Compile Data Set for Download or QSAR

Found 6 hits of ic50 for UniProtKB: P63104   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
14-3-3 protein zeta/delta (Homo sapiens)	BDBM50246102 (CHEMBL4096939) Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@]1(C)CCCCCCCCCCCC[C@](C)(NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)N1)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(N)=O |r,TLB:60:72:75:79.77.78,THB:77:76:73:79.78.80,77:78:75.76.81:73,80:78:75:81.72.73,80:72:75:79.77.78| Show InChI InChI=1S/C68H109N13O21/c1-35(2)23-45(57(92)72-37(5)55(90)74-44(54(70)89)28-42(62(97)98)63(99)100)75-59(94)47(29-51(85)86)76-58(93)46(24-36(3)4)78-64(101)67(8)22-18-16-14-12-10-9-11-13-15-17-21-66(7,80-50(84)34-71-56(91)43(73-38(6)82)19-20-49(69)83)65(102)79-53(61(96)77-48(30-52(87)88)60(95)81-67)68-31-39-25-40(32-68)27-41(26-39)33-68/h35-37,39-48,53H,9-34H2,1-8H3,(H2,69,83)(H2,70,89)(H,71,91)(H,72,92)(H,73,82)(H,74,90)(H,75,94)(H,76,93)(H,77,96)(H,78,101)(H,79,102)(H,80,84)(H,81,95)(H,85,86)(H,87,88)(H,97,98)(H,99,100)/t37-,39?,40?,41?,43-,44-,45-,46-,47-,48-,53+,66-,67-,68?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Genomics Centre of the Max Planck Society Curated by ChEMBL					Assay Description Inhibition of TAMRA-labeled cRaf peptide binding to 14-3-3zeta (1 to 230 residues) (unknown origin) after 1 hr by fluorescence polarization assay				J Med Chem 60: 8982-8988 (2017) Article DOI: 10.1021/acs.jmedchem.7b01221 BindingDB Entry DOI: 10.7270/Q2ZW1PBD
					More data for this Ligand-Target Pair
14-3-3 protein zeta/delta (Homo sapiens)	BDBM50246112 (CHEMBL4069746) Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@]1(C)CCCCCCCCCCCC[C@](C)(NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C59H101N13O18/c1-32(2)25-38(51(84)63-35(7)49(82)68-43(31-73)48(61)81)65-54(87)41(28-46(77)78)66-52(85)39(26-33(3)4)70-57(90)59(10)24-20-18-16-14-12-11-13-15-17-19-23-58(9,71-45(76)30-62-50(83)37(64-36(8)74)21-22-44(60)75)56(89)69-40(27-34(5)6)53(86)67-42(29-47(79)80)55(88)72-59/h32-35,37-43,73H,11-31H2,1-10H3,(H2,60,75)(H2,61,81)(H,62,83)(H,63,84)(H,64,74)(H,65,87)(H,66,85)(H,67,86)(H,68,82)(H,69,89)(H,70,90)(H,71,76)(H,72,88)(H,77,78)(H,79,80)/t35-,37-,38-,39-,40-,41-,42-,43-,58-,59-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Genomics Centre of the Max Planck Society Curated by ChEMBL					Assay Description Inhibition of TAMRA-labeled cRaf peptide binding to 14-3-3zeta (1 to 230 residues) (unknown origin) after 1 hr by fluorescence polarization assay				J Med Chem 60: 8982-8988 (2017) Article DOI: 10.1021/acs.jmedchem.7b01221 BindingDB Entry DOI: 10.7270/Q2ZW1PBD
					More data for this Ligand-Target Pair
14-3-3 protein zeta/delta (Homo sapiens)	BDBM50246119 (CHEMBL4068123) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C50H85N13O18/c1-22(2)14-30(57-38(67)20-53-44(75)29(56-28(11)65)12-13-37(51)66)47(78)60-33(17-25(7)8)49(80)61-34(18-39(68)69)46(77)55-26(9)42(73)58-32(16-24(5)6)48(79)62-35(19-40(70)71)50(81)59-31(15-23(3)4)45(76)54-27(10)43(74)63-36(21-64)41(52)72/h22-27,29-36,64H,12-21H2,1-11H3,(H2,51,66)(H2,52,72)(H,53,75)(H,54,76)(H,55,77)(H,56,65)(H,57,67)(H,58,73)(H,59,81)(H,60,78)(H,61,80)(H,62,79)(H,63,74)(H,68,69)(H,70,71)/t26-,27-,29-,30-,31-,32-,33-,34-,35-,36-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Genomics Centre of the Max Planck Society Curated by ChEMBL					Assay Description Inhibition of TAMRA-labeled cRaf peptide binding to 14-3-3zeta (1 to 230 residues) (unknown origin) after 1 hr by fluorescence polarization assay				J Med Chem 60: 8982-8988 (2017) Article DOI: 10.1021/acs.jmedchem.7b01221 BindingDB Entry DOI: 10.7270/Q2ZW1PBD
					More data for this Ligand-Target Pair
14-3-3 protein zeta/delta (Homo sapiens)	BDBM50246102 (CHEMBL4096939) Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@]1(C)CCCCCCCCCCCC[C@](C)(NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)N1)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(N)=O |r,TLB:60:72:75:79.77.78,THB:77:76:73:79.78.80,77:78:75.76.81:73,80:78:75:81.72.73,80:72:75:79.77.78| Show InChI InChI=1S/C68H109N13O21/c1-35(2)23-45(57(92)72-37(5)55(90)74-44(54(70)89)28-42(62(97)98)63(99)100)75-59(94)47(29-51(85)86)76-58(93)46(24-36(3)4)78-64(101)67(8)22-18-16-14-12-10-9-11-13-15-17-21-66(7,80-50(84)34-71-56(91)43(73-38(6)82)19-20-49(69)83)65(102)79-53(61(96)77-48(30-52(87)88)60(95)81-67)68-31-39-25-40(32-68)27-41(26-39)33-68/h35-37,39-48,53H,9-34H2,1-8H3,(H2,69,83)(H2,70,89)(H,71,91)(H,72,92)(H,73,82)(H,74,90)(H,75,94)(H,76,93)(H,77,96)(H,78,101)(H,79,102)(H,80,84)(H,81,95)(H,85,86)(H,87,88)(H,97,98)(H,99,100)/t37-,39?,40?,41?,43-,44-,45-,46-,47-,48-,53+,66-,67-,68?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Genomics Centre of the Max Planck Society Curated by ChEMBL					Assay Description Inhibition of 14-3-3zeta (unknown origin) in human U87 cells assessed as decrease in exogenous 14-3-3zeta-induced MMP1 mRNA levels after 24 hrs by RT...				J Med Chem 60: 8982-8988 (2017) Article DOI: 10.1021/acs.jmedchem.7b01221 BindingDB Entry DOI: 10.7270/Q2ZW1PBD
					More data for this Ligand-Target Pair
14-3-3 protein zeta/delta (Homo sapiens)	BDBM50102295 (4-(4-Formyl-5-hydroxy-6-methyl-3-phosphonooxymethy...) Show SMILES Cc1nc(N=Nc2ccc(cc2)C(O)=O)c(COP(O)(O)=O)c(C=O)c1O |w:5.5| Show InChI InChI=1S/C15H14N3O8P/c1-8-13(20)11(6-19)12(7-26-27(23,24)25)14(16-8)18-17-10-4-2-9(3-5-10)15(21)22/h2-6,20H,7H2,1H3,(H,21,22)(H2,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rheinische Friedrich-Wilhelms-Universit£t Curated by ChEMBL					Assay Description Inhibition of PRAS40 binding to human GST-tagged 14-3-3 protein zeta/delta expressed in Escherichia coli BL21(DE3) by ELISA				J Med Chem 61: 1276-1284 (2018) Article DOI: 10.1021/acs.jmedchem.7b01780 BindingDB Entry DOI: 10.7270/Q2B27XQN
					More data for this Ligand-Target Pair				3D Structure (crystal)
14-3-3 protein zeta/delta (Homo sapiens)	BDBM50102295 (4-(4-Formyl-5-hydroxy-6-methyl-3-phosphonooxymethy...) Show SMILES Cc1nc(N=Nc2ccc(cc2)C(O)=O)c(COP(O)(O)=O)c(C=O)c1O |w:5.5| Show InChI InChI=1S/C15H14N3O8P/c1-8-13(20)11(6-19)12(7-26-27(23,24)25)14(16-8)18-17-10-4-2-9(3-5-10)15(21)22/h2-6,20H,7H2,1H3,(H,21,22)(H2,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eindhoven University of Technology Curated by ChEMBL					Assay Description Binding affinity to GST-tagged 14-3-3-zeta (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of interaction with PRAS40...				J Med Chem 61: 3755-3778 (2018) Article DOI: 10.1021/acs.jmedchem.7b00574 BindingDB Entry DOI: 10.7270/Q2RB7781
					More data for this Ligand-Target Pair				3D Structure (crystal)