Compile Data Set for Download or QSAR

Found 21 hits of ec50 for UniProtKB: P04273   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Major prion protein (Mesocricetus auratus)	BDBM50451083 (CHEMBL1429474) Show SMILES O=C(CSc1ncnc2sc3CCCc3c12)NCC1CCCO1 Show InChI InChI=1S/C16H19N3O2S2/c20-13(17-7-10-3-2-6-21-10)8-22-15-14-11-4-1-5-12(11)23-16(14)19-9-18-15/h9-10H,1-8H2,(H,17,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.02E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451084 (CHEMBL1631214) Show SMILES CC1CCCCC1NC(=O)COc1ncnc2sc3CCCc3c12 Show InChI InChI=1S/C18H23N3O2S/c1-11-5-2-3-7-13(11)21-15(22)9-23-17-16-12-6-4-8-14(12)24-18(16)20-10-19-17/h10-11,13H,2-9H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.16E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451088 (CHEMBL4215683) Show SMILES CCC[C@@H]1Nc2ccccc2N1CC(=O)N1CCCc2ccccc12 |r| Show InChI InChI=1S/C21H25N3O/c1-2-8-20-22-17-11-4-6-13-19(17)24(20)15-21(25)23-14-7-10-16-9-3-5-12-18(16)23/h3-6,9,11-13,20,22H,2,7-8,10,14-15H2,1H3/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.17E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451086 (CHEMBL4218996) Show SMILES O=C(CN1C(=O)N[C@@]2(CCCc3ccccc23)C1=O)N1CCCCC1 |r| Show InChI InChI=1S/C19H23N3O3/c23-16(21-11-4-1-5-12-21)13-22-17(24)19(20-18(22)25)10-6-8-14-7-2-3-9-15(14)19/h2-3,7,9H,1,4-6,8,10-13H2,(H,20,25)/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.17E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451087 (CHEMBL1631213) Show SMILES CC1Cc2ccccc2N1C(=O)COc1ncnc2sccc12 Show InChI InChI=1S/C17H15N3O2S/c1-11-8-12-4-2-3-5-14(12)20(11)15(21)9-22-16-13-6-7-23-17(13)19-10-18-16/h2-7,10-11H,8-9H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.17E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451085 (CHEMBL1631211) Show SMILES O=C(Nc1sc2CCCCc2c1C#N)c1cc2CCCCc2s1 Show InChI InChI=1S/C18H18N2OS2/c19-10-13-12-6-2-4-8-15(12)23-18(13)20-17(21)16-9-11-5-1-3-7-14(11)22-16/h9H,1-8H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.17E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451089 (CHEMBL4206759) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@@H](C2)NC(=O)CN1C(=O)c2cccc3cccc1c23 |r| Show InChI InChI=1S/C20H20N2O2/c23-18(21-16-10-12-7-8-14(16)9-12)11-22-17-6-2-4-13-3-1-5-15(19(13)17)20(22)24/h1-6,12,14,16H,7-11H2,(H,21,23)/t12-,14+,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.18E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451090 (CHEMBL1631209) Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)NC1CCCc2ccccc12 Show InChI InChI=1S/C21H21N3O2/c25-20(23-17-11-5-7-14-6-1-2-8-15(14)17)13-12-19-22-18-10-4-3-9-16(18)21(26)24-19/h1-4,6,8-10,17H,5,7,11-13H2,(H,23,25)(H,22,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.18E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451075 (CHEMBL1311517) Show SMILES O=C(NC1CCCC1)C1CCCN1C(=O)Nc1ccccc1 Show InChI InChI=1S/C17H23N3O2/c21-16(18-13-9-4-5-10-13)15-11-6-12-20(15)17(22)19-14-7-2-1-3-8-14/h1-3,7-8,13,15H,4-6,9-12H2,(H,18,21)(H,19,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.19E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451091 (CHEMBL1631206) Show SMILES O=C(COC(=O)c1c2CCCc2nc2ccccc12)NC1CCCC1 Show InChI InChI=1S/C20H22N2O3/c23-18(21-13-6-1-2-7-13)12-25-20(24)19-14-8-3-4-10-16(14)22-17-11-5-9-15(17)19/h3-4,8,10,13H,1-2,5-7,9,11-12H2,(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451092 (CHEMBL4215372) Show SMILES [H][C@]12CCCC[C@]1([H])[C@@H](C#N)[C@H](NC(=O)CN1CCCC[C@H]1C)S2 |r| Show InChI InChI=1S/C17H27N3OS/c1-12-6-4-5-9-20(12)11-16(21)19-17-14(10-18)13-7-2-3-8-15(13)22-17/h12-15,17H,2-9,11H2,1H3,(H,19,21)/t12-,13-,14-,15+,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.23E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451076 (CHEMBL1418383) Show SMILES O=C(CN1C(=O)COc2ccccc12)N1CCCc2ccccc12 Show InChI InChI=1S/C19H18N2O3/c22-18(20-11-5-7-14-6-1-2-8-15(14)20)12-21-16-9-3-4-10-17(16)24-13-19(21)23/h1-4,6,8-10H,5,7,11-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.24E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451095 (CHEMBL1631123) Show SMILES CN1\C(=C\C(=O)Nc2cccs2)c2ccccc2CC1(C)C Show InChI InChI=1S/C18H20N2OS/c1-18(2)12-13-7-4-5-8-14(13)15(20(18)3)11-16(21)19-17-9-6-10-22-17/h4-11H,12H2,1-3H3,(H,19,21)/b15-11+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.24E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451093 (CHEMBL4210951) Show SMILES CC(=O)NC(=O)NC=C Show InChI InChI=1S/C5H8N2O2/c1-3-6-5(9)7-4(2)8/h3H,1H2,2H3,(H2,6,7,8,9)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.24E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451079 (CHEMBL4205700) Show SMILES O=C(CC1CNc2ccccc12)NC1CCc2ccccc2C1 Show InChI InChI=1S/C20H22N2O/c23-20(12-16-13-21-19-8-4-3-7-18(16)19)22-17-10-9-14-5-1-2-6-15(14)11-17/h1-8,16-17,21H,9-13H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.25E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451077 (CHEMBL4202679) Show SMILES O=C(N[C@@H]1CCc2ccccc2C1)C(=O)O[C@@H]1C=CCc2ccccc12 |r,c:19| Show InChI InChI=1S/C22H21NO3/c24-21(23-18-13-12-15-6-1-2-8-17(15)14-18)22(25)26-20-11-5-9-16-7-3-4-10-19(16)20/h1-8,10-11,18,20H,9,12-14H2,(H,23,24)/t18-,20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.27E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50451078 (CHEMBL1631117) Show SMILES Cc1cccc2cc(C#N)c(nc12)N1CCCN(CC1)C(=O)C1CCC1 Show InChI InChI=1S/C21H24N4O/c1-15-5-2-8-17-13-18(14-22)20(23-19(15)17)24-9-4-10-25(12-11-24)21(26)16-6-3-7-16/h2,5,8,13,16H,3-4,6-7,9-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.29E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50333113 (8-methyl-7-(2-(piperidin-1-yl)ethylthio)-2,3-dihyd...) Show SMILES Cc1cc2cc3OCCOc3cc2nc1SCCN1CCCCC1 Show InChI InChI=1S/C19H24N2O2S/c1-14-11-15-12-17-18(23-9-8-22-17)13-16(15)20-19(14)24-10-7-21-5-3-2-4-6-21/h11-13H,2-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.32E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50333112 (3-amino-N-cyclopentyl-8-methylthieno[2,3-b]quinoli...) Show SMILES Cc1cccc2cc3c(N)c(sc3nc12)C(=O)NC1CCCC1 Show InChI InChI=1S/C18H19N3OS/c1-10-5-4-6-11-9-13-14(19)16(23-18(13)21-15(10)11)17(22)20-12-7-2-3-8-12/h4-6,9,12H,2-3,7-8,19H2,1H3,(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.37E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50333111 (2-(2-(butylamino)-1H-benzo[d]imidazol-1-yl)-1-(ind...) Show SMILES CCCCNc1nc2ccccc2n1CC(=O)N1CCc2ccccc12 Show InChI InChI=1S/C21H24N4O/c1-2-3-13-22-21-23-17-9-5-7-11-19(17)25(21)15-20(26)24-14-12-16-8-4-6-10-18(16)24/h4-11H,2-3,12-15H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.42E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair
Major prion protein (Mesocricetus auratus)	BDBM50333110 (CHEMBL1631113 | N-(1-(indolin-1-yl)-3-methyl-1-oxo...) Show SMILES CCC(C)C(NC(=O)c1ccccc1)C(=O)N1CCc2ccccc12 Show InChI InChI=1S/C21H24N2O2/c1-3-15(2)19(22-20(24)17-10-5-4-6-11-17)21(25)23-14-13-16-9-7-8-12-18(16)23/h4-12,15,19H,3,13-14H2,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.43E+3	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Binding affinity to Syrian hamster PrPC assessed as inhibition of PrPC protein conversion to PrPSc by Western blot				Bioorg Med Chem 25: 5875-5888 (2017) Article DOI: 10.1016/j.bmc.2017.09.024 BindingDB Entry DOI: 10.7270/Q2QR50Q1
					More data for this Ligand-Target Pair