Compile Data Set for Download or QSAR

Found 11 hits of ic50 for UniProtKB: P29172   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142855 (US8940738, 11) Show SMILES Cc1nc(no1)-c1ccc(cc1)[C@H]1CN(CCO1)c1nc(-c2ccncn2)c(O)c(=O)n1C |r| Show InChI InChI=1S/C22H21N7O4/c1-13-25-20(27-33-13)15-5-3-14(4-6-15)17-11-29(9-10-32-17)22-26-18(16-7-8-23-12-24-16)19(30)21(31)28(22)2/h3-8,12,17,30H,9-11H2,1-2H3/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142848 (US8940738, 4) Show SMILES Cc1nc(no1)-c1ccc(cc1)[C@H]1CN(CCO1)c1nc(cc(=O)n1C)-c1ncncc1F |r| Show InChI InChI=1S/C22H20FN7O3/c1-13-26-21(28-33-13)15-5-3-14(4-6-15)18-11-30(7-8-32-18)22-27-17(9-19(31)29(22)2)20-16(23)10-24-12-25-20/h3-6,9-10,12,18H,7-8,11H2,1-2H3/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.40	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142850 (US8940738, 6) Show SMILES Cn1c(nc(cc1=O)-c1ncncc1F)N1CCNC(C1)c1ccc(cc1)[N+]#[C-] Show InChI InChI=1S/C20H18FN7O/c1-22-14-5-3-13(4-6-14)17-11-28(8-7-24-17)20-26-16(9-18(29)27(20)2)19-15(21)10-23-12-25-19/h3-6,9-10,12,17,24H,7-8,11H2,2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.1	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142845 (US8940738, 1) Show SMILES CN1C(=O)CC(N=C1N1CCO[C@H](C1)c1ccc(F)cc1)c1ncncc1F |r,c:6| Show InChI InChI=1S/C19H19F2N5O2/c1-25-17(27)8-15(18-14(21)9-22-11-23-18)24-19(25)26-6-7-28-16(10-26)12-2-4-13(20)5-3-12/h2-5,9,11,15-16H,6-8,10H2,1H3/t15?,16-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.5	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142846 (US8940738, 2) Show SMILES C[C@@H]1COCCN1c1nc(cc(=O)n1C)-c1ncncc1F |r| Show InChI InChI=1S/C14H16FN5O2/c1-9-7-22-4-3-20(9)14-18-11(5-12(21)19(14)2)13-10(15)6-16-8-17-13/h5-6,8-9H,3-4,7H2,1-2H3/t9-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19.7	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142849 (US8940738, 5) Show SMILES Cn1c(nc(cc1=O)-c1ncncc1F)N1CCCC(C1)c1ccc(cc1)N1CCCC1 Show InChI InChI=1S/C24H27FN6O/c1-29-22(32)13-21(23-20(25)14-26-16-27-23)28-24(29)31-12-4-5-18(15-31)17-6-8-19(9-7-17)30-10-2-3-11-30/h6-9,13-14,16,18H,2-5,10-12,15H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33.1	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142847 (US8940738, 3) Show SMILES Cn1c(nc(cc1=O)-c1ncncc1F)N1CCOC[C@H]1CF |r| Show InChI InChI=1S/C14H15F2N5O2/c1-20-12(22)4-11(13-10(16)6-17-8-18-13)19-14(20)21-2-3-23-7-9(21)5-15/h4,6,8-9H,2-3,5,7H2,1H3/t9-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33.4	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142852 (US8940738, 8) Show SMILES COc1ccc(CCNc2nc(cc(=O)n2C)-c2ncncc2F)cc1OC Show InChI InChI=1S/C19H20FN5O3/c1-25-17(26)9-14(18-13(20)10-21-11-23-18)24-19(25)22-7-6-12-4-5-15(27-2)16(8-12)28-3/h4-5,8-11H,6-7H2,1-3H3,(H,22,24)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75.3	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142851 (US8940738, 7) Show SMILES Cc1cccc(N2CCN(CC2)c2nc(cc(=O)n2C)-c2ncncc2F)c1C Show InChI InChI=1S/C21H23FN6O/c1-14-5-4-6-18(15(14)2)27-7-9-28(10-8-27)21-25-17(11-19(29)26(21)3)20-16(22)12-23-13-24-20/h4-6,11-13H,7-10H2,1-3H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	78.3	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142854 (US8940738, 10) Show SMILES CN(CCc1ccc(cc1)[N+]([O-])=O)c1nc(cc(=O)n1C)-c1ncncc1F Show InChI InChI=1S/C18H17FN6O3/c1-23(8-7-12-3-5-13(6-4-12)25(27)28)18-22-15(9-16(26)24(18)2)17-14(19)10-20-11-21-17/h3-6,9-11H,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	165	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Bos taurus (Bovine))	BDBM142853 (US8940738, 9) Show SMILES Cn1c(NCC(=O)c2ccc(Cl)cc2)nc(cc1=O)-c1ncncc1F Show InChI InChI=1S/C17H13ClFN5O2/c1-24-15(26)6-13(16-12(19)7-20-9-22-16)23-17(24)21-8-14(25)10-2-4-11(18)5-3-10/h2-7,9H,8H2,1H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	608	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM beta-mercaptoethanol, 0.02% Tween 20, 10% glycer...				US Patent US8940738 (2015) BindingDB Entry DOI: 10.7270/Q2M32TG6
					More data for this Ligand-Target Pair