| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase iota |
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| Ligand | BDBM50318907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1612844 (CHEMBL3854644) |
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| IC50 | 6200±n/a nM |
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| Citation |  Korzhnev, DM; Hadden, MK Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics. J Med Chem59:9321-9336 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase iota |
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| Name: | DNA polymerase iota |
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| Synonyms: | DNA polymerase iota | Eta2 | POLI | POLI_HUMAN | RAD30 homolog B | RAD30B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82997.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_100972 |
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| Residue: | 740 |
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| Sequence: | MEKLGVEPEEEGGGDDDEEDAEAWAMELADVGAAASSQGVHDQVLPTPNASSRVIVHVDL
DCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVN
GEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSG
HVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKP
NQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQD
GRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMV
NVKMPFHLTLLSVCFCNLKALNTAKKGLIDYYLMPSLSTTSRSGKHSFKMKDTHMEDFPK
DKETNRDFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLCSLPEGVDQEVFKQLPVDIQ
EEILSGKSREKFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRDHLSSSKQVSSVSPC
EPGTSGFNSSSSSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSFP
NLQSEQLFSRNHTTDSHKQTVATDSHEGLTENREPDSVDEKITFPSDIDPQVFYELPEAV
QKELLAEWKRAGSDFHIGHK
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| BDBM50318907 |
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| n/a |
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| Name | BDBM50318907 |
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| Synonyms: | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester | 2-Ethoxy-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester | Amias | Atacand | Blopress | CANDESARTAN CILEXETIL | CHEMBL1014 | Candesartan | Kenzen | Parapres | TCV-116 | candesartancilexetil |
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| Type | Small organic molecule |
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| Emp. Form. | C33H34N6O6 |
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| Mol. Mass. | 610.6597 |
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| SMILES | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |
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| Structure | 
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