Compile Data Set for Download or QSAR

Found 743 hits of ec50 for UniProtKB: P30874   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578124 (CHEMBL4866325) Show SMILES Cc1cc(C)cc(c1)-c1cncc(-c2nc3cc(F)ccc3[nH]2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0130	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578111 (CHEMBL4861425) Show SMILES Cc1cc(C)cc(c1)-c1cncc(-c2nc3cc(C)cc(C)c3[nH]2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0130	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578123 (CHEMBL4872591) Show SMILES Cc1ccc2[nH]c(nc2c1)-c1cncc(-c2cc(C)cc(C)c2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0130	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578122 (CHEMBL4849848) Show SMILES Cc1cc(C)cc(c1)-c1cncc(-c2nc3cc(ccc3[nH]2)C(F)(F)F)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0140	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578121 (CHEMBL4860633) Show SMILES Cc1cc(C)cc(c1)-c1cncc(-c2nc3cc(Cl)ccc3[nH]2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0150	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578128 (CHEMBL4873269) Show SMILES COc1cc(F)cc(c1)-c1cncc(-c2nc3cc(C)ccc3[nH]2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0170	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578126 (CHEMBL4853282) Show SMILES Cc1cc(F)cc(c1)-c1cncc(-c2nc3cc(F)ccc3[nH]2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0190	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578120 (CHEMBL4858892) Show SMILES Cc1cc(C)cc(c1)-c1cncc(-c2nc3cc(ccc3[nH]2)C#N)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0270	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50272772 (10-(4-Amino-butyl)-19-(2-amino-3-phenyl-propionyla...) Show SMILES C[C@@H](O)[C@@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 |r| Show InChI InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29-,34-,36+,37+,38-,39-,40+,41+,42+/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0300	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578109 (CHEMBL4863880) Show SMILES Cc1cc(C)cc(NC(=O)c2cncc(-c3cc(C)cc(C)c3)c2N2CCC(N)CC2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0300	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578110 (CHEMBL4845867) Show SMILES Cc1cc(C)cc(c1)C(=O)Nc1cncc(-c2cc(C)cc(C)c2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0400	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578118 (CHEMBL4870834) Show SMILES Cc1cc(C(=O)Nc2cncc(-c3cc(Cl)cc(Cl)c3)c2N2CCC(N)CC2)n(C)n1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0410	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578129 (CHEMBL4862195) Show SMILES COc1cc(OC)cc(c1)-c1cncc(-c2nc3cc(C)ccc3[nH]2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0480	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578127 (CHEMBL4876263) Show SMILES COc1cc(F)cc(c1)-c1cncc(-c2nc3cc(F)ccc3[nH]2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0780	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578119 (CHEMBL4851978) Show SMILES Cc1cc(C)cc(c1)-c1cncc(-c2nc3ccccc3[nH]2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0800	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578125 (CHEMBL4878917) Show SMILES NC1CCN(CC1)c1c(cncc1-c1cc(F)cc(Cl)c1)-c1nc2cc(F)ccc2[nH]1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0810	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM449020 (US10696689, Compound 3-17) Show SMILES COc1cc(F)cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(F)cc(Cl)c2)c1N1CCC2NCCOC2C1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
CRINETICS PHARMACEUTICALS, INC. US Patent					Assay Description On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...				US Patent US10696689 (2020) BindingDB Entry DOI: 10.7270/Q2FN197F
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM449019 (2-{4-[(4αS,8αS)-octahydro-1H-pyrido[3,4-...) Show SMILES COc1cc(cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CC[C@@H]2NCCO[C@H]2C1)C#N |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
CRINETICS PHARMACEUTICALS, INC. US Patent					Assay Description On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...				US Patent US10696689 (2020) BindingDB Entry DOI: 10.7270/Q2FN197F
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM449018 (US10696689, Compound 3-15) Show SMILES CNc1ncc(-c2cc(C)cc(F)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(OC)cc(F)cc2[nH]1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
CRINETICS PHARMACEUTICALS, INC. US Patent					Assay Description On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...				US Patent US10696689 (2020) BindingDB Entry DOI: 10.7270/Q2FN197F
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM449017 (US10696689, Compound 3-14) Show SMILES COc1cc(F)cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CCC2NCCOC2C1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
CRINETICS PHARMACEUTICALS, INC. US Patent					Assay Description On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...				US Patent US10696689 (2020) BindingDB Entry DOI: 10.7270/Q2FN197F
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM449011 (US10696689, Compound 3-8) Show SMILES COc1cc(F)cc(c1)-c1cnc(N)c(-c2nc3c(F)cc(F)cc3[nH]2)c1N1CCC2NCCOC2C1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
CRINETICS PHARMACEUTICALS, INC. US Patent					Assay Description On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...				US Patent US10696689 (2020) BindingDB Entry DOI: 10.7270/Q2FN197F
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM449010 (US10696689, Compound 3-7) Show SMILES Nc1ncc(-c2cc(F)cc(Cl)c2)c(N2CCC3NCCOC3C2)c1-c1nc2c(F)cc(F)cc2[nH]1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
CRINETICS PHARMACEUTICALS, INC. US Patent					Assay Description On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...				US Patent US10696689 (2020) BindingDB Entry DOI: 10.7270/Q2FN197F
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM449006 (US10696689, Compound 3-1) Show SMILES Cc1cc(F)cc(c1)-c1cnc(N)c(-c2nc3c(F)cc(F)cc3[nH]2)c1N1CCC2NCCOC2C1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
CRINETICS PHARMACEUTICALS, INC. US Patent					Assay Description On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...				US Patent US10696689 (2020) BindingDB Entry DOI: 10.7270/Q2FN197F
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM448916 (US10696689, Compound 1-1) Show SMILES COc1cc(cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CCC(N)CC1)C#N Show InChI InChI=1S/C26H26FN7O/c1-14-7-16(11-17(27)8-14)19-13-31-25(30)22(24(19)34-5-3-18(29)4-6-34)26-32-20-9-15(12-28)10-21(35-2)23(20)33-26/h7-11,13,18H,3-6,29H2,1-2H3,(H2,30,31)(H,32,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
CRINETICS PHARMACEUTICALS, INC. US Patent					Assay Description On the day of the assay, the media is aspirated and the cells are treated with 50 μL of 1.6 μM NKH477 (Sigma # N3290) plus various dilution...				US Patent US10696689 (2020) BindingDB Entry DOI: 10.7270/Q2FN197F
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM81767 (15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...) Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r| Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Institut Henri Beaufour Curated by ChEMBL					Assay Description Inhibition of forskolin-induced cAMP accumulation in CHO-K1 cells expressing human sst2 receptor				Bioorg Med Chem Lett 15: 3555-9 (2005) Article DOI: 10.1016/j.bmcl.2005.05.061 BindingDB Entry DOI: 10.7270/Q2W66MH6
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM527751 (US11186590, Compound 3-17) Show SMILES COc1cc(F)cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(F)cc(Cl)c2)c1N1CC[C@@H]2NCCO[C@H]2C1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
TBA					Assay Description Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human somatostatin receptor subtype 2 ar...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KHT
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM449019 (2-{4-[(4αS,8αS)-octahydro-1H-pyrido[3,4-...) Show SMILES COc1cc(cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CC[C@@H]2NCCO[C@H]2C1)C#N |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
TBA					Assay Description Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human somatostatin receptor subtype 2 ar...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KHT
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM527749 (US11186590, Compound 3-15) Show SMILES CNc1ncc(-c2cc(C)cc(F)c2)c(N2CC[C@@H]3NCCO[C@H]3C2)c1-c1nc2cc(F)cc(OC)c2[nH]1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
TBA					Assay Description Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human somatostatin receptor subtype 2 ar...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KHT
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM527748 (US11186590, Compound 3-14) Show SMILES COc1cc(F)cc2nc([nH]c12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CC[C@@H]2NCCO[C@H]2C1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
TBA					Assay Description Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human somatostatin receptor subtype 2 ar...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KHT
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM527737 (US11186590, Compound 3-1) Show SMILES Cc1cc(F)cc(c1)-c1cnc(N)c(-c2nc3cc(F)cc(F)c3[nH]2)c1N1CC[C@@H]2NCCO[C@H]2C1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
TBA					Assay Description Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human somatostatin receptor subtype 2 ar...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KHT
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM527741 (US11186590, Compound 3-7) Show SMILES Nc1ncc(-c2cc(F)cc(Cl)c2)c(N2CC[C@@H]3NCCO[C@H]3C2)c1-c1nc2cc(F)cc(F)c2[nH]1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
TBA					Assay Description Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human somatostatin receptor subtype 2 ar...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KHT
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM527742 (US11186590, Compound 3-8) Show SMILES COc1cc(F)cc(c1)-c1cnc(N)c(-c2nc3cc(F)cc(F)c3[nH]2)c1N1CC[C@@H]2NCCO[C@H]2C1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
TBA					Assay Description Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human somatostatin receptor subtype 2 ar...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KHT
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM527731 (US11186590, Compound 1-1) Show SMILES COc1cc(cc2nc([nH]c12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CCC(N)CC1)C#N Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<0.100	n/a	n/a	n/a	n/a
TBA					Assay Description Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human somatostatin receptor subtype 2 ar...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KHT
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578117 (CHEMBL4854548) Show SMILES Cn1ncc(C(=O)Nc2cncc(-c3cc(Cl)cc(Cl)c3)c2N2CCC(N)CC2)c1C(F)(F)F Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578116 (CHEMBL4862497) Show SMILES Cc1nn(C)cc1C(=O)Nc1cncc(-c2cc(Cl)cc(Cl)c2)c1N1CCC(N)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.120	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50405847 (CHEMBL5286005) Show SMILES CCN(CC)CC1CCC(CC1)C(=O)Oc1ccc2nc(sc2c1)S(N)(=O)=O |(3.47,-2.89,;3.51,-4.43,;4.85,-5.14,;6.17,-4.34,;6.14,-2.8,;4.91,-6.68,;3.59,-7.48,;3.62,-9.02,;2.32,-9.83,;.97,-9.11,;.91,-7.57,;2.22,-6.77,;-.34,-9.92,;-1.69,-9.18,;-.29,-11.46,;1.07,-12.2,;1.1,-13.74,;2.45,-14.45,;3.76,-13.64,;5.24,-14.08,;6.11,-12.81,;5.14,-11.59,;3.7,-12.1,;2.35,-11.4,;7.64,-12.8,;9.18,-12.8,;8.41,-14.12,;8.4,-11.46,)| Show InChI InChI=1S/C19H27N3O4S2/c1-3-22(4-2)12-13-5-7-14(8-6-13)18(23)26-15-9-10-16-17(11-15)27-19(21-16)28(20,24)25/h9-11,13-14H,3-8,12H2,1-2H3,(H2,20,24,25)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	n/a	n/a	0.120	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Dihydrofolate reductase in Escherichia coli				Citation and Details
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578114 (CHEMBL4862717) Show SMILES NC1CCN(CC1)c1c(NC(=O)c2cn3ccccc3n2)cncc1-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.140	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50405838 (CHEMBL5279239) Show SMILES CCCCCC(=O)Oc1ccc2nc(sc2c1)S(N)(=O)=O Show InChI InChI=1S/C13H16N2O4S2/c1-2-3-4-5-12(16)19-9-6-7-10-11(8-9)20-13(15-10)21(14,17)18/h6-8H,2-5H2,1H3,(H2,14,17,18)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	n/a	n/a	0.140	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Dihydrofolate reductase in Escherichia coli				Citation and Details
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50405839 (CHEMBL5283444) Show SMILES NS(=O)(=O)c1nc2ccc(OC(=O)CC3CCCC3)cc2s1 Show InChI InChI=1S/C14H16N2O4S2/c15-22(18,19)14-16-11-6-5-10(8-12(11)21-14)20-13(17)7-9-3-1-2-4-9/h5-6,8-9H,1-4,7H2,(H2,15,18,19)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	n/a	n/a	0.160	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Dihydrofolate reductase in rat liver				Citation and Details
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM405587 (US10351547, Compound 2-1 | US10597377, Compound 2-...) Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CCC(N)CC1)-c1cccc(C#N)c1O Show InChI InChI=1S/C28H25FN4O/c1-17-11-20(13-21(29)12-17)25-16-32-26-6-5-18(23-4-2-3-19(15-30)28(23)34)14-24(26)27(25)33-9-7-22(31)8-10-33/h2-6,11-14,16,22,34H,7-10,31H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	0.170	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Dihydrofolate reductase in rat liver				Citation and Details
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50405841 (CHEMBL5279994) Show SMILES Cn1cccc1C(=O)Oc1ccc2nc(sc2c1)S(N)(=O)=O Show InChI InChI=1S/C13H11N3O4S2/c1-16-6-2-3-10(16)12(17)20-8-4-5-9-11(7-8)21-13(15-9)22(14,18)19/h2-7H,1H3,(H2,14,18,19)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem		n/a	n/a	n/a	n/a	0.170	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Dihydrofolate reductase in rat liver				Citation and Details
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578113 (CHEMBL4854239) Show SMILES NC1CCN(CC1)c1c(NC(=O)c2ccccc2)cncc1-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.210	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM405588 (US10351547, Compound 2-2 | US10464918, Compound A ...) Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1 Show InChI InChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB	n/a	n/a	n/a	n/a	0.25	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Dihydrofolate reductase in Escherichia coli				Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50405842 (CHEMBL5273084) Show SMILES NS(=O)(=O)c1nc2cc(O)ccc2s1 Show InChI InChI=1S/C7H6N2O3S2/c8-14(11,12)7-9-5-3-4(10)1-2-6(5)13-7/h1-3,10H,(H2,8,11,12)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	n/a	n/a	0.310	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Dihydrofolate reductase in rat liver				Citation and Details
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM405596 (US10351547, Compound 2-10 | US10597377, Compound 2...) Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cc(F)cc(C#N)c1O)-c1cc(F)cc(F)c1 Show InChI InChI=1S/C27H21F3N4O/c28-18-7-16(8-19(29)11-18)24-14-33-25-2-1-15(22-12-20(30)9-17(13-31)27(22)35)10-23(25)26(24)34-5-3-21(32)4-6-34/h1-2,7-12,14,21,35H,3-6,32H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	0.340	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Dihydrofolate reductase in Escherichia coli				Citation and Details
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50546596 (CHEMBL4741372) Show SMILES CN(C[C@@H]1CCCN1)Cc1c(cnc2ncn(-c3cc(O)cc(c3)C(F)(F)F)c(=O)c12)-c1cc(C)cc(C)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.398	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SST2 expressed in CHOK1 cells assessed as inhibition of NKH477-stimulated intracellular cAMP levels				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127496 BindingDB Entry DOI: 10.7270/Q2183B4R
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50546596 (CHEMBL4741372) Show SMILES CN(C[C@@H]1CCCN1)Cc1c(cnc2ncn(-c3cc(O)cc(c3)C(F)(F)F)c(=O)c12)-c1cc(C)cc(C)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SST2 expressed in CHOK1 cells assessed as inhibition of NKH477-stimulated intracellular cAMP levels				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127496 BindingDB Entry DOI: 10.7270/Q2183B4R
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50578115 (CHEMBL4856293) Show SMILES Cc1nc(C(=O)Nc2cncc(-c3cc(Cl)cc(Cl)c3)c2N2CCC(N)CC2)c(C)o1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.470	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Glo...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116424 BindingDB Entry DOI: 10.7270/Q2CF9TXZ
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50546560 (CHEMBL4778342) Show SMILES CN(C[C@@H]1CCCN1)Cc1c(cnc2ncn(-c3cc(O)cc(F)c3)c(=O)c12)-c1cc(C)cc(Cl)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.501	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human SST2 expressed in CHOK1 cells assessed as inhibition of NKH477-stimulated intracellular cAMP levels				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127496 BindingDB Entry DOI: 10.7270/Q2183B4R
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM527740 (US11186590, Compound 3-6) Show SMILES CNc1ncc(-c2cc(F)cc(F)c2)c(N2CC[C@@H]3NCCO[C@H]3C2)c1-c1nc2cc(F)cc(F)c2[nH]1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.550	n/a	n/a	n/a	n/a
TBA					Assay Description Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human somatostatin receptor subtype 2 ar...				Citation and Details BindingDB Entry DOI: 10.7270/Q2S75KHT
					More data for this Ligand-Target Pair

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