Found 3 hits of ic50 for UniProtKB: P60472 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
(Escherichia coli (strain K12)) | BDBM50601419
(CHEMBL5182237)Show SMILES OC(Cc1cccc(c1)-c1cccc2oc3ccccc3c12)(P(O)(O)=O)P(O)(O)=O | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01292
BindingDB Entry DOI: 10.7270/Q2Z60T43 |
More data for this
Ligand-Target Pair | |
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
(Escherichia coli (strain K12)) | BDBM50458053
(CHEMBL4214440)Show SMILES C\C(=N/NC(N)=N)c1sc(nc1C)-c1ccc(cc1)C#CC1CC1 Show InChI InChI=1S/C18H19N5S/c1-11-16(12(2)22-23-18(19)20)24-17(21-11)15-9-7-14(8-10-15)6-5-13-3-4-13/h7-10,13H,3-4H2,1-2H3,(H4,19,20,23)/b22-12+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Azhar University
Curated by ChEMBL
| Assay Description
Inhibition of Escherichia coli UPPS using IPP and FPP as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by ... |
Eur J Med Chem 148: 195-209 (2018)
Article DOI: 10.1016/j.ejmech.2018.02.031
BindingDB Entry DOI: 10.7270/Q2RR21VD |
More data for this
Ligand-Target Pair | |
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
(Escherichia coli (strain K12)) | BDBM25271
(3-[(3,7-dimethyloctyl)oxy]-1-(2-hydrogen phosphona...)Show SMILES CC(C)CCCC(C)CCOc1ccc[n+](CC(P(O)(O)=O)P(O)([O-])=O)c1 Show InChI InChI=1S/C17H31NO7P2/c1-14(2)6-4-7-15(3)9-11-25-16-8-5-10-18(12-16)13-17(26(19,20)21)27(22,23)24/h5,8,10,12,14-15,17H,4,6-7,9,11,13H2,1-3H3,(H3-,19,20,21,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Escherichia coli UPPS in presence of IPP and FPP |
J Med Chem 62: 2564-2581 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01878
BindingDB Entry DOI: 10.7270/Q2S75KV9 |
More data for this
Ligand-Target Pair | |
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