Found 502 hits of ec50 for UniProtKB: P21912 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231814
(CHEMBL4078870 | US11725000, Compound 289)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)NC23CC4CC(CC(C4)C2)C3)C(F)(F)F)cc1OC |TLB:28:29:32.31.36:34,THB:30:31:34:38.29.37,30:29:32.31.36:34,37:29:32:36.35.34,37:35:32:38.30.29,28:29:32:36.35.34| Show InChI InChI=1S/C33H37F3N4O6S/c1-45-26-7-5-20(13-27(26)46-2)18-40-19-24(6-8-30(40)42)25-14-28(33(34,35)36)38-31(37-25)47(43,44)9-3-4-29(41)39-32-15-21-10-22(16-32)12-23(11-21)17-32/h5-8,13-14,19,21-23H,3-4,9-12,15-18H2,1-2H3,(H,39,41) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing tBid assessed as reduction in apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231814
(CHEMBL4078870 | US11725000, Compound 289)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)NC23CC4CC(CC(C4)C2)C3)C(F)(F)F)cc1OC |TLB:28:29:32.31.36:34,THB:30:31:34:38.29.37,30:29:32.31.36:34,37:29:32:36.35.34,37:35:32:38.30.29,28:29:32:36.35.34| Show InChI InChI=1S/C33H37F3N4O6S/c1-45-26-7-5-20(13-27(26)46-2)18-40-19-24(6-8-30(40)42)25-14-28(33(34,35)36)38-31(37-25)47(43,44)9-3-4-29(41)39-32-15-21-10-22(16-32)12-23(11-21)17-32/h5-8,13-14,19,21-23H,3-4,9-12,15-18H2,1-2H3,(H,39,41) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231783
(CHEMBL4078220 | US11725000, Compound 155)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)N2CCCCC2)C(F)(F)F)cc1OC Show InChI InChI=1S/C28H31F3N4O6S/c1-40-22-10-8-19(15-23(22)41-2)17-35-18-20(9-11-26(35)37)21-16-24(28(29,30)31)33-27(32-21)42(38,39)14-6-7-25(36)34-12-4-3-5-13-34/h8-11,15-16,18H,3-7,12-14,17H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613029
(US11725000, Compound 291)Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)(=O)CCC(OCc1ccccc1)c1ccccc1)-c1cccs1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613071
(US11725000, Compound 334)Show SMILES Cc1cc(nc(n1)S(C)(=O)=O)-c1cc(F)c(=O)n(Cc2ccc3OCOc3c2)c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613028
(US11725000, Compound 290)Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)CCC(OCc1ccccc1)c1ccccc1)-c1cccs1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613062
(US11725000, Compound 325)Show SMILES Cc1cc(nc(n1)S(=O)(=O)CCC(OCc1ccccc1F)c1ccccc1)-c1c[nH]c(=O)c(F)c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613061
(US11725000, Compound 324)Show SMILES COc1ccc(Cn2cc(cc(F)c2=O)-c2cc(C)nc(n2)S(C)(=O)=O)cc1OC | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613053
(US11725000, Compound 316)Show SMILES Cc1cc(nc(n1)S(=O)(=O)CCC(OCc1ccc(F)cc1F)c1ccccc1)-c1cc(F)c(=O)n(Cc2ccc(Cl)c(Cl)c2)c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613050
(US11725000, Compound 313)Show SMILES Cc1cc(nc(n1)S(=O)CCC(OCc1ccc(F)cc1F)c1ccccc1)-c1cc(F)c(=O)n(CC2CCOCC2)c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613047
(US11725000, Compound 310)Show SMILES CCOc1cccc(Cn2cc(cc(F)c2=O)-c2cc(C)nc(n2)S(=O)CCC(OCc2ccc(F)cc2F)c2ccccc2)c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613046
(US11725000, Compound 309)Show SMILES Cc1cc(nc(n1)S(=O)(=O)CCC(OCc1ccc(F)cc1F)c1ccccc1)-c1cc(F)c(=O)n(CC2CCCCC2)c1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613039
(US11725000, Compound 301)Show SMILES COc1ccc(Cn2cc(cc(F)c2=O)-c2nc(nc3sccc23)S(=O)CCC(OCc2ccccc2F)c2ccccc2)cc1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613034
(US11725000, Compound 296)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)-c2ccccc2F)cc1OC | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613030
(US11725000, Compound 292)Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)(=O)CCC(Cl)c1ccccc1)-c1cccs1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613011
(US11725000, Compound 273)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCO)C(F)F)cc1OC | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM612765
(US11725000, Compound 27)Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)CCc1ccccc1)-c1cccs1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231789
(CHEMBL4091379 | US11725000, Compound 127)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)cc1OC Show InChI InChI=1S/C20H18F3N3O5S/c1-30-15-6-4-12(8-16(15)31-2)10-26-11-13(5-7-18(26)27)14-9-17(20(21,22)23)25-19(24-14)32(3,28)29/h4-9,11H,10H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231785
(CHEMBL4064603 | US11725000, Compound 152)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)N2CCCC2)C(F)(F)F)cc1OC Show InChI InChI=1S/C27H29F3N4O6S/c1-39-21-9-7-18(14-22(21)40-2)16-34-17-19(8-10-25(34)36)20-15-23(27(28,29)30)32-26(31-20)41(37,38)13-5-6-24(35)33-11-3-4-12-33/h7-10,14-15,17H,3-6,11-13,16H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231795
(CHEMBL4070501 | US11725000, Compound 109)Show SMILES COc1cccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)c1 Show InChI InChI=1S/C19H16F3N3O4S/c1-29-14-5-3-4-12(8-14)10-25-11-13(6-7-17(25)26)15-9-16(19(20,21)22)24-18(23-15)30(2,27)28/h3-9,11H,10H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 57 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM612761
(US11725000, Compound 23)Show SMILES [O-][n+]1cccc2cc(CS(=O)(=O)c3nc(cc(n3)C(F)(F)F)-c3cccs3)ccc12 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 57 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM612770
(US11725000, Compound 32)Show SMILES COC(=O)CCCS(=O)c1nc(cc(n1)C(F)(F)F)-c1cccs1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM612759
(US11725000, Compound 21)Show SMILES O[N+]1(CCNCC1)c1ccc(CS(=O)c2nc(cc(n2)C(F)(F)F)-c2cccs2)cc1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 66 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231821
(CHEMBL4061878 | US11725000, Compound 106)Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(Cl)cc2)c1 Show InChI InChI=1S/C18H13ClF3N3O3S/c1-29(27,28)17-23-14(8-15(24-17)18(20,21)22)12-4-7-16(26)25(10-12)9-11-2-5-13(19)6-3-11/h2-8,10H,9H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 66 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231820
(CHEMBL4092330 | US11725000, Compound 113)Show SMILES CCCOc1cccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)c1 Show InChI InChI=1S/C21H20F3N3O4S/c1-3-9-31-16-6-4-5-14(10-16)12-27-13-15(7-8-19(27)28)17-11-18(21(22,23)24)26-20(25-17)32(2,29)30/h4-8,10-11,13H,3,9,12H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 69 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM612763
(US11725000, Compound 25)Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)CCN1CCCC1=O)-c1cccs1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 69 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231825
(CHEMBL4090123 | US11725000, Compound 26)Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)(=O)CCc1ccccc1)-c1cccs1 Show InChI InChI=1S/C17H13F3N2O2S2/c18-17(19,20)15-11-13(14-7-4-9-25-14)21-16(22-15)26(23,24)10-8-12-5-2-1-3-6-12/h1-7,9,11H,8,10H2 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | n/a | n/a | 94 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231793
(CHEMBL4082074 | US11725000, Compound 110)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)cc1 Show InChI InChI=1S/C19H16F3N3O4S/c1-29-14-6-3-12(4-7-14)10-25-11-13(5-8-17(25)26)15-9-16(19(20,21)22)24-18(23-15)30(2,27)28/h3-9,11H,10H2,1-2H3 | PDB
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| n/a | n/a | n/a | n/a | 94 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613012
(US11725000, Compound 274)Show SMILES COc1ccc(OC2CCCN(C2)c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)cc1OC | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613013
(US11725000, Compound 275)Show SMILES COc1ccc(Cn2cc(ccc2=O)C2=C[C](=O)=[N](C)C(=N2)S(C)(=O)=O)cc1OC |c:21,t:15| | PDB
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| | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613065
(US11725000, Compound 328)Show SMILES Cc1cc(nc(n1)S(=O)(=O)CCC(OCc1ccccc1F)c1ccccc1)-c1cnc(OCc2ccc3n(C)ncc3c2)c(F)c1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613052
(US11725000, Compound 315)Show SMILES Cc1cc(nc(n1)S(=O)CCC(OCc1ccc(F)cc1F)c1ccccc1)-c1cc(F)c(=O)n(Cc2ccc(Cl)c(Cl)c2)c1 | PDB
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| | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613049
(US11725000, Compound 312)Show SMILES Cc1cc(nc(n1)S(=O)(=O)CCC(OCc1ccc(F)cc1F)c1ccccc1)-c1cc(F)c(=O)n(CC2CCNCC2)c1 | PDB
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| | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613045
(US11725000, Compound 308)Show SMILES Cc1cc(nc(n1)S(=O)CCC(OCc1ccc(F)cc1F)c1ccccc1)-c1cc(F)c(=O)n(CC2CCCCC2)c1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613042
(US11725000, Compound 304)Show SMILES COc1ccc(Cn2cc(cc(F)c2=O)-c2cc(C)nc(n2)S(=O)CCC(C)OCc2ccccc2F)cc1F | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613041
(US11725000, Compound 303)Show SMILES COc1ccc(Cn2cc(cc(F)c2=O)-c2cc(C)nc(n2)S(=O)(=O)CCC(C)=O)cc1F | PDB
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TBA
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Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613037
(US11725000, Compound 299)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)CCC(OCc2ccccc2)c2ccccc2)-c2cccs2)cc1OC | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613036
(US11725000, Compound 298)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCC(OCc2ccccc2)c2ccccc2)-c2ccccc2F)cc1OC | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM613035
(US11725000, Compound 297)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)CCC(OCc2ccccc2)c2ccccc2)-c2ccccc2F)cc1OC | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231809
(CHEMBL4070722 | US11725000, Compound 29)Show SMILES CCOC(=O)CCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1cccs1 Show InChI InChI=1S/C14H13F3N2O4S2/c1-2-23-12(20)5-7-25(21,22)13-18-9(10-4-3-6-24-10)8-11(19-13)14(15,16)17/h3-4,6,8H,2,5,7H2,1H3 | PDB
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| | n/a | n/a | n/a | n/a | 104 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM612762
(US11725000, Compound 24)Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)Cc1ccc2ncccc2c1)-c1cccs1 | PDB
UniProtKB/SwissProt
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| | n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231794
(CHEMBL4071549 | US11725000, Compound 112)Show SMILES CCOc1cccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)c1 Show InChI InChI=1S/C20H18F3N3O4S/c1-3-30-15-6-4-5-13(9-15)11-26-12-14(7-8-18(26)27)16-10-17(20(21,22)23)25-19(24-16)31(2,28)29/h4-10,12H,3,11H2,1-2H3 | PDB
UniProtKB/SwissProt
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UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231817
(CHEMBL4086114 | US11725000, Compound 151)Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)N(C)C)C(F)(F)F)cc1OC Show InChI InChI=1S/C25H27F3N4O6S/c1-31(2)22(33)6-5-11-39(35,36)24-29-18(13-21(30-24)25(26,27)28)17-8-10-23(34)32(15-17)14-16-7-9-19(37-3)20(12-16)38-4/h7-10,12-13,15H,5-6,11,14H2,1-4H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 164 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231787
(CHEMBL4093871 | US11725000, Compound 143)Show SMILES COCCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(OC)c(OC)c2)c1 Show InChI InChI=1S/C22H22F3N3O6S/c1-32-8-9-35(30,31)21-26-16(11-19(27-21)22(23,24)25)15-5-7-20(29)28(13-15)12-14-4-6-17(33-2)18(10-14)34-3/h4-7,10-11,13H,8-9,12H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 216 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231788
(CHEMBL4083596 | US11725000, Compound 146)Show SMILES CCCCCCCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(OC)c(OC)c2)c1 Show InChI InChI=1S/C26H30F3N3O5S/c1-4-5-6-7-8-13-38(34,35)25-30-20(15-23(31-25)26(27,28)29)19-10-12-24(33)32(17-19)16-18-9-11-21(36-2)22(14-18)37-3/h9-12,14-15,17H,4-8,13,16H2,1-3H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 253 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231797
(CHEMBL4089942 | US11725000, Compound 105)Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2cccc(Cl)c2)c1 Show InChI InChI=1S/C18H13ClF3N3O3S/c1-29(27,28)17-23-14(8-15(24-17)18(20,21)22)12-5-6-16(26)25(10-12)9-11-3-2-4-13(19)7-11/h2-8,10H,9H2,1H3 | PDB
UniProtKB/SwissProt
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UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 257 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM612758
(US11725000, Compound 20)Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)Cc1ccc(cc1)-c1ccccc1)-c1cccs1 | PDB
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| | n/a | n/a | n/a | n/a | 257 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231786
(CHEMBL4073188 | US11725000, Compound 144)Show SMILES COCCCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(OC)c(OC)c2)c1 Show InChI InChI=1S/C23H24F3N3O6S/c1-33-9-4-10-36(31,32)22-27-17(12-20(28-22)23(24,25)26)16-6-8-21(30)29(14-16)13-15-5-7-18(34-2)19(11-15)35-3/h5-8,11-12,14H,4,9-10,13H2,1-3H3 | PDB
UniProtKB/SwissProt
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UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 282 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM50231818
(CHEMBL4101603 | US11725000, Compound 147)Show SMILES CCCCCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(OC)c(OC)c2)c1 Show InChI InChI=1S/C24H26F3N3O5S/c1-4-5-6-11-36(32,33)23-28-18(13-21(29-23)24(25,26)27)17-8-10-22(31)30(15-17)14-16-7-9-19(34-2)20(12-16)35-3/h7-10,12-13,15H,4-6,11,14H2,1-3H3 | PDB
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 364 | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ... |
ACS Med Chem Lett 8: 407-412 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00489
BindingDB Entry DOI: 10.7270/Q29Z9745 |
More data for this
Ligand-Target Pair | |
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
(Homo sapiens (Human)) | BDBM612766
(US11725000, Compound 28) | PDB
UniProtKB/SwissProt
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| | n/a | n/a | n/a | n/a | 499 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B35DW |
More data for this
Ligand-Target Pair | |
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