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Compile Data Set for Download or QSAR

Found 31 hits of ic50 for UniProtKB: P0A0H5   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455315
PNG
(CHEMBL4207799)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2occc2C)cc1
Show InChI InChI=1S/C18H21N3O4S/c1-11(2)13-4-6-14(7-5-13)25-10-15(22)20-21-18(26)19-17(23)16-12(3)8-9-24-16/h4-9,11H,10H2,1-3H3,(H,20,22)(H2,19,21,23,26)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455340
PNG
(CHEMBL4203400)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)Cc2ccco2)cc1
Show InChI InChI=1S/C18H21N3O4S/c1-12(2)13-5-7-14(8-6-13)25-11-17(23)20-21-18(26)19-16(22)10-15-4-3-9-24-15/h3-9,12H,10-11H2,1-2H3,(H,20,23)(H2,19,21,22,26)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455342
PNG
(CHEMBL4207223)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccc(C)o2)cc1
Show InChI InChI=1S/C18H21N3O4S/c1-11(2)13-5-7-14(8-6-13)24-10-16(22)20-21-18(26)19-17(23)15-9-4-12(3)25-15/h4-9,11H,10H2,1-3H3,(H,20,22)(H2,19,21,23,26)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455332
PNG
(CHEMBL4216971)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)\C=C\c2cc3ccccc3o2)cc1
Show InChI InChI=1S/C23H23N3O4S/c1-15(2)16-7-9-18(10-8-16)29-14-22(28)25-26-23(31)24-21(27)12-11-19-13-17-5-3-4-6-20(17)30-19/h3-13,15H,14H2,1-2H3,(H,25,28)(H2,24,26,27,31)/b12-11+
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455322
PNG
(CHEMBL4207751)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccc(Br)o2)cc1
Show InChI InChI=1S/C17H18BrN3O4S/c1-10(2)11-3-5-12(6-4-11)24-9-15(22)20-21-17(26)19-16(23)13-7-8-14(18)25-13/h3-8,10H,9H2,1-2H3,(H,20,22)(H2,19,21,23,26)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455343
PNG
(CHEMBL4202875)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccc(o2)-c2ccccc2)cc1
Show InChI InChI=1S/C23H23N3O4S/c1-15(2)16-8-10-18(11-9-16)29-14-21(27)25-26-23(31)24-22(28)20-13-12-19(30-20)17-6-4-3-5-7-17/h3-13,15H,14H2,1-2H3,(H,25,27)(H2,24,26,28,31)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455327
PNG
(CHEMBL4217383)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C21H22N4O3S/c1-13(2)14-7-9-15(10-8-14)28-12-19(26)24-25-21(29)23-20(27)17-11-22-18-6-4-3-5-16(17)18/h3-11,13,22H,12H2,1-2H3,(H,24,26)(H2,23,25,27,29)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455326
PNG
(CHEMBL4210049)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cc3ccccc3[nH]2)cc1
Show InChI InChI=1S/C21H22N4O3S/c1-13(2)14-7-9-16(10-8-14)28-12-19(26)24-25-21(29)23-20(27)18-11-15-5-3-4-6-17(15)22-18/h3-11,13,22H,12H2,1-2H3,(H,24,26)(H2,23,25,27,29)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455329
PNG
(CHEMBL4217904)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)NC(=S)NNC(=O)COc1ccc(cc1)C(C)C
Show InChI InChI=1S/C22H24N4O4S/c1-13(2)14-4-7-16(8-5-14)30-12-20(27)25-26-22(31)24-21(28)19-10-15-6-9-17(29-3)11-18(15)23-19/h4-11,13,23H,12H2,1-3H3,(H,25,27)(H2,24,26,28,31)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455328
PNG
(CHEMBL4212965)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)NC(=S)NNC(=O)COc1ccc(cc1)C(C)C
Show InChI InChI=1S/C22H24N4O4S/c1-13(2)14-4-6-16(7-5-14)30-12-20(27)25-26-22(31)24-21(28)19-11-15-10-17(29-3)8-9-18(15)23-19/h4-11,13,23H,12H2,1-3H3,(H,25,27)(H2,24,26,28,31)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455344
PNG
(CHEMBL4204244)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cc3cc(F)ccc3[nH]2)cc1
Show InChI InChI=1S/C21H21FN4O3S/c1-12(2)13-3-6-16(7-4-13)29-11-19(27)25-26-21(30)24-20(28)18-10-14-9-15(22)5-8-17(14)23-18/h3-10,12,23H,11H2,1-2H3,(H,25,27)(H2,24,26,28,30)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455325
PNG
(CHEMBL4205150)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cc3ccccc3s2)cc1
Show InChI InChI=1S/C21H21N3O3S2/c1-13(2)14-7-9-16(10-8-14)27-12-19(25)23-24-21(28)22-20(26)18-11-15-5-3-4-6-17(15)29-18/h3-11,13H,12H2,1-2H3,(H,23,25)(H2,22,24,26,28)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455324
PNG
(CHEMBL4202906)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cc3ccccc3o2)cc1
Show InChI InChI=1S/C21H21N3O4S/c1-13(2)14-7-9-16(10-8-14)27-12-19(25)23-24-21(29)22-20(26)18-11-15-5-3-4-6-17(15)28-18/h3-11,13H,12H2,1-2H3,(H,23,25)(H2,22,24,26,29)
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n/an/a 6.00E+4n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455314
PNG
(CHEMBL4206383)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccccn2)cc1
Show InChI InChI=1S/C18H20N4O3S/c1-12(2)13-6-8-14(9-7-13)25-11-16(23)21-22-18(26)20-17(24)15-5-3-4-10-19-15/h3-10,12H,11H2,1-2H3,(H,21,23)(H2,20,22,24,26)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455334
PNG
(CHEMBL4202918)
Show SMILES Cc1cc(\C=C(\C#N)C(=O)Nc2cccc(Br)c2)c(C)n1-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H18BrN3O3/c1-14-10-17(15(2)27(14)21-8-6-16(7-9-21)23(29)30)11-18(13-25)22(28)26-20-5-3-4-19(24)12-20/h3-12H,1-2H3,(H,26,28)(H,29,30)/b18-11-
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455323
PNG
(CHEMBL4215071)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)\C=C\c2ccco2)cc1
Show InChI InChI=1S/C19H21N3O4S/c1-13(2)14-5-7-16(8-6-14)26-12-18(24)21-22-19(27)20-17(23)10-9-15-4-3-11-25-15/h3-11,13H,12H2,1-2H3,(H,21,24)(H2,20,22,23,27)/b10-9+
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455316
PNG
(CHEMBL4209106)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2nc3ccccc3[nH]2)cc1
Show InChI InChI=1S/C20H21N5O3S/c1-12(2)13-7-9-14(10-8-13)28-11-17(26)24-25-20(29)23-19(27)18-21-15-5-3-4-6-16(15)22-18/h3-10,12H,11H2,1-2H3,(H,21,22)(H,24,26)(H2,23,25,27,29)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455317
PNG
(CHEMBL4205678)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cc3ccccc3n2C)cc1
Show InChI InChI=1S/C22H24N4O3S/c1-14(2)15-8-10-17(11-9-15)29-13-20(27)24-25-22(30)23-21(28)19-12-16-6-4-5-7-18(16)26(19)3/h4-12,14H,13H2,1-3H3,(H,24,27)(H2,23,25,28,30)
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n/an/a 2.40E+5n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455331
PNG
(CHEMBL4213509)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cc3ccc(Cl)cc3[nH]2)cc1
Show InChI InChI=1S/C21H21ClN4O3S/c1-12(2)13-4-7-16(8-5-13)29-11-19(27)25-26-21(30)24-20(28)18-9-14-3-6-15(22)10-17(14)23-18/h3-10,12,23H,11H2,1-2H3,(H,25,27)(H2,24,26,28,30)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455318
PNG
(CHEMBL4205382)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cccs2)cc1
Show InChI InChI=1S/C17H19N3O3S2/c1-11(2)12-5-7-13(8-6-12)23-10-15(21)19-20-17(24)18-16(22)14-4-3-9-25-14/h3-9,11H,10H2,1-2H3,(H,19,21)(H2,18,20,22,24)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455320
PNG
(CHEMBL4218100)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccc[nH]2)cc1
Show InChI InChI=1S/C17H20N4O3S/c1-11(2)12-5-7-13(8-6-12)24-10-15(22)20-21-17(25)19-16(23)14-4-3-9-18-14/h3-9,11,18H,10H2,1-2H3,(H,20,22)(H2,19,21,23,25)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455339
PNG
(CHEMBL4213618)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2coc3ccccc23)cc1
Show InChI InChI=1S/C21H21N3O4S/c1-13(2)14-7-9-15(10-8-14)27-12-19(25)23-24-21(29)22-20(26)17-11-28-18-6-4-3-5-16(17)18/h3-11,13H,12H2,1-2H3,(H,23,25)(H2,22,24,26,29)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455336
PNG
(CHEMBL4213682)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccoc2)cc1
Show InChI InChI=1S/C17H19N3O4S/c1-11(2)12-3-5-14(6-4-12)24-10-15(21)19-20-17(25)18-16(22)13-7-8-23-9-13/h3-9,11H,10H2,1-2H3,(H,19,21)(H2,18,20,22,25)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455335
PNG
(CHEMBL4212230)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccco2)cc1
Show InChI InChI=1S/C17H19N3O4S/c1-11(2)12-5-7-13(8-6-12)24-10-15(21)19-20-17(25)18-16(22)14-4-3-9-23-14/h3-9,11H,10H2,1-2H3,(H,19,21)(H2,18,20,22,25)
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n/an/a 2.75E+5n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455337
PNG
(CHEMBL4218276)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccsc2)cc1
Show InChI InChI=1S/C17H19N3O3S2/c1-11(2)12-3-5-14(6-4-12)23-9-15(21)19-20-17(24)18-16(22)13-7-8-25-10-13/h3-8,10-11H,9H2,1-2H3,(H,19,21)(H2,18,20,22,24)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455338
PNG
(CHEMBL4208725)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccno2)cc1
Show InChI InChI=1S/C16H18N4O4S/c1-10(2)11-3-5-12(6-4-11)23-9-14(21)19-20-16(25)18-15(22)13-7-8-17-24-13/h3-8,10H,9H2,1-2H3,(H,19,21)(H2,18,20,22,25)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455321
PNG
(CHEMBL4216553)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cccnc2)cc1
Show InChI InChI=1S/C18H20N4O3S/c1-12(2)13-5-7-15(8-6-13)25-11-16(23)21-22-18(26)20-17(24)14-4-3-9-19-10-14/h3-10,12H,11H2,1-2H3,(H,21,23)(H2,20,22,24,26)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455319
PNG
(CHEMBL4211951)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cnco2)cc1
Show InChI InChI=1S/C16H18N4O4S/c1-10(2)11-3-5-12(6-4-11)23-8-14(21)19-20-16(25)18-15(22)13-7-17-9-24-13/h3-7,9-10H,8H2,1-2H3,(H,19,21)(H2,18,20,22,25)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455341
PNG
(CHEMBL4211577)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C18H20N4O3S/c1-12(2)13-3-5-15(6-4-13)25-11-16(23)21-22-18(26)20-17(24)14-7-9-19-10-8-14/h3-10,12H,11H2,1-2H3,(H,21,23)(H2,20,22,24,26)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455330
PNG
(CHEMBL4208574)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C21H21ClN4O3S/c1-12(2)13-3-6-16(7-4-13)29-11-19(27)25-26-21(30)24-20(28)18-10-14-9-15(22)5-8-17(14)23-18/h3-10,12,23H,11H2,1-2H3,(H,25,27)(H2,24,26,28,30)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair
Ribonuclease P protein component


(Staphylococcus aureus)
BDBM50455333
PNG
(CHEMBL4204405)
Show SMILES CC(C)c1ccc(OCC(=O)NNC(=S)NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H21N3O3S/c1-13(2)14-8-10-16(11-9-14)25-12-17(23)21-22-19(26)20-18(24)15-6-4-3-5-7-15/h3-11,13H,12H2,1-2H3,(H,21,23)(H2,20,22,24,26)
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Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus RnpA-mediated mRNA degradation after 15 to 30 mins by ethidium bromide staining based agarose gel electrophoresis


Bioorg Med Chem Lett 28: 1127-1131 (2018)


Article DOI: 10.1016/j.bmcl.2018.01.022
BindingDB Entry DOI: 10.7270/Q2NP2702
More data for this
Ligand-Target Pair