens (Human)) | BDBM50266693
(CHEBI:5391 | Glucagen Hypokit | Glucagon | Glucago...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 61: 5580-5593 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR |
More data for this
Ligand-Target Pair | |
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