Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA polymerase iota (Homo sapiens (Human)) | BDBM4078 (6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Health Center Curated by ChEMBL | Assay Description Inhibition of human recombinant DNA polymerase iota expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at ... | J Med Chem 59: 9321-9336 (2016) BindingDB Entry DOI: 10.7270/Q2ZC84TJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase iota (Homo sapiens (Human)) | BDBM60996 (5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Health Center Curated by ChEMBL | Assay Description Inhibition of human recombinant DNA polymerase iota expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at ... | J Med Chem 59: 9321-9336 (2016) BindingDB Entry DOI: 10.7270/Q2ZC84TJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase iota (Homo sapiens (Human)) | BDBM50318907 (2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Health Center Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase iota preincubated for 15 mins followed by replicating non-damaged DNA substrate addition measured after 30 mins in... | J Med Chem 59: 9321-9336 (2016) BindingDB Entry DOI: 10.7270/Q2ZC84TJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase iota (Homo sapiens (Human)) | BDBM50428818 (CHEMBL3142662) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kobe Gakuin University Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase iota using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins | Bioorg Med Chem 21: 403-11 (2012) Article DOI: 10.1016/j.bmc.2012.11.024 BindingDB Entry DOI: 10.7270/Q2833TC4 | |||||||||||
More data for this Ligand-Target Pair |