BindingDB PrimarySearch

Found 17 hits of ic50 for UniProtKB: P55926
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50157090 (6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Anhui Medical University Curated by ChEMBL					Assay Description Inhibition of ASIC1a in rat dorsal root ganglion neurons assessed as reduction in peak current preincubated for 120 secs followed by acid medium stim...				Bioorg Med Chem 26: 3158-3165 (2018) Article DOI: 10.1016/j.bmc.2018.04.042 BindingDB Entry DOI: 10.7270/Q2PZ5CBD
Anhui Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM16173 (3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...) Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Anhui Medical University Curated by ChEMBL					Assay Description Inhibition of ASIC1 in Sprague-Dawley rat articular chondrocytes assessed as decrease in acid-induced intracellular calcium level by Fluo-3AM dye bas...				Bioorg Med Chem 26: 3158-3165 (2018) Article DOI: 10.1016/j.bmc.2018.04.042 BindingDB Entry DOI: 10.7270/Q2PZ5CBD
Anhui Medical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50009859 ((+-)-2-(p-isobutylphenyl)propionic acid \| (+-)-alp...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50009859 ((+-)-2-(p-isobutylphenyl)propionic acid \| (+-)-alp...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50074922 ((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid \|...) Show SMILES CC(C(O)=O)c1ccc(c(F)c1)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50250133 (Butibufen) Show SMILES CCC(C(O)=O)c1ccc(CC(C)C)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.82E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50169044 ((-)-ibuprofen \| (2R)-2-(4-isobutylphenyl)propanoic...) Show SMILES CC(C)Cc1ccc(cc1)[C@@H](C)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.88E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50009859 ((+-)-2-(p-isobutylphenyl)propionic acid \| (+-)-alp...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.95E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50009859 ((+-)-2-(p-isobutylphenyl)propionic acid \| (+-)-alp...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.95E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50009859 ((+-)-2-(p-isobutylphenyl)propionic acid \| (+-)-alp...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.95E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50169047 ((S)-2-(4-Isobutyl-phenyl)-propionic acid \| (S)-2-(...) Show SMILES CC(C)Cc1ccc(cc1)[C@H](C)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.47E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50250130 (CHEMBL4083814) Show SMILES CC(C)Cc1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4.17E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50009859 ((+-)-2-(p-isobutylphenyl)propionic acid \| (+-)-alp...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.13E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50009859 ((+-)-2-(p-isobutylphenyl)propionic acid \| (+-)-alp...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.13E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50250132 (CHEMBL4080879) Show SMILES CC(C)Cc1ccc(cc1)C(F)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.55E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50295285 ((4-Isobutyl-phenyl)-acetic acid \| 2-(4-isobutylphe...) Show SMILES CC(C)Cc1ccc(CC(O)=O)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.02E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Acid-sensing ion channel 1 (Rattus norvegicus)	BDBM50250131 (CHEMBL190275) Show SMILES CC(C(O)=O)c1ccc(C)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1.00E+7	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair